Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1543579457', 'doi': 'https://doi.org/10.1016/s0021-9258(19)70434-7', 'title': 'Equilibrium binding of inducer to lac repressor.operator DNA complex.', 'display_name': 'Equilibrium binding of inducer to lac repressor.operator DNA complex.', 'publication_year': 1980, 'publication_date': '1980-11-01', 'ids': {'openalex': 'https://openalex.org/W1543579457', 'doi': 'https://doi.org/10.1016/s0021-9258(19)70434-7', 'mag': '1543579457', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7000771'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(19)70434-7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0021-9258(19)70434-7', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000836539', 'display_name': "Ronald B. O'Gorman", 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I122411786', 'display_name': 'California Institute of Technology', 'ror': 'https://ror.org/05dxps055', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I122411786']}, {'id': 'https://openalex.org/I74775410', 'display_name': 'Rice University', 'ror': 'https://ror.org/008zs3103', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74775410']}, {'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}, {'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': "R.B. O'Gorman", 'raw_affiliation_strings': [' California Institute of Technology, Pasadena, California 91109,', ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', '1ICity of Hope National Medical Center, Duarte, California 91020', 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.'], 'affiliations': [{'raw_affiliation_string': ' California Institute of Technology, Pasadena, California 91109,', 'institution_ids': ['https://openalex.org/I122411786']}, {'raw_affiliation_string': ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', 'institution_ids': ['https://openalex.org/I74775410']}, {'raw_affiliation_string': 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': '1ICity of Hope National Medical Center, Duarte, California 91020', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025532762', 'display_name': 'John Rosenberg', 'orcid': 'https://orcid.org/0000-0001-7616-4376'}, 'institutions': [{'id': 'https://openalex.org/I122411786', 'display_name': 'California Institute of Technology', 'ror': 'https://ror.org/05dxps055', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I122411786']}, {'id': 'https://openalex.org/I74775410', 'display_name': 'Rice University', 'ror': 'https://ror.org/008zs3103', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74775410']}, {'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}, {'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J.M. Rosenberg', 'raw_affiliation_strings': [' California Institute of Technology, Pasadena, California 91109,', ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', '1ICity of Hope National Medical Center, Duarte, California 91020', 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.'], 'affiliations': [{'raw_affiliation_string': ' California Institute of Technology, Pasadena, California 91109,', 'institution_ids': ['https://openalex.org/I122411786']}, {'raw_affiliation_string': ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', 'institution_ids': ['https://openalex.org/I74775410']}, {'raw_affiliation_string': 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': '1ICity of Hope National Medical Center, Duarte, California 91020', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007620187', 'display_name': 'Olga B. Kallai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I122411786', 'display_name': 'California Institute of Technology', 'ror': 'https://ror.org/05dxps055', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I122411786']}, {'id': 'https://openalex.org/I74775410', 'display_name': 'Rice University', 'ror': 'https://ror.org/008zs3103', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74775410']}, {'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}, {'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'O.B. Kallai', 'raw_affiliation_strings': [' California Institute of Technology, Pasadena, California 91109,', ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', '1ICity of Hope National Medical Center, Duarte, California 91020', 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.'], 'affiliations': [{'raw_affiliation_string': ' California Institute of Technology, Pasadena, California 91109,', 'institution_ids': ['https://openalex.org/I122411786']}, {'raw_affiliation_string': ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', 'institution_ids': ['https://openalex.org/I74775410']}, {'raw_affiliation_string': 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': '1ICity of Hope National Medical Center, Duarte, California 91020', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004767550', 