Publication Information

{'id': 'https://openalex.org/W1566391955', 'doi': 'https://doi.org/10.1080/10532528.2002.10559802', 'title': 'PDE-5 Inhibition and Sexual Response: Pharmacological Mechanisms and Clinical Outcomes', 'display_name': 'PDE-5 Inhibition and Sexual Response: Pharmacological Mechanisms and Clinical Outcomes', 'publication_year': 2002, 'publication_date': '2002-03-01', 'ids': {'openalex': 'https://openalex.org/W1566391955', 'doi': 'https://doi.org/10.1080/10532528.2002.10559802', 'mag': '1566391955', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12836729'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10532528.2002.10559802', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25405442', 'display_name': 'Annual Review of Sex Research', 'issn_l': '1053-2528', 'issn': ['1053-2528', '2168-3654'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310319847', 'host_organization_name': 'Routledge', 'host_organization_lineage': ['https://openalex.org/P4310319847'], 'host_organization_lineage_names': ['Routledge'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111522839', 'display_name': 'Raymond C. Rosen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802203029', 'display_name': 'Johnson University', 'ror': 'https://ror.org/04dpnfr42', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2802203029']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Raymond C. Rosen', 'raw_affiliation_strings': ['\rUMDNJ-Robert Wood Johnson Medical School, Department of Psychiatry \r, \rUSA'], 'affiliations': [{'raw_affiliation_string': '\rUMDNJ-Robert Wood Johnson Medical School, Department of Psychiatry \r, \rUSA', 'institution_ids': ['https://openalex.org/I2802203029']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057057606', 'display_name': 'Kevin E. McKenna', 'orcid': 'https://orcid.org/0009-0004-6145-9111'}, 'institutions': [{'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kevin E. McKenna', 'raw_affiliation_strings': ['\rNorthwestern University Medical School, Departments of Physiology and Urology \r, \rUSA'], 'affiliations': [{'raw_affiliation_string': '\rNorthwestern University Medical School, Departments of Physiology and Urology \r, \rUSA', 'institution_ids': ['https://openalex.org/I111979921']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.219, 'has_fulltext': False, 'cited_by_count': 79, 'citation_normalized_percentile': {'value': 0.876708, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '13', 'issue': '1', 'first_page': '36', 'last_page': '88'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10459', 'display_name': 'Sexual function and dysfunction studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10459', 'display_name': 'Sexual function and dysfunction studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9872, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12335', 'display_name': 'Sexuality, Behavior, and Technology', 'score': 0.9827, 'subfield': {'id': 'https://openalex.org/subfields/3203', 'display_name': 'Clinical Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vardenafil', 'display_name': 'Vardenafil', 'score': 0.9544609}, {'id': 'https://openalex.org/keywords/cyclic-guanosine-monophosphate', 'display_name': 'Cyclic guanosine monophosphate', 'score': 0.8337537}, {'id': 'https://openalex.org/keywords/premature-ejaculation', 'display_name': 'Premature ejaculation', 'score': 0.50149393}, {'id': 'https://openalex.org/keywords/sexual-stimulation', 'display_name': 'Sexual stimulation', 'score': 0.426874}], 'concepts': [{'id': 'https://openalex.org/C2776768464', 'wikidata': 'https://www.wikidata.org/wiki/Q191521', 'display_name': 'Sildenafil', 'level': 2, 'score': 0.96757853}, {'id': 'https://openalex.org/C2778822586', 'wikidata': 'https://www.wikidata.org/wiki/Q424161', 'display_name': 'Vardenafil', 'level': 4, 'score': 0.9544609}, {'id': 'https://openalex.org/C2780816001', 'wikidata': 'https://www.wikidata.org/wiki/Q424156', 'display_name': 'Tadalafil', 'level': 3, 'score': 0.93623644}, {'id': 'https://openalex.org/C2780994212', 'wikidata': 'https://www.wikidata.org/wiki/Q422511', 'display_name': 'Cyclic guanosine monophosphate', 'level': 3, 'score': 0.8337537}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.78599846}, {'id': 'https://openalex.org/C2779929075', 'wikidata': 'https://www.wikidata.org/wiki/Q184674', 'display_name': 'Erectile dysfunction', 'level': 2, 'score': 