Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1558942866', 'doi': 'https://doi.org/10.1002/9780470513774.ch4', 'title': 'Turnover and Metabolism of Hyaluronan', 'display_name': 'Turnover and Metabolism of Hyaluronan', 'publication_year': 2007, 'publication_date': '2007-09-28', 'ids': {'openalex': 'https://openalex.org/W1558942866', 'doi': 'https://doi.org/10.1002/9780470513774.ch4', 'mag': '1558942866', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2680348'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/9780470513774.ch4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S9764341', 'display_name': 'Novartis Foundation symposium', 'issn_l': '1528-2511', 'issn': ['1528-2511', '1935-4657'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'other', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009812909', 'display_name': 'J. R. E. Fraser', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'J. R. E. Fraser', 'raw_affiliation_strings': ['Department of Medicine, University of Melbourne, Parkville Victoria, Australia.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Melbourne, Parkville Victoria, Australia.', 'institution_ids': ['https://openalex.org/I165779595']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109850253', 'display_name': 'Torvard C. Laurent', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123387679', 'display_name': 'Uppsala University', 'ror': 'https://ror.org/048a87296', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I123387679']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'T. C. Laurent', 'raw_affiliation_strings': ['Department of Medical & Physiological Chemistry, University of Uppsala, Biomedical Center, Box 575, S-751 23 Uppsala, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical & Physiological Chemistry, University of Uppsala, Biomedical Center, Box 575, S-751 23 Uppsala, Sweden', 'institution_ids': ['https://openalex.org/I123387679']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.551, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 206, 'citation_normalized_percentile': {'value': 0.99985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': None, 'issue': None, 'first_page': '41', 'last_page': '59'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11131', 'display_name': 'Proteoglycans and glycosaminoglycans research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11131', 'display_name': 'Proteoglycans and glycosaminoglycans research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10869', 'display_name': 'Polysaccharides and Plant Cell Walls', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation and Glycoproteins Research', 'score': 0.9828, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.6462651}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.50614756}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32300735}], 'mesh': [{'descriptor_ui': 'D006820', 'descriptor_name': 'Hyaluronic Acid', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001692', 'descriptor_name': 'Biological Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006820', 'descriptor_name': 'Hyaluronic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/9780470513774.ch4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S9764341', 'display_name': 'Novartis Foundation symposium', 'issn_l': '1528-2511', 'issn': ['1528-2511', '1935-4657'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2680348', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W102012657', 'https://openalex.org/W118641700', 'https://openalex.org/W142946895', 'https://openalex.org/W1519926076', 'https://openalex.org/W1522132599', 'https://openalex.org/W1539353994', 'https://openalex.org/W1551661793', 'https://openalex.org/W1580846545', 'https://openalex.org/W1955333425', 'https://openalex.org/W1964823749', 'https://openalex.org/W1975806311', 'https://openalex.org/W1983319906', 'https://openalex.org/W2000191410', 'https://openalex.org/W2000706326', 'https://openalex.org/W2010628683', 'https://openalex.org/W2038901925', 'https://openalex.org/W2059818859', 'https://openalex.org/W2068148601', 'https://openalex.org/W2069252600', 'https://openalex.org/W2069399203', 'https://openalex.org/W2071619399', 'https://openalex.org/W2077563248', 