'display_name': 'Richard E. Dickerson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I122411786', 'display_name': 'California Institute of Technology', 'ror': 'https://ror.org/05dxps055', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I122411786']}, {'id': 'https://openalex.org/I74775410', 'display_name': 'Rice University', 'ror': 'https://ror.org/008zs3103', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74775410']}, {'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}, {'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R.E. Dickerson', 'raw_affiliation_strings': [' California Institute of Technology, Pasadena, California 91109,', ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', '1ICity of Hope National Medical Center, Duarte, California 91020', 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.'], 'affiliations': [{'raw_affiliation_string': ' California Institute of Technology, Pasadena, California 91109,', 'institution_ids': ['https://openalex.org/I122411786']}, {'raw_affiliation_string': ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', 'institution_ids': ['https://openalex.org/I74775410']}, {'raw_affiliation_string': 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': '1ICity of Hope National Medical Center, Duarte, California 91020', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062946182', 'display_name': 'Keiichi Itakura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}, {'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}, {'id': 'https://openalex.org/I122411786', 'display_name': 'California Institute of Technology', 'ror': 'https://ror.org/05dxps055', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I122411786']}, {'id': 'https://openalex.org/I74775410', 'display_name': 'Rice University', 'ror': 'https://ror.org/008zs3103', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74775410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K. Itakura', 'raw_affiliation_strings': [' California Institute of Technology, Pasadena, California 91109,', ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', '1ICity of Hope National Medical Center, Duarte, California 91020', 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': '1ICity of Hope National Medical Center, Duarte, California 91020', 'institution_ids': ['https://openalex.org/I1301076528']}, {'raw_affiliation_string': ' California Institute of Technology, Pasadena, California 91109,', 'institution_ids': ['https://openalex.org/I122411786']}, {'raw_affiliation_string': ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', 'institution_ids': ['https://openalex.org/I74775410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024542312', 'display_name': 'Arthur D. Riggs', 'orcid': 'https://orcid.org/0000-0002-8184-5288'}, 'institutions': [{'id': 'https://openalex.org/I122411786', 'display_name': 'California Institute of Technology', 'ror': 'https://ror.org/05dxps055', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I122411786']}, {'id': 'https://openalex.org/I74775410', 'display_name': 'Rice University', 'ror': 'https://ror.org/008zs3103', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74775410']}, {'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}, {'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A.D. Riggs', 'raw_affiliation_strings': [' California Institute of Technology, Pasadena, California 91109,', ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', '1ICity of Hope National Medical Center, Duarte, California 91020', 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.'], 'affiliations': [{'raw_affiliation_string': ' California Institute of Technology, Pasadena, California 91109,', 'institution_ids': ['https://openalex.org/I122411786']}, {'raw_affiliation_string': ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', 'institution_ids': ['https://openalex.org/I74775410']}, {'raw_affiliation_string': 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': '1ICity of Hope National Medical Center, Duarte, California 91020', 'institution_ids': ['https://openalex.org/I1301076528']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066306898', 'display_name': 'Kathleen S. Matthews', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I122411786', 'display_name': 'California Institute of Technology', 'ror': 'https://ror.org/05dxps055', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I122411786']}, {'id': 'https://openalex.org/I74775410', 'display_name': 'Rice University', 'ror': 'https://ror.org/008zs3103', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74775410']}, {'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}, {'id': 'https://openalex.org/I1301076528', 'display_name': 'City Of Hope National Medical Center', 'ror': 'https://ror.org/00w6g5w60', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K.S. Matthews', 