Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1574143785', 'doi': 'https://doi.org/10.1016/s0021-9258(18)45497-x', 'title': 'Differential transcription of Xenopus oocyte and somatic-type 5 S genes in a Xenopus oocyte extract.', 'display_name': 'Differential transcription of Xenopus oocyte and somatic-type 5 S genes in a Xenopus oocyte extract.', 'publication_year': 1987, 'publication_date': '1987-12-01', 'ids': {'openalex': 'https://openalex.org/W1574143785', 'doi': 'https://doi.org/10.1016/s0021-9258(18)45497-x', 'mag': '1574143785', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2445754'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)45497-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0021-9258(18)45497-x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085316602', 'display_name': 'Larry Millstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210146328', 'display_name': 'Scripps Clinic', 'ror': 'https://ror.org/05kwjwj05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1311914864', 'https://openalex.org/I4210146328']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L Millstein', 'raw_affiliation_strings': ['Dept. of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.', 'institution_ids': ['https://openalex.org/I4210146328']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111473100', 'display_name': 'P Eversole-Cire', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210146328', 'display_name': 'Scripps Clinic', 'ror': 'https://ror.org/05kwjwj05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1311914864', 'https://openalex.org/I4210146328']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P Eversole-Cire', 'raw_affiliation_strings': ['Dept. of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.', 'institution_ids': ['https://openalex.org/I4210146328']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049066267', 'display_name': 'Jerónimo Blanco', 'orcid': 'https://orcid.org/0000-0003-3765-0640'}, 'institutions': [{'id': 'https://openalex.org/I4210146328', 'display_name': 'Scripps Clinic', 'ror': 'https://ror.org/05kwjwj05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1311914864', 'https://openalex.org/I4210146328']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J Blanco', 'raw_affiliation_strings': ['Dept. of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.', 'institution_ids': ['https://openalex.org/I4210146328']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060525515', 'display_name': 'Joel Gottesfeld', 'orcid': 'https://orcid.org/0000-0002-4643-5777'}, 'institutions': [{'id': 'https://openalex.org/I4210146328', 'display_name': 'Scripps Clinic', 'ror': 'https://ror.org/05kwjwj05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1311914864', 'https://openalex.org/I4210146328']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J M Gottesfeld', 'raw_affiliation_strings': ['Dept. of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.', 'institution_ids': ['https://openalex.org/I4210146328']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.708, 'has_fulltext': False, 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.586337, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '262', 'issue': '35', 'first_page': '17100', 'last_page': '17110'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11764', 'display_name': 'Evolution and Genetic Dynamics', 'score': 0.9687, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10432', 'display_name': 'DNA and Nucleic Acid Chemistry', 'score': 0.9663, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription', 'score': 0.46822828}], 'concepts': [{'id': 'https://openalex.org/C2779535977', 'wikidata': 'https://www.wikidata.org/wiki/Q1342298', 'display_name': 'Xenopus', 'level': 3, 'score': 0.9729301}, {'id': 'https://openalex.org/C2776690073', 'wikidata': 'https://www.wikidata.org/wiki/Q3246226', 'display_name': 'Oocyte', 'level': 3, 'score': 0.9104413}, {'id': 'https://openalex.org/C134305767', 'wikidata': 'https://www.wikidata.org/wiki/Q725508', 'display_name': 'Somatic cell', 'level': 3, 'score': 0.7434553}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.53619695}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.50082874}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.46822828}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45231503}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.349384}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.32371137}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.124484956}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)45497-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)45497-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1480337892', 'https://openalex.org/W1482729845', 'https://openalex.org/W1500663188', 'https://openalex.org/W1512918473', 'https://openalex.org/W1513717105', 'https://openalex.org/W1522226780', 'https://openalex.org/W1533383578', 'https://openalex.org/W1550569215', 'https://openalex.org/W1561042132', 