Title: Concerted Regulation of Gonad Differentiation by Transcription Factors and Growth Factors
Abstract: Concerted Regulation of Gonad Differentiation by Transcription Factors and Growth Factors Taiga Suzuki, Taiga Suzuki Department of Developmental Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444-8585, Japan Institute for Virus Research, Kyoto University, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8397, JapanSearch for more papers by this authorHirofumi Mizusaki, Hirofumi Mizusaki Department of Developmental Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444-8585, JapanSearch for more papers by this authorKen Kawabe, Ken Kawabe Department of Developmental Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444-8585, Japan Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Higashi-ku, Fukuoka 812-8582, JapanSearch for more papers by this authorMegumi Kasahara, Megumi Kasahara Department of Natural Sciences, Hyogo University of Teacher Education, Yashiro-cho, Katoh-gun 673-1494, JapanSearch for more papers by this authorHidefumi Yoshioka, Hidefumi Yoshioka Department of Natural Sciences, Hyogo University of Teacher Education, Yashiro-cho, Katoh-gun 673-1494, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology, JapanSearch for more papers by this authorKen-Ichirou Morohashi, Corresponding Author Ken-Ichirou Morohashi Department of Developmental Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444-8585, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology, JapanDepartment of Developmental Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444-8585, JapanSearch for more papers by this author Taiga Suzuki, Taiga Suzuki Department of Developmental Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444-8585, Japan Institute for Virus Research, Kyoto University, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8397, JapanSearch for more papers by this authorHirofumi Mizusaki, Hirofumi Mizusaki Department of Developmental Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444-8585, JapanSearch for more papers by this authorKen Kawabe, Ken Kawabe Department of Developmental Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444-8585, Japan Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Higashi-ku, Fukuoka 812-8582, JapanSearch for more papers by this authorMegumi Kasahara, Megumi Kasahara Department of Natural Sciences, Hyogo University of Teacher Education, Yashiro-cho, Katoh-gun 673-1494, JapanSearch for more papers by this authorHidefumi Yoshioka, Hidefumi Yoshioka Department of Natural Sciences, Hyogo University of Teacher Education, Yashiro-cho, Katoh-gun 673-1494, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology, JapanSearch for more papers by this authorKen-Ichirou Morohashi, Corresponding Author Ken-Ichirou Morohashi Department of Developmental Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444-8585, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology, JapanDepartment of Developmental Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444-8585, JapanSearch for more papers by this author Book Editor(s):Derek Chadwick, Derek Chadwick OrganizerSearch for more papers by this authorJamie Goode, Jamie GoodeSearch for more papers by this author First published: 21 March 2002 https://doi.org/10.1002/0470868732.ch7Citations: 3Book Series:Novartis Foundation Symposia Series Editor(s): Novartis Foundation, Novartis FoundationSearch for more papers by this author AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Summary It is well known that signals from growth factors regulate gene transcription thus initiating certain steps of cellular and tissue differentiation during development. In gonad differentiation several transcription factors have been identified as the genes underlying human diseases displaying gonadal defects and as the genes necessary for gonad differentiation as demonstrated by gene disruption studies. In addition, one of the growth factors, WNT4, is known to be involved in gonadal differentiation. However, it remains unclear which gene is directly downstream of the WNT4 signal. We have recently demonstrated that Dax1 (NR0B1) gene transcription is significantly up-regulated by the presence of SF1 (NR5A1). Functional analysis showed that DAX1 acts as a repressor against SF1 through direct interaction between the repeated sequences at the N-terminus of DAX1 and a ligand-binding domain of SF1. Considering that the expressions of these factors during gonad differentiation show a sexually dimorphic pattern, it is likely that the Dax1 gene transcription is up-regulated by WNT4 signal and thereafter DAX1 suppresses the genes downstream of SF1 such as Amh and steroidogenic genes in female gonads. Citing Literature The Genetics and Biology of Sex Determination: Novartis Foundation Symposium 244, Volume 244 RelatedInformation
Publication Year: 2002
Publication Date: 2002-03-21
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 11
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