Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1526529090', 'doi': 'https://doi.org/10.1111/j.1365-2125.2010.03852.x', 'title': 'Evaluation of pharmacokinetic parameters and dipeptidyl peptidase‐4 inhibition following single doses of sitagliptin in healthy, young Japanese males', 'display_name': 'Evaluation of pharmacokinetic parameters and dipeptidyl peptidase‐4 inhibition following single doses of sitagliptin in healthy, young Japanese males', 'publication_year': 2011, 'publication_date': '2011-02-01', 'ids': {'openalex': 'https://openalex.org/W1526529090', 'doi': 'https://doi.org/10.1111/j.1365-2125.2010.03852.x', 'mag': '1526529090', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21284702', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3045552'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2125.2010.03852.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2010.03852.x', 'source': {'id': 'https://openalex.org/S13842274', 'display_name': 'British Journal of Clinical Pharmacology', 'issn_l': '0306-5251', 'issn': ['0306-5251', '1365-2125'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2010.03852.x', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085084466', 'display_name': 'Gary Herman', 'orcid': 'https://orcid.org/0000-0003-4433-6529'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gary A. Herman', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015788670', 'display_name': 'Goutam C. Mistry', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Goutam C. Mistry', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041468249', 'display_name': 'Bingming Yi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bingming Yi', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076907136', 'display_name': 'Arthur Bergman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Arthur J. Bergman', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005640058', 'display_name': 'Amy Q. Wang', 'orcid': 'https://orcid.org/0000-0001-7368-1917'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amy Q. Wang', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101855164', 'display_name': 'Wei Zeng', 'orcid': 'https://orcid.org/0000-0003-4421-2120'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Zeng', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100379172', 'display_name': 'Li Chen', 'orcid': 'https://orcid.org/0000-0001-7670-8062'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Li Chen', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000956002', 'display_name': 'Karen Snyder', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Karen Snyder', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018550848', 'display_name': 'Jon Ruckle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210124370', 'display_name': 'Radiant Research (United States)', 'ror': 'https://ror.org/03fz1e596', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210124370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jon L. Ruckle', 'raw_affiliation_strings': ['Radiant Research, Honolulu, HI, USA'], 'affiliations': [{'raw_affiliation_string': 'Radiant Research, Honolulu, HI, USA', 'institution_ids': ['https://openalex.org/I4210124370']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048351488', 'display_name': 'Patrick Larson', 'orcid': 'https://orcid.org/0000-0001-5152-040X'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patrick J. Larson', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024193480', 'display_name': 'Michael J. Davies', 'orcid': 'https://orcid.org/0000-0003-1526-0801'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael J. Davies', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002660940', 'display_name': 'Ronald B. Langdon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ronald B. Langdon', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026975469', 'display_name': 'Keith Gottesdiener', 'orcid': 'https://orcid.org/0000-0001-9121-2145'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Keith M. Gottesdiener', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103478464', 'display_name': 'John A. Wagner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'MSD (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John A. Wagner', 'raw_affiliation_strings': ['Merck Whitehouse Station NJ'], 'affiliations': [{'raw_affiliation_string': 'Merck Whitehouse Station NJ', 'institution_ids': ['https://openalex.org/I1285764155']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4330, 'currency': 'USD', 'value_usd': 4330, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.951, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.946398, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '71', 