Title: Primary Antibiotic Resistance of Helicobacter pylori Isolated from Beijing Children
Abstract: HelicobacterVolume 16, Issue 5 p. 356-362 Primary Antibiotic Resistance of Helicobacter pylori Isolated from Beijing Children Guodong Liu, Guodong Liu National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing State Key Laboratory for Infectious Disease Prevention and Control, BeijingSearch for more papers by this authorXiwei Xu, Xiwei Xu Department of Internal Medicine, Beijing Children’s Hospital Affiliated to Capital Medical University, BeijingSearch for more papers by this authorLihua He, Lihua He National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing State Key Laboratory for Infectious Disease Prevention and Control, BeijingSearch for more papers by this authorZhaolu Ding, Zhaolu Ding Department of Internal Medicine, Beijing Children’s Hospital Affiliated to Capital Medical University, BeijingSearch for more papers by this authorYixin Gu, Yixin Gu National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing State Key Laboratory for Infectious Disease Prevention and Control, BeijingSearch for more papers by this authorJianzhong Zhang, Jianzhong Zhang National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing State Key Laboratory for Infectious Disease Prevention and Control, BeijingSearch for more papers by this authorLiya Zhou, Liya Zhou Department of Gastroenterology, Peking University Third Hospital, Beijing, ChinaSearch for more papers by this author Guodong Liu, Guodong Liu National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing State Key Laboratory for Infectious Disease Prevention and Control, BeijingSearch for more papers by this authorXiwei Xu, Xiwei Xu Department of Internal Medicine, Beijing Children’s Hospital Affiliated to Capital Medical University, BeijingSearch for more papers by this authorLihua He, Lihua He National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing State Key Laboratory for Infectious Disease Prevention and Control, BeijingSearch for more papers by this authorZhaolu Ding, Zhaolu Ding Department of Internal Medicine, Beijing Children’s Hospital Affiliated to Capital Medical University, BeijingSearch for more papers by this authorYixin Gu, Yixin Gu National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing State Key Laboratory for Infectious Disease Prevention and Control, BeijingSearch for more papers by this authorJianzhong Zhang, Jianzhong Zhang National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing State Key Laboratory for Infectious Disease Prevention and Control, BeijingSearch for more papers by this authorLiya Zhou, Liya Zhou Department of Gastroenterology, Peking University Third Hospital, Beijing, ChinaSearch for more papers by this author First published: 19 September 2011 https://doi.org/10.1111/j.1523-5378.2011.00856.xCitations: 48 Reprint requests to: Jianzhong Zhang, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Road, Changping, Beijing 102206, China. E-mail: [email protected] and Liya Zhou, Department of Gastroenterology, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 100191, China. E-mail: [email protected] The authors, Guodong Liu, Xiwei Xu and Lihua He, contributed equally to this work as the first authors. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Background: The antimicrobials resistance of Helicobacter pylori (H. pylori) was able to sharply decline the eradication rate of H. pylori both in adults and children, but there are limited studies about the primary antibiotic resistance and the related gene mutations, specifically in China. Materials and Methods: The primary resistance to 9 antibiotics of 73 H. pylori strains isolated from gastric biopsies of children recruited at Beijing Children’s Hospital was assessed, and the mutations in 23S rRNA gene of 65 macrolide-resistant strains and in gyrA and gyrB of 12 quinolone-resistant strains were investigated. Results: The resistance rate to clarithromycin, azithromycin, metronidazole, levofloxacin, moxifloxacin, and rifampicin was 84.9%, 87.7%, 61.6%, 13.7%, 15.1%, and 6.8%, respectively. No resistance to amoxicillin, gentamicin, and tetracycline was observed. Dual, triple, and quadruple antibacterial resistant percentage was 46.6% (34/73), 15.1% (11/73), and 2.7% (2/73), respectively. The gene mutation rate of A2142C, A2142G, and A2143G in 23S rRNA gene was 1.5% (1/65), 6.2% (4/65), and 84.6% (55/65), respectively. The detection rate of mutations of Asn87, Asp91, and Met191 in GyrA was 41.7% (5/12), 25% (3/12), and 25% (3/12), respectively. Conclusion: The high prevalence of primary antibiotic resistance was out of expectation in H. pylori strains isolated from the children in Beijing. Antibiotic susceptibility should be made clear before the antibiotic was used in the anti-H. pylori therapy in this population. The A2143G was the most populated mutation in macrolide-resistant strains, and Asn87 and Asp91 of GyrA were the most common mutation points in quinolone resistance strains. Citing Literature Volume16, Issue5October 2011Pages 356-362 RelatedInformation
Publication Year: 2011
Publication Date: 2011-09-19
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 75
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