Title: Induction of oocyte maturation in starfish by 1-methyladenosine
Abstract: Both 1-methyladenine and 1-methyladenosine initiate ovulation and oocyte maturation when added to starfish gonads in vitro. When the two substances are added to isolated oocytes separated from the ovarian wall tissues, however, only 1-methyladenine is capable of stimulating oocyte maturation. Incubation of isolated ovarian wall tissue or homogenates with 1-methyladenosine renders the incubation mixture capable of stimulating oocyte maturation. Heating and proteolytic digestion destroys the capacity of ovarian wall homogenates to convert 1-methyladenosine to an active material. These data suggest that there are rather stringent molecular structural requirements within the oocyte for the induction of oocyte maturation. There appears to be an enzyme contained in the ovarian wall tissues (none oocyte) that is capable of converting 1-methyladenosine from an active to an inactive state. It is suggested that this is probably a ribonucleosidase, which cleaves the ribose from the 1-methyladenosine.
Publication Year: 1971
Publication Date: 1971-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 33
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