'raw_affiliation_strings': [' California Institute of Technology, Pasadena, California 91109,', ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', '1ICity of Hope National Medical Center, Duarte, California 91020', 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.'], 'affiliations': [{'raw_affiliation_string': ' California Institute of Technology, Pasadena, California 91109,', 'institution_ids': ['https://openalex.org/I122411786']}, {'raw_affiliation_string': ' Department of Biochemistry, Rice Uniuersity, Houston, Texas 77001, YDiuision of Chemistry and Chemical Engineering,', 'institution_ids': ['https://openalex.org/I74775410']}, {'raw_affiliation_string': 'Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.', 'institution_ids': ['https://openalex.org/I170201317']}, {'raw_affiliation_string': '1ICity of Hope National Medical Center, Duarte, California 91020', 'institution_ids': ['https://openalex.org/I1301076528']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 1.614, 'has_fulltext': False, 'cited_by_count': 94, 'citation_normalized_percentile': {'value': 0.973181, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '255', 'issue': '21', 'first_page': '10107', 'last_page': '10114'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13187', 'display_name': 'Protein-DNA Interaction Dynamics in Living Cells', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13187', 'display_name': 'Protein-DNA Interaction Dynamics in Living Cells', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10432', 'display_name': 'G-Quadruplex DNA Structures and Functions', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/inducer', 'display_name': 'Inducer', 'score': 0.9259044}, {'id': 'https://openalex.org/keywords/lac-repressor', 'display_name': 'Lac repressor', 'score': 0.8958132}, {'id': 'https://openalex.org/keywords/operator', 'display_name': 'Operator (biology)', 'score': 0.6216152}, {'id': 'https://openalex.org/keywords/cooperativity', 'display_name': 'Cooperativity', 'score': 0.606152}, {'id': 'https://openalex.org/keywords/cooperative-binding', 'display_name': 'Cooperative binding', 'score': 0.59813064}, {'id': 'https://openalex.org/keywords/protein-dna-interaction', 'display_name': 'Protein-DNA Interaction', 'score': 0.530148}, {'id': 'https://openalex.org/keywords/kinetics-of-protein-dna-interaction', 'display_name': 'Kinetics of Protein-DNA Interaction', 'score': 0.504934}], 'concepts': [{'id': 'https://openalex.org/C2225953', 'wikidata': 'https://www.wikidata.org/wiki/Q1661899', 'display_name': 'Inducer', 'level': 3, 'score': 0.9259044}, {'id': 'https://openalex.org/C113629113', 'wikidata': 'https://www.wikidata.org/wiki/Q4345509', 'display_name': 'Lac repressor', 'level': 5, 'score': 0.8958132}, {'id': 'https://openalex.org/C158448853', 'wikidata': 'https://www.wikidata.org/wiki/Q425218', 'display_name': 'Repressor', 'level': 4, 'score': 0.8856225}, {'id': 'https://openalex.org/C17020691', 'wikidata': 'https://www.wikidata.org/wiki/Q139677', 'display_name': 'Operator (biology)', 'level': 5, 'score': 0.6216152}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.62057716}, {'id': 'https://openalex.org/C170344550', 'wikidata': 'https://www.wikidata.org/wiki/Q311359', 'display_name': 'lac operon', 'level': 4, 'score': 0.6133747}, {'id': 'https://openalex.org/C166014724', 'wikidata': 'https://www.wikidata.org/wiki/Q337217', 'display_name': 'Cooperativity', 'level': 2, 'score': 0.606152}, {'id': 'https://openalex.org/C187250156', 'wikidata': 'https://www.wikidata.org/wiki/Q2902610', 'display_name': 'Cooperative binding', 'level': 3, 'score': 0.59813064}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.52276087}, {'id': 'https://openalex.org/C185581394', 'wikidata': 'https://www.wikidata.org/wiki/Q145911', 'display_name': 'Base pair', 'level': 3, 'score': 0.5158612}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4681922}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.3948304}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.39285967}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3687504}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.33899415}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33665448}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.32376814}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.20388132}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.18617296}, {'id': 'https://openalex.org/C22744801', 'wikidata': 'https://www.wikidata.org/wiki/Q172778', 'display_name': 'Plasmid', 'level': 3, 'score': 0.074018806}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(19)70434-7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(19)70434-7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/10', 'display_name': 'Reduced inequalities', 'score': 