Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1526965567', 'doi': 'https://doi.org/10.1016/s0021-9258(17)35230-4', 'title': 'Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide.', 'display_name': 'Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide.', 'publication_year': 1991, 'publication_date': '1991-01-01', 'ids': {'openalex': 'https://openalex.org/W1526965567', 'doi': 'https://doi.org/10.1016/s0021-9258(17)35230-4', 'mag': '1526965567', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1985959'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(17)35230-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0021-9258(17)35230-4', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5082111082', 'display_name': 'Isao Sakaida', 'orcid': 'https://orcid.org/0000-0002-8365-7547'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'I Sakaida', 'raw_affiliation_strings': ['Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19104.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19104.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045385617', 'display_name': 'Andrew P. Thomas', 'orcid': 'https://orcid.org/0000-0002-9026-7467'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A P Thomas', 'raw_affiliation_strings': ['Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19104.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19104.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5113060230', 'display_name': 'J L Farber', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J L Farber', 'raw_affiliation_strings': ['Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19104.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19104.', 'institution_ids': ['https://openalex.org/I149251103']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 13.234, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 102, 'citation_normalized_percentile': {'value': 0.975624, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '266', 'issue': '2', 'first_page': '717', 'last_page': '722'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11465', 'display_name': 'Drug-Induced Hepatotoxicity and Protection', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11465', 'display_name': 'Drug-Induced Hepatotoxicity and Protection', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10966', 'display_name': 'Liver physiology and pathology', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9884, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C98539663', 'wikidata': 'https://www.wikidata.org/wiki/Q220599', 'display_name': 'Cytosol', 'level': 3, 'score': 0.79337907}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.73536295}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6197808}, {'id': 'https://openalex.org/C2776200302', 'wikidata': 'https://www.wikidata.org/wiki/Q827450', 'display_name': 'Hepatocyte', 'level': 3, 'score': 0.51386833}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.48162955}, {'id': 'https://openalex.org/C145148216', 'wikidata': 'https://www.wikidata.org/wiki/Q36496', 'display_name': 'Ion', 'level': 2, 'score': 0.44989437}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4003017}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32162955}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20994732}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.12354344}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.104890674}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.06324664}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(17)35230-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(17)35230-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1490154674', 'https://openalex.org/W1492343139', 'https://openalex.org/W1495233477', 'https://openalex.org/W1508115172', 'https://openalex.org/W1533764872', 'https://openalex.org/W1593868340', 'https://openalex.org/W1600993549', 'https://openalex.org/W1603146813', 'https://openalex.org/W1609961433', 'https://openalex.org/W1668382251', 'https://openalex.org/W1676883243', 'https://openalex.org/W1829437181', 'https://openalex.org/W1947487531', 'https://openalex.org/W1980188935', 'https://openalex.org/W1984734797', 'https://openalex.org/W1985309550', 'https://openalex.org/W1989115445', 'https://openalex.org/W1992218597', 'https://openalex.org/W1994122285', 'https://openalex.org/W1994924034', 'https://openalex.org/W2010070719', 