Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1561751955', 'doi': 'https://doi.org/10.1016/s0021-9258(18)42741-x', 'title': 'Immunochemical detection of advanced glycosylation end products in vivo.', 'display_name': 'Immunochemical detection of advanced glycosylation end products in vivo.', 'publication_year': 1992, 'publication_date': '1992-03-01', 'ids': {'openalex': 'https://openalex.org/W1561751955', 'doi': 'https://doi.org/10.1016/s0021-9258(18)42741-x', 'mag': '1561751955', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1371995'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)42741-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0021-9258(18)42741-x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020525832', 'display_name': 'Zenji Makita', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Z Makita', 'raw_affiliation_strings': ['Laboratory of Medical Biochemistry, Rockefeller University, New York, New York 10021.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Medical Biochemistry, Rockefeller University, New York, New York 10021.', 'institution_ids': ['https://openalex.org/I83399316']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021790851', 'display_name': 'Helen Vlassara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'H Vlassara', 'raw_affiliation_strings': ['Laboratory of Medical Biochemistry, Rockefeller University, New York, New York 10021.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Medical Biochemistry, Rockefeller University, New York, New York 10021.', 'institution_ids': ['https://openalex.org/I83399316']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025863770', 'display_name': 'Anthony Cerami', 'orcid': 'https://orcid.org/0000-0002-7634-0955'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A Cerami', 'raw_affiliation_strings': ['Laboratory of Medical Biochemistry, Rockefeller University, New York, New York 10021.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Medical Biochemistry, Rockefeller University, New York, New York 10021.', 'institution_ids': ['https://openalex.org/I83399316']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108156383', 'display_name': 'Richard Bucala', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R Bucala', 'raw_affiliation_strings': ['Laboratory of Medical Biochemistry, Rockefeller University, New York, New York 10021.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Medical Biochemistry, Rockefeller University, New York, New York 10021.', 'institution_ids': ['https://openalex.org/I83399316']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 8.416, 'has_fulltext': False, 'cited_by_count': 496, 'citation_normalized_percentile': {'value': 0.999963, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '267', 'issue': '8', 'first_page': '5133', 'last_page': '5138'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation and Glycoproteins Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation and Glycoproteins Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11142', 'display_name': 'Advanced Glycation End Products research', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10835', 'display_name': 'Carbohydrate Chemistry and Synthesis', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2777313579', 'wikidata': 'https://www.wikidata.org/wiki/Q898365', 'display_name': 'Glycosylation', 'level': 2, 'score': 0.7598183}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.66936713}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6242058}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.49239314}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.25593382}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.12264037}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)42741-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)42741-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1483156553', 'https://openalex.org/W1515414814', 'https://openalex.org/W1527149838', 'https://openalex.org/W1556333628', 'https://openalex.org/W1557253076', 'https://openalex.org/W1577347418', 'https://openalex.org/W1609735481', 'https://openalex.org/W1637445535', 'https://openalex.org/W1676406316', 'https://openalex.org/W1964956691', 'https://openalex.org/W1975744247', 'https://openalex.org/W1976068063', 'https://openalex.org/W1979670728', 'https://openalex.org/W1980896336', 'https://openalex.org/W1983501542', 'https://openalex.org/W1984649628', 'https://openalex.org/W1985527057', 'https://openalex.org/W1992592000', 'https://openalex.org/W2016184962', 'https://openalex.org/W2023544998', 'https://openalex.org/W2029222146', 