Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1573294096', 'doi': 'https://doi.org/10.1523/jneurosci.04-09-02213.1984', 'title': 'Kappa opioid receptors modulate cardiorespiratory function in hindbrain nuclei of rat', 'display_name': 'Kappa opioid receptors modulate cardiorespiratory function in hindbrain nuclei of rat', 'publication_year': 1984, 'publication_date': '1984-09-01', 'ids': {'openalex': 'https://openalex.org/W1573294096', 'doi': 'https://doi.org/10.1523/jneurosci.04-09-02213.1984', 'mag': '1573294096', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6148384', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6564800'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.04-09-02213.1984', 'pdf_url': 'http://www.jneurosci.org/content/jneuro/4/9/2213.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jneurosci.org/content/jneuro/4/9/2213.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089666580', 'display_name': 'A.M. Hassen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I148314036', 'display_name': 'Uniformed Services University of the Health Sciences', 'ror': 'https://ror.org/04r3kq386', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I148314036']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'AH Hassen', 'raw_affiliation_strings': ['Neurobiology Research Unit, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814'], 'affiliations': [{'raw_affiliation_string': 'Neurobiology Research Unit, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814', 'institution_ids': ['https://openalex.org/I148314036']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110028885', 'display_name': 'G Feuerstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I148314036', 'display_name': 'Uniformed Services University of the Health Sciences', 'ror': 'https://ror.org/04r3kq386', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I148314036']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G Feuerstein', 'raw_affiliation_strings': ['Neurobiology Research Unit, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814'], 'affiliations': [{'raw_affiliation_string': 'Neurobiology Research Unit, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814', 'institution_ids': ['https://openalex.org/I148314036']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109872282', 'display_name': 'AI Faden', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I148314036', 'display_name': 'Uniformed Services University of the Health Sciences', 'ror': 'https://ror.org/04r3kq386', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I148314036']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'AI Faden', 'raw_affiliation_strings': ['Neurobiology Research Unit, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814'], 'affiliations': [{'raw_affiliation_string': 'Neurobiology Research Unit, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814', 'institution_ids': ['https://openalex.org/I148314036']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.103, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 49, 'citation_normalized_percentile': {'value': 0.803084, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '4', 'issue': '9', 'first_page': '2213', 'last_page': '2221'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13047', 'display_name': 'Pharmacological Receptor Mechanisms and Effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13047', 'display_name': 'Pharmacological Receptor Mechanisms and Effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/respiratory-rate', 'display_name': 'Respiratory Rate', 'score': 0.42196396}], 'concepts': [{'id': 'https://openalex.org/C2778750930', 'wikidata': 'https://www.wikidata.org/wiki/Q4540629', 'display_name': '(+)-Naloxone', 'level': 4, 'score': 0.5588695}, {'id': 'https://openalex.org/C62525196', 'wikidata': 'https://www.wikidata.org/wiki/Q3311945', 'display_name': 'Microinjection', 'level': 2, 'score': 0.44556063}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.43747684}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4335608}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42917424}, {'id': 'https://openalex.org/C8213797', 'wikidata': 'https://www.wikidata.org/wiki/Q754250', 'display_name': 'Respiratory rate', 'level': 4, 'score': 0.42196396}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.37063974}, {'id': 'https://openalex.org/C2777953023', 'wikidata': 'https://www.wikidata.org/wiki/Q1073121', 'display_name': 'Heart rate', 'level': 3, 'score': 0.32167745}, {'id': 'https://openalex.org/C2781063702', 'wikidata': 'https://www.wikidata.org/wiki/Q427523', 'display_name': 'Opioid', 'level': 3, 'score': 0.29312027}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.18930554}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.1689077}], 'mesh': [{'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008526', 'descriptor_name': 'Medulla Oblongata', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D012143', 'descriptor_name': 'Respiratory Physiological Phenomena', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001575', 'descriptor_name': 'Benzomorphans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001575', 'descriptor_name': 'Benzomorphans', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004399', 'descriptor_name': 'Dynorphins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004399', 'descriptor_name': 