Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1533200296', 'doi': 'https://doi.org/10.1128/jcm.30.3.655-662.1992', 'title': 'Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers', 'display_name': 'Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers', 'publication_year': 1992, 'publication_date': '1992-03-01', 'ids': {'openalex': 'https://openalex.org/W1533200296', 'doi': 'https://doi.org/10.1128/jcm.30.3.655-662.1992', 'mag': '1533200296', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1551982', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/265127'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jcm.30.3.655-662.1992', 'pdf_url': 'https://jcm.asm.org/content/jcm/30/3/655.full.pdf', 'source': {'id': 'https://openalex.org/S53087977', 'display_name': 'Journal of Clinical Microbiology', 'issn_l': '0095-1137', 'issn': ['0095-1137', '1070-633X', '1098-660X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://jcm.asm.org/content/jcm/30/3/655.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079779458', 'display_name': 'M L Clements', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M L Clements', 'raw_affiliation_strings': ['Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': 'Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074126857', 'display_name': 'Kanta Subbarao', 'orcid': 'https://orcid.org/0000-0003-1713-3056'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'E K Subbarao', 'raw_affiliation_strings': ['Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': 'Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008188983', 'display_name': 'Louis Fries', 'orcid': 'https://orcid.org/0000-0001-6147-2915'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L F Fries', 'raw_affiliation_strings': ['Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': 'Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036869113', 'display_name': 'Ruth A. Karron', 'orcid': 'https://orcid.org/0000-0002-4448-4946'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R A Karron', 'raw_affiliation_strings': ['Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': 'Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035001752', 'display_name': 'William T. London', 'orcid': 'https://orcid.org/0000-0003-3936-682X'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W T London', 'raw_affiliation_strings': ['Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': 'Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062733502', 'display_name': 'Brian R. Murphy', 'orcid': 'https://orcid.org/0000-0002-3771-5283'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'B R Murphy', 'raw_affiliation_strings': ['Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.'], 'affiliations': [{'raw_affiliation_string': 'Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.', 'institution_ids': ['https://openalex.org/I145311948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.955, 'has_fulltext': False, 'cited_by_count': 83, 'citation_normalized_percentile': {'value': 0.957749, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '30', 'issue': '3', 'first_page': '655', 'last_page': '662'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11243', 'display_name': 'Respiratory viral infections research', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10976', 'display_name': 'Viral gastroenteritis research and epidemiology', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/h5n1-genetic-structure', 'display_name': 'H5N1 genetic structure', 'score': 0.57499707}], 'concepts': [{'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.87660587}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.83045757}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.7874872}, {'id': 'https://openalex.org/C134164806', 'wikidata': 'https://www.wikidata.org/wiki/Q409485', 'display_name': 'Neuraminidase', 'level': 3, 'score': 0.7419739}, {'id': 'https://openalex.org/C519248777', 'wikidata': 'https://www.wikidata.org/wiki/Q160122', 'display_name': 'Influenza A virus subtype H5N1', 