Publication Information

{'id': 'https://openalex.org/W1565685840', 'doi': 'https://doi.org/10.1016/s0021-9258(18)43823-9', 'title': 'Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis.', 'display_name': 'Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis.', 'publication_year': 1994, 'publication_date': '1994-12-01', 'ids': {'openalex': 'https://openalex.org/W1565685840', 'doi': 'https://doi.org/10.1016/s0021-9258(18)43823-9', 'mag': '1565685840', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7982951'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)43823-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0021-9258(18)43823-9', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019023544', 'display_name': 'Michelle Guiton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'M Guiton', 'raw_affiliation_strings': ['Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom.', 'institution_ids': ['https://openalex.org/I36234482']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037000199', 'display_name': 'Frank J. Gunn‐Moore', 'orcid': 'https://orcid.org/0000-0003-3422-3387'}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'F J Gunn-Moore', 'raw_affiliation_strings': ['Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom.', 'institution_ids': ['https://openalex.org/I36234482']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045462148', 'display_name': 'Trevor N. Stitt', 'orcid': 'https://orcid.org/0000-0002-2614-0277'}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'T N Stitt', 'raw_affiliation_strings': ['Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom.', 'institution_ids': ['https://openalex.org/I36234482']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111766903', 'display_name': 'G.D. Yancopoulos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'G D Yancopoulos', 'raw_affiliation_strings': ['Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom.', 'institution_ids': ['https://openalex.org/I36234482']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038362347', 'display_name': 'Jeremy M. Tavaré', 'orcid': 'https://orcid.org/0000-0002-2034-9969'}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'J M Tavaré', 'raw_affiliation_strings': ['Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom.', 'institution_ids': ['https://openalex.org/I36234482']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 1.177, 'has_fulltext': False, 'cited_by_count': 51, 'citation_normalized_percentile': {'value': 0.811475, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '269', 'issue': '48', 'first_page': '30370', 'last_page': '30377'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11663', 'display_name': 'Viral Infectious Diseases and Gene Expression in Insects', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11663', 'display_name': 'Viral Infectious Diseases and Gene Expression in Insects', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9917, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/identification', 'display_name': 'Identification', 'score': 0.4502756}, {'id': 'https://openalex.org/keywords/site-directed-mutagenesis', 'display_name': 'Site-directed mutagenesis', 'score': 0.41425747}], 'concepts': [{'id': 'https://openalex.org/C97124661', 'wikidata': 'https://www.wikidata.org/wiki/Q14897782', 'display_name': 'Tropomyosin receptor kinase B', 'level': 4, 'score': 0.93803275}, {'id': 'https://openalex.org/C150109051', 'wikidata': 'https://www.wikidata.org/wiki/Q3630494', 'display_name': 'Autophosphorylation', 'level': 4, 'score': 0.9207835}, {'id': 'https://openalex.org/C79186569', 'wikidata': 'https://www.wikidata.org/wiki/Q14897880', 'display_name': 'Tropomyosin receptor kinase C', 'level': 5, 'score': 0.6557807}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.58395725}, {'id': 'https://openalex.org/C171034665', 'wikidata': 'https://www.wikidata.org/wiki/Q14897694', 'display_name': 'Tropomyosin receptor kinase A', 'level': 4, 'score': 0.519083}, {'id': 'https://openalex.org/C160539049', 'wikidata': 'https://www.wikidata.org/wiki/Q3064187', 'display_name': 'Neurotrophic factors', 'level': 3, 'score': 0.51353526}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.49783468}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46030405}, {'id': 'https://openalex.org/C116834253', 'wikidata': 'https://www.wikidata.org/wiki/Q2039217', 'display_name': 'Identification (biology)', 'level': 2, 'score': 0.4502756}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.43249428}, {'id': 'https://openalex.org/C103408237', 'wikidata': 'https://www.wikidata.org/wiki/Q2642668', 'display_name': 'Site-directed mutagenesis', 'level': 4, 'score': 0.41425747}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.39327782}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3758132}, {'id': 'https://openalex.org/C92020748', 'wikidata': 'https://www.wikidata.org/wiki/Q420457', 'display_name': 'Neurotrophin', 'level': 3, 'score': 0.32339913}, {'id': 'https://openalex.org/C180361614', 'wikidata': 'https://www.wikidata.org/wiki/Q7202242', 'display_name': 'Platelet-derived growth factor receptor', 'level': 4, 'score': 0.31387514}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30428714}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.29935437}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.28674898}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.1921654}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.1302608}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09948805}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)43823-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)43823-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land', 'score': 0.69}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W1493815818', 'https://openalex.org/W1505356419', 'https://openalex.org/W1510919372', 'https://openalex.org/W1524030768', 'https://openalex.org/W1528493806', 'https://openalex.org/W1537076792', 'https://openalex.org/W1541458650', 'https://openalex.org/W1548061249', 'https://openalex.org/W1553799143', 'https://openalex.org/W1555409791', 'https://openalex.org/W1568597946', 'https://openalex.org/W1572009433', 'https://openalex.org/W1572716768', 'https://openalex.org/W1602851982', 'https://openalex.org/W1605892702', 'https://openalex.org/W1616609814', 'https://openalex.org/W1624505911', 'https://openalex.org/W1632558799', 'https://openalex.org/W1778137154', 'https://openalex.org/W1827566752', 'https://openalex.org/W1857349425', 'https://openalex.org/W1885217342', 'https://openalex.org/W1892553999', 'https://openalex.org/W1925991305', 'https://openalex.org/W1973505460', 'https://openalex.org/W1973615656', 'https://openalex.org/W1983460534', 'https://openalex.org/W1987628941', 'https://openalex.org/W1992494265', 'https://openalex.org/W1992628345', 'https://openalex.org/W1994954884', 'https://openalex.org/W2004311501', 'https://openalex.org/W2007796735', 'https://openalex.org/W2014677270', 'https://openalex.org/W2016638288', 'https://openalex.org/W2019673113', 'https://openalex.org/W2020257412', 'https://openalex.org/W2030156849', 'https://openalex.org/W2039812926', 'https://openalex.org/W2053286013', 'https://openalex.org/W2053799953', 'https://openalex.org/W2058199689', 'https://openalex.org/W2061050597', 'https://openalex.org/W2067894097', 'https://openalex.org/W2087696642', 'https://openalex.org/W2088167128', 'https://openalex.org/W2089802627', 'https://openalex.org/W2092683047', 'https://openalex.org/W2131162128', 'https://openalex.org/W2157516468', 'https://openalex.org/W2237210219', 'https://openalex.org/W2429828313', 'https://openalex.org/W248614516', 'https://openalex.org/W74885494', 'https://openalex.org/W97763042'], 