Application of RNA Interference to Treat Conditions Associated with Dysregulation of Transient Receptor Potential Vanilloid 1 Channel

Name: Work Video:
Duration: 3 min 30 s
Vickram Ramkumar; Debashree Mukherjea; Sarvesh Jajoo; Tejbeer Kaur; Leonard P. Rybak
{'id': 'https://openalex.org/W156388281', 'doi': 'https://doi.org/10.1007/978-3-642-12168-5_9', 'title': 'Application of RNA Interference to Treat Conditions Associated with Dysregulation of Transient Receptor Potential Vanilloid 1 Channel', 'display_name': 'Application of RNA Interference to Treat Conditions Associated with Dysregulation of Transient Receptor Potential Vanilloid 1 Channel', 'publication_year': 2010, 'publication_date': '2010-01-01', 'ids': {'openalex': 'https://openalex.org/W156388281', 'doi': 'https://doi.org/10.1007/978-3-642-12168-5_9', 'mag': '156388281'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/978-3-642-12168-5_9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210196523', 'display_name': 'RNA technologies', 'issn_l': '2197-9731', 'issn': ['2197-9731', '2197-9758'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319972', 'host_organization_name': 'Springer International Publishing', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319972'], 'host_organization_lineage_names': ['Springer Nature', 'Springer International Publishing'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'book-chapter', 'type_crossref': 'book-chapter', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059572673', 'display_name': 'Vickram Ramkumar', 'orcid': 'https://orcid.org/0000-0001-6852-5303'}, 'institutions': [{'id': 'https://openalex.org/I196729704', 'display_name': 'Southern Illinois University School of Medicine', 'ror': 'https://ror.org/0232r4451', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196729704', 'https://openalex.org/I2801502357']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Vickram Ramkumar', 'raw_affiliation_strings': ['Department of Pharmacology, Southern Illinois University School of Medicine, 19629, Springfield, IL, 62794-9629, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Southern Illinois University School of Medicine, 19629, Springfield, IL, 62794-9629, USA', 'institution_ids': ['https://openalex.org/I196729704']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041281654', 'display_name': 'Debashree Mukherjea', 'orcid': 'https://orcid.org/0000-0001-5092-9860'}, 'institutions': [{'id': 'https://openalex.org/I196729704', 'display_name': 'Southern Illinois University School of Medicine', 'ror': 'https://ror.org/0232r4451', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196729704', 'https://openalex.org/I2801502357']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Debashree Mukherjea', 'raw_affiliation_strings': ['Department of Surgery, Southern Illinois University School of Medicine, 19629, Springfield, IL, 62794-9629, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, Southern Illinois University School of Medicine, 19629, Springfield, IL, 62794-9629, USA', 'institution_ids': ['https://openalex.org/I196729704']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018100467', 'display_name': 'Sarvesh Jajoo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196729704', 'display_name': 'Southern Illinois University School of Medicine', 'ror': 'https://ror.org/0232r4451', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196729704', 'https://openalex.org/I2801502357']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sarvesh Jajoo', 'raw_affiliation_strings': ['Department of Pharmacology, Southern Illinois University School of Medicine, 19629, Springfield, IL, 62794-9629, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Southern Illinois University School of Medicine, 19629, Springfield, IL, 62794-9629, USA', 'institution_ids': ['https://openalex.org/I196729704']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046030065', 'display_name': 'Tejbeer Kaur', 'orcid': 'https://orcid.org/0000-0003-3626-2670'}, 'institutions': [{'id': 'https://openalex.org/I196729704', 'display_name': 'Southern Illinois University School of Medicine', 'ror': 'https://ror.org/0232r4451', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196729704', 'https://openalex.org/I2801502357']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tejbeer Kaur', 'raw_affiliation_strings': ['Department of Pharmacology, Southern Illinois University School of Medicine, 19629, Springfield, IL, 62794-9629, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Southern Illinois University School of Medicine, 19629, Springfield, IL, 62794-9629, USA', 'institution_ids': ['https://openalex.org/I196729704']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052036878', 'display_name': 'Leonard P. Rybak', 'orcid': 'https://orcid.org/0000-0002-9365-5924'}, 'institutions': [{'id': 'https://openalex.org/I196729704', 'display_name': 'Southern Illinois University School of Medicine', 'ror': 'https://ror.org/0232r4451', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196729704', 'https://openalex.org/I2801502357']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Leonard P. Rybak', 'raw_affiliation_strings': ['Department of Surgery, Southern Illinois University School of Medicine, 19629, Springfield, IL, 62794-9629, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, Southern Illinois University School of Medicine, 19629, Springfield, IL, 62794-9629, USA', 'institution_ids': ['https://openalex.org/I196729704']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5059572673'], 'corresponding_institution_ids': ['https://openalex.org/I196729704'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 64}, 'biblio': {'volume': None, 'issue': None, 'first_page': '209', 'last_page': '226'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11204', 'display_name': 'Ion Channels and Receptors', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11204', 'display_name': 'Ion Channels and Receptors', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10196', 'display_name': 'Pain Mechanisms and Treatments', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/resiniferatoxin', 'display_name': 'Resiniferatoxin', 'score': 0.60346776}, {'id': 'https://openalex.org/keywords/capsazepine', 'display_name': 'Capsazepine', 'score': 0.5672311}, {'id': 