'level': 3, 'score': 0.6533494}, {'id': 'https://openalex.org/C2777546802', 'wikidata': 'https://www.wikidata.org/wiki/Q834390', 'display_name': 'Influenza A virus', 'level': 3, 'score': 0.6359275}, {'id': 'https://openalex.org/C82988372', 'wikidata': 'https://www.wikidata.org/wiki/Q5628866', 'display_name': 'H5N1 genetic structure', 'level': 5, 'score': 0.57499707}, {'id': 'https://openalex.org/C2781416681', 'wikidata': 'https://www.wikidata.org/wiki/Q287246', 'display_name': 'Orthomyxoviridae', 'level': 4, 'score': 0.5587378}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5254784}, {'id': 'https://openalex.org/C2778692840', 'wikidata': 'https://www.wikidata.org/wiki/Q9136673', 'display_name': 'Hemagglutinin (influenza)', 'level': 3, 'score': 0.45747802}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20829812}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.05248341}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D009980', 'descriptor_name': 'Influenza A virus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005814', 'descriptor_name': 'Genes, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009980', 'descriptor_name': 'Influenza A virus', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009980', 'descriptor_name': 'Influenza A virus', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': False}, {'descriptor_ui': 'D009980', 'descriptor_name': 'Influenza A virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007252', 'descriptor_name': 'Influenza Vaccines', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D007252', 'descriptor_name': 'Influenza Vaccines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012453', 'descriptor_name': 'Saimiri', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014613', 'descriptor_name': 'Vaccines, Attenuated', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D014613', 'descriptor_name': 'Vaccines, Attenuated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014774', 'descriptor_name': 'Virulence', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014774', 'descriptor_name': 'Virulence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jcm.30.3.655-662.1992', 'pdf_url': 'https://jcm.asm.org/content/jcm/30/3/655.full.pdf', 'source': {'id': 'https://openalex.org/S53087977', 'display_name': 'Journal of Clinical Microbiology', 'issn_l': '0095-1137', 'issn': ['0095-1137', '1070-633X', '1098-660X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc265127', 'pdf_url': 'https://europepmc.org/articles/pmc265127?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC265127', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1551982', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jcm.30.3.655-662.1992', 'pdf_url': 'https://jcm.asm.org/content/jcm/30/3/655.full.pdf', 'source': {'id': 'https://openalex.org/S53087977', 'display_name': 'Journal of Clinical Microbiology', 'issn_l': '0095-1137', 'issn': ['0095-1137', '1070-633X', '1098-660X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1486091801', 'https://openalex.org/W1505328910', 'https://openalex.org/W1512317716', 'https://openalex.org/W1544994312', 'https://openalex.org/W1547933601', 'https://openalex.org/W1555885901', 'https://openalex.org/W1607447270', 'https://openalex.org/W1613633768', 'https://openalex.org/W1632503918', 'https://openalex.org/W1717163386', 'https://openalex.org/W1742145174', 'https://openalex.org/W1797262858', 'https://openalex.org/W1914843804', 'https://openalex.org/W1955847643', 'https://openalex.org/W1966115135', 'https://openalex.org/W2006025628', 'https://openalex.org/W2019728563', 'https://openalex.org/W2022288313', 'https://openalex.org/W2027751877', 'https://openalex.org/W2060324099', 'https://openalex.org/W2063507839', 'https://openalex.org/W2064433163', 'https://openalex.org/W2067341120', 'https://openalex.org/W2071881067', 'https://openalex.org/W2075933757', 'https://openalex.org/W2094595216', 'https://openalex.org/W2098069272', 'https://openalex.org/W2112422676', 'https://openalex.org/W2113352847', 'https://openalex.org/W2138270253', 