0.65}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1516369506', 'https://openalex.org/W1530055903', 'https://openalex.org/W1581129475', 'https://openalex.org/W1607046039', 'https://openalex.org/W1965853090', 'https://openalex.org/W1966153019', 'https://openalex.org/W1969842104', 'https://openalex.org/W1987887385', 'https://openalex.org/W1988889290', 'https://openalex.org/W1997570030', 'https://openalex.org/W1998093640', 'https://openalex.org/W2003928272', 'https://openalex.org/W2005392755', 'https://openalex.org/W2005942782', 'https://openalex.org/W2012231491', 'https://openalex.org/W2040907350', 'https://openalex.org/W2041701954', 'https://openalex.org/W2048343334', 'https://openalex.org/W2050482128', 'https://openalex.org/W2061845131', 'https://openalex.org/W2072108216', 'https://openalex.org/W2073176687', 'https://openalex.org/W2073874317', 'https://openalex.org/W2074533598', 'https://openalex.org/W2076097108', 'https://openalex.org/W2077914787', 'https://openalex.org/W2088705097', 'https://openalex.org/W2089881006', 'https://openalex.org/W2094258217', 'https://openalex.org/W2161003434', 'https://openalex.org/W2279626446', 'https://openalex.org/W2320909563', 'https://openalex.org/W2594257548', 'https://openalex.org/W4211174861', 'https://openalex.org/W4213369627'], 'related_works': ['https://openalex.org/W2976588661', 'https://openalex.org/W2811441309', 'https://openalex.org/W2612607994', 'https://openalex.org/W2171546080', 'https://openalex.org/W2051168915', 'https://openalex.org/W2048697962', 'https://openalex.org/W2027679381', 'https://openalex.org/W1985443602', 'https://openalex.org/W1603900493', 'https://openalex.org/W1588856937'], 'abstract_inverted_index': {'The': [0, 24, 39, 58, 98, 151], 'characteristics': [1], 'of': [2, 12, 26, 33, 50, 55, 60, 67, 71, 85, 104, 114, 117, 186, 201, 211, 213, 222, 231, 241, 255], 'inducer': [3, 37, 51, 77, 93, 105, 157, 187, 245], 'binding': [4, 73, 78, 103, 158, 185, 200, 212, 240], 'to': [5, 106, 123, 145, 162, 188, 206, 253, 277], 'lactose': [6], 'repressor': [7, 91, 107, 190, 207, 264], 'protein': [8, 35], 'in': [9, 47, 82, 94, 109, 183, 258, 268], 'the': [10, 31, 34, 48, 56, 61, 68, 72, 83, 102, 110, 131, 135, 148, 156, 163, 167, 177, 184, 189, 199, 202, 223, 232, 239, 242, 256], 'presence': [11, 25, 84, 111], 'a': [13, 44, 95], 'small': [14], '(29': [15], 'base': [16], 'pair)': [17], 'operator': [18, 27, 86, 118, 192, 203, 215, 266], 'DNA': [19, 28, 87, 119, 193, 204, 216], 'fragment': [20, 205, 217], 'have': [21], 'been': [22], 'examined.': [23], 'fragments': [29, 120], 'decreases': [30], 'affinity': [32], 'for': [36, 53, 101, 138, 166, 198, 248, 265, 275], 'molecules.': [38], 'maximum': [40], 'change': [41], 'observed': [42], 'is': [43], '20-fold': [45], 'increase': [46], 'concentration': [49], 'necessary': [52], 'half-saturation': [54], 'protein.': [57], 'non-linearity': [59], 'Scatchard': [62], 'type': [63, 174], 'plots': [64, 70], 'and': [65, 112, 160, 172, 235, 262], 'slopes': [66], 'Hill': [69], 'data': [74, 100], 'indicate': [75, 237], 'that': [76, 238], 'exhibits': [79], 'cooperative': [80], 'behavior': [81], 'fragments,': [88], 'while': [89], 'free': [90, 261], 'binds': [92], 'noncooperative': [96], 'fashion.': [97], 'experimental': [99], 'both': [108], 'absence': [113], 'saturating': [115], 'amounts': [116], 'were': [121, 170], 'compared': [122], 'curves': [124, 159], 'predicted': [125, 155], 'by': [126, 134], 'several': [127], 'different': [128], 'models.': [129, 150], 'Using': [130], 'limits': [132], 'placed': [133], 'measured': [136, 164], 'values': [137, 165], 'repressor-operator': [139], 'DNA-inducer': [140], 'interaction,': [141], 'it': [142], 'was': [143], 'possible': [144], 'discriminate': [146], 'between': [147, 260], 'various': [149], 'models': [152, 175, 226], 'which': [153], 'accurately': [154], 'conformed': [161], 'other': [168], 'parameters': [169], 'Monod-Wyman-Changeux': [171], 'Koshland': [173], 'with': [176, 229], 'following': [178], 'features:': [179], '1)': [180], 'positive': [181], 'cooperativity': [182], '.': [191], 'complex;': [194], '2)': [195], 'two': [196, 244], 'sites': [197], 'protein;': [208], '3)': [209], 'effect': [210], 'each': [214], 'on': [218], 'all': [219, 230], 'four': [220], 'subunits': [221], 'repressor.': [224], 'These': [225], 'are': [227], 'consistent': [228], 'available': [233], 'data,': [234], 'they': [236], 'first': [243], 'molecules': [246], 'accounts': [247], 'greater': [249], 'than': [250], 'or': [251], 'equal': [252], '60%': [254], 'difference': [257, 271], 'affinities': [259], 'induced': [263], 'DNA;': [267], 'vivo': [269], 'this': [270], 'should': [272], 'be': [273], 'sufficient': [274], 'induction': [276], 'occur.': [278]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1543579457', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-19T12:42:53.599306', 'created_date': '2016-06-24'}