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'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Gender equality', 'score': 0.64, 'id': 'https://metadata.un.org/sdg/5'}, {'display_name': 'Good health and well-being', 'score': 0.41, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 16, 'referenced_works': ['https://openalex.org/W1965019476', 'https://openalex.org/W1977161163', 'https://openalex.org/W1983417944', 'https://openalex.org/W2001671445', 'https://openalex.org/W2046719161', 'https://openalex.org/W2052754205', 'https://openalex.org/W2066810845', 'https://openalex.org/W2085979852', 'https://openalex.org/W2087829753', 'https://openalex.org/W2101552088', 'https://openalex.org/W2123650181', 'https://openalex.org/W2164795861', 'https://openalex.org/W2166017140', 'https://openalex.org/W2510724013', 'https://openalex.org/W2518068651', 'https://openalex.org/W3021700502'], 'related_works': ['https://openalex.org/W4283818330', 'https://openalex.org/W3127779677', 'https://openalex.org/W3027442846', 'https://openalex.org/W2517885069', 'https://openalex.org/W2419160852', 'https://openalex.org/W2405475375', 'https://openalex.org/W2312762963', 'https://openalex.org/W2084014691', 'https://openalex.org/W2083192581', 'https://openalex.org/W2063941454'], 'abstract_inverted_index': {'非アルコール性脂肪肝炎(NASH)を背景肝とした肝細胞癌(HCC)の発癌病態を検討するため,当施設で治療を行ったHCC症例中,非B非C型で,背景肝がNASHと診断された10例についてその臨床病理像や背景因子を検討した.【対象.方法】当施設で肝切除(173例)又はablation(216例)を行ったHCC': [0], '389症例中,HBs抗原・HCV抗体ともに陰性であったのは29例(7.5%)であった.そのうち臨床病理学的にNASHと診断された症例10例(2.6%)を対象とし,宿主因子,背景肝病理組織,血液検査所見,背景肝機能,腫瘍因子について検討した.【成績】(1)性・年齢は,男性7例,女性3例,平均年齢70.9±8.1歳であった.(2)Body': [1], 'Mass': [2], 'Index(BMI)が25': [3], 'Kg/m2以上の肥満者は6例(60%)であったが,生活習慣病の合併率は,糖尿病6例(60%),高脂血症2例(20%),高血圧7例(70%)であった.(3)背景肝病理組織は10例中4例(40%)が肝硬変,6例(60%)が脂肪肝炎であった.また脂肪肝炎のstageはBruntの分類でS1:2:3=1:2:3と,線維化の程度が軽度から中等度の例が半数を占めた.(4)肝予備能を反映する血清アルブミン(Alb)値とプロトロンビン(PT)活性は肝硬変群においても,それぞれ4.1±0.5': [4], 'g/dl,79.0±8.2%と正常であった.さらに肝硬変群をChild-Pughで分類するとAが3例,Bが1例であった.一方ICG': [5], 'R15は肝硬変群が31.8±25.0%であったが,慢性肝炎群においても20.5±16.5%と高値であった.(5)腫瘍因子に関しては2個以上の多結節病変を有する症例が9例(90%)で,このうちいずれかの結節が高分化型HCCであった多中心性発生は6例(67%)であった.【まとめ】NASH由来と診断されたHCCは,高齢で生活習慣病の合併率が高頻度であった.背景肝組織は肝硬変を合併しない脂肪肝炎からの発癌が多く,多中心性発生が高頻度であった.【結語】NASHに合併したHCCの背景肝は60%が脂肪肝炎であり,67%が多中心性発癌であった.また,脂肪肝炎例においては線維化が軽度の症例も認められ,HCCの合併を考慮した厳重なフォローが必要と考えられた.': [6]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W153362528', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-09-17T08:34:46.182733', 'created_date': '2016-06-24'}