'https://openalex.org/W2085369940', 'https://openalex.org/W2100881010', 'https://openalex.org/W2129829062', 'https://openalex.org/W2143535754', 'https://openalex.org/W2170425634', 'https://openalex.org/W2321057107', 'https://openalex.org/W2342373299', 'https://openalex.org/W2402354042', 'https://openalex.org/W2414240029', 'https://openalex.org/W2415570212', 'https://openalex.org/W2419187403', 'https://openalex.org/W2483120689', 'https://openalex.org/W2883164299', 'https://openalex.org/W4247918759', 'https://openalex.org/W42810645', 'https://openalex.org/W4289962293', 'https://openalex.org/W77007549'], 'related_works': ['https://openalex.org/W4387497383', 'https://openalex.org/W2948807893', 'https://openalex.org/W2778153218', 'https://openalex.org/W2748952813', 'https://openalex.org/W2527526854', 'https://openalex.org/W2078814861', 'https://openalex.org/W2062208111', 'https://openalex.org/W1986764834', 'https://openalex.org/W1976181487', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'The': [0, 32, 224], 'highest': [1], 'concentrations': [2], 'of': [3, 41, 55, 121, 131, 145, 182, 201], 'hyaluronan': [4, 62, 146], 'occur': [5], 'in': [6, 27, 37, 47, 52, 87, 95, 111, 124, 158, 190, 207, 211, 237], 'synovial': [7], 'fluid,': [8], 'vitreous': [9], 'body,': [10], 'skin': [11, 42], 'and': [12, 20, 26, 30, 43, 136, 150, 185, 192, 210, 232], 'certain': [13], 'specialized': [14], 'tissues': [15, 89], 'such': [16], 'as': [17, 73, 75], 'umbilical': [18], 'cord': [19], 'rooster': [21], 'comb,': [22], 'during': [23], 'fetal': [24], 'development,': [25], 'tissue': [28], 'repair': [29], 'regeneration.': [31], 'largest': [33], 'amounts': [34], 'are': [35, 187], 'found': [36], 'the': [38, 48, 53, 84, 199, 217], 'intercellular': [39], 'matrix': [40], 'musculoskeletal': [44], 'tissues.': [45], 'Turnover': [46, 86], 'bloodstream': [49], 'is': [50, 63, 108, 138, 147, 169], 'normally': [51], 'range': [54], '0.3–1.0': [56], 'µg': [57], 'min−1/kg': [58], 'body': [59], 'weight.': [60], 'Circulating': [61], 'mostly': [64], 'derived': [65], 'from': [66, 77, 227], 'lymph.': [67], 'Lymph': [68], 'nodes': [69, 209], 'may': [70, 90, 175], 'nevertheless': [71], 'extract': [72], 'much': [74, 120], '80–90%': [76], 'peripheral': [78, 88], 'lymph': [79, 101, 193, 208], 'before': [80], 'it': [81, 122, 137], 'can': [82, 234], 'reach': [83], 'bloodstream.': [85], 'be': [91, 176, 235], 'effected': [92, 189], 'by': [93, 98, 102, 154, 195], 'degradation': [94, 144, 181], 'situ,': [96], 'or': [97, 104, 116, 134], 'transfer': [99], 'into': [100], 'diffusion': [103], 'hydrodynamic': [105], 'forces.': [106], 'Hyaluronan': [107], 'firmly': [109], 'bound': [110], 'specific': [112], 'association': [113], 'with': [114, 128, 160, 179, 216], 'cells': [115, 197, 214, 219], 'binding': [117], 'proteins': [118], 'but': [119], 'exists': [123], 'freely': [125], 'mobilized': [126], 'compartments': [127], 'a': [129, 155], 'half-life': [130], 'two': [132], 'days': [133], 'less,': [135], 'metabolized': [139], 'after': [140], 'transport': [141], 'elsewhere.': [142], 'Metabolic': [143], 'principally': [148], 'intracellular': [149], 'relies': [151], 'on': [152], 'uptake': [153], 'receptor': [156], 'which,': [157], 'contrast': [159], 'other': [161], 'hyaluronan-binding': [162], 'structures,': [163], 'also': [164, 220], 'binds': [165], 'chondroitin': [166], 'sulphate.': [167], 'It': [168], 'suggested': [170], 'that': [171, 206], 'this': [172], 'dual': [173], 'specificity': [174], 'primarily': [177, 188], 'associated': [178], 'metabolic': [180, 225], 'hyaluronan.': [183, 223], 'Uptake': [184], 'metabolism': [186], 'liver': [191], 'node': [194], 'endothelial': [196, 218], 'lining': [198], 'sinusoids': [200], 'each.': [202], 'Further': [203], 'studies': [204], 'indicate': [205], 'spleen,': [212], 'macrophage-like': [213], 'intertwined': [215], 'take': [221], 'up': [222], 'cycle': [226], 'polymer': [228], 'to': [229], 'monosaccharides,': [230], 'acetate': [231], 'beyond': [233], 'completed': [236], 'vivo': [238], 'within': [239], '10': [240], 'minutes.': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1558942866', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-17T11:24:19.588689', 'created_date': '2016-06-24'}