'https://openalex.org/keywords/visceral-pain', 'display_name': 'Visceral pain', 'score': 0.5259552}, {'id': 'https://openalex.org/keywords/capsaicin', 'display_name': 'Capsaicin', 'score': 0.5144832}], 'concepts': [{'id': 'https://openalex.org/C160145004', 'wikidata': 'https://www.wikidata.org/wiki/Q413209', 'display_name': 'TRPV1', 'level': 4, 'score': 0.9574501}, {'id': 'https://openalex.org/C155164980', 'wikidata': 'https://www.wikidata.org/wiki/Q304043', 'display_name': 'Transient receptor potential channel', 'level': 3, 'score': 0.88574433}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.6270381}, {'id': 'https://openalex.org/C2776354303', 'wikidata': 'https://www.wikidata.org/wiki/Q3277888', 'display_name': 'Resiniferatoxin', 'level': 5, 'score': 0.60346776}, {'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.5799655}, {'id': 'https://openalex.org/C22615655', 'wikidata': 'https://www.wikidata.org/wiki/Q203221', 'display_name': 'Small interfering RNA', 'level': 4, 'score': 0.5795958}, {'id': 'https://openalex.org/C2780071552', 'wikidata': 'https://www.wikidata.org/wiki/Q5036336', 'display_name': 'Capsazepine', 'level': 5, 'score': 0.5672311}, {'id': 'https://openalex.org/C2779794527', 'wikidata': 'https://www.wikidata.org/wiki/Q4116360', 'display_name': 'Visceral pain', 'level': 4, 'score': 0.5259552}, {'id': 'https://openalex.org/C2780051329', 'wikidata': 'https://www.wikidata.org/wiki/Q273169', 'display_name': 'Capsaicin', 'level': 3, 'score': 0.5144832}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.4541641}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.43356663}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4322691}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39359057}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.34962165}, {'id': 'https://openalex.org/C15490471', 'wikidata': 'https://www.wikidata.org/wiki/Q2734305', 'display_name': 'Nociception', 'level': 3, 'score': 0.34843987}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.31879717}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.30662578}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2871406}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.1848428}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.15886381}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08554301}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.0851503}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/978-3-642-12168-5_9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210196523', 'display_name': 'RNA technologies', 'issn_l': '2197-9731', 'issn': ['2197-9731', '2197-9758'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319972', 'host_organization_name': 'Springer International Publishing', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319972'], 'host_organization_lineage_names': ['Springer Nature', 'Springer International Publishing'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.84, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 77, 'referenced_works': ['https://openalex.org/W1492591187', 'https://openalex.org/W1497394880', 'https://openalex.org/W1536798405', 'https://openalex.org/W1562645017', 'https://openalex.org/W1569255175', 'https://openalex.org/W1589228373', 'https://openalex.org/W183069189', 'https://openalex.org/W1964302331', 'https://openalex.org/W1965402438', 'https://openalex.org/W1984096754', 'https://openalex.org/W1988375390', 'https://openalex.org/W1991477055', 'https://openalex.org/W1999126601', 'https://openalex.org/W2001026574', 'https://openalex.org/W2004222535', 'https://openalex.org/W2007034094', 'https://openalex.org/W2011909645', 'https://openalex.org/W2012071423', 'https://openalex.org/W2014693947', 'https://openalex.org/W2019659882', 'https://openalex.org/W2020653824', 'https://openalex.org/W2023573955', 'https://openalex.org/W2024424546', 'https://openalex.org/W2024741520', 'https://openalex.org/W2026545561', 'https://openalex.org/W2026842778', 'https://openalex.org/W2027396764', 'https://openalex.org/W2029342741', 'https://openalex.org/W2031151714', 'https://openalex.org/W2033425777', 'https://openalex.org/W2035257142', 'https://openalex.org/W2040044089', 'https://openalex.org/W2041008378', 'https://openalex.org/W2042511912', 'https://openalex.org/W2050781058', 'https://openalex.org/W2051613742', 'https://openalex.org/W2051628180', 'https://openalex.org/W2056291238', 'https://openalex.org/W2059674658', 'https://openalex.org/W2063338540', 'https://openalex.org/W2065650184', 'https://openalex.org/W2065687666', 'https://openalex.org/W2067986789', 'https://openalex.org/W2071297569', 'https://openalex.org/W2075136399', 'https://openalex.org/W2075838219', 'https://openalex.org/W2077198344', 'https://openalex.org/W2077427556', 'https://openalex.org/W2078507813', 'https://openalex.org/W2079261707', 'https://openalex.org/W2079741969', 'https://openalex.org/W2080252996', 'https://openalex.org/W2084670585', 'https://openalex.org/W2091185281', 'https://openalex.org/W2092918915', 'https://openalex.org/W2094323845', 'https://openalex.org/W2095273084', 'https://openalex.org/W2100514946', 'https://openalex.org/W2104721296', 'https://openalex.org/W2110531566', 'https://openalex.org/W2118626190', 'https://openalex.org/W2118905516', 'https://openalex.org/W2122192823', 'https://openalex.org/W2122778205', 'https://openalex.org/W2127140021', 'https://openalex.org/W2130600650', 'https://openalex.org/W2134742719', 'https://openalex.org/W2139993130', 'https://openalex.org/W2152268495', 'https://openalex.org/W2161972691', 'https://openalex.org/W2162542519', 'https://openalex.org/W2188134002', 'https://openalex.org/W2231105911', 'https://openalex.org/W2408830807', 'https://openalex.org/W2410167918', 'https://openalex.org/W2418229467', 'https://openalex.org/W4250415733'], 'related_works': ['https://openalex.org/W2890882009', 'https://openalex.org/W2767735742', 'https://openalex.org/W2549249366', 'https://openalex.org/W231299636', 'https://openalex.org/W2137278164', 'https://openalex.org/W2078110538', 'https://openalex.org/W2026842778', 'https://openalex.org/W2022023122', 'https://openalex.org/W2011066025', 'https://openalex.org/W156388281'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W156388281', 'counts_by_year': [], 'updated_date': '2024-12-06T14:49:14.532932', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