'Dynorphins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006339', 'descriptor_name': 'Heart Rate', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006339', 'descriptor_name': 'Heart Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008526', 'descriptor_name': 'Medulla Oblongata', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008845', 'descriptor_name': 'Microinjections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011919', 'descriptor_name': 'Rats, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017473', 'descriptor_name': 'Receptors, Opioid, kappa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012119', 'descriptor_name': 'Respiration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012119', 'descriptor_name': 'Respiration', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012121', 'descriptor_name': 'Respiration, Artificial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013990', 'descriptor_name': 'Tidal Volume', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.04-09-02213.1984', 'pdf_url': 'http://www.jneurosci.org/content/jneuro/4/9/2213.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6564800', 'pdf_url': 'https://europepmc.org/articles/pmc6564800?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6564800', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6148384', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.04-09-02213.1984', 'pdf_url': 'http://www.jneurosci.org/content/jneuro/4/9/2213.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.4}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1870867636', 'https://openalex.org/W1952039887', 'https://openalex.org/W1983735311', 'https://openalex.org/W2018126125', 'https://openalex.org/W2025519089', 'https://openalex.org/W2032526893', 'https://openalex.org/W2054282995', 'https://openalex.org/W2056146741', 'https://openalex.org/W2071087516', 'https://openalex.org/W2087487352', 'https://openalex.org/W2088578487', 'https://openalex.org/W2258246535', 'https://openalex.org/W2332470175'], 'related_works': ['https://openalex.org/W3008946689', 'https://openalex.org/W2994721411', 'https://openalex.org/W2473584654', 'https://openalex.org/W2466293440', 'https://openalex.org/W2375807291', 'https://openalex.org/W2123587639', 'https://openalex.org/W2085668441', 'https://openalex.org/W2072438695', 'https://openalex.org/W2064703990', 'https://openalex.org/W1998234721'], 'abstract_inverted_index': {'The': [0, 166], 'respiratory': [1, 78, 124], 'and': [2, 21, 31, 65, 77, 95, 103, 116], 'cardiovascular': [3, 131, 203], 'effects': [4, 125], 'of': [5, 28, 57, 126, 138, 154, 168, 210, 219], 'selective': [6], 'kappa': [7], 'opioid': [8], 'agonists': [9], 'were': [10, 161, 205], 'compared': [11], 'following': [12, 69, 195, 207, 237, 248], 'microinjection': [13], '(0.1': [14], 'microliter)': [15], 'into': [16], 'the': [17, 22, 40, 97, 123, 243], 'nucleus': [18, 23], 'ambiguus': [19], '(NA)': [20], 'tractus': [24], 'solitarius': [25], '(NTS)': [26], 'regions': [27], 'spontaneously': [29, 37], 'breathing': [30, 38], 'artificially': [32], 'respired': [33], 'pentobarbital-anesthetized': [34], 'rats.': [35], 'In': [36, 133], 'animals,': [39, 135], 'benzomorphan': [41], 'derivative': [42], 'MRZ': [43, 84, 127, 139, 186], '2549': [44], '(MRZ,': [45], '3': [46], 'X': [47, 51, 86, 90, 107, 111, 143, 147, 179, 183, 188, 213, 224, 228], '10(-11)': [48], 'to': [49, 88, 109, 145, 181, 226], '16': [50, 89, 110, 146, 182], '10(-9)': [52, 91, 108, 112, 144, 148, 180, 184, 189, 214, 225, 229], 'mol)': [53, 92, 113, 149, 190, 215, 230], 'elicited': [54, 150, 191], 'dose-related': [55, 152], 'decreases': [56], 'mean': [58], 'arterial': [59], 'pressure': [60], '(MAP),': [61], 'heart': [62], 'rate': [63, 79], '(HR),': [64], 'tidal': [66], 'volume': [67], '(TV)': [68], 'NA': [70, 136, 238], 'injection;': [71], 'bremazocine': [72], '(BREM)': [73], 'decreased': [74, 114, 246], 'MAP,': [75], 'HR,': [76], '(RR).': [80], 'Following': [81], 'NTS': [82, 196, 208, 249], 'injection,': [83], '(3': [85, 106, 142, 178], '10(-10)': [87], 'lowered': [93, 232], 'MAP': [94, 115, 155, 233, 247], 'TV,': [96], 'highest': [98], 'dose': [99, 245], 'also': [100], 'lowering': [101], 'HR': [102, 236], 'RR;': [104], 'BREM': [105, 141, 169, 211], 'HR.': [117, 158], 'Naloxone': [118], '(200': [119], 'micrograms/kg,': [120], 'i.v.)': [121], 'reversed': [122, 163], 'without': [128, 156, 173, 234], 'consistently': [129], 'altering': [130, 157, 235], 'activity.': [132], 'ventilated': [134, 199, 241], 'injections': [137], 'or': [140, 216], 'a': [151, 192], 'decrease': [153], 'These': [159], 'responses': [160, 204], 'not': [162], 'by': [164], 'naloxone.': [165], 'stereoisomer': [167], '(+': [170], 'BREM)': [171], 'was': [172], 'effect': [174], 'at': [175], 'similar': [176], 'doses': [177, 218], 'mol).': [185], '(16': [187, 212], 'naloxone-reversible': [193], 'tachycardia': [194], 'injection': [197], 'in': [198, 240], 'animals;': [200, 242], 'no': [201], 'other': [202], 'observed': [206], 'administration': [209], 'lower': [217, 244], 'MRZ.': [220], 'Dynorphin': [221], '(1–13)': [222], '(6': [223], '60': [227], 'significantly': [231], 'microinjections': [239], 'injections.(ABSTRACT': [250], 'TRUNCATED': [251], 'AT': [252], '250': [253], 'WORDS)': [254]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1573294096', 'counts_by_year': [{'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-12-17T08:08:29.589424', 'created_date': '2016-06-24'}