Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1525304663', 'doi': 'https://doi.org/10.4049/jimmunol.0900753', 'title': 'CD4+CD25+ Regulatory T Cells Resist a Novel Form of CD28- and Fas-Dependent p53-Induced T Cell Apoptosis', 'display_name': 'CD4+CD25+ Regulatory T Cells Resist a Novel Form of CD28- and Fas-Dependent p53-Induced T Cell Apoptosis', 'publication_year': 2009, 'publication_date': '2009-12-01', 'ids': {'openalex': 'https://openalex.org/W1525304663', 'doi': 'https://doi.org/10.4049/jimmunol.0900753', 'mag': '1525304663', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19949106', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4436589'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0900753', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/184/1/94.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jimmunol.org/content/jimmunol/184/1/94.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100776448', 'display_name': 'Nagendra Singh', 'orcid': 'https://orcid.org/0000-0003-2540-6990'}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nagendra Singh', 'raw_affiliation_strings': ['*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and'], 'affiliations': [{'raw_affiliation_string': '*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and', 'institution_ids': ['https://openalex.org/I25041050']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050058974', 'display_name': 'Mutsumi Yamamoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}, {'id': 'https://openalex.org/I4210124771', 'display_name': 'Bipar', 'ror': 'https://ror.org/027364b18', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I17606148', 'https://openalex.org/I197681013', 'https://openalex.org/I4210088668', 'https://openalex.org/I4210099460', 'https://openalex.org/I4210124771', 'https://openalex.org/I4210138120']}, {'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Mutsumi Yamamoto', 'raw_affiliation_strings': ['*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and', '†Department of Microbiology and Immunology and', '‡Institute of Infectious Disease and Immunology, Loyola University Chicago, Maywood, IL 60153'], 'affiliations': [{'raw_affiliation_string': '*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and', 'institution_ids': ['https://openalex.org/I25041050']}, {'raw_affiliation_string': '†Department of Microbiology and Immunology and', 'institution_ids': ['https://openalex.org/I4210124771']}, {'raw_affiliation_string': '‡Institute of Infectious Disease and Immunology, Loyola University Chicago, Maywood, IL 60153', 'institution_ids': ['https://openalex.org/I1925986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039663004', 'display_name': 'Mariko Takami', 'orcid': 'https://orcid.org/0009-0003-9607-4425'}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}, {'id': 'https://openalex.org/I4210124771', 'display_name': 'Bipar', 'ror': 'https://ror.org/027364b18', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I17606148', 'https://openalex.org/I197681013', 'https://openalex.org/I4210088668', 'https://openalex.org/I4210099460', 'https://openalex.org/I4210124771', 'https://openalex.org/I4210138120']}, {'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Mariko Takami', 'raw_affiliation_strings': ['*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and', '†Department of Microbiology and Immunology and', '‡Institute of Infectious Disease and Immunology, Loyola University Chicago, Maywood, IL 60153'], 'affiliations': [{'raw_affiliation_string': '*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and', 'institution_ids': ['https://openalex.org/I25041050']}, {'raw_affiliation_string': '†Department of Microbiology and Immunology and', 'institution_ids': ['https://openalex.org/I4210124771']}, {'raw_affiliation_string': '‡Institute of Infectious Disease and Immunology, Loyola University Chicago, Maywood, IL 60153', 'institution_ids': ['https://openalex.org/I1925986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037439029', 'display_name': 'Yoichi Seki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}, {'id': 'https://openalex.org/I4210124771', 'display_name': 'Bipar', 'ror': 'https://ror.org/027364b18', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I17606148', 'https://openalex.org/I197681013', 'https://openalex.org/I4210088668', 'https://openalex.org/I4210099460', 'https://openalex.org/I4210124771', 'https://openalex.org/I4210138120']}, {'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Yoichi Seki', 'raw_affiliation_strings': ['*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and', '†Department of Microbiology and Immunology and', '‡Institute of Infectious Disease and Immunology, Loyola University Chicago, Maywood, IL 60153'], 'affiliations': [{'raw_affiliation_string': '*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and', 