Publication Information

{'id': 'https://openalex.org/W1555034521', 'doi': 'https://doi.org/10.1002/mds.26319', 'title': "L‐dopa increases <b>α</b>‐synuclein DNA methylation in Parkinson's disease patients <i>in vivo</i> and <i>in vitro</i>", 'display_name': "L‐dopa increases <b>α</b>‐synuclein DNA methylation in Parkinson's disease patients <i>in vivo</i> and <i>in vitro</i>", 'publication_year': 2015, 'publication_date': '2015-07-14', 'ids': {'openalex': 'https://openalex.org/W1555034521', 'doi': 'https://doi.org/10.1002/mds.26319', 'mag': '1555034521', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26173746'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/mds.26319', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S163027424', 'display_name': 'Movement Disorders', 'issn_l': '0885-3185', 'issn': ['0885-3185', '1531-8257'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103059156', 'display_name': 'Ina Schmitt', 'orcid': 'https://orcid.org/0009-0002-3418-8796'}, 'institutions': [{'id': 'https://openalex.org/I2801533059', 'display_name': 'German Center for Neurodegenerative Diseases', 'ror': 'https://ror.org/043j0f473', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I2801533059']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ina Schmitt', 'raw_affiliation_strings': ['Department of Neurology, UKB, Bonn, Germany', 'German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, UKB, Bonn, Germany', 'institution_ids': []}, {'raw_affiliation_string': 'German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany', 'institution_ids': ['https://openalex.org/I2801533059']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051976734', 'display_name': 'Oliver Kaut', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Oliver Kaut', 'raw_affiliation_strings': ['Department of Neurology, UKB, Bonn, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, UKB, Bonn, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077445371', 'display_name': 'Hassan Khazneh', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hassan Khazneh', 'raw_affiliation_strings': ['Department of Neurology, UKB, Bonn, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, UKB, Bonn, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082075600', 'display_name': 'Laura deBoni', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Laura deBoni', 'raw_affiliation_strings': ['Department of Neurology, UKB, Bonn, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, UKB, Bonn, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013955860', 'display_name': 'Ashar Ahmad', 'orcid': 'https://orcid.org/0000-0001-6417-4454'}, 'institutions': [{'id': 'https://openalex.org/I135140700', 'display_name': 'University of Bonn', 'ror': 'https://ror.org/041nas322', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I135140700']}, {'id': 'https://openalex.org/I4210164149', 'display_name': 'Bonn Aachen International Center for Information Technology', 'ror': 'https://ror.org/054zhq066', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I135140700', 'https://openalex.org/I155417937', 'https://openalex.org/I4210164149', 'https://openalex.org/I4923324']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ashar Ahmad', 'raw_affiliation_strings': ['Bonn-Aachen International Center for IT, University of Bonn, Germany'], 'affiliations': [{'raw_affiliation_string': 'Bonn-Aachen International Center for IT, University of Bonn, Germany', 'institution_ids': ['https://openalex.org/I135140700', 'https://openalex.org/I4210164149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001790127', 'display_name': 'Daniela Berg', 'orcid': 'https://orcid.org/0000-0001-5796-5442'}, 'institutions': [{'id': 'https://openalex.org/I2801533059', 'display_name': 'German Center for Neurodegenerative Diseases', 'ror': 'https://ror.org/043j0f473', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I2801533059']}, {'id': 'https://openalex.org/I4210141865', 'display_name': 'Hertie Institute for Clinical Brain Research', 'ror': 'https://ror.org/04zzwzx41', 'country_code': 'DE', 'type': 'other', 'lineage': ['https://openalex.org/I4210141865', 'https://openalex.org/I8087733']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Daniela Berg', 'raw_affiliation_strings': ['Department of Neurodegeneration Hertie Institute for Clinical Brain Research Tübingen Germany', 'German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany'], 'affiliations': [{'raw_affiliation_string': 'German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany', 'institution_ids': ['https://openalex.org/I2801533059']}, {'raw_affiliation_string': 'Department of Neurodegeneration Hertie Institute for Clinical Brain Research Tübingen Germany', 'institution_ids': ['https://openalex.org/I4210141865']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024773860', 'display_name': 'Christine Klein', 'orcid': 'https://orcid.org/0000-0003-2102-3431'}, 'institutions': [{'id': 'https://openalex.org/I9341345', 'display_name': 'University of Lübeck', 'ror': 'https://ror.org/00t3r8h32', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I9341345']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christine