Title: Transplantation of activated macrophages overcomes central nervous system regrowth failure
Abstract: The FASEB JournalVolume 10, Issue 11 p. 1296-1302 Research Communications Transplantation of activated macrophages overcomes central nervous system regrowth failure Orly Lazarov-Spiegler, Corresponding Author Orly Lazarov-Spiegler n/[email protected] Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, IsraelTo whom correspondence and reprint requests should be addressed.Search for more papers by this authorArieh S. Solomon, Arieh S. Solomon Goldschleger Eye Research Institute, Tel Aviv University Sackler School of Medicine, Sheba Medical Center, Tel Hashomer, IsraelSearch for more papers by this authorAdi Ben Zeev-Brann, Adi Ben Zeev-Brann Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, IsraelSearch for more papers by this authorDavid L. Hirschberg, David L. Hirschberg Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, IsraelSearch for more papers by this authorVered Lavie, Vered Lavie Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, IsraelSearch for more papers by this authorMichal Schwartz, Corresponding Author Michal Schwartz n/[email protected] Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, IsraelTo whom correspondence and reprint requests should be addressed.Search for more papers by this author Orly Lazarov-Spiegler, Corresponding Author Orly Lazarov-Spiegler n/[email protected] Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, IsraelTo whom correspondence and reprint requests should be addressed.Search for more papers by this authorArieh S. Solomon, Arieh S. Solomon Goldschleger Eye Research Institute, Tel Aviv University Sackler School of Medicine, Sheba Medical Center, Tel Hashomer, IsraelSearch for more papers by this authorAdi Ben Zeev-Brann, Adi Ben Zeev-Brann Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, IsraelSearch for more papers by this authorDavid L. Hirschberg, David L. Hirschberg Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, IsraelSearch for more papers by this authorVered Lavie, Vered Lavie Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, IsraelSearch for more papers by this authorMichal Schwartz, Corresponding Author Michal Schwartz n/[email protected] Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, IsraelTo whom correspondence and reprint requests should be addressed.Search for more papers by this author First published: 01 September 1996 https://doi.org/10.1096/fasebj.10.11.8836043Citations: 203AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Macrophages have long been known to play a key role in the healing processes of tissues that regenerate after injury; however, the nature of their involvement in healing of the injured central nervous system (CNS) is still a subject of controversy. Here we show that the absence of regrowth in transected rat optic nerve (which, like all other CNS nerves in mammals, cannot regenerate after injury) can be overcome by local transplantation of macrophages preincubated ex vivo with segments of a nerve (e.g., sciatic nerve) that can regenerate after injury. The observed effect of the transplanted macrophages was found to be an outcome of their stimulated activity, as indicated by phagocytosis. Thus, macrophage phagocytic activity was stimulated by their preincu- bation with sciatic nerve segments but inhibited by their preincubation with optic nerve segments. We conclude that the inability of nerves of the mammal. ian CNS to regenerate is related to the failure of their macrophages recruited after injury to acquire growth-supportive activity. We attribute this failure to the presence of a CNS resident macrophage inhibitory activity, which may be the biochemical basis underlying the immune privilege of the CNS. The transplantation of suitably activated macrophages into injured nerves may overcome multiple malfunctioning aspects of the CNS response to trauma, and thus may be developed into a novel, practical, and multipotent therapy for CNS injuries.—Lazarov-Spiegler, O., Solomon, A. S., Ben Zeev-Brann, A., Hirschberg, D. L., Lavie, V., Schwartz, M. Transplantation of activated macrophages overcomes central nervous system regrowth failure. FASEB J. 10, 1296-1302 (1996) Citing Literature Volume10, Issue11September 1996Pages 1296-1302 RelatedInformation
Publication Year: 1996
Publication Date: 1996-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 279
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