0.7378748}, {'id': 'https://openalex.org/C74534348', 'wikidata': 'https://www.wikidata.org/wiki/Q410798', 'display_name': 'cGMP-specific phosphodiesterase type 5', 'level': 3, 'score': 0.66772324}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.539173}, {'id': 'https://openalex.org/C2779892816', 'wikidata': 'https://www.wikidata.org/wiki/Q319312', 'display_name': 'Premature ejaculation', 'level': 2, 'score': 0.50149393}, {'id': 'https://openalex.org/C2776110084', 'wikidata': 'https://www.wikidata.org/wiki/Q3490562', 'display_name': 'Sexual stimulation', 'level': 2, 'score': 0.426874}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.40157366}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.12753108}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C11171543', 'wikidata': 'https://www.wikidata.org/wiki/Q41630', 'display_name': 'Psychoanalysis', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002243', 'descriptor_name': 'Carbolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007172', 'descriptor_name': 'Erectile Dysfunction', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010410', 'descriptor_name': 'Penile Erection', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010726', 'descriptor_name': 'Phosphodiesterase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D010726', 'descriptor_name': 'Phosphodiesterase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006152', 'descriptor_name': 'Cyclic GMP', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006152', 'descriptor_name': 'Cyclic GMP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007172', 'descriptor_name': 'Erectile Dysfunction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007172', 'descriptor_name': 'Erectile Dysfunction', 'qualifier_ui': 'Q000523', 'qualifier_name': 'psychology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009130', 'descriptor_name': 'Muscle, Smooth', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009130', 'descriptor_name': 'Muscle, Smooth', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010410', 'descriptor_name': 'Penile Erection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010726', 'descriptor_name': 'Phosphodiesterase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011687', 'descriptor_name': 'Purines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068677', 'descriptor_name': 'Sildenafil Citrate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013450', 'descriptor_name': 'Sulfones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068581', 'descriptor_name': 'Tadalafil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014227', 'descriptor_name': 'Triazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069058', 'descriptor_name': 'Vardenafil Dihydrochloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014665', 'descriptor_name': 'Vasodilator Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014665', 'descriptor_name': 'Vasodilator Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014665', 'descriptor_name': 'Vasodilator Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10532528.2002.10559802', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25405442', 'display_name': 'Annual Review of Sex Research', 'issn_l': '1053-2528', 'issn': ['1053-2528', '2168-3654'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310319847', 'host_organization_name': 'Routledge', 'host_organization_lineage': ['https://openalex.org/P4310319847'], 'host_organization_lineage_names': ['Routledge'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12836729', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.83, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 152, 'referenced_works': ['https://openalex.org/W1480732407', 'https://openalex.org/W1518811922', 'https://openalex.org/W1535533915', 'https://openalex.org/W154676168', 'https://openalex.org/W1551572547', 'https://openalex.org/W1558292706', 'https://openalex.org/W1596787745', 'https://openalex.org/W1597353303', 'https://openalex.org/W165225870', 'https://openalex.org/W174236887', 'https://openalex.org/W1855888973', 'https://openalex.org/W1928328877', 'https://openalex.org/W1966264960', 'https://openalex.org/W1970134738', 'https://openalex.org/W1971186748', 'https://openalex.org/W1971406218', 'https://openalex.org/W1971858313', 'https://openalex.org/W1974756485', 'https://openalex.org/W1975636012', 'https://openalex.org/W1976024273', 