'institution_ids': ['https://openalex.org/I25041050']}, {'raw_affiliation_string': '†Department of Microbiology and Immunology and', 'institution_ids': ['https://openalex.org/I4210124771']}, {'raw_affiliation_string': '‡Institute of Infectious Disease and Immunology, Loyola University Chicago, Maywood, IL 60153', 'institution_ids': ['https://openalex.org/I1925986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036516284', 'display_name': 'Mayuko Takezaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mayuko Takezaki', 'raw_affiliation_strings': ['*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and'], 'affiliations': [{'raw_affiliation_string': '*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and', 'institution_ids': ['https://openalex.org/I25041050']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054796938', 'display_name': 'Andrew L. Mellor', 'orcid': 'https://orcid.org/0000-0002-9553-6160'}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew L. Mellor', 'raw_affiliation_strings': ['*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and'], 'affiliations': [{'raw_affiliation_string': '*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and', 'institution_ids': ['https://openalex.org/I25041050']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5032348618', 'display_name': 'Makio Iwashima', 'orcid': 'https://orcid.org/0000-0003-3849-0212'}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}, {'id': 'https://openalex.org/I4210124771', 'display_name': 'Bipar', 'ror': 'https://ror.org/027364b18', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I17606148', 'https://openalex.org/I197681013', 'https://openalex.org/I4210088668', 'https://openalex.org/I4210099460', 'https://openalex.org/I4210124771', 'https://openalex.org/I4210138120']}, {'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Makio Iwashima', 'raw_affiliation_strings': ['*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and', '†Department of Microbiology and Immunology and', '‡Institute of Infectious Disease and Immunology, Loyola University Chicago, Maywood, IL 60153'], 'affiliations': [{'raw_affiliation_string': '*Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912; and', 'institution_ids': ['https://openalex.org/I25041050']}, {'raw_affiliation_string': '†Department of Microbiology and Immunology and', 'institution_ids': ['https://openalex.org/I4210124771']}, {'raw_affiliation_string': '‡Institute of Infectious Disease and Immunology, Loyola University Chicago, Maywood, IL 60153', 'institution_ids': ['https://openalex.org/I1925986']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.70608, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '184', 'issue': '1', 'first_page': '94', 'last_page': '104'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/regulatory-t-cell', 'display_name': 'Regulatory T cell', 'score': 0.4776427}], 'concepts': [{'id': 'https://openalex.org/C148125776', 'wikidata': 'https://www.wikidata.org/wiki/Q1622348', 'display_name': 'CD28', 'level': 4, 'score': 0.67240983}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.66065127}, {'id': 'https://openalex.org/C79484868', 'wikidata': 'https://www.wikidata.org/wiki/Q5971673', 'display_name': 'IL-2 receptor', 'level': 4, 'score': 0.63172364}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5276158}, {'id': 'https://openalex.org/C2778296632', 'wikidata': 'https://www.wikidata.org/wiki/Q1550619', 'display_name': 'Regulatory T cell', 'level': 5, 'score': 0.4776427}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.42686749}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.41645384}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.40249372}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38312298}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3419022}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20335704}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.14820048}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D019014', 'descriptor_name': 'fas Receptor', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015496', 'descriptor_name': 'CD4-Positive T-Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015496', 'descriptor_name': 'CD4-Positive T-Lymphocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D015496', 'descriptor_name': 'CD4-Positive T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D015496', 'descriptor_name': 'CD4-Positive T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019014', 'descriptor_name': 'fas Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019014', 'descriptor_name': 'fas Receptor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0900753', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/184/1/94.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4436589', 'pdf_url': 'https://europepmc.org/articles/pmc4436589?