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[206, 426], 'to:': [207, 427], 'S': [208, 428, 1230], 'EC1': [231, 451], '2': [232, 452], 'AD,': [233, 453], 'UK.': [234, 454], 'e-mail:': [235, 455], '[email': [236, 456], 'protected]Search': [237, 457], 'author': [243, 463, 951], 'First': [464], 'published:': [465], '21': [466], 'May': [467, 1397], '2013': [468, 848], 'https://doi.org/10.1002/path.4211Citations:': [469], '9': [470], 'No': [471], 'conflicts': [472], 'interest': [474], 'were': [475, 664, 673], 'declared.': [476], 'Read': [477], 'full': [479, 490], 'textAboutPDF': [480], 'ToolsRequest': [481], 'permissionExport': [482], 'citationAdd': [483], 'to': [484, 506, 529, 788, 801, 948, 962, 1351, 1652], 'favoritesTrack': [485], 'citation': [486], 'ShareShare': [487], 'Give': [488], 'accessShare': [489, 492], 'text': [491], 'full-text': [493, 508, 532], 'accessPlease': [494], 'review': [495], 'our': [496], 'Terms': [497, 520], 'Conditions': [499, 522], 'Use': [501, 1347], 'check': [503], 'box': [504], 'below': [505, 528], 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[571, 925], 'induction': [574], 'phenotypic': [577, 827], 'change': [578, 781], 'are': [579, 601, 830, 1293, 1377, 1444], 'unknown.': [580], 'Moreover,': [581], 'recent': [582], 'reports': [583], 'indicate': [584], 'that': [585, 755, 791, 809, 1297], 'dysplastic': [587, 599, 627, 737, 763, 767, 792, 844], 'phenotype': [588, 768, 984], 'may': [589, 785], 'not': [590, 771, 924], 'be': [591, 709, 775, 786, 815, 946], 'immutable:': [592], 'basal': [594, 738, 1561], '(CD),': [597], 'unequivocal': [598], 'seen': [602], 'crypts': [605, 620, 628, 660, 818, 1562], 'other': [610, 1052], 'lesions': [612, 1292], 'gastrointestinal': [615, 821, 1502, 1517], 'tract,': [616], 'but': [617, 784], 'upper': [619, 659, 726, 743], 'epithelium': [623, 646, 663, 740, 747, 758, 1172, 1218], 'associated': [624, 680], 'these': [626], 'show': [629, 748], 'definitive': [631], 'morphology': [632], 'differentiated': [635, 644], 'epithelium.': [636, 730, 1304], 'genotypic': [638, 840], 'relationship': [639], 'CD': 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'mutations,': [751, 1678], 'thus': [752], 'showing': [753], 'definitively': [754], 'derived': [760], 'epithelium:': [765], 'therefore': [770], 'fixed': [772], 'can': [774, 814], 'reversed.': [776], 'mechanism': [778], 'unclear': [783], 'related': [787], 'possibility': [790], 'can,': [794], 'probably': [795], 'early': [796, 1295, 1450, 1706], 'their': [798], 'progression,': [799], 'respond': [800], 'differentiation': [802], 'signals.': [803], 'it': [805], 'also': [807], 'clear': [808], 'heavy': [811], 'mutational': [812], 'burden': [813], 'borne': [816], 'tract': [822, 1518], 'without': [823, 1045], 'development': [825, 1621], 'dysplasia.': [828], 'evidently': [831], 'some': [832], 'way': [833], 'understanding': [835], 'plasticity': [837], 'correlates': [841], 'phenotype.': [845], 'Copyright': [846], '©': [847], 'Pathological': [849], 'Society': [850], 'Great': [852], 'Britain': [853], 'Ireland.': [855], 'Published': [856], 'John': [858], '&': [860], 'Sons,': [861], 'Ltd.': [862], 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[947], 'corresponding': [950], 'article.': [954], 'References': [955], '1Fléjou': [956], 'J-F.': [957], 'oesophagus:': [959], 'metaplasia': [961, 1196, 1375], 'cancer.': [965, 1406], 'Gut': [966, 1177, 1389], '2004;': [967], '54:': [968], 'i6–12.': [969], '2Bignold': [970], 'L.': [971], 'Pathogenetic': [972], 'mechanisms': [973], 'nuclear': [975], 'pleomorphism': [976], 'based': [980], 'on': [981], 'mutator': [983], 'theory': [985], 'carcinogenesis.': [987, 1538], 'Histol': [988], 'Histopathol': [989], '2003;': [990, 1410, 1487], '18:': [991], '657–664.': [992], '3Riddell': [993], 'R,': [994, 1041, 1210, 1723], 'Goldman': [995], 'H,': [996, 1435], 'Ransohoff': [997], 'D,': [998, 1066, 1129, 1617, 1673, 1695], 'et': [999, 1023, 1069, 1103, 1134, 1160, 1211, 1263, 1288, 1324, 1345, 1372, 1399, 1419, 1440, 1467, 1551, 1586, 1618, 1646, 1674, 1698, 1724, 1750], 'al.': [1000, 1024, 1070, 1104, 1135, 1161, 1212, 1264, 1289, 1325, 1346, 