Title: The Effect of the Clinical Digital Rectal Exam on the Complexed Prostate-Specific Antigen Versus the Total Prostate-Specific Antigen
Abstract: Background: The total serum prostate-specific antigen has been used as a screening tool to determine prostate health and is routinely done after a clinical exam which may include a digital rectal exam. The complexed prostate-specific antigen is a portion of the total prostate-specific antigen and may be a better indicator for prostate health. The purpose of this paper is to evaluate the effect that the digital rectal exam has on both the total prostate-specific antigen and the complexed prostate-specific antigen. The evidence will be evaluated using the GRADE system. Method: An exhaustive search of available medical literature was conducted using Medline, Web of Science, Cochrane Systematic Reviews and CINAHL. Results: There were four studies included in the review. The change in total and complexed prostate-specific antigen serum values in ng/mL post digital rectal examination was evaluated across the studies. Due to the fact that the complexed prostate-specific antigen is a subset of the total prostate-specific antigen the consequences of the digital rectal examination was compared using a percent change. Conclusion: The complexed prostate-specific antigen is affected less by the digital rectal exam and would indicate that it may be a more reliable marker for prostate health compared to the total prostate-specific antigen. This recommendation needs to be used with caution as the overall GRADE of evidence was considered low and additional research is likely to have an impact on the confidence of the recommendation[TC1] . [TC1]No references are included in the abstract. Degree Type Capstone Project Rights Terms of use for work posted in CommonKnowledge. This capstone project is available at CommonKnowledge: http://commons.pacificu.edu/pa/264 Copyright and terms of use If you have downloaded this document directly from the web or from CommonKnowledge, see the “Rights” section on the previous page for the terms of use. If you have received this document through an interlibrary loan/document delivery service, the following terms of use apply: Copyright in this work is held by the author(s). You may download or print any portion of this document for personal use only, or for any use that is allowed by fair use (Title 17, §107 U.S.C.). Except for personal or fair use, you or your borrowing library may not reproduce, remix, republish, post, transmit, or distribute this document, or any portion thereof, without the permission of the copyright owner. [Note: If this document is licensed under a Creative Commons license (see “Rights” on the previous page) which allows broader usage rights, your use is governed by the terms of that license.] Inquiries regarding further use of these materials should be addressed to: CommonKnowledge Rights, Pacific University Library, 2043 College Way, Forest Grove, OR 97116, (503) 352-7209. Email inquiries may be directed to:. [email protected] This capstone project is available at CommonKnowledge: http://commons.pacificu.edu/pa/264 NOTICE TO READERS This work is not a peer-reviewed publication. The Master’s Candidate author of this work has made every effort to provide accurate information and to rely on authoritative sources in the completion of this work. However, neither the author nor the faculty advisor(s) warrants the completeness, accuracy or usefulness of the information provided in this work. This work should not be considered authoritative or comprehensive in and of itself and the author and advisor(s) disclaim all responsibility for the results obtained from use of the information contained in this work. Knowledge and practice change constantly, and readers are advised to confirm the information found in this work with other more current and/or comprehensive sources. The student author attests that this work is completely his/her original authorship and that no material in this work has been plagiarized, fabricated or incorrectly attributed. The Effect of the Clinical Digital Rectal Exam on the Complexed Prostate Specific Antigen Versus the Total Prostate A course paper presented to the College of Health Professions in partial fulfillment of the requirements of the degree of Pacific University School of Physician Assistant Studies Clinical Graduate Project Instructors: Torry Cobb, DHSc, MPH, PA Annjanette Sommers MS, PAC -Specific Antigen
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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