Title: Direct effects of serotonin, and 5-HT2, α1 and H1 receptor-antagonists on embryonic chick skin in vitro: A morphological and functional study
Abstract: Ketanserin (K), a 5-HT2, alpha 1 and H1 receptor antagonist, at a concentration of 5 micrograms/ml inhibits keratinisation, but increases DNA-, collagen and glycosaminoglycan (GAG) synthesis in embryonic chick skin in vitro. On the other hand, serotonin (S) at a concentration of 10 micrograms/ml stimulates keratinisation and does not enhance DNA, collagen and GAG synthesis. 5 nM doses of ketanserin and serotonin give analogous results. The effects of other 5-HT2-receptor antagonists (e.g. BW 501 and cinanserin) are comparable to those of K, whereas prazosin (an alpha 1 receptor antagonist) and pyrilamin (an H1 receptor antagonist) do not show any effect on embryonic chick skin in vitro.
Publication Year: 1990
Publication Date: 1990-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 3
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