'https://openalex.org/W2138329453', 'https://openalex.org/W2151174547', 'https://openalex.org/W2327607807', 'https://openalex.org/W2329475809'], 'related_works': ['https://openalex.org/W4321004657', 'https://openalex.org/W4321003900', 'https://openalex.org/W2413764076', 'https://openalex.org/W2242151891', 'https://openalex.org/W2167554327', 'https://openalex.org/W2065991003', 'https://openalex.org/W2036315754', 'https://openalex.org/W1945113601', 'https://openalex.org/W1528684958', 'https://openalex.org/W1492839266'], 'abstract_inverted_index': {'The': [0, 252], 'transfer': [1], 'of': [2, 43, 69, 92, 156, 194, 234, 236, 247, 295, 304], 'six': [3, 57, 111], 'internal': [4, 66, 112], 'RNA': [5, 67, 77, 113], 'segments': [6, 78, 114], 'from': [7, 79, 115, 131], 'the': [8, 29, 37, 70, 80, 90, 99, 116, 126, 132, 139, 157, 167, 184, 199, 205, 210, 215, 225], 'avian': [9, 30, 117, 283, 296], 'influenza': [10, 18, 31, 46, 71, 82, 118, 135, 187, 237, 284, 299], 'A/Mallard/New': [11, 72], 'York/6750/78': [12, 73], '(H2N2)': [13], 'virus': [14, 33, 74, 103, 120, 189, 285, 301, 305], 'reproducibly': [15], 'attenuates': [16], 'human': [17, 81, 134, 149, 186, 298], 'A': [19, 32, 47, 119, 136, 188, 238, 300], 'viruses': [20, 49, 60, 239], 'for': [21, 138, 240, 271], 'squirrel': [22, 145], 'monkeys': [23, 146, 152], 'and': [24, 39, 75, 104, 122, 128, 147, 153, 171, 208, 254, 297], 'adult': [25, 148], 'humans.': [26, 308], 'To': [27, 88], 'identify': [28], 'genes': [34, 124, 196, 212], 'that': [35, 192, 229, 257, 267], 'specify': [36], 'attenuation': [38, 200, 216, 235], 'host': [40], 'range': [41], 'restriction': [42, 303], 'avian-human': [44], '(ah)': [45], 'reassortant': [48, 59, 109, 161], '(referred': [50], 'to': [51, 141, 198, 214, 224, 280], 'as': [52], 'ah': [53, 108, 160], 'reassortants),': [54], 'we': [55, 94], 'isolated': [56], 'single-gene': [58], '(SGRs),': [61], 'each': [62, 96, 174, 193, 262], 'having': [63], 'a': [64, 105, 264, 292], 'single': [65], 'segment': [68], 'seven': [76], 'A/Los': [83, 100], 'Angeles/2/87': [84, 101], '(H3N2)': [85], 'wild-type': [86, 102, 133, 185], 'virus.': [87, 274], 'assess': [89], 'level': [91], 'attenuation,': [93], 'compared': [95], 'SGR': [97], 'with': [98, 222, 250], '6-2': [106, 158], 'gene': [107, 159, 289], '(having': [110], 'parent': [121], 'two': [123], 'encoding': [125], 'hemagglutinin': [127], 'neuraminidase': [129], 'glycoproteins': [130], 'virus)': [137], 'ability': [140], 'replicate': [142], 'in': [143, 260, 307], 'seronegative': [144], 'volunteers.': [150], 'In': [151, 165, 202], 'humans,': [154, 166], 'replication': [155, 306], 'was': [162, 268, 277], 'highly': [163], 'restricted.': [164], 'NS,': [168], 'M,': [169], 'PB2,': [170, 207], 'PB1': [172], 'SGRs': [173, 248, 256], 'replicated': [175], 'significantly': [176], 'less': [177, 180], 'efficiently': [178], '(P': [179], 'than': [181, 183], '0.05)': [182], 'parent,': [190], 'suggesting': [191], 'these': [195], 'contributes': [197], 'phenotype.': [201, 217], 'monkeys,': [203], 'only': [204], 'NP,': [206], 'possibly': [209], 'M': [211, 255, 288], 'contributed': [213], 'These': [218], 'discordant': [219], 'observations,': [220], 'particularly': [221], 'regard': [223], 'NP': [226], 'SGR,': [227], 'indicate': [228], 'not': [230, 269, 278], 'all': [231], 'genetic': [232], 'determinants': [233], 'humans': [241, 261], 'can': [242], 'be': [243], 'identified': [244], 'during': [245], 'studies': [246], 'conducted': [249], 'monkeys.': [251], 'PB2': [253, 286], 'were': [258], 'attenuated': [259], 'exhibited': [263], 'new': [265], 'phenotype': [266], 'observed': [270], 'either': [272], 'parental': [273], 'Thus,': [275], 'it': [276], 'possible': [279], 'determine': [281], 'whether': [282], 'or': [287, 291], 'itself': [290], 'specific': [293], 'constellation': [294], 'specified': [302]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1533200296', 'counts_by_year': [{'year': 2023, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-10T10:08:56.101321', 'created_date': '2016-06-24'}