Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1527607010', 'doi': 'https://doi.org/10.1002/psc.2478', 'title': 'Identification and mapping of a linear epitope of centromere protein F using monoclonal antibodies', 'display_name': 'Identification and mapping of a linear epitope of centromere protein F using monoclonal antibodies', 'publication_year': 2013, 'publication_date': '2013-01-07', 'ids': {'openalex': 'https://openalex.org/W1527607010', 'doi': 'https://doi.org/10.1002/psc.2478', 'mag': '1527607010', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23297090'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/psc.2478', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S184443419', 'display_name': 'Journal of Peptide Science', 'issn_l': '1075-2617', 'issn': ['1075-2617', '1099-1387'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080718549', 'display_name': 'Simon Welner', 'orcid': 'https://orcid.org/0000-0002-8829-3703'}, 'institutions': [{'id': 'https://openalex.org/I101527212', 'display_name': 'Statens Serum Institut', 'ror': 'https://ror.org/0417ye583', 'country_code': 'DK', 'type': 'facility', 'lineage': ['https://openalex.org/I101527212']}, {'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}, {'id': 'https://openalex.org/I4210165112', 'display_name': 'Leo Pharma (Denmark)', 'ror': 'https://ror.org/05tzrdd39', 'country_code': 'DK', 'type': 'company', 'lineage': ['https://openalex.org/I4210165112']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Simon Welner', 'raw_affiliation_strings': ['Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark', 'IGM – Bioorganic Chemistry, Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 1871 Frederiksberg C Denmark', 'Present address: LEO Pharma A/S Industriparken 55 2750 Ballerup Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark', 'institution_ids': ['https://openalex.org/I101527212']}, {'raw_affiliation_string': 'IGM – Bioorganic Chemistry, Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 1871 Frederiksberg C Denmark', 'institution_ids': ['https://openalex.org/I124055696']}, {'raw_affiliation_string': 'Present address: LEO Pharma A/S Industriparken 55 2750 Ballerup Denmark', 'institution_ids': ['https://openalex.org/I4210165112']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072220744', 'display_name': 'Nicole Hartwig Trier', 'orcid': 'https://orcid.org/0000-0003-1548-2009'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}, {'id': 'https://openalex.org/I101527212', 'display_name': 'Statens Serum Institut', 'ror': 'https://ror.org/0417ye583', 'country_code': 'DK', 'type': 'facility', 'lineage': ['https://openalex.org/I101527212']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Nicole H. Trier', 'raw_affiliation_strings': ['Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark', 'Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen Universitetsparken 2 2100 Copenhagen Ø Denmark', 'IGM – Bioorganic Chemistry, Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 1871 Frederiksberg C Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen Universitetsparken 2 2100 Copenhagen Ø Denmark', 'institution_ids': ['https://openalex.org/I124055696']}, {'raw_affiliation_string': 'Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark', 'institution_ids': ['https://openalex.org/I101527212']}, {'raw_affiliation_string': 'IGM – Bioorganic Chemistry, Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 1871 Frederiksberg C Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087463104', 'display_name': 'Gunnar Houen', 'orcid': 'https://orcid.org/0000-0002-5948-4156'}, 'institutions': [{'id': 'https://openalex.org/I101527212', 'display_name': 'Statens Serum Institut', 'ror': 'https://ror.org/0417ye583', 'country_code': 'DK', 'type': 'facility', 'lineage': ['https://openalex.org/I101527212']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Gunnar Houen', 'raw_affiliation_strings': ['Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark', 'institution_ids': ['https://openalex.org/I101527212']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081555211', 'display_name': 'Paul R. Hansen', 'orcid': 'https://orcid.org/0000-0001-9357-8001'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': True, 'raw_author_name': 'Paul R. Hansen', 'raw_affiliation_strings': ['Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen Universitetsparken 2 2100 Copenhagen Ø Denmark', 'IGM – Bioorganic Chemistry, Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 1871 Frederiksberg C Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen Universitetsparken 2 2100 Copenhagen Ø Denmark', 'institution_ids': ['https://openalex.org/I124055696']}, {'raw_affiliation_string': 'IGM – Bioorganic Chemistry, Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 1871 Frederiksberg C Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}], 'institution_assertions': [{'id': 'https://openalex.org/I177969490', 'display_name': 'University of Southern Denmark', 'ror': 'https://ror.org/03yrrjy16', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I177969490']}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5081555211'], 'corresponding_institution_ids': ['https://openalex.org/I124055696'], 'apc_list': {'value': 3660, 'currency': 'USD', 'value_usd': 3660, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.349, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.939563, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '19', 'issue': '2', 'first_page': '95', 'last_page': '101'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation in Health and Disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11157', 'display_name': 'Genomic Aberrations and Treatment of Chronic Lymphocytic Leukemia', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/linear-epitope', 'display_name': 'Linear epitope', 'score': 0.7630366}, {'id': 'https://openalex.org/keywords/conformational-epitope', 'display_name': 'Conformational epitope', 'score': 0.6612588}, {'id': 'https://openalex.org/keywords/epitope-mapping', 'display_name': 'Epitope mapping', 'score': 0.6107707}, {'id': 'https://openalex.org/keywords/antibody-engineering', 'display_name': 'Antibody Engineering', 'score': 0.459552}], 'concepts': [{'id': 'https://openalex.org/C195616568', 