Title: The early stages of neuromuscular regeneration after crushing the sciatic nerve in the rat
Abstract: Crushing of the sciatic nerve was performed on 84 rats and the functional recovery, reinnervation and distribution of fibre types were studied at short intervals between the crush and the 133rd day. The amplitude of evoked muscle potentials increased from the 25th day and regained a normal value after the 42nd day. Evidence of reinnervation of muscle fibres was observed as early as the 14th day. Apparently complete reinnervation was seen in some muscles 33 days after the crush. Type-grouping took place from the 42nd day; it was preceded from the 28th day by a stage characterized by the presence of numerous intermediate fibres. It may be concluded that the delay between reinnervation and functional recovery on the one hand and the occurrence of type grouping of muscle fibres on the other represents the time necessary for the reversal of the enzymatic pattern in muscle fibres being reinnervated by axons different from the original ones. The transitional stage observed between the normal pattern and the type grouping is probably the morphological expression of this evolution.
Publication Year: 1975
Publication Date: 1975-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 39
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