'https://openalex.org/W1567391238', 'https://openalex.org/W1751409276', 'https://openalex.org/W1969001854', 'https://openalex.org/W1978660686', 'https://openalex.org/W1980424753', 'https://openalex.org/W1982233852', 'https://openalex.org/W1987501468', 'https://openalex.org/W1989080074', 'https://openalex.org/W1989377878', 'https://openalex.org/W2005107879', 'https://openalex.org/W2006624258', 'https://openalex.org/W2007490638', 'https://openalex.org/W2017522407', 'https://openalex.org/W2024651141', 'https://openalex.org/W2030628228', 'https://openalex.org/W2032410345', 'https://openalex.org/W2033466465', 'https://openalex.org/W2035627599', 'https://openalex.org/W2038597359', 'https://openalex.org/W2040562485', 'https://openalex.org/W2062379045', 'https://openalex.org/W2064377347', 'https://openalex.org/W2064865590', 'https://openalex.org/W2078039023', 'https://openalex.org/W2085889764', 'https://openalex.org/W2096628378', 'https://openalex.org/W2100837269', 'https://openalex.org/W2107332774', 'https://openalex.org/W2109011373', 'https://openalex.org/W2109448523', 'https://openalex.org/W2132679646', 'https://openalex.org/W2147355227', 'https://openalex.org/W2148828258', 'https://openalex.org/W2150438280', 'https://openalex.org/W2157108864', 'https://openalex.org/W2163960566', 'https://openalex.org/W2190230654', 'https://openalex.org/W4254341024', 'https://openalex.org/W82455627'], 'related_works': ['https://openalex.org/W4238500351', 'https://openalex.org/W2395802134', 'https://openalex.org/W2206057871', 'https://openalex.org/W2103940975', 'https://openalex.org/W2066157280', 'https://openalex.org/W2052062680', 'https://openalex.org/W1995549066', 'https://openalex.org/W1987501468', 'https://openalex.org/W1885440769', 'https://openalex.org/W1574143785'], 'abstract_inverted_index': {'We': [0, 38, 207], 'have': [1], 'measured': [2], 'the': [3, 75, 110, 124, 134, 139, 176, 184, 202, 212, 227, 234, 263], 'transcription': [4, 95, 112, 128, 143, 149, 161, 173, 245], 'of': [5, 21, 74, 86, 100, 113, 162, 244, 259, 262], 'Xenopus': [6, 60, 63, 264], 'laevis': [7, 24], 'oocyte': [8, 190], 'and': [9, 31, 62, 106, 123, 165, 186, 217, 229, 253], 'somatic-type': [10, 41, 76, 101], '5': [11, 42, 54, 77, 88, 93, 102, 140, 179, 197, 219, 265], 'S': [12, 43, 55, 78, 89, 94, 103, 141, 180, 198, 220, 266], 'RNA': [13, 120], 'genes': [14, 44, 65, 167, 249], 'in': [15, 175, 183, 201, 211], 'S-150': [16, 185, 213], 'extracts': [17], 'prepared': [18], 'from': [19], 'ovaries': [20], 'mature': [22], 'X.': [23], 'females': [25], '(Glikin,': [26], 'G.': [27], 'C.,': [28], 'Ruberti,': [29], 'I.,': [30], 'Worcel,': [32], 'A.': [33], '(1984)': [34], 'Cell': [35], '37,': [36], '33-41).': [37], 'find': [39], 'that': [40, 73, 119, 209], 'are': [45, 66, 130], 'transcribed': [46, 68, 194], 'at': [47, 69], 'least': [48], '40-fold': [49], 'more': [50], 'efficiently': [51], 'than': [52], 'oocyte-type': [53, 87, 196, 218], 'genes.': [56, 267], 'Since': [57], 'adenovirus': [58], 'VA,': [59], 'OAX,': [61], 'tRNAMet': [64], 'all': [67], 'levels': [70], 'similar': [71], 'to': [72], 'gene,': [79, 164], 'this': [80], 'difference': [81], 'reflects': [82], 'a': [83, 97, 255], 'low': [84], 'level': [85], 'gene': [90], 'transcription.': [91], 'Somatic-type': [92, 178], 'is': [96, 192, 205, 238], 'linear': [98], 'function': [99], 'DNA': [104, 181, 199], 'concentration': [105], 'this,': [107], 'together': [108], 'with': [109, 155], 'efficient': [111], 'other': [114], 'class': [115, 126], 'III': [116, 122, 127], 'genes,': [117, 221], 'suggests': [118], 'polymerase': [121], 'general': [125], 'factors': [129, 210, 246], 'not': [131, 147, 159, 239], 'limiting': [132], 'under': [133, 150, 172], 'conditions': [135, 152, 174], 'used': [136], 'here.': [137], 'Moreover,': [138], 'gene-specific': [142], 'factor': [144], 'TFIIIA': [145, 157, 170], 'does': [146, 158], 'limit': [148], 'these': [151, 248], 'as': [153, 250], 'preincubation': [154], 'purified': [156], 'alter': [160], 'either': [163], 'both': [166], 'exhibit': [168], 'characteristic': [169], 'footprints': [171], 'S-150.': [177], 'incubated': [182], 'then': [187], 'injected': [188], 'into': [189], 'nuclei': [191], 'actively': [193], 'whereas': [195], 'treated': [200], 'same': [203], 'manner': [204], 'inactive.': [206], 'conclude': [208], 'distinguish': [214], 'between': [215], 'somatic': [216], 'assembling': [222], 'active': [223], 'complexes': [224, 231], 'preferentially': [225, 232], 'on': [226, 233], 'former': [228], 'inactive': [230], 'latter.': [235], 'This': [236], 'process': [237], 'explained': [240], 'by': [241], 'binding': [242], 'properties': [243], 'for': [247], 'currently': [251], 'understood': [252], 'represents': [254], 'previously': [256], 'unrecognized': [257], 'mechanism': [258], 'transcriptional': [260], 'regulation': [261]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1574143785', 'counts_by_year': [], 'updated_date': '2024-12-08T04:15:15.654031', 'created_date': '2016-06-24'}