'https://openalex.org/W2012768907', 'https://openalex.org/W2026454478', 'https://openalex.org/W2027858926', 'https://openalex.org/W2033655366', 'https://openalex.org/W2061052410', 'https://openalex.org/W2072655765', 'https://openalex.org/W2085514543', 'https://openalex.org/W2092933559', 'https://openalex.org/W2093182332', 'https://openalex.org/W2095214547', 'https://openalex.org/W2141260882', 'https://openalex.org/W2154949526'], 'related_works': ['https://openalex.org/W2493538936', 'https://openalex.org/W2422474779', 'https://openalex.org/W2396501310', 'https://openalex.org/W2395877311', 'https://openalex.org/W2048213734', 'https://openalex.org/W2027459446', 'https://openalex.org/W1990451572', 'https://openalex.org/W1989673413', 'https://openalex.org/W1568635045', 'https://openalex.org/W1499732058'], 'abstract_inverted_index': {'Abstract': [0], 'Digital': [1], 'imaging': [2], 'fluorescence': [3], 'microscopy': [4], 'was': [5, 54, 136, 195], 'used': [6], 'to': [7, 49, 210], 'study': [8], 'the': [9, 16, 32, 50, 87, 90, 98, 107, 110, 116, 121, 126, 131, 145, 149, 158, 175, 182, 201, 211, 214, 220, 225, 231, 240, 243, 266, 277], 'effect': [10], 'of': [11, 22, 31, 34, 43, 60, 66, 89, 97, 109, 118, 123, 133, 157, 192, 206, 233, 242, 259, 268, 279, 281], 'tert-butyl': [12], 'hydroperoxide': [13], '(TBHP)': [14], 'on': [15], 'cytosolic': [17], 'free': [18], 'calcium': [19, 165, 203, 216, 255], 'concentration': [20], '([Ca2+]i)': [21], 'single': [23], 'rat': [24], 'hepatocytes': [25, 37, 99, 124, 159, 245], 'in': [26, 80, 152, 162, 188, 200, 253], 'primary': [27], 'culture.': [28], 'Within': [29], 'minutes': [30], 'addition': [33, 108], 'TBHP,': [35], 'individual': [36], 'displayed': [38], 'one': [39], 'or': [40, 106, 113, 141, 173], 'more': [41], 'peaks': [42], 'increased': [44], '[Ca2+]i': [45, 61, 128, 153, 177, 222], 'that': [46, 62, 239], 'promptly': [47], 'returned': [48], 'prestimulation': [51], 'level.': [52], 'This': [53], 'followed': [55], 'by': [56, 138, 197, 246, 271], 'a': [57, 64, 102, 163], 'slower': [58], 'increase': [59], 'reached': [63], 'plateau': [65, 146, 183], '696': [67], '+/-': [68, 73], '260': [69], 'nM': [70], '(basal': [71], '194': [72], 'nM)': [74], 'after': [75, 92], '20': [76], 'min.': [77, 95], 'Another': [78], 'rise': [79, 151, 187], '[Ca2+]i,': [81], 'abrupt': [82, 150, 186], 'and': [83, 148, 179, 185, 224, 228, 275], 'much': [84], 'larger,': [85], 'preceded': [86], 'death': [88, 194], 'cells': [91], 'about': [93], '45': [94], 'Pretreatment': [96], 'with': [100, 160], 'deferoxamine,': [101, 139], 'ferric': [103], 'iron': [104], 'chelator,': [105], 'antioxidants': [111], "N,N'-diphenyl-p-phenylenediamine": [112], 'catechol': [114], 'prevented': [115, 218], 'loss': [117], 'viability.': [119], 'Neither': [120], 'number': [122], 'displaying': [125], 'initial': [127, 176, 221], 'transients': [129, 178], 'nor': [130], 'magnitude': [132], 'these': [134], 'oscillations': [135], 'affected': [137], "N,N'-diphenyl-p-phenyl-enediamine,": [140], 'catechol.': [142], 'However,': [143], 'both': [144, 181, 219], 'phase': [147, 184], 'were': [154], 'prevented.': [155], 'Treatment': [156], 'TBHP': [161, 247], 'low': [164, 202], 'buffer': [166], '(less': [167], 'than': [168], '2': [169], 'microM': [170], 'Ca2+)': [171], 'reduced': [172], 'abolished': [174], 'eliminated': [180], '[Ca2+]i.': [189], 'The': [190], 'onset': [191, 232, 280], 'cell': [193, 234, 269, 282], 'delayed': [196, 226], '10': [198], 'min': [199], 'medium.': [204], 'Addition': [205], '3.5': [207], 'mM': [208], 'EGTA': [209], 'cultures': [212], 'lowered': [213], 'basal': [215], 'concentration,': [217], 'spikes': [223], 'changes,': [227], 'further': [229], 'prolonged': [230], 'death.': [235, 283], 'These': [236], 'data': [237], 'indicate': [238], 'killing': [241], 'cultured': [244], 'can': [248], 'be': [249], 'dissociated': [250], 'from': [251], 'changes': [252], 'intracellular': [254], 'homeostasis.': [256], 'An': [257], 'influx': [258], 'extracellular': [260], 'Ca2+': [261], 'ions': [262], 'may': [263], 'aggravate': [264], 'somewhat': [265], 'mechanisms': [267], 'injury': [270], 'an': [272], 'oxidative': [273], 'stress': [274], 'accelerate': [276], 'time': [278]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1526965567', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-14T11:34:38.842197', 'created_date': '2016-06-24'}