'https://openalex.org/W1976627705', 'https://openalex.org/W1976851726', 'https://openalex.org/W1981160225', 'https://openalex.org/W1982190405', 'https://openalex.org/W1984339345', 'https://openalex.org/W1984494359', 'https://openalex.org/W1991468702', 'https://openalex.org/W1992192228', 'https://openalex.org/W1994371282', 'https://openalex.org/W1995725983', 'https://openalex.org/W1995746404', 'https://openalex.org/W1996798982', 'https://openalex.org/W1998143238', 'https://openalex.org/W2001724263', 'https://openalex.org/W2002519594', 'https://openalex.org/W2002740692', 'https://openalex.org/W2004927473', 'https://openalex.org/W2006890104', 'https://openalex.org/W2009151010', 'https://openalex.org/W2010409808', 'https://openalex.org/W2014711248', 'https://openalex.org/W2016488409', 'https://openalex.org/W2016523306', 'https://openalex.org/W2019414944', 'https://openalex.org/W2020033114', 'https://openalex.org/W2024971368', 'https://openalex.org/W2027202120', 'https://openalex.org/W2029049173', 'https://openalex.org/W2033209259', 'https://openalex.org/W2033224815', 'https://openalex.org/W2034977824', 'https://openalex.org/W2038961111', 'https://openalex.org/W2041816586', 'https://openalex.org/W2044055093', 'https://openalex.org/W2044670482', 'https://openalex.org/W2045150258', 'https://openalex.org/W2046940559', 'https://openalex.org/W2049212547', 'https://openalex.org/W2049472065', 'https://openalex.org/W2050550352', 'https://openalex.org/W2050697795', 'https://openalex.org/W2052633895', 'https://openalex.org/W2054477341', 'https://openalex.org/W205590328', 'https://openalex.org/W2055915536', 'https://openalex.org/W2056350462', 'https://openalex.org/W2057179563', 'https://openalex.org/W2060171960', 'https://openalex.org/W2061914766', 'https://openalex.org/W2062907730', 'https://openalex.org/W2064160275', 'https://openalex.org/W2066341883', 'https://openalex.org/W2066691970', 'https://openalex.org/W2067814588', 'https://openalex.org/W2068913937', 'https://openalex.org/W2069897728', 'https://openalex.org/W2070486940', 'https://openalex.org/W2074646239', 'https://openalex.org/W2075065959', 'https://openalex.org/W2076357493', 'https://openalex.org/W2079630871', 'https://openalex.org/W2081043534', 'https://openalex.org/W2081192590', 'https://openalex.org/W2081313899', 'https://openalex.org/W2084631183', 'https://openalex.org/W2085095071', 'https://openalex.org/W2086240335', 'https://openalex.org/W2086890301', 'https://openalex.org/W2087687799', 'https://openalex.org/W2088440680', 'https://openalex.org/W2091520090', 'https://openalex.org/W2091768129', 'https://openalex.org/W2092243607', 'https://openalex.org/W2093201674', 'https://openalex.org/W2093852618', 'https://openalex.org/W2095282096', 'https://openalex.org/W2097091663', 'https://openalex.org/W2101186984', 'https://openalex.org/W2104389323', 'https://openalex.org/W2104432375', 'https://openalex.org/W2115742279', 'https://openalex.org/W2116394364', 'https://openalex.org/W2122818722', 'https://openalex.org/W2123293252', 'https://openalex.org/W2126172182', 'https://openalex.org/W2132823116', 'https://openalex.org/W2133586909', 'https://openalex.org/W2135433525', 'https://openalex.org/W2145394555', 'https://openalex.org/W2148004435', 'https://openalex.org/W2148499749', 'https://openalex.org/W2148551246', 'https://openalex.org/W2149199031', 'https://openalex.org/W2158596999', 'https://openalex.org/W2159368029', 'https://openalex.org/W2160186435', 'https://openalex.org/W2160843536', 'https://openalex.org/W2163771402', 'https://openalex.org/W2163917074', 'https://openalex.org/W2164189667', 'https://openalex.org/W2166389885', 'https://openalex.org/W2168038873', 'https://openalex.org/W22857079', 'https://openalex.org/W2297358297', 'https://openalex.org/W2312423425', 'https://openalex.org/W2312845168', 'https://openalex.org/W2314125128', 'https://openalex.org/W2318873158', 'https://openalex.org/W2327323427', 'https://openalex.org/W2328344459', 'https://openalex.org/W2332355610', 'https://openalex.org/W2338144962', 'https://openalex.org/W2404610942', 'https://openalex.org/W2406062456', 'https://openalex.org/W2473456356', 'https://openalex.org/W2478365786', 'https://openalex.org/W2604420502', 'https://openalex.org/W2936997974', 'https://openalex.org/W3023728595', 'https://openalex.org/W30651601', 'https://openalex.org/W3148052688', 'https://openalex.org/W32071369', 'https://openalex.org/W4246020463', 'https://openalex.org/W4249083504', 