Title: A novel mutation of the leptin gene in an Indian patient
Abstract: Clinical GeneticsVolume 86, Issue 4 p. 391-393 LETTER TO THE EDITOR A novel mutation of the leptin gene in an Indian patient S. Thakur, Corresponding Author S. Thakur Department of Genetics and Fetal Medicine, Fortis La Femme GKII, New Delhi, India Correspondence: Dr Seema Thakur Department of Genetics and Fetal Medicine Fortis La Femme GKII S-549, GK II New Delhi, 110048 India Tel.: +91 11 40579400 Fax: 91-11-41436103 e-mail: [email protected]Search for more papers by this authorA. Kumar, A. Kumar Department of Paediatrics, Fortis Hospital, Delhi, IndiaSearch for more papers by this authorS. Dubey, S. Dubey Department of Medical Genetics, Sir Ganga Ram Hospital, Delhi, IndiaSearch for more papers by this authorR. Saxena, R. Saxena Department of Medical Genetics, Sir Ganga Ram Hospital, Delhi, IndiaSearch for more papers by this authorA.N.C. Peters, A.N.C. Peters Department of Bariatric Surgery, Fortis Hospital, Delhi, IndiaSearch for more papers by this authorA. Singhal, A. Singhal Department of Medical Genetics, Sir Ganga Ram Hospital, Delhi, IndiaSearch for more papers by this author S. Thakur, Corresponding Author S. Thakur Department of Genetics and Fetal Medicine, Fortis La Femme GKII, New Delhi, India Correspondence: Dr Seema Thakur Department of Genetics and Fetal Medicine Fortis La Femme GKII S-549, GK II New Delhi, 110048 India Tel.: +91 11 40579400 Fax: 91-11-41436103 e-mail: [email protected]Search for more papers by this authorA. Kumar, A. Kumar Department of Paediatrics, Fortis Hospital, Delhi, IndiaSearch for more papers by this authorS. Dubey, S. Dubey Department of Medical Genetics, Sir Ganga Ram Hospital, Delhi, IndiaSearch for more papers by this authorR. Saxena, R. Saxena Department of Medical Genetics, Sir Ganga Ram Hospital, Delhi, IndiaSearch for more papers by this authorA.N.C. Peters, A.N.C. Peters Department of Bariatric Surgery, Fortis Hospital, Delhi, IndiaSearch for more papers by this authorA. Singhal, A. Singhal Department of Medical Genetics, Sir Ganga Ram Hospital, Delhi, IndiaSearch for more papers by this author First published: 05 December 2013 https://doi.org/10.1111/cge.12289Citations: 26Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Montague CT, Farooqi IS, Whitehead JP et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997: 387: 903–908. 2Saeed S, Butt TA, Anwer M, Arslan M, Froguel P. High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families. Mol Genet Metab 2012: 106: 121–126. 3Gibson WT, Farooqi IS, Moreau M et al. Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. J Clin Endocrinol Metab 2004: 89: 4821–4826. 4Fatima W, Shahid A, Imran M et al. Leptin deficiency and leptin gene mutations in obese children from Pakistan. Int J Obes 2011: 6: 419–427. 5Paz-Filho GJ, Babikian T, Asarnow R et al. Leptin replacement improves cognitive development. PLoS ONE 2008: 3: e3098. 6Mazen I, El-Gammal M, Abdel-Hamid M, Amr K. A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient. Mol Genet Metab 2009: 97: 305–308. 7Fischer-Posovszky P, von Schnurbein J, Moepps B et al. A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. J Clin Endocrinol Metab 2010: 95: 2836–2840. Citing Literature Volume86, Issue4October 2014Pages 391-393 ReferencesRelatedInformation
Publication Year: 2013
Publication Date: 2013-12-05
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 34
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