Publication Information

{'id': 'https://openalex.org/W1545911557', 'doi': 'https://doi.org/10.18632/oncotarget.3443', 'title': 'Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel', 'display_name': 'Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel', 'publication_year': 2015, 'publication_date': '2015-01-31', 'ids': {'openalex': 'https://openalex.org/W1545911557', 'doi': 'https://doi.org/10.18632/oncotarget.3443', 'mag': '1545911557', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25788267', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4467444'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3443', 'pdf_url': 'https://www.oncotarget.com/article/3443/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/3443/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100599742', 'display_name': 'Jong Hyun Lee', 'orcid': 'https://orcid.org/0000-0003-1046-897X'}, 'institutions': [{'id': 'https://openalex.org/I35928602', 'display_name': 'Kyung Hee University', 'ror': 'https://ror.org/01zqcg218', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I35928602']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jong Hyun Lee', 'raw_affiliation_strings': ['College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul, Republic of Korea.', 'institution_ids': ['https://openalex.org/I35928602']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5115591363', 'display_name': 'Chulwon Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I35928602', 'display_name': 'Kyung Hee University', 'ror': 'https://ror.org/01zqcg218', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I35928602']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Chulwon Kim', 'raw_affiliation_strings': ['College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul, Republic of Korea.', 'institution_ids': ['https://openalex.org/I35928602']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034304968', 'display_name': 'Gautam Sethi', 'orcid': 'https://orcid.org/0000-0002-8677-8475'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Gautam Sethi', 'raw_affiliation_strings': ['Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore. Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore. Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037236595', 'display_name': 'Kwang Seok Ahn', 'orcid': 'https://orcid.org/0000-0002-2882-0612'}, 'institutions': [{'id': 'https://openalex.org/I35928602', 'display_name': 'Kyung Hee University', 'ror': 'https://ror.org/01zqcg218', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I35928602']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kwang Seok Ahn', 'raw_affiliation_strings': ['College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul, Republic of Korea.'], 'affiliations': [{'raw_affiliation_string': 'College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul, Republic of Korea.', 'institution_ids': ['https://openalex.org/I35928602']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.05, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 155, 'citation_normalized_percentile': {'value': 0.999954, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '6', 'issue': '8', 'first_page': '6386', 'last_page': '6405'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14331', 'display_name': 'Medicinal Plant Pharmacodynamics Research', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11591', 'display_name': 'NF-κB Signaling Pathways', 'score': 0.9888, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778923194', 'wikidata': 'https://www.wikidata.org/wiki/Q14912019', 'display_name': 'STAT3', 'level': 3, 'score': 0.73574567}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.6988714}, {'id': 'https://openalex.org/C2777292972', 'wikidata': 'https://www.wikidata.org/wiki/Q423762', 'display_name': 'Paclitaxel', 'level': 3, 'score': 0.6857867}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.67990327}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.47607583}, {'id': 'https://openalex.org/C190232843', 'wikidata': 'https://www.wikidata.org/wiki/Q1950808', 'display_name': 'Small hairpin RNA', 'level': 4, 'score': 0.4282383}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.42796654}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.40958977}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.38707113}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3054464}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23453265}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.15572661}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.103232205}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.089652926}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D050828', 'descriptor_name': 'Protein Inhibitors of Activated STAT', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050826', 'descriptor_name': 'Suppressor of Cytokine Signaling Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013859', 'descriptor_name': 'Thiocarbamates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020014', 'descriptor_name': 'K562 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050828', 'descriptor_name': 'Protein Inhibitors of Activated STAT', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071223', 'descriptor_name': 'Suppressor of Cytokine Signaling 3 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050826', 'descriptor_name': 'Suppressor of Cytokine Signaling Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013859', 'descriptor_name': 'Thiocarbamates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3443', 'pdf_url': 'https://www.oncotarget.com/article/3443/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4467444', 'pdf_url': 'https://europepmc.org/articles/pmc4467444?