Klein', 'raw_affiliation_strings': ['Institute of Neurogenetics, University of Lübeck Lübeck Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Neurogenetics, University of Lübeck Lübeck Germany', 'institution_ids': ['https://openalex.org/I9341345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054001409', 'display_name': 'Holger Fröhlich', 'orcid': 'https://orcid.org/0000-0002-5328-1243'}, 'institutions': [{'id': 'https://openalex.org/I4210164149', 'display_name': 'Bonn Aachen International Center for Information Technology', 'ror': 'https://ror.org/054zhq066', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I135140700', 'https://openalex.org/I155417937', 'https://openalex.org/I4210164149', 'https://openalex.org/I4923324']}, {'id': 'https://openalex.org/I135140700', 'display_name': 'University of Bonn', 'ror': 'https://ror.org/041nas322', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I135140700']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Holger Fröhlich', 'raw_affiliation_strings': ['Bonn-Aachen International Center for IT, University of Bonn, Germany'], 'affiliations': [{'raw_affiliation_string': 'Bonn-Aachen International Center for IT, University of Bonn, Germany', 'institution_ids': ['https://openalex.org/I4210164149', 'https://openalex.org/I135140700']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074359060', 'display_name': 'Ullrich Wüllner', 'orcid': 'https://orcid.org/0000-0002-3132-0790'}, 'institutions': [{'id': 'https://openalex.org/I2801533059', 'display_name': 'German Center for Neurodegenerative Diseases', 'ror': 'https://ror.org/043j0f473', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I2801533059']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Ullrich Wüllner', 'raw_affiliation_strings': ['Department of Neurology, UKB, Bonn, Germany', 'German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, UKB, Bonn, Germany', 'institution_ids': []}, {'raw_affiliation_string': 'German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany', 'institution_ids': ['https://openalex.org/I2801533059']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5074359060'], 'corresponding_institution_ids': ['https://openalex.org/I2801533059'], 'apc_list': {'value': 4070, 'currency': 'USD', 'value_usd': 4070, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 6.093, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 89, 'citation_normalized_percentile': {'value': 0.999912, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '30', 'issue': '13', 'first_page': '1794', 'last_page': '1801'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10106', 'display_name': 'Autism Spectrum Disorder Research', 'score': 0.9656, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.7356268}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.7060129}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.6958675}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.4547895}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.4540823}, {'id': 'https://openalex.org/C2777427615', 'wikidata': 'https://www.wikidata.org/wiki/Q954257', 'display_name': 'Degenerative disease', 'level': 3, 'score': 0.43174073}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4143746}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.41117668}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34329078}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.33715388}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32415348}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.3227284}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.32115346}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.24625018}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.18116626}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.12856647}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.060547292}], 'mesh': [{'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D015259', 'descriptor_name': 'Dopamine Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007980', 'descriptor_name': 'Levodopa', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000367', 'descriptor_name': 'Age Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018899', 'descriptor_name': 'CpG Islands', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018899', 'descriptor_name': 'CpG Islands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018899', 'descriptor_name': 'CpG Islands', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015259', 'descriptor_name': 'Dopamine Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015259', 'descriptor_name': 'Dopamine Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007980', 'descriptor_name': 'Levodopa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007980', 'descriptor_name': 'Levodopa', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D008214', 'descriptor_name': 'Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008214', 'descriptor_name': 'Lymphocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012372', 'descriptor_name': 'ROC Curve', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012044', 