1373, 1400, 1420, 1441, 1468, 1552, 1587, 1619, 1647, 1675, 1699, 1725, 1751], 'Dysplasia': [1001], 'inflammatory': [1003, 1599], 'bowel': [1004], 'disease:': [1005], 'standardized': [1006], 'classification': [1007], 'provisional': [1009], 'clinical': [1010], 'applications.': [1011], 'Hum': [1012, 1035], 'Pathol': [1013, 1036, 1057, 1093, 1124, 1150, 1636, 1769], '1983;': [1014], '14:': [1015], '931–968.': [1016], '4Reid': [1017], 'BJ,': [1018, 1418], 'Haggit': [1019], 'RE,': [1020], 'Rubin': [1021], 'CE,': [1022], 'Observer': [1025], 'variation': [1026], 'esophagus.': [1034, 1146, 1333], '1988;': [1037], '19:': [1038], '166–178.': [1039], '5Odze': [1040], 'Maley': [1042], 'C.': [1043], 'Neoplasia': [1044], 'dysplasia:': [1046, 1084], 'lessons': [1047], 'Barrett': [1049, 1145], 'esophagus': [1050, 1081, 1119, 1270], 'tubal': [1053], 'gut': [1054], 'neoplasms.': [1055], 'Arch': [1056], 'Lab': [1058], 'Med': [1059, 1277], '2010;': [1060, 1094, 1542, 1609], '134:': [1061], '896–906.': [1062], '6Srivastava': [1063], 'A,': [1064, 1258, 1260, 1342, 1371, 1437, 1491, 1581, 1745], 'Coco': [1065], 'Sanchez': [1067, 1101], 'C,': [1068, 1546, 1645], 'Risk': [1071], 'conventional': [1073], 'adenocarcinoma': [1076], 'prospective': [1086], 'follow-up': [1087], 'study': [1088, 1115], '214': [1090], 'patients.': [1091], 'Mod': [1092], '23(S1):': [1095], '168A.': [1096], '7Lomo': [1097], 'LC,': [1098], 'Blount': [1099], 'PL,': [1100], 'maturation:': [1109], 'clinical,': [1111], 'pathologic,': [1112], 'molecular': [1114], 'cohort.': [1120], 'Am': [1121, 1147], 'J': [1122, 1148, 1407, 1635], 'Surg': [1123, 1149], '2006;': [1125, 1431, 1525], '30:': [1126], '423–435.': [1127], '8Coco': [1128], 'Goldblum': [1130], 'J,': [1131, 1133, 1749], 'Hornick': [1132], 'Interobserver': [1136], 'variability': [1137], '2011;': [1151, 1202, 1363], '35:': [1152], '45–54.': [1153], '9Leedham': [1154], 'SJ,': [1155, 1669], 'Preston': [1156], 'SL,': [1157, 1462], 'SAC,': [1159], 'Individual': [1162], 'heterogeneity': [1165], 'origin': [1168, 1474], 'metaplastic': [1170, 1303], 'glandular': [1171], 'human': [1174, 1199, 1359, 1557, 1629, 1683], '2008;': [1178, 1336, 1637], '57:': [1179, 1280], '1041–1048.': [1180], '10Gutierrez-Gonzalez,': [1181], 'L': [1182, 1232], 'T,': [1184, 1344, 1693], 'M,': [1186, 1208, 1439], 'Al.': [1187], 'E.': [1188], 'origins': [1191], 'intestinal': [1195, 1217, 1567], 'stomach.': [1200], 'Gastroenterology': [1201, 1224, 1362, 1687, 1714, 1740], '140:': [1203, 1364], '1251–1260.': [1204], '11Galandiuk': [1205], 'S,': [1206, 1613, 1615, 1643], 'Jeffery': [1209], 'Field': [1213], 'cancerization': [1214, 1681], "Crohn's": [1222], 'ileocolitis.': [1223], '2012;': [1225, 1279, 1390, 1509, 1770], '142:': [1226], '855–864,': [1227], 'e8.': [1228], '12': [1229], 'Hamilton,': [1231], 'Aaltonen': [1233], '(eds).': [1234], 'Pathology': [1235], 'genetics': [1237], 'tumours': [1239], 'digestive': [1242, 1602], 'system.': [1243], 'In': [1244], 'World': [1245, 1763], 'Health': [1246, 1764], 'Organization': [1247, 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[1422, 1566], 'evolutionary': [1424], 'ecological': [1426], 'process.': [1427], 'Nat': [1428], 'Rev': [1429, 1524], '6:': [1432], '924–935.': [1433], '21Lamlum': [1434], 'Papadopoulou': [1436], 'Ilyas': [1438], 'APC': [1442], 'sufficient': [1445], 'growth': [1448], 'colorectal': [1451, 1472], 'adenomas.': [1452], 'Proc': [1453, 1572, 1604], 'Natl': [1454, 1573, 1605], 'Acad': [1455, 1574, 1606], 'USA': [1457, 1576, 1608], '2000;': [1458], '97:': [1459], '2225–2228.': [1460], '22Preston': [1461], 'Wong': [1463], 'W-M,': [1464], 'Chan': [1465, 1549], 'AO-O,': [1466], 'Bottom-up': [1469], 'histogenesis': [1470], 'adenomas:': [1473], 'monocryptal': [1477], 'adenoma': [1478], 'initial': [1480], 'fission.': [1484], '63:': [1488], '3819–3825.': [1489], '23Schepers': [1490], 'Clevers': [1492], 'H.': [1493], 'Wnt': [1494], 'signaling,': [1495], 'cells,': [1497], 'cancer': [1499], 'tract.': [1503], 'Cold': [1504], 'Spring': [1505], 'Harb': [1506], 'Perspect': [1507], '4:': [1510], 'a007989.': 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