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467444', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25788267', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3443', 'pdf_url': 'https://www.oncotarget.com/article/3443/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1488478985', 'https://openalex.org/W1514949226', 'https://openalex.org/W1548640328', 'https://openalex.org/W1553166169', 'https://openalex.org/W1668039320', 'https://openalex.org/W1965464733', 'https://openalex.org/W1965769603', 'https://openalex.org/W1966912859', 'https://openalex.org/W1976475029', 'https://openalex.org/W1976792034', 'https://openalex.org/W1979335806', 'https://openalex.org/W1979562553', 'https://openalex.org/W1980499191', 'https://openalex.org/W1987333155', 'https://openalex.org/W1989625387', 'https://openalex.org/W1990663594', 'https://openalex.org/W1993520606', 'https://openalex.org/W1996098638', 'https://openalex.org/W2000707284', 'https://openalex.org/W2003163223', 'https://openalex.org/W2003681585', 'https://openalex.org/W2006379003', 'https://openalex.org/W2019029343', 'https://openalex.org/W2020666846', 'https://openalex.org/W2021029373', 'https://openalex.org/W2022633707', 'https://openalex.org/W2024282024', 'https://openalex.org/W2024964331', 'https://openalex.org/W2029813057', 'https://openalex.org/W2034210115', 'https://openalex.org/W2052592595', 'https://openalex.org/W2059184946', 'https://openalex.org/W2068256245', 'https://openalex.org/W2073320643', 'https://openalex.org/W2074702359', 'https://openalex.org/W2074936397', 'https://openalex.org/W2088998131', 'https://openalex.org/W2094500359', 'https://openalex.org/W2099805317', 'https://openalex.org/W2102153675', 'https://openalex.org/W2105594055', 'https://openalex.org/W2117139840', 'https://openalex.org/W2118310862', 'https://openalex.org/W2119596771', 'https://openalex.org/W2136277895', 'https://openalex.org/W2137158350', 'https://openalex.org/W2139462220', 'https://openalex.org/W2140966985', 'https://openalex.org/W2142588992', 'https://openalex.org/W2147245214', 'https://openalex.org/W2166049962', 'https://openalex.org/W2175094091', 'https://openalex.org/W2183345893', 'https://openalex.org/W2410462200', 'https://openalex.org/W2949785438', 'https://openalex.org/W4229545369', 'https://openalex.org/W77757396'], 'related_works': ['https://openalex.org/W4390297994', 'https://openalex.org/W4385147205', 'https://openalex.org/W2413319726', 'https://openalex.org/W2079627504', 'https://openalex.org/W2023001964', 'https://openalex.org/W2021611122', 'https://openalex.org/W2006345152', 'https://openalex.org/W1974120005', 'https://openalex.org/W1510249552', 'https://openalex.org/W146197187'], 'abstract_inverted_index': {'//': [0, 52, 57], 'Jong': [1], 'Hyun': [2], 'Lee': [3], '1': [4, 8, 17, 18], ',': [5, 9], 'Chulwon': [6], 'Kim': [7], 'Gautam': [10, 49], 'Sethi': [11], '2': [12, 32], 'and': [13, 86, 106, 119, 139, 152, 176, 196, 209, 215], 'Kwang': [14, 53], 'Seok': [15, 54], 'Ahn': [16], 'College': [19], 'of': [20, 30, 34, 40, 44, 83, 88, 124, 129, 137, 144, 174, 193, 207], 'Korean': [21], 'Medicine,': [22, 41], 'Kyung': [23], 'Hee': [24], 'University,': [25], 'Hoegidong': [26], 'Dongdaemungu,': [27], 'Seoul,': [28], 'Republic': [29], 'Korea': [31], 'Department': [33], 'Pharmacology,': [35], 'Yong': [36], 'Loo': [37], 'Lin': [38], 'School': [39], 'National': [42], 'University': [43], 'Singapore,': [45], 'Singapore': [46], 'Correspondence': [47], 'to:': [48], 'Sethi,': [50], 'email:': [51, 56], 'Ahn,': [55], 'Keywords': [58], ':': [59, 66, 71, 76], 'Brassinin,': [60], 'STAT3,': [61], 'PIAS-3,': [62], 'SOCS-3,': [63, 210], 'apoptosis': [64], 'Received': [65], 'December': [67], '16,': [68], '2014': [69], 'Accepted': [70], 'January': [72, 77], '21,': [73], '2015': [74, 79], 'Published': [75], '31,': [78], 'Abstract': [80], 'Persistent': [81], 'phosphorylation': [82, 151], 'signal': [84], 'transducers': [85], 'activators': [87], 'transcription': [89], '3': [90], '(STAT3)': [91], 'is': [92], 'frequently': [93], 'observed': [94], 'in': [95, 110, 146, 183], 'tumor': [96, 181, 213], 'cells.': [97, 113], 'We': [98, 198], 'found': [99], 'that': [100, 200], 'brassinin': [101], '(BSN)': [102], 'suppressed': [103], 'both': [104], 'constitutive': [105], 'IL-6-inducible': [107], 'STAT3': [108, 138, 150, 203], 'activation': [109], 'lung': [111, 186], 'cancer': [112, 187], 'Moreover,': [114], 'BSN': [115, 155, 175, 201], 'induced': [116, 166], 'PIAS-3': [117, 130, 208], 'protein': [118], 'mRNA,': [120], 'whereas': [121], 'the': [122, 180], 'expression': [123], 'SOCS-3': [125, 145], 'was': [126], 'reduced.': [127], 'Knockdown': [128], 'by': [131, 141], 'small': [132], 'interfering': [133], 'RNA': [134], 'prevented': [135], 'inhibition': [136], 'cytotoxicity': [140], 'BSN.': [142], 'Overexpression': [143], 'BSN-treated': [147], 'cells': [148], 'increased': [149], 'cell': [153], 'viability.': [154], 'down-regulated': [156], 'STAT3-regulated': [157], 'gene': [158], 'products,': [159], 'inhibited': [160], 'proliferation,': [161], 'invasion,': [162], 'as': [163, 165], 'well': [164], 'apoptosis.': [167], 'Most': [168], 'importantly,': [169], 'when': [170], 'administered': [171], 'intraperitoneally,': [172], 'combination': [173], 'paclitaxel': [177], 'significantly': [178], 'decreased': [179], 'development': [182], 'a': [184], 'xenograft': [185], 'mouse': [188], 'model': [189], 'associated': [190], 'with': [191], 'down-modulation': [192], 'phospho-STAT3,': [194], 'Ki-67': [195], 'CD31.': [197], 'suggest': [199], 'inhibits': [202], 'signaling': [204], 'through': [205], 'modulation': [206], 'thereby': [211], 'attenuating': [212], 'growth': [214], 'increasing': [216], 'sensitivity': [217], 'to': [218], 'paclitaxel.': [219]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1545911557', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 33}, {'year': 2020, 'cited_by_count': 34}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-24T16:34:45.627428', 'created_date': '2016-06-24'}