'wikidata': 'https://www.wikidata.org/wiki/Q128711', 'display_name': 'Epitope', 'level': 3, 'score': 0.9548005}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.7721094}, {'id': 'https://openalex.org/C78598654', 'wikidata': 'https://www.wikidata.org/wiki/Q17140316', 'display_name': 'Linear epitope', 'level': 4, 'score': 0.7630366}, {'id': 'https://openalex.org/C2780632150', 'wikidata': 'https://www.wikidata.org/wiki/Q5160267', 'display_name': 'Conformational epitope', 'level': 4, 'score': 0.6612588}, {'id': 'https://openalex.org/C2781241564', 'wikidata': 'https://www.wikidata.org/wiki/Q1347450', 'display_name': 'Epitope mapping', 'level': 4, 'score': 0.6107707}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.5993871}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.56660664}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.55430156}, {'id': 'https://openalex.org/C63491729', 'wikidata': 'https://www.wikidata.org/wiki/Q14762596', 'display_name': 'Centromere', 'level': 4, 'score': 0.49696615}, {'id': 'https://openalex.org/C163764329', 'wikidata': 'https://www.wikidata.org/wiki/Q785022', 'display_name': 'Autoantibody', 'level': 3, 'score': 0.48962933}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.43560958}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.42325547}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37934157}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.37543964}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35987347}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.18398803}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.099781334}, {'id': 'https://openalex.org/C30481170', 'wikidata': 'https://www.wikidata.org/wiki/Q37748', 'display_name': 'Chromosome', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D002868', 'descriptor_name': 'Chromosomal Proteins, Non-Histone', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D002868', 'descriptor_name': 'Chromosomal Proteins, Non-Histone', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D018604', 'descriptor_name': 'Epitope Mapping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008840', 'descriptor_name': 'Microfilament Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D008840', 'descriptor_name': 'Microfilament Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000918', 'descriptor_name': 'Antibody Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002868', 'descriptor_name': 'Chromosomal Proteins, Non-Histone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008840', 'descriptor_name': 'Microfilament Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/psc.2478', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S184443419', 'display_name': 'Journal of Peptide Science', 'issn_l': '1075-2617', 'issn': ['1075-2617', '1099-1387'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23297090', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.41, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1969139439', 'https://openalex.org/W1972473951', 'https://openalex.org/W1986027402', 'https://openalex.org/W1989275845', 'https://openalex.org/W1995656483', 'https://openalex.org/W1997442618', 'https://openalex.org/W2013706715', 'https://openalex.org/W2019739862', 'https://openalex.org/W2020418092', 'https://openalex.org/W2026171879', 'https://openalex.org/W2031307490', 'https://openalex.org/W2051710717', 'https://openalex.org/W2053715992', 'https://openalex.org/W2056242758', 'https://openalex.org/W2077938714', 'https://openalex.org/W2090392397', 'https://openalex.org/W2099451628', 'https://openalex.org/W2100147739', 'https://openalex.org/W2107424534', 'https://openalex.org/W2112157366', 'https://openalex.org/W2137809107', 'https://openalex.org/W2139853103', 'https://openalex.org/W2161625347', 'https://openalex.org/W2168672282', 'https://openalex.org/W2285370255', 'https://openalex.org/W2416687506', 'https://openalex.org/W4211045835', 'https://openalex.org/W86407692'], 'related_works': ['https://openalex.org/W3096915742', 'https://openalex.org/W2554660632', 'https://openalex.org/W2503828389', 'https://openalex.org/W2471846512', 'https://openalex.org/W2383594963', 'https://openalex.org/W2285385630', 'https://openalex.org/W2133337718', 'https://openalex.org/W2050578141', 'https://openalex.org/W2046215010', 'https://openalex.org/W1527607010'], 'abstract_inverted_index': {'Autoantibodies': [0], 'against': [1], 'centromere': [2, 44], 'protein': [3, 45], '‐F': [4], 'have': [5], 'been': [6], 'reported': [7], 'to': [8], 'be': [9], 'associated': [10], 'with': [11, 16], 'various': [12], 'types': [13], 'of': [14, 21, 41, 54, 64, 77, 91, 100, 107], 'cancer': [15], 'poor': [17], 'prognosis.': [18], 'The': [19, 48, 83], 'characterization': [20], 'these': [22], 'autoantibody': [23], 'specificities': [24], 'is': [25], 'important': [26], 'in': [27], 'both': [28], 'diagnostics': [29], 'and': [30, 61, 126], 'basic': [31], 'research.': [32], 'In': [33, 96], 'this': [34], 'study,': [35], 'we': [36], 'mapped': [37], 'the': [38, 65, 75, 98, 101, 108], 'epitope': [39, 49, 84, 110], '(NELSRIRSEKA)': [40], 'two': [42], 'monoclonal': [43], 'F': [46], 'antibodies.': [47], 'was': [50, 85, 111], 'localized': [51], 'by': [52, 58], 'screening': [53, 76], 'overlapping': [55], 'peptides': [56], 'followed': [57], 'a': [59], 'fast': [60], 'efficient': [62], 'estimation': [63], 'minimal': [66], 'peptide': [67, 81], 'length': [68], 'required': [69], 'for': [70], 'antibody': [71], 'recognition,': [72], 'based': [73], 'on': [74], 'terminally': [78], 'truncated': [79, 93], 'resin‐bound': [80], 'analogs.': [82, 119], 'determined': [86, 112], 'through': [87, 113], 'competitive': [88, 114], 'inhibition': [89, 115], 'assays': [90, 116], 'systematically': [92], 'free': [94], 'peptides.': [95], 'addition,': [97], 'importance': [99], 'involved': [102], 'amino': [103], 'acid': [104], 'side': [105], 'chains': [106], 'identified': [109], 'using': [117], 'alanine‐substituted': [118], 'Copyright': [120], '©': [121], '2013': [122], 'European': [123], 'Peptide': [124], 'Society': [125], 'John': [127], 'Wiley': [128], '&': [129], 'Sons,': [130], 'Ltd.': [131]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1527607010', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-19T18:35:45.683298', 'created_date': '2016-06-24'}