'https://openalex.org/W2032055976', 'https://openalex.org/W2032794311', 'https://openalex.org/W2049401036', 'https://openalex.org/W2051493401', 'https://openalex.org/W2058345849', 'https://openalex.org/W2077034296', 'https://openalex.org/W2080904568', 'https://openalex.org/W2090421214', 'https://openalex.org/W2117086217', 'https://openalex.org/W2128635872', 'https://openalex.org/W2155456675', 'https://openalex.org/W2323841763', 'https://openalex.org/W2335364913', 'https://openalex.org/W2337292567', 'https://openalex.org/W2419314875', 'https://openalex.org/W4293247451', 'https://openalex.org/W954287625'], 'related_works': ['https://openalex.org/W4387497383', 'https://openalex.org/W2948807893', 'https://openalex.org/W2899084033', 'https://openalex.org/W2778153218', 'https://openalex.org/W2748952813', 'https://openalex.org/W2607424097', 'https://openalex.org/W2606230654', 'https://openalex.org/W2398689458', 'https://openalex.org/W2319480705', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'Reducing': [0], 'sugars': [1, 199], 'react': [2], 'with': [3, 15, 100, 151, 157, 181, 200, 254], 'protein': [4], 'amino': [5], 'groups': [6], 'to': [7, 76, 88, 122, 173, 231, 235, 268], 'form': [8, 113, 169, 194], 'a': [9, 139, 175], 'diverse': [10, 149], 'group': [11], 'of': [12, 37, 55, 65, 79, 98, 110, 126, 138, 148, 198, 217, 252], 'protein-bound': [13], 'moieties': [14], 'fluorescent': [16], 'and': [17, 34, 43, 59, 119, 207], 'cross-linking': [18], 'properties.': [19], 'These': [20, 162, 238], 'compounds,': [21], 'called': [22], 'advanced': [23], 'glycosylation': [24], 'end': [25], 'products': [26], '(AGEs),': [27], 'have': [28, 49], 'been': [29, 50], 'implicated': [30], 'in': [31, 68, 82, 94, 114, 170, 184], 'the': [32, 53, 63, 77, 108, 136, 146, 187, 196, 218, 243, 250, 263], 'structural': [33], 'functional': [35], 'alterations': [36], 'proteins': [38, 150, 202, 255], 'that': [39, 165, 189, 242], 'occur': [40], 'during': [41], 'aging': [42], 'long-term': [44], 'diabetes.': [45], 'Although': [46], 'several': [47], 'AGEs': [48, 111, 127, 167, 182, 266], 'identified': [51], 'on': [52], 'basis': [54], 'de': [56], 'novo': [57], 'synthesis': [58], 'tissue': [60, 118, 166], 'isolation': [61], 'procedures,': [62], 'measurement': [64], 'AGE': [66, 80, 90, 141, 192, 245], 'compounds': [67], 'vivo': [69, 171], 'has': [70], 'remained': [71], 'difficult.': [72], 'As': [73], 'an': [74, 89], 'approach': [75], 'study': [78], 'formation': [81], 'vivo,': [83], 'we': [84], 'prepared': [85, 183], 'polyclonal': [86], 'antiserum': [87, 104], 'epitope(s)': [91, 142], 'which': [92, 112, 143, 168, 179, 247], 'forms': [93, 144, 248], 'vitro': [95], 'after': [96, 145], 'incubation': [97, 147, 197], 'glucose': [99, 158, 253], 'ribonuclease': [101], '(RNase).': [102], 'This': [103], 'proved': [105], 'suitable': [106], 'for': [107, 130, 233], 'detection': [109], 'vivo.': [115], 'Both': [116], 'diabetic': [117], 'serum': [120], 'known': [121, 219], 'contain': [123, 174], 'elevated': [124], 'levels': [125], 'readily': [128], 'competed': [129], 'antibody': [131], 'binding.': [132], 'Cross-reactivity': [133], 'studies': [134], 'revealed': [135], 'presence': [137], 'common': [140, 176], 'glucose.': [152], 'Cross-reactive': [153], 'epitopes': [154], 'also': [155], 'formed': [156], '6-phosphate': [159], 'or': [160, 227], 'fructose.': [161], 'data': [163, 239], 'suggest': [164, 241], 'appear': [172], 'immunological': [177], 'epitope': [178, 246], 'cross-reacts': [180], 'vitro,': [185], 'supporting': [186], 'concept': [188], 'immunologically': [190, 260], 'similar': [191], 'structures': [193], 'from': [195, 249, 262], 'different': [201], '(Horiuchi,': [203], 'S.,': [204], 'Araki,': [205], 'N.,': [206], 'Morino,': [208], 'Y.': [209], '(1991)': [210], 'J.': [211], 'Biol.': [212], 'Chem.': [213], '266,': [214], '7329-7332).': [215], 'None': [216], 'AGEs,': [220], 'such': [221], 'as': [222], '4-furanyl-2-furoyl-1H-imidazole,': [223], '1-alkyl-2-formyl-3,4-diglycosylpyrrole,': [224], 'pyrraline,': [225], 'carboxymethyllysine,': [226], 'pentosidine,': [228], 'were': [229], 'found': [230], 'compete': [232], 'binding': [234], 'anti-AGE': [236], 'antibody.': [237], 'further': [240], 'dominant': [244], 'reaction': [251], 'under': [256], 'native': [257], 'conditions': [258], 'is': [259], 'distinct': [261], 'structurally': [264], 'defined': [265], 'described': [267], 'date.': [269]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1561751955', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 17}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2025-01-07T08:57:12.765695', 'created_date': '2016-06-24'}