'related_works': ['https://openalex.org/W3202960261', 'https://openalex.org/W3198499435', 'https://openalex.org/W3026620415', 'https://openalex.org/W2166761266', 'https://openalex.org/W2136566388', 'https://openalex.org/W2123526306', 'https://openalex.org/W2103580807', 'https://openalex.org/W2041041031', 'https://openalex.org/W1997405480', 'https://openalex.org/W1527229950'], 'abstract_inverted_index': {'Brain-derived': [0], 'neurotrophic': [1], 'factor': [2], '(BDNF)': [3], 'interacts': [4], 'with': [5, 19, 63], 'the': [6, 11, 20, 29, 50, 134, 146, 149, 163, 249], 'TrkB': [7, 59, 61, 119, 167, 198], 'receptor': [8, 22, 52, 150], 'tyrosine': [9, 12, 68, 170, 226], 'kinase,': [10], 'kinase': [13], 'domain': [14], 'of': [15, 24, 31, 112, 145, 148, 165, 203, 239, 251], 'which': [16], 'has': [17], 'homology': [18], 'insulin': [21, 51], 'subfamily': [23], 'protein': [25], 'kinases.': [26], 'This': [27, 174], 'includes': [28], 'conservation': [30], 'three': [32], 'regulatory': [33], 'tyrosines': [34, 178, 186, 252], '(residues': [35], '670,': [36, 179], '674,': [37, 180], 'and': [38, 56, 60, 88, 97, 171, 181, 187, 227, 254], '675)': [39], 'known': [40], 'to': [41, 70, 151], 'play': [42], 'a': [43, 156, 200, 220, 235, 240, 245], 'crucial': [44], 'role': [45, 247], 'in': [46, 73, 107, 125, 138, 217, 256], 'signal': [47], 'transmission': [48], 'by': [49, 115, 259], '(tyrosines': [53], '1158,': [54], '1162,': [55], '1163).': [57], 'Wild-type': [58, 197], 'mutants': [62, 135], 'Y670F,': [64, 210], 'Y674F/Y675F,': [65, 207], 'Y751F': [66, 221], '(the': [67], 'reported': [69], 'be': [71], 'important': [72], 'phosphatidylinositol': [74], '3-kinase': [75], 'binding': [76, 101], '(Obermeier,': [77], 'A.,': [78], 'Lammers,': [79], 'R.,': [80], 'Wiesmuller,': [81], 'K.': [82], 'H.,': [83], 'June,': [84], 'G.,': [85], 'Schlessinger,': [86], 'J.,': [87], 'Ullrich,': [89], 'A.': [90], '(1993)': [91], 'J.': [92], 'Biol.': [93], 'Chem.': [94], '268,': [95], '22963-22966)),': [96], 'K540R': [98], '(consensus': [99], 'ATP': [100], 'lysine)': [102], 'substitutions': [103], 'were': [104, 122, 136, 193], 'transiently': [105], 'expressed': [106, 137], 'COS': [108, 218], 'cells': [109, 127, 142], 'for': [110, 143, 248], 'analysis': [111, 144], 'phosphorylation': [113, 120, 164, 175, 229, 250], 'sites': [114, 121, 232], 'two-dimensional': [116], 'phosphopeptide': [117], 'mapping.': [118], 'also': [123], 'studied': [124], 'MG86': [126], 'stably': [128], 'expressing': [129], 'wild-type': [130, 166, 260], 'TrkB.': [131, 261], 'In': [132], 'addition,': [133], 'Chinese': [139], 'hamster': [140], 'ovary': [141], 'ability': [147], 'mediate': [152], 'BDNF-stimulated': [153, 237], 'transcription': [154], 'from': [155], '12-O-tetradecanoylphorbol-13-acetate': [157], 'response': [158], 'element': [159], '(TRE).': [160], 'BDNF': [161], 'stimulated': [162], 'on': [168, 177], 'multiple': [169], 'serine': [172, 228], 'residues.': [173], 'occurred': [176], '675': [182, 255], 'plus': [183], 'two': [184, 190], 'other': [185], 'at': [188, 230], 'least': [189], 'serines': [191], 'that': [192], 'not': [194, 209], 'unequivocally': [195], 'identified.': [196], 'mediated': [199, 234], 'pronounced': [201], 'stimulation': [202], 'TRE-dependent': [204], 'transcription.': [205], 'A': [206], 'but': [208, 233], 'substitution': [211, 222], 'dramatically': [212, 224], 'inhibited': [213], 'this': [214], 'response.': [215], 'Surprisingly,': [216], 'cells,': [219], 'induced': [223], 'lower': [225], 'all': [231], 'normal': [236], 'activation': [238], 'TRE.': [241], 'Our': [242], 'results': [243], 'demonstrate': [244], 'critical': [246], '674': [253], 'BDNF-dependent': [257], 'signaling': [258]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1565685840', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2025-01-07T08:57:27.725476', 'created_date': '2016-06-24'}