Publication Information

{'id': 'https://openalex.org/W1577017898', 'doi': 'https://doi.org/10.4049/jimmunol.0801347', 'title': 'Cutting Edge: Phenotypic Characterization and Differentiation of Human CD8+ T Cells Producing IL-17', 'display_name': 'Cutting Edge: Phenotypic Characterization and Differentiation of Human CD8+ T Cells Producing IL-17', 'publication_year': 2009, 'publication_date': '2009-02-09', 'ids': {'openalex': 'https://openalex.org/W1577017898', 'doi': 'https://doi.org/10.4049/jimmunol.0801347', 'mag': '1577017898', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19201830'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0801347', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.4049/jimmunol.0801347', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072030694', 'display_name': 'Takaaki Kondo', 'orcid': 'https://orcid.org/0000-0002-3272-0841'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takaaki Kondo', 'raw_affiliation_strings': ['Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan;'], 'affiliations': [{'raw_affiliation_string': 'Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan;', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031545161', 'display_name': 'Hiroshi Takata', 'orcid': 'https://orcid.org/0000-0003-1457-6919'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Takata', 'raw_affiliation_strings': ['Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064499342', 'display_name': 'Fumichika Matsuki', 'orcid': 'https://orcid.org/0000-0002-2219-3160'}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fumichika Matsuki', 'raw_affiliation_strings': ['Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5078546233', 'display_name': 'Masafumi Takiguchi', 'orcid': 'https://orcid.org/0000-0002-8516-6442'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Masafumi Takiguchi', 'raw_affiliation_strings': ['Center for AIDS Research, International Research Center Aiming at the control of AIDS, International Collaborative Reseach Group for Life Science'], 'affiliations': [{'raw_affiliation_string': 'Center for AIDS Research, International Research Center Aiming at the control of AIDS, International Collaborative Reseach Group for Life Science', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.502, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 170, 'citation_normalized_percentile': {'value': 0.999915, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '182', 'issue': '4', 'first_page': '1794', 'last_page': '1798'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C148125776', 'wikidata': 'https://www.wikidata.org/wiki/Q1622348', 'display_name': 'CD28', 'level': 4, 'score': 0.7550367}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.66572404}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.57849187}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.5081053}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.46066183}, {'id': 'https://openalex.org/C129374314', 'wikidata': 'https://www.wikidata.org/wiki/Q909381', 'display_name': 'Interleukin 21', 'level': 4, 'score': 0.4321692}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.43164176}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.43142512}, {'id': 'https://openalex.org/C94205230', 'wikidata': 'https://www.wikidata.org/wiki/Q5005868', 'display_name': 'C-C chemokine receptor type 6', 'level': 5, 'score': 0.41880208}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41703174}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.36157718}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3313249}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.22054732}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.12844843}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1275363}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.10905036}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.09039402}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C12823836', 'wikidata': 'https://www.wikidata.org/wiki/Q24720618', 'display_name': 'Chemokine receptor', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D020381', 'descriptor_name': 'Interleukin-17', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004797', 'descriptor_name': 'Enzyme-Linked Immunosorbent Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020381', 'descriptor_name': 'Interleukin-17', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D020381', 'descriptor_name': 'Interleukin-17', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017493', 'descriptor_name': 'Leukocyte Common Antigens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017493', 'descriptor_name': 'Leukocyte Common Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017493', 'descriptor_name': 'Leukocyte Common Antigens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054399', 'descriptor_name': 'Receptors, CCR6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054399', 'descriptor_name': 'Receptors, CCR6', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D054399', 'descriptor_name': 'Receptors, CCR6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018127', 'descriptor_name': 'Tumor Necrosis Factor Receptor Superfamily, Member 7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018127', 'descriptor_name': 'Tumor Necrosis Factor Receptor Superfamily, Member 7', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018127', 'descriptor_name': 'Tumor Necrosis Factor Receptor Superfamily, Member 7', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0801347', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19201830', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0801347', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1912634928', 'https://openalex.org/W1924258068', 'https://openalex.org/W1964063928', 'https://openalex.org/W2012077729', 'https://openalex.org/W2012680181', 'https://openalex.org/W2027066826', 'https://openalex.org/W2053901884', 'https://openalex.org/W2058393233', 'https://openalex.org/W2060527543', 'https://openalex.org/W2085321949', 'https://openalex.org/W2106471879', 'https://openalex.org/W2107235439', 'https://openalex.org/W2123093300', 'https://openalex.org/W2126302947', 'https://openalex.org/W2131678280', 'https://openalex.org/W2136310945', 'https://openalex.org/W2141188376', 'https://openalex.org/W2155779547', 'https://openalex.org/W2157579285', 'https://openalex.org/W2158854771'], 'related_works': ['https://openalex.org/W2370976773', 'https://openalex.org/W2185606143', 'https://openalex.org/W2164750677', 'https://openalex.org/W2149296311', 'https://openalex.org/W2118370262', 'https://openalex.org/W2107242383', 'https://openalex.org/W2095259705', 'https://openalex.org/W2060451389', 'https://openalex.org/W2018916009', 'https://openalex.org/W1964440670'], 'abstract_inverted_index': {'Although': [0], 'IL-17-producing': [1], 'CD8(+)': [2, 46, 140], 'T': [3, 47, 141], 'cells': [4, 16, 38, 48, 70, 95, 99, 122], '(Tc17': [5], 'cells)': [6], 'have': [7, 123], 'recently': [8], 'been': [9], 'identified,': [10], 'the': [11, 28, 77, 89, 103, 111, 133], 'detailed': [12], 'information': [13], 'about': [14], 'these': [15, 98], 'still': [17], 'remains': [18], 'unclear.': [19], 'In': [20], 'this': [21], 'article': [22], 'we': [23], 'describe': [24], 'a': [25, 42, 62, 73, 124], 'study': [26], 'investigating': [27], 'phenotype': [29, 126], 'and': [30, 49, 61, 107, 113, 127], 'differentiation': [31], 'of': [32, 45, 65, 76, 88, 93], 'human': [33], 'Tc17': [34, 37, 69, 78, 94, 121], 'cells.': [35, 142], 'Human': [36], 'were': [39, 50, 100], 'detected': [40], 'in': [41, 53, 84, 90], 'minor': [43], 'population': [44, 80], 'predominantly': [51], 'found': [52], 'CD27(-/+)CD28(+)CD45RA(-)': [54], 'memory': [55], 'subsets.': [56], 'They': [57], 'also': [58], 'expressed': [59, 110], 'CCR6': [60], 'high': [63], 'level': [64], 'CCR5.': [66], 'Though': [67], 'most': [68], 'produced': [71], 'IFN-gamma,': [72], 'small': [74], 'part': [75], 'cell': [79], 'was': [81], 'IFN-gamma': [82], 'negative': [83], 'some': [85], 'individuals.': [86], 'Analysis': [87], 'vitro': [91], 'induction': [92], 'showed': [96], 'that': [97, 108, 120, 129, 136], 'induced': [101], 'from': [102, 132], 'CD27(+)CD28(+)CD45RA(+)': [104], 'naive': [105], 'subset': [106], 'they': [109, 130], 'CD27(-)CD28(+)CD45RA(-)': [112], 'CCR6(+)': [114], 'phenotype.': [115], 'These': [116], 'results': [117], 'together': [118], 'indicate': [119], 'unique': [125], 'suggest': [128], 'differentiate': [131, 137], 'same': [134], 'precursors': [135], 'into': [138], 'IFN-gamma-producing': [139]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1577017898', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-12-17T02:37:39.139036', 'created_date': '2016-06-24'}