Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1535621031', 'doi': 'https://doi.org/10.1002/stem.5530130608', 'title': 'Origin of the avian neural crestt', 'display_name': 'Origin of the avian neural crestt', 'publication_year': 1995, 'publication_date': '1995-01-01', 'ids': {'openalex': 'https://openalex.org/W1535621031', 'doi': 'https://doi.org/10.1002/stem.5530130608', 'mag': '1535621031', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8590865'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/stem.5530130608', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S65139510', 'display_name': 'Stem Cells', 'issn_l': '1066-5099', 'issn': ['1066-5099', '1549-4918'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019521298', 'display_name': 'Marianne Bronner‐Fraser', 'orcid': 'https://orcid.org/0000-0003-4274-1862'}, 'institutions': [{'id': 'https://openalex.org/I204250578', 'display_name': 'University of California, Irvine', 'ror': 'https://ror.org/04gyf1771', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I204250578']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Marianne Bronner‐Fraser', 'raw_affiliation_strings': ['Developmental Biology Center, University of California at Irvine, Irvine, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Developmental Biology Center, University of California at Irvine, Irvine, California, USA', 'institution_ids': ['https://openalex.org/I204250578']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5019521298'], 'corresponding_institution_ids': ['https://openalex.org/I204250578'], 'apc_list': {'value': 4140, 'currency': 'USD', 'value_usd': 4140, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.175, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.242238, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '13', 'issue': '6', 'first_page': '640', 'last_page': '646'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10268', 'display_name': 'Developmental Biology and Gene Regulation', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10268', 'display_name': 'Developmental Biology and Gene Regulation', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 0.9834, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11077', 'display_name': 'Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities', 'score': 0.9368, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neural-fold', 'display_name': 'Neural fold', 'score': 0.93388265}, {'id': 'https://openalex.org/keywords/neurulation', 'display_name': 'Neurulation', 'score': 0.7512932}, {'id': 'https://openalex.org/keywords/neuroepithelial-cell', 'display_name': 'Neuroepithelial cell', 'score': 0.7491829}, {'id': 'https://openalex.org/keywords/organogenesis', 'display_name': 'Organogenesis', 'score': 0.44819984}], 'concepts': [{'id': 'https://openalex.org/C103607123', 'wikidata': 'https://www.wikidata.org/wiki/Q7002059', 'display_name': 'Neural fold', 'level': 5, 'score': 0.93388265}, {'id': 'https://openalex.org/C126749454', 'wikidata': 'https://www.wikidata.org/wiki/Q1348455', 'display_name': 'Neural crest', 'level': 3, 'score': 0.918766}, {'id': 'https://openalex.org/C2780594696', 'wikidata': 'https://www.wikidata.org/wiki/Q1127402', 'display_name': 'Neural tube', 'level': 3, 'score': 0.9127251}, {'id': 'https://openalex.org/C197849852', 'wikidata': 'https://www.wikidata.org/wiki/Q2314823', 'display_name': 'Neural plate', 'level': 4, 'score': 0.80544305}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.78188634}, {'id': 'https://openalex.org/C102225024', 'wikidata': 'https://www.wikidata.org/wiki/Q1388375', 'display_name': 'Neurulation', 'level': 5, 'score': 0.7512932}, {'id': 'https://openalex.org/C200707615', 'wikidata': 'https://www.wikidata.org/wiki/Q13652744', 'display_name': 'Neuroepithelial cell', 'level': 4, 'score': 0.7491829}, {'id': 'https://openalex.org/C2779329299', 'wikidata': 'https://www.wikidata.org/wiki/Q272474', 'display_name': 'Ectoderm', 'level': 4, 'score': 0.650531}, {'id': 'https://openalex.org/C30503417', 'wikidata': 'https://www.wikidata.org/wiki/Q958938', 'display_name': 'Organogenesis', 'level': 3, 'score': 0.44819984}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.44112912}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.33269966}, {'id': 'https://openalex.org/C136834591', 'wikidata': 'https://www.wikidata.org/wiki/Q2944097', 'display_name': 'Neural stem cell', 'level': 3, 'score': 0.33051467}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.2593342}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.23544744}, {'id': 'https://openalex.org/C87073359', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryogenesis', 'level': 3, 'score': 0.18954378}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09975749}, {'id': 'https://openalex.org/C129536746', 'wikidata': 'https://www.wikidata.org/wiki/Q1141026', 'display_name': 'Gastrulation', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001717', 'descriptor_name': 'Birds', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D009432', 'descriptor_name': 'Neural Crest', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001717', 'descriptor_name': 