'https://openalex.org/W4298243721', 'https://openalex.org/W4302557902', 'https://openalex.org/W55666145', 'https://openalex.org/W599031189', 'https://openalex.org/W645526489', 'https://openalex.org/W71118622', 'https://openalex.org/W73681936', 'https://openalex.org/W83717282'], 'related_works': ['https://openalex.org/W3131933335', 'https://openalex.org/W2601322913', 'https://openalex.org/W2466143905', 'https://openalex.org/W2403883158', 'https://openalex.org/W2129396892', 'https://openalex.org/W2117041872', 'https://openalex.org/W2112789978', 'https://openalex.org/W2090709439', 'https://openalex.org/W2053047722', 'https://openalex.org/W1982339811'], 'abstract_inverted_index': {'Phosphodiesterase': [0], 'type-5': [1], '(PDE-5)': [2], 'inhibitors': [3, 260], 'are': [4, 173, 190, 247], 'a': [5, 51, 196, 215, 240], 'new': [6], 'class': [7, 64, 180], 'of': [8, 17, 23, 28, 70, 95, 100, 109, 129, 139, 153, 211, 218, 258, 264], 'vasoactive': [9], 'drugs': [10, 230], 'that': [11, 143], 'have': [12, 78, 133, 146, 185], 'been': [13, 79, 86, 134, 186], 'developed': [14, 187], 'for': [15, 68, 203], 'treatment': [16, 69, 94, 152, 263], 'erectile': [18], 'dysfunction': [19, 289], '(ED).': [20], 'The': [21, 112, 126, 137, 279], 'mechanism': [22], 'action': [24, 219], 'involves': [25], 'active': [26], 'inhibition': [27], 'the': [29, 45, 59, 93, 98, 105, 110, 151, 209, 255, 262], 'PDE-5': [30, 55, 198, 259], 'enzyme': [31], 'and': [32, 40, 53, 107, 123, 156, 164, 189, 226, 236, 268, 287], 'resulting': [33], 'increase': [34], 'in': [35, 44, 62, 92, 131, 150, 178, 208, 261, 275], 'cyclic': [36], 'guanosine': [37], 'monophosphate': [38], '(cGMP)': [39], 'smooth': [41], 'muscle': [42], 'relaxation': [43], 'penis.': [46], 'Sildenafil': [47, 84], 'citrate': [48], '(Viagra)': [49], 'is': [50, 58, 114, 195, 201, 223], 'potent': [52, 225], 'selective': [54, 227], 'inhibitor,': [56, 199], 'which': [57, 200], 'first': [60], 'drug': [61, 113], 'this': [63, 82, 179], 'to': [65, 88, 104, 171, 205, 220, 232, 244, 252, 272], 'be': [66, 89, 233, 273], 'approved': [67], 'ED.': [71], 'More': [72], 'than': [73], '10': [74], 'million': [75], 'men': [76], 'worldwide': [77], 'treated': [80], 'with': [81, 117, 239], 'drug.': [83], 'has': [85, 214], 'shown': [87], 'generally': [90, 234], 'effective': [91, 202], 'ED,': [96, 265], 'although': [97, 169], 'degree': [99], 'efficacy': [101], 'varies': [102], 'according': [103], 'etiology': [106], 'severity': [108], 'disorder.': [111], 'well': [115, 237], 'tolerated,': [116, 238], 'relatively': [118], 'few': [119], 'contraindications': [120], '(e.g.,': [121], 'nitrates)': [122], 'safety': [124], 'risks.': [125], 'cardiovascular': [127], 'effects': [128], 'sildenafil,': [130, 221], 'particular,': [132], 'extensively': [135], 'investigated.': [136], 'results': [138, 170], 'recent': [140], 'studies': [141, 251], 'suggest': [142], 'sildenafil': [144], 'may': [145], 'an': [147], 'additional': [148, 176], 'role': [149], 'other': [154], 'male': [155], 'female': [157, 165], 'sexual': [158, 166, 288], 'disorders,': [159], 'such': [160], 'as': [161], 'premature': [162], 'ejaculation': [163], 'arousal': [167], 'disorder,': [168], 'date': [172], 'inconclusive.': [174], 'Two': [175], 'agents': [177], '(tadalafil': [181], '[Cialis],': [182], 'vardenafil': [183], '[Levitra])': [184], 'recently': [188], 'under': [191], 'regulatory': [192], 'review.': [193], 'Tadalafil': [194], 'long-acting': [197], 'up': [204], '36': [206], 'hr': [207], 'majority': [210], 'men.': [212], 'Vardenafil': [213], 'similar': [216, 241], 'duration': [217], 'but': [222], 'more': [224], 'biochemically.': [228], 'Both': [229], 'appear': [231], 'safe': [235], 'side-effect': [242], 'profile': [243], 'sildenafil.': [245], 'There': [246], 'no': [248], 'controlled': [249], 'comparison': [250], 'date.': [253], 'Despite': [254], 'overall': [256], 'effectiveness': [257], 'significant': [266], 'psychological': [267], 'interpersonal': [269], 'issues': [270], 'need': [271], 'addressed': [274], 'their': [276], 'clinical': [277], 'use.': [278], 'potential': [280], 'impact': [281], 'on': [282], 'societal': [283], 'attitudes': [284], 'toward': [285], 'sexuality': [286], 'also': [290], 'warrants': [291], 'consideration.': [292]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1566391955', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-15T05:37:24.741374', 'created_date': '2016-06-24'}