'descriptor_name': 'Regression Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012737', 'descriptor_name': 'Sex Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/mds.26319', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S163027424', 'display_name': 'Movement Disorders', 'issn_l': '0885-3185', 'issn': ['0885-3185', '1531-8257'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26173746', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.4}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1620767969', 'https://openalex.org/W1974473791', 'https://openalex.org/W1985034219', 'https://openalex.org/W1985444222', 'https://openalex.org/W1988803985', 'https://openalex.org/W1997992120', 'https://openalex.org/W2006435194', 'https://openalex.org/W2009573330', 'https://openalex.org/W2017040646', 'https://openalex.org/W2041078258', 'https://openalex.org/W2048505369', 'https://openalex.org/W2052159570', 'https://openalex.org/W2062626153', 'https://openalex.org/W2064330668', 'https://openalex.org/W2065498897', 'https://openalex.org/W2078250483', 'https://openalex.org/W2089920521', 'https://openalex.org/W2117347068', 'https://openalex.org/W2121091193', 'https://openalex.org/W2121346405', 'https://openalex.org/W2122118508', 'https://openalex.org/W2123431154', 'https://openalex.org/W2132310402', 'https://openalex.org/W2134886133', 'https://openalex.org/W2142286857', 'https://openalex.org/W2154028719', 'https://openalex.org/W2156909104', 'https://openalex.org/W2170654934'], 'related_works': ['https://openalex.org/W2902329290', 'https://openalex.org/W2221018455', 'https://openalex.org/W2151182744', 'https://openalex.org/W2107880877', 'https://openalex.org/W2054863651', 'https://openalex.org/W2052355316', 'https://openalex.org/W2046964473', 'https://openalex.org/W2024490794', 'https://openalex.org/W1998349112', 'https://openalex.org/W1981953400'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'Increasing': [2], 'gene': [3, 22, 28], 'dosages': [4], 'of': [5, 21, 50, 59, 74, 120, 146, 167, 172, 190, 206, 208, 218], 'α‐synuclein': [6, 27, 51, 80, 147, 191, 219], 'induce': [7], 'familial': [8], "Parkinson's": [9], 'disease': [10, 160], '(PD);': [11], 'thus,': [12], 'the': [13, 72, 104, 165, 179], 'hypothesis': [14], 'has': [15], 'been': [16], 'put': [17], 'forward': [18], 'that': [19], 'regulation': [20], 'expression,': [23], 'in': [24, 53, 69, 84, 92, 103, 131, 150, 192, 199], 'particular': [25], 'altered': [26], 'methylation,': [29], 'might': [30], 'be': [31, 38], 'associated': [32], 'with': [33, 97, 117, 135, 227], 'sporadic': [34, 61, 93, 115, 132, 193], 'PD': [35, 62, 94, 116, 133, 194], 'and': [36, 64, 68, 82, 100, 123, 140, 164, 237, 243], 'could': [37], 'used': [39], 'as': [40], 'a': [41, 47, 101, 118, 232], 'biological': [42], 'marker.': [43], 'Methods': [44], 'We': [45], 'performed': [46], 'thorough': [48], 'analysis': [49, 217], 'methylation': [52, 81, 110, 128, 145, 156, 220], 'bisulfite‐treated': [54], 'DNA': [55], 'from': [56, 114], 'peripheral': [57], 'blood': [58, 196], '490': [60], 'patients': [63, 134], '485': [65], 'healthy': [66, 112], 'controls': [67], 'addition': [70], 'analyzed': [71, 105], 'effect': [73, 207], 'levodopa': [75], '(': [76], 'l': [77, 137, 141, 173, 209], '‐dopa)': [78], 'on': [79, 159], 'expression': [83], 'cultured': [85, 151], 'mononuclear': [86, 152], 'cells.': [87, 153], 'Results': [88], 'α‐Synuclein': [89, 109, 127, 155], 'was': [90, 129, 175, 202, 212], 'hypomethylated': [91], 'patients,': [95], 'correlated': [96], 'sex,': [98, 162], 'age,': [99, 163], 'polymorphism': [102], 'sequence': [106], 'stretch': [107], '(rs3756063).': [108], 'separated': [111], 'individuals': [113, 226], 'specificity': [119], '74%': [121], '(male)': [122], '78%': [124], '(female),': [125], 'respectively.': [126], 'increased': [130], 'higher': [136], '‐dopa': [138, 142, 174], 'dosage,': [139], 'specifically': [143], 'induced': [144], 'intron': [148], '1': [149], 'Conclusions': [154], 'levels': [157], 'depended': [158], 'status,': [161], 'genotype': [166], 'rs3756063.': [168], 'The': [169, 188, 216], 'pharmacological': [170], 'action': [171], 'not': [176, 213], 'limited': [177], 'to': [178, 223], 'dopamine': [180], 'precursor': [181], 'function': [182], 'but': [183], 'included': [184], 'epigenetic': [185], 'off‐target': [186], 'effects.': [187], 'hypomethylation': [189], "patients'": [195], 'already': [197], 'observed': [198], 'previous': [200], 'studies': [201], 'probably': [203], 'underestimated': [204], 'because': [205], '‐dopa,': [210], 'which': [211, 230], 'known': [214], 'previously.': [215], 'can': [221], 'help': [222], 'identify': [224], 'nonparkinsonian': [225], 'reasonable': [228], 'specificity,': [229], 'offers': [231], 'valuable': [233], 'tool': [234], 'for': [235], 'researchers': [236], 'clinicians.': [238], '©': [239], '2015': [240], 'International': [241], 'Parkinson': [242], 'Movement': [244], 'Disorder': [245], 'Society': [246]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1555034521', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2025-01-09T20:15:54.554057', 'created_date': '2016-06-24'}