'issue': '3', 'first_page': '429', 'last_page': '436'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10401', 'display_name': 'Management of Diabetes Mellitus and Cardiovascular Risk', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10401', 'display_name': 'Management of Diabetes Mellitus and Cardiovascular Risk', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Role of Fibroblast Activation in Cancer Progression', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Role of Neuropeptides in Physiology and Disease', 'score': 0.9903, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sitagliptin-phosphate', 'display_name': 'Sitagliptin Phosphate', 'score': 0.84611416}, {'id': 'https://openalex.org/keywords/dipeptidyl-peptidase-4-inhibitor', 'display_name': 'Dipeptidyl peptidase-4 inhibitor', 'score': 0.6419127}, {'id': 'https://openalex.org/keywords/pharmacodynamics', 'display_name': 'Pharmacodynamics', 'score': 0.608801}, {'id': 'https://openalex.org/keywords/dipeptidyl-peptidase-4-inhibitors', 'display_name': 'Dipeptidyl Peptidase-4 Inhibitors', 'score': 0.476885}], 'concepts': [{'id': 'https://openalex.org/C2779284873', 'wikidata': 'https://www.wikidata.org/wiki/Q419832', 'display_name': 'Sitagliptin', 'level': 4, 'score': 0.98820627}, {'id': 'https://openalex.org/C2910260750', 'wikidata': 'https://www.wikidata.org/wiki/Q419832', 'display_name': 'Sitagliptin Phosphate', 'level': 5, 'score': 0.84611416}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.733099}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.67052}, {'id': 'https://openalex.org/C2778763485', 'wikidata': 'https://www.wikidata.org/wiki/Q419770', 'display_name': 'Dipeptidyl peptidase-4 inhibitor', 'level': 4, 'score': 0.6419127}, {'id': 'https://openalex.org/C111113717', 'wikidata': 'https://www.wikidata.org/wiki/Q725307', 'display_name': 'Pharmacodynamics', 'level': 3, 'score': 0.608801}, {'id': 'https://openalex.org/C2777288759', 'wikidata': 'https://www.wikidata.org/wiki/Q4164182', 'display_name': 'Dosing', 'level': 2, 'score': 0.51657236}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.50995123}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.495448}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.49260217}, {'id': 'https://openalex.org/C2780026642', 'wikidata': 'https://www.wikidata.org/wiki/Q40924', 'display_name': 'Urine', 'level': 2, 'score': 0.4539984}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.45180005}, {'id': 'https://openalex.org/C2777180221', 'wikidata': 'https://www.wikidata.org/wiki/Q3025883', 'display_name': 'Type 2 diabetes', 'level': 3, 'score': 0.44355452}, {'id': 'https://openalex.org/C156490143', 'wikidata': 'https://www.wikidata.org/wiki/Q412214', 'display_name': 'Dipeptidyl peptidase-4', 'level': 4, 'score': 0.44300216}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.41950026}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.3240687}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D054873', 'descriptor_name': 'Dipeptidyl-Peptidase IV Inhibitors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044466', 'descriptor_name': 'Asian Continental Ancestry Group', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054873', 'descriptor_name': 'Dipeptidyl-Peptidase IV Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054873', 'descriptor_name': 'Dipeptidyl-Peptidase IV Inhibitors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012107', 'descriptor_name': 'Research Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068900', 'descriptor_name': 'Sitagliptin Phosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013223', 'descriptor_name': 'Statistics as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2125.2010.03852.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2010.03852.x', 'source': {'id': 'https://openalex.org/S13842274', 'display_name': 'British Journal of Clinical Pharmacology', 'issn_l': '0306-5251', 'issn': ['0306-5251', '1365-2125'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3045552', 'pdf_url': 'https://europepmc.org/articles/pmc3045552?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045552', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21284702', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2125.2010.03852.