Title: Prediction of residual/recurrent disease by HPV Genotype after loop excision procedure for high-grade cervical intraepithelial neoplasia with negative margins
Abstract: Australian and New Zealand Journal of Obstetrics and GynaecologyVolume 51, Issue 2 p. 114-118 Original Article Prediction of residual/recurrent disease by HPV Genotype after loop excision procedure for high-grade cervical intraepithelial neoplasia with negative margins Dongmei WU, Dongmei WU Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Fujian University of Traditional Chinese MedicineSearch for more papers by this authorYizhen ZHENG, Yizhen ZHENG Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Fujian University of Traditional Chinese MedicineSearch for more papers by this authorWei CHEN, Wei CHEN Department of Gynecology, Fujian Province Tumor Hospital, Fuzhou, ChinaSearch for more papers by this authorCiren GUO, Ciren GUO Department of Gynecology, Fujian Province Tumor Hospital, Fuzhou, ChinaSearch for more papers by this authorJiang YU, Jiang YU Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Fujian University of Traditional Chinese MedicineSearch for more papers by this authorGuilin CHEN, Guilin CHEN Department of Gynecology, Fujian Province Tumor Hospital, Fuzhou, ChinaSearch for more papers by this authorYanling HUANG, Yanling HUANG Department of Gynecology, Fujian Province Tumor Hospital, Fuzhou, ChinaSearch for more papers by this author Dongmei WU, Dongmei WU Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Fujian University of Traditional Chinese MedicineSearch for more papers by this authorYizhen ZHENG, Yizhen ZHENG Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Fujian University of Traditional Chinese MedicineSearch for more papers by this authorWei CHEN, Wei CHEN Department of Gynecology, Fujian Province Tumor Hospital, Fuzhou, ChinaSearch for more papers by this authorCiren GUO, Ciren GUO Department of Gynecology, Fujian Province Tumor Hospital, Fuzhou, ChinaSearch for more papers by this authorJiang YU, Jiang YU Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Fujian University of Traditional Chinese MedicineSearch for more papers by this authorGuilin CHEN, Guilin CHEN Department of Gynecology, Fujian Province Tumor Hospital, Fuzhou, ChinaSearch for more papers by this authorYanling HUANG, Yanling HUANG Department of Gynecology, Fujian Province Tumor Hospital, Fuzhou, ChinaSearch for more papers by this author First published: 31 January 2011 https://doi.org/10.1111/j.1479-828X.2010.01280.xCitations: 12 Dongmei Wu, Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, No.13 Hudongzhi Road, Fuzhou 350003, China.Email: [email protected] This work was supported by Natural Science Foundation of Fujian Province (2010J01182). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Aims: This study aims to evaluate whether the preconisation of high-risk human papillomavirus (HR-HPV) genotype and multiple HPV infection is predictive for residual/recurrent disease during the follow-up of high-grade cervical intraepithelial neoplasia (CIN) treated by loop electrosurgical excision procedure (LEEP) with negative margins. Methods: Two hundred and thirty-six women (mean age 37; range 20-61) with CIN2/3 treated by LEEP conisation with negative margins confirmed by pathology examination of the surgical specimen were included. The cervical cells for HPV genotype testing by the polymerase chain reaction (PCR) were collected before, and 6, 12, 24 months after treatment, respectively. HPV genotype and multiple HPV infection were evaluated as possible predictors of residual/recurrent disease. Results: Residual/recurrent disease was demonstrated by colposcopy-guided biopsy in 62 patients (26.3%) who underwent loop conisation with negative margins. Preoperative infection with either HPV16 (P = 0.007), HPV18 (P = 0.000), HPV33 (P = 0.001) or HPV45 (P = 0.019) was associated with higher rates of residual/recurrent lesions after conisation with negative margins. Preoperative infection with multiple HPV types was associated with the highest rate of residual/recurrent lesions compared with infection with single HPV type and HPV-negative cases (χ2 = 16.599, P < 0.001). Conclusions: Results demonstrate that the presence of HPV-16, 18, 33 and 45, as well as multiple HPV types pre-LEEP, is associated with higher rates of residual/recurrent disease after LEEP. Citing Literature Volume51, Issue2April 2011Pages 114-118 RelatedInformation
Publication Year: 2011
Publication Date: 2011-01-31
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 24
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot