Abstract: The process of tooth development — or odontogenesis — is a complex series of reciprocal cellular interactions, by which teeth form from epithelial and mesenchymal cells in the stomatodeum. As tooth development progresses from the early bell stage to late bell stage of development, epithelial/mesenchymal interactions signal further histo-differentiation of the four cell layers of the enamel organ in preparation for amelogenesis. Amelogenesis begins with secretion of a partially mineralised enamel matrix by terminally differentiated ameloblasts. The secretory stage begins immediately after dentinogenesis at future cusp tips and following ameloblast differentiation. For root formation to begin, epithelial tissue is required to map out the shape of the tooth and initiate and mediate root odontoblast differentiation and subsequent dentine secretion. Enamel mineralisation occurs in a tissue-specific microenvironment. The size, morphology and stability of the formed crystals are determined by the degree of supersaturation of calcium and phosphate in the fluid phase.
Publication Year: 2013
Publication Date: 2013-11-30
Language: en
Type: other
Indexed In: ['crossref']
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Cited By Count: 1
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