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436589', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19949106', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0900753', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/184/1/94.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.83, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W118130514', 'https://openalex.org/W1488633968', 'https://openalex.org/W1490733948', 'https://openalex.org/W1490870966', 'https://openalex.org/W1516581843', 'https://openalex.org/W1529380529', 'https://openalex.org/W1531973880', 'https://openalex.org/W1576121165', 'https://openalex.org/W1582077486', 'https://openalex.org/W1599982743', 'https://openalex.org/W1650797637', 'https://openalex.org/W1816717084', 'https://openalex.org/W1974351164', 'https://openalex.org/W1985099044', 'https://openalex.org/W1985490087', 'https://openalex.org/W1993210315', 'https://openalex.org/W2006352968', 'https://openalex.org/W2012206253', 'https://openalex.org/W2017185316', 'https://openalex.org/W2021811080', 'https://openalex.org/W2023809975', 'https://openalex.org/W2041154353', 'https://openalex.org/W2048086309', 'https://openalex.org/W2051972593', 'https://openalex.org/W2053958882', 'https://openalex.org/W2055542550', 'https://openalex.org/W2058715880', 'https://openalex.org/W2059990804', 'https://openalex.org/W2074545297', 'https://openalex.org/W2076779192', 'https://openalex.org/W2083741938', 'https://openalex.org/W2084416533', 'https://openalex.org/W2086776723', 'https://openalex.org/W2091420555', 'https://openalex.org/W2091783976', 'https://openalex.org/W2093718923', 'https://openalex.org/W2099787406', 'https://openalex.org/W2100474263', 'https://openalex.org/W2109372137', 'https://openalex.org/W2112240302', 'https://openalex.org/W2124052729', 'https://openalex.org/W2125827510', 'https://openalex.org/W2135135219', 'https://openalex.org/W2135280067', 'https://openalex.org/W2139191751', 'https://openalex.org/W2146828787', 'https://openalex.org/W2148226248', 'https://openalex.org/W2157740207', 'https://openalex.org/W2159101109', 'https://openalex.org/W2166438464', 'https://openalex.org/W2171026458'], 'related_works': ['https://openalex.org/W3193529407', 'https://openalex.org/W2969453961', 'https://openalex.org/W2391459333', 'https://openalex.org/W2044402738', 'https://openalex.org/W2005978956', 'https://openalex.org/W1979841260', 'https://openalex.org/W1975332625', 'https://openalex.org/W1592696248', 'https://openalex.org/W1542374316', 'https://openalex.org/W1525304663'], 'abstract_inverted_index': {'Abstract': [0], 'Ag': [1], 'receptor': [2], 'stimulation': [3], 'of': [4, 33, 48, 92, 99, 103, 112, 115, 171, 192], 'preactivated': [5], 'T': [6, 35, 49, 60, 76, 93, 119, 128, 151, 155, 173, 194], 'cells': [7, 36, 61, 77, 129, 152, 156, 195], 'causes': [8], 'rapid': [9], 'cell': [10, 23, 50, 94, 120, 174], 'death': [11, 24, 175], 'in': [12, 30, 196], 'an': [13], 'IL-2–': [14], 'and': [15, 66, 74, 101, 157, 179, 182, 186], 'Fas-dependent': [16], 'manner.': [17], 'This': [18], 'phenomenon,': [19], 'known': [20], 'as': [21], 'activation-induced': [22], '(AICD),': [25], 'plays': [26], 'a': [27, 45, 105, 168, 184], 'pivotal': [28], 'role': [29], 'the': [31, 123, 137, 190], 'removal': [32], 'Ag-reactive': [34], 'after': [37, 84, 160], 'initial': [38], 'expansion.': [39], 'In': [40], 'this': [41, 90, 113], 'study,': [42], 'we': [43], 'report': [44], 'novel': [46, 169], 'form': [47, 114], 'apoptosis': [51, 83, 95, 116], 'that': [52], 'is': [53], 'distinct': [54], 'from': [55], 'classic': [56, 88], 'AICD.': [57], 'When': [58], 'peripheral': [59], 'were': [62], 'activated': [63], 'with': [64, 143], 'anti-CD3': [65, 145], 'anti-CD28': [67, 147], 'Abs': [68], 'precoated': [69], 'onto': [70], 'plastic': [71], 'plates,': [72], 'CD4+CD25−': [73], 'CD8': [75], 'initially': [78], 'expanded': [79, 158], 'but': [80], 'underwent': [81], 'massive': [82], '4': [85, 133], 'd.': [86, 134, 162], 'Unlike': [87], 'AICD,': [89], 'type': [91], 'pathway': [96], 'requires': [97], 'engagement': [98, 181], 'CD28': [100, 180], 'expression': [102], 'p53,': [104], 'tumor-suppressor': [106], 'gene.': [107], 'The': [108, 163], 'most': [109], 'striking': [110], 'feature': [111], 'was': [117, 141], 'regulatory': [118, 150, 193], 'resistance.': [121], 'Under': [122], 'same': [124], 'stimulating': [125], 'conditions,': [126], 'CD4+CD25+': [127], 'grew': [130], 'continuously': [131], 'beyond': [132], 'Consequently,': [135], 'when': [136], 'entire': [138], 'CD4': [139], 'population': [140], 'cultured': [142], 'plate-bound': [144], 'plus': [146], 'Ab,': [148], 'CD4+CD25+FoxP3+': [149], 'outgrew': [153], 'nonregulatory': [154], '>7000-fold': [159], '11': [161], 'data': [164], 'presented': [165], 'herein': [166], 'demonstrate': [167], 'process': [170], 'Ag-induced