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[98], 'Thermodynamics': [99], 'Kinetic': [101], 'Folding.': [102], '2.3': [103], 'Networks': [105], 'Silico': [108], 'Evolution': [109, 135], 'Molecules.': [111, 356], '2.4': [112], 'Designed': [113], 'Switches.': [117], '2.5': [118], 'Outlook': [119], 'Problems': [122], 'in': [123, 133, 495, 688, 734, 744, 782, 857, 875, 903], 'Design.': [125, 707], '3': [126], 'Fitness': [127], 'Landscapes,': [128], 'Error': [129, 154, 162], 'Thresholds,': [130], 'Cofactors': [132, 174], 'Aptamer': [134, 255, 459, 473, 812, 815, 833, 836, 850, 863, 908, 966], '(Adam': [136, 443], 'Kun,': [137], 'Marie-Christine': [138], 'Maurel,': [139], 'Mauro': [140], 'Santos,': [141], 'Eors': [143], 'Szathmary).': [144], '3.1': [145], '3.2': [147], 'Functionality': [148], 'Landscapes': [149], 'Inferred': [150, 156], 'Examples.': [152], '3.3': [153], 'Thresholds': [155], 'Landscapes:': [159], 'The': [160, 178, 251, 297, 476, 522, 906, 931, 942, 954, 956], 'Realistic': [161], 'Threshold': [163], 'Neurospora': [166], 'VS': [167], 'Ribozyme.': [168], '3.4': [169], 'Looking': [170], 'Catalytic': [172, 513, 523, 550], 'Partners:': [173], 'Aptamers.': [176, 615, 637, 779, 822, 828, 844, 848], '3.5': [177], 'Use': [179, 871], 'Coenzymes:': [181], 'World': [185, 189], 'Protein': [188, 336, 367, 383, 621], 'via': [190, 667], 'Translation': [191], 'Genetic': [194, 454], 'Code.': [195], '3.6': [196], 'Outlook.': [197, 530, 565, 714, 788], '2:': [199], 'Target-binding': [204], 'Oligonucleotides.': [205, 488], '4': [206], 'Aptamers': [207, 222, 226, 230, 235, 239, 244, 260, 274, 278, 282, 286, 290, 316, 334, 392, 420, 428, 465, 578, 595, 639, 695, 716, 731, 741, 752, 771, 793, 856, 948, 974], 'Small': [209], 'Molecules': [210, 536], '(Heiko': [211], 'Fickert,': [212], 'Iris': [213], 'G.': [214, 798], 'Fransson,': [215], 'Ulrich': [217], 'Hahn).': [218], '4.1': [219], '4.2': [221], 'Nucleotides/Nucleosides/Nucleobases.': [224], '4.3': [225], 'Cofactors.': [228], '4.4': [229], 'Amino': [232], 'Acids.': [233, 413, 432], '4.5': [234], 'Carbohydrates.': [237], '4.6': [238], 'Products.': [242], '4.7': [243], 'Organic': [246, 496], 'or': [247, 606], 'Fluorescent': [248], 'Dyes.': [249], '4.8': [250], 'Chimeric': [252], 'Approach': [253], '4.9': [257], '5': [259], 'Antibiotics': [262], '(Christina': [263], 'Lorenz': [264], 'Renee': [266], 'Schroeder).': [267], '5.1': [268], '5.2': [270], 'RNA-binding': [271], 'Antibiotics.': [272], '5.3': [273], 'Tetracyclines.': [276], '5.4': [277], 'Streptomycin.': [280], '5.5': [281], 'Aminoglycosides.': [284], '5.6': [285], 'Chloramphenicol.': [288], '5.7': [289], 'Peptide': [293, 298], 'Antibiotic': [294, 299], 'Viomycin.': [295], '5.7.1': [296], 'Viomycin': [300], 'as': [301, 335, 579, 596, 640, 653, 717, 732, 742], 'a': [302], 'Primordial': [303], 'Lead': [304, 698], 'Molecule.': [305], '5.8': [306], 'What': [307], 'Have': [308], 'We': [309], 