'Birds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019070', 'descriptor_name': 'Cell Lineage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009432', 'descriptor_name': 'Neural Crest', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/stem.5530130608', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S65139510', 'display_name': 'Stem Cells', 'issn_l': '1066-5099', 'issn': ['1066-5099', '1549-4918'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8590865', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1565566882', 'https://openalex.org/W1595587758', 'https://openalex.org/W1969124915', 'https://openalex.org/W1987402927', 'https://openalex.org/W1992865216', 'https://openalex.org/W2022804978', 'https://openalex.org/W2027030154', 'https://openalex.org/W2048083836', 'https://openalex.org/W2065200502', 'https://openalex.org/W2079867266', 'https://openalex.org/W2086913146', 'https://openalex.org/W2096548029', 'https://openalex.org/W2103412450', 'https://openalex.org/W2115164560', 'https://openalex.org/W2120981619', 'https://openalex.org/W2136633961', 'https://openalex.org/W2138526982', 'https://openalex.org/W2140034535', 'https://openalex.org/W2140962540', 'https://openalex.org/W2261964875', 'https://openalex.org/W2416447723', 'https://openalex.org/W4243652998'], 'related_works': ['https://openalex.org/W4388156499', 'https://openalex.org/W4386784061', 'https://openalex.org/W4210927509', 'https://openalex.org/W2806390543', 'https://openalex.org/W2410015923', 'https://openalex.org/W2079504814', 'https://openalex.org/W1993888492', 'https://openalex.org/W1981725414', 'https://openalex.org/W1973497708', 'https://openalex.org/W1620478163'], 'abstract_inverted_index': {'Neural': [0, 75], 'crest': [1, 73, 76, 102, 124, 136, 181, 198, 208, 248], 'cells': [2, 11, 77, 137, 149, 173, 199, 212, 231, 280], 'are': [3, 213, 225], 'derived': [4], 'from': [5, 62, 79, 217], 'a': [6, 152, 201, 240], 'population': [7], 'of': [8, 40, 48, 70, 144], 'multipotent': [9], 'stem': [10], 'within': [12], 'the': [13, 26, 41, 49, 66, 80, 100, 105, 111, 131, 175, 221, 233, 254, 264], 'neural': [14, 20, 72, 91, 101, 112, 123, 135, 140, 154, 163, 165, 169, 180, 183, 194, 197, 207, 210, 223, 229, 247, 265, 268, 278], 'tube.': [15], 'They': [16], 'emerge': [17], 'shortly': [18], 'after': [19, 168], 'tube': [21, 92, 141, 170, 184, 195, 211, 230, 266, 279], 'closure,': [22, 171], 'migrate': [23], 'extensively': [24], 'in': [25, 30, 219], 'embryo': [27], 'and': [28, 38, 46, 52, 68, 90, 110, 182, 189, 196, 209, 273], 'localize': [29], 'numerous': [31], 'sites,': [32], 'where': [33], 'they': [34], 'differentiate': [35], 'into': [36, 147], 'neurons': [37], 'glia': [39], 'peripheral': [42], 'nervous': [43], 'system,': [44], 'cartilage': [45], 'bone': [47], 'face,': [50], 'melanocytes': [51], 'various': [53], 'other': [54], 'cell': [55, 284], 'types.': [56], 'This': [57], 'review': [58], 'summarizes': [59], 'recent': [60], 'experiments': [61, 96, 218, 251], 'our': [63], 'laboratory': [64], 'delineating': [65], 'origin': [67], 'lineage': [69, 145], 'avian': [71], 'cells.': [74, 93, 249], 'arise': [78], 'ectoderm,': [81], 'which': [82, 220], 'also': [83], 'gives': [84], 'rise': [85], 'to': [86, 133, 139, 177, 235, 243, 263, 281], 'presumptive': [87, 108], 'epidermal,': [88], 'placodal': [89], 'Fate': [94], 'mapping': [95], 'have': [97, 174, 232], 'demonstrated': [98], 'that': [99, 127, 151, 193, 206, 253], 'arises': [103], 'at': [104, 237], 'juncture': [106], 'between': [107, 116], 'epidermis': [109, 132], 'plate.': [113], 'Inductive': [114], 'interactions': [115], 'these': [117], 'two': [118], 'early': [119, 255], 'tissues': [120], 'can': [121, 156], 'generate': [122, 134], 'cells,': [125], 'suggesting': [126, 192], 'signals': [128, 275], 'travel': [129], 'through': [130], 'prior': [138], 'closure.': [142], 'Injection': [143], 'tracer': [146], 'individual': [148], 'reveals': [150], 'single': [153], 'fold': [155], 'form': [157, 178], 'all': [158], 'ectodermal': [159], 'derivatives': [160], '(i.e.,': [161], 'epidermis,': [162], 'tube,': [164], 'crest).': [166], 'Even': [167], 'neuroepithelial': [172], 'capacity': [176, 234], 'multiple': [179], 'derivatives,': [185], 'including': [186], 'both': [187], 'dorsal': [188], 'ventral': [190], 'phenotypes,': [191], 'share': [200], 'common': [202], 'precursor.': [203], 'Further': [204], 'evidence': [205], 'intimately': [214], 'related': [215], 'comes': [216], 'cranial': [222], 'folds': [224], 'ablated.': [226], 'The': [227], 'remaining': [228], 'regulate,': [236], 'least': [238], 'for': [239, 245], 'limited': [241], 'time,': [242, 271], 'compensate': [244], 'missing': [246], 'These': [250], 'suggest': [252], 'neuroepithelium': [256], 'has': [257], 'no': [258], 'clear': [259], 'segregation': [260], 'with': [261], 'respect': [262], 'or': [267], 'crest.': [269], 'With': [270], 'dorsalizing': [272], 'ventralizing': [274], 'may': [276], 'cause': [277], 'acquire': [282], 'specific': [283], 'fates.': [285]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1535621031', 'counts_by_year': [{'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2025-01-25T15:00:56.284620', 'created_date': '2016-06-24'}