Title: Functional Significance of Cranial Neural Crest Cells During Tooth Development and Regeneration
Abstract: Teeth are complex organs that develop through a series of interactions between the dental epithelium and neural crest-derived mesenchyme of the early mammalian embryo. Studies of the molecular regulation of tooth patterning and morphogenesis in the last two decades have demonstrated the involvement of major gene families that are used reiteratively during tooth development. Here, we specifically review the developmental mechanisms and molecular basis underlying tooth shape (type of tooth), tooth number, and number of rows, as well as the generation of successional dentitions, with a focus on the contribution of the cranial neural crest-derived mesenchyme. In addition, we discuss the fate of neural crest-derived mesenchymal cells during tooth formation and the presence of mesenchymal stem cells in the adult tooth.
Publication Year: 2013
Publication Date: 2013-11-26
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 2
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