'Learned': [310], 'Antibiotic-binding': [313], 'Aptamers?': [314], '6': [315], 'Proteins': [318, 359, 380], '(Shahid': [319], 'Nimjee,': [321], 'Christopher': [322], 'P.': [323, 916], 'Rusconi,': [324], 'Bruce': [326], 'A.': [327, 540], 'Sullenger).': [328], '6.1': [329], '6.2': [331], 'Properties': [332, 426, 790], 'Inhibitors.': [337], '6.3': [338], 'Cytokines/Growth': [339], 'Factors.': [340], '6.4': [341], 'Nucleic': [342, 394, 412, 431, 576, 613], 'Acid': [343, 395, 577, 614], 'Binding': [344, 816], 'Proteins.': [345], '6.5': [346], 'Serine': [347], 'Proteases.': [348], '6.6': [349], 'Antibodies/Immunoglobulins.': [350], '6.7': [351], 'Cell': [352], 'Surface': [353], 'Receptor/Cell': [354], 'Adhesion': [355], '6.8': [357], 'Complement': [358, 362], '-': [360, 368, 372, 381, 870, 977], 'Human': [361, 373, 928], 'C5.': [363], '6.9': [364], 'Extracellular': [365], 'Membrane': [366], 'Tenascin-C.': [369], '6.10': [370], 'Lipoproteins': [371], 'Non-pancreatic': [374], 'Secretory': [375], 'Phospholipase': [376], 'A2.': [377], '6.11': [378], 'Prion': [379, 382], 'PrP': [384], 'Sc': [385], '.': [386], '6.12': [387], 'Peptides.': [388], '6.13': [389], '7': [391], 'Structures': [396], '(Jean-Jacques': [397], 'Toulme,': [398], 'Fabien': [399], 'Darfeuille,': [400], 'Carmelo': [401], 'Di': [402], 'Primo,': [403], 'Eric': [405], 'Dausse).': [406], '7.1': [407], '7.2': [409], 'Targeting': [410, 923], 'Double-stranded': [411], '7.3': [414], 'Loop-Loop': [415], 'Interactions.': [416], '7.4': [417], 'Chemically': [418], 'Modified': [419], 'Recognizing': [421], 'Targets.': [423, 813], '7.5': [424], 'Biological': [425], 'Targeted': [429], '7.6': [433], '8': [435], 'Riboswitches:': [436], 'Metabolite-binding': [438], 'RNAs': [439], 'Controlling': [440], 'Gene': [441, 605], 'Expression': [442], 'Roth,': [444], 'Rdiger': [445], 'Welz,': [446], 'Ronald': [448], 'R.': [449], 'Breaker).': [450], '8.1': [451], '8.2': [453], 'Control': [455], 'Riboswitches.': [457, 462], '8.3': [458], 'Domains': [460], '8.4': [463], 'Specific': [466], 'Guanine': [468], 'Adenine.': [470], '8.5': [471], 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'Biosensors': [654], '(Scott': [655], 'Knudsen': [657], 'Andrew': [659], 'D.': [660, 801], 'Ellington).': [661], '13.1': [662], '13.2': [664], 'Creating': [665], 'Aptazymes': [666, 687], 'Rational': [668, 705], 'Design': [669], 'Methodologies.': [674], '13.3': [675], 'Effector': [676], 'Activation.': [677], '13.4': [678], 'Aptazyme': [679], 'Structural': [680], 'Diversity.': [683], '13.5': [684], 'Uses': [685], 'Biology': [689], 'Biotechnology.': [691], '14': [692], 'Conversion': [693], 'into': [696], 'Small-Molecule': [697], 'Compounds': [699], '(Andreas': [700], 'Jenne).': [701], '14.1': [702], '14.2': [704], '14.3': [708], '14.4': [711], '15': [715, 950], 'Ligands': [718, 733, 743], 'Affinity': [720, 735, 745], 'Chromatography': [721, 737], 'Capillary': [723, 746], 