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2010.03852.x', 'source': {'id': 'https://openalex.org/S13842274', 'display_name': 'British Journal of Clinical Pharmacology', 'issn_l': '0306-5251', 'issn': ['0306-5251', '1365-2125'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.77, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W102408304', 'https://openalex.org/W1525055187', 'https://openalex.org/W1585447752', 'https://openalex.org/W1966523582', 'https://openalex.org/W1967130535', 'https://openalex.org/W1980991034', 'https://openalex.org/W1994743271', 'https://openalex.org/W2005867761', 'https://openalex.org/W2048981028', 'https://openalex.org/W2051462052', 'https://openalex.org/W2054185381', 'https://openalex.org/W2074126864', 'https://openalex.org/W2082627462', 'https://openalex.org/W2083473802', 'https://openalex.org/W2084948079', 'https://openalex.org/W2085862152', 'https://openalex.org/W2104025164', 'https://openalex.org/W2109211688', 'https://openalex.org/W2123629330', 'https://openalex.org/W2126893537', 'https://openalex.org/W2129578585', 'https://openalex.org/W2138045215', 'https://openalex.org/W2147779427', 'https://openalex.org/W2148561001', 'https://openalex.org/W2150849997', 'https://openalex.org/W2159205789', 'https://openalex.org/W23768266', 'https://openalex.org/W3192932278'], 'related_works': ['https://openalex.org/W4288042649', 'https://openalex.org/W4247872015', 'https://openalex.org/W4229796543', 'https://openalex.org/W3026628716', 'https://openalex.org/W2987512097', 'https://openalex.org/W2797646286', 'https://openalex.org/W2147698512', 'https://openalex.org/W2120582497', 'https://openalex.org/W2048045369', 'https://openalex.org/W2017851835'], 'abstract_inverted_index': {'Sitagliptin': [0, 202], 'is': [1], 'a': [2, 144, 153], 'selective': [3], 'inhibitor': [4], 'of': [5, 28, 60, 99, 143, 169, 216, 231], 'dipeptidyl': [6], 'peptidase-4': [7], '(DPP-4)': [8], 'used': [9], 'to': [10, 19, 105, 149], 'treat': [11], 'type': [12, 237], '2': [13, 238], 'diabetes.': [14, 239], 'The': [15, 86, 112, 131], 'present': [16], 'aim': [17], 'was': [18, 120, 140, 203], 'evaluate': [20], 'pharmacokinetic': [21], '(PK),': [22], 'pharmacodynamic': [23], '(PD)': [24], 'and': [25, 63, 68, 78, 163, 191, 199, 207, 219], 'safety': [26], 'characteristics': [27], 'sitagliptin': [29, 62, 100, 119, 170, 232], 'following': [30], 'single': [31, 57], 'doses': [32, 59, 168], 'in': [33, 53, 103, 137, 173, 189, 233], 'healthy,': [34], 'young': [35], 'Japanese': [36, 47, 146, 198, 234], 'males.In': [37], 'this': [38, 223], 'alternating': [39], 'two-panel,': [40], 'randomized,': [41], 'controlled': [42], 'double-blind': [43], 'study,': [44], 'six': [45], 'healthy': [46, 95], 'male': [48], 'subjects': [49], '(aged': [50], '20-46': [51], 'years)': [52], 'each': [54], 'panel': [55], 'received': [56, 65], 'oral': [58], '5-400mg': [61], 'two': [64], 'placebo.': [66], 'Plasma': [67], 'urine': [69, 139], 'drug': [70], 'concentrations': [71, 98, 108], 'were': [72, 88, 195, 209], 'measured': [73], 'from': [74, 82, 93, 178, 222], '0-48h': [75], 'post': [76, 84], 'dose': [77, 129, 133], 'plasma': [79, 118], 'DPP-4': [80, 176, 192], 'inhibition': [81, 177, 193], '0-24h': [83, 179], 'dose.': [85], 'results': [87], 'compared': [89], 'with': [90, 122, 227, 236], 'historical': [91], 'data': [92], 'young,': [94], 'non-Japanese': [96, 200], 'males.Plasma': [97], 'increased': [101], 'approximately': [102], 'proportion': [104], 'dose;': [106], 'maximum': [107], 'occurred': [109], '2-6h': [110], 'post-dose.': [111], 'mean': [113, 132], 'apparent': [114], 'terminal': [115], 'half-life': [116, 124], 'for': [117, 161], '9-14h,': [121], 'the': [123, 128, 138], 'slightly': [125], 'decreasing': [126], 'as': [127], 'increased.': [130], 'fraction': [134], 'excreted': [135], 'unchanged': [136], '0.73-1.00.': [141], 'Ingestion': [142], 'traditional': [145], 'breakfast': [147], 'prior': [148], 'dosing': [150, 230], 'had': [151], 'only': [152], 'minor': [154], 'effect': [155], 'on': [156], 'PK': [157, 190, 218], 'parameters.': [158], 'After': [159], 'correction': [160], 'dilution': [162], 'competition': [164], 'effects': [165], 'during': [166], 'assay,': [167], '≥50mg': [171], 'resulted': [172], 'weighted': [174], 'average': [175], 'post-dose': [180], '>94%': [181], '(without': [182], 'correction,': [183], '>78%).': [184], 'No': [185], 'clinically': [186], 'meaningful': [187], 'differences': [188], 'parameters': [194], 'found': [196], 'between': [197], 'subjects.': [201], 'generally': [204], 'well': [205], 'tolerated': [206], 'there': [208], 'no': [210], 'serious': [211], 'adverse': [212], 'experiences': [213], 'or': [214], 'episodes': [215], 'hypoglycaemia.The': [217], 'PD': [220], 'findings': [221], 'study': [224], 'are': [225], 'consistent': [226], 'once': [228], 'daily': [229], 'patients': [235]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1526529090', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-08-12T23:24:32.110808', 'created_date': '2016-06-24'}