'Electrophoresis': [724], 'Applications': [725, 869, 902], '(Eric': [726], 'Peyrin).': [727], '15.1': [728], '15.2': [730], 'Liquid': [736], '(and': [738], 'Electrochromatography).': [739], '15.3': [740], 'Electrophoresis.': [747], '15.4': [748], 'Concluding': [749], 'Remarks.': [750], '16': [751], 'Imaging': [756], '(Sandra': [757], 'Borkowski': [758], 'Ludger': [760], 'Dinkelborg).': [762], '16.1': [763], 'Imaging:': [766], 'Modalities': [767], 'Requirements.': [769], '16.2': [770], 'Imaging.': [775, 786, 965], '16.3': [776], 'Labeling': [777], '16.4': [780], 'SPECT': [783], 'PET': [785], '16.5': [787], '17': [789], 'Therapeutic': [792, 855, 868, 933], '(Sharon': [794], 'T.': [795], 'Cload,': [796], 'Thomas': [797], 'McCauley,': [799], 'Anthony': [800, 915], 'Keefe,': [802], 'Judith': [803], 'Healy,': [805], 'Charles': [807], 'Wilson).': [808], '17.1': [809], '17.2': [811], '17.3': [814], 'Characteristics.': [817], '17.4': [818], 'Chemical': [819], 'Modification': [820], '17.5': [823], 'Routes': [824], 'Administration': [826], '17.6': [829], 'Opportunities': [830], 'Alternative': [832], 'Formulations.': [834], '17.7': [835], 'Pharmacokinetics': [837], 'Biodistribution.': [839], '17.8': [840], 'Toxicity': [841], 'Profile': [842], '17.9': [845], 'Immunogenicity': [846], '17.10': [849], 'Manufacture.': [851], '17.11': [852], 'Examples': [853], 'Development.': [858], '17.12': [859], 'Prospects': [861], 'Therapeutics.': [864, 967], '18': [865], 'Spiegelmers': [866], 'Chiral': [873], 'Principles': [874], 'Evolutionary': [876, 889, 896], 'Techniques': [878], '(Dirk': [879], 'Eulberg,': [880], 'Florian': [881], 'Jarosch,': [882], 'Stefan': [883], 'Vonhoff,': [884], 'Sven': [886], 'Klussmann).': [887], '18.1': [888], 'Techniques.': [891], '18.2': [892], 'Chirality.': [893], '18.3': [894], 'Mirror-Image': [895], 'Techniques:': [897], 'Selection-Reflection.': [898], '18.4': [899], '19': [901], 'Clinic:': [905], 'Anti-VEGF': [907], '(Tony': [909], 'Realini,': [910], 'Eugene': [911], 'W.M.': [912], 'Ng,': [913], 'Adamis).': [917], '19.1': [918], '19.2': [920], 'Rationale': [921], 'VEGF.': [924], '19.3': [925], 'VEGF': [926, 932, 936], 'Disease.': [929], '19.4': [930], 'Dilemma.': [934], '19.5': [935], 'Inhibition.': [937], '19.6': [938], 'Enter': [939], 'Macugen.': [940], '19.7': [941], 'Future.': [943], 'Epilogue': [944], 'Personal': [946], 'Perspecitve:': [947], 'after': [949], 'Years': [951], '(Larry': [952], 'Gold).': [953], 'Beginning.': [955], 'First': [957], 'Patent.': [958], 'NeXagen': [961], 'NeXstar.': [963], 'Diagnostic': [964], 'Aptamer-based': [968], 'Diagnostics': [969], 'at': [970], 'SomaLogic.': [971], 'Do': [972], 'Exist?': [975], 'Conclusions': [976], 'SELEX': [978], 'Discovery.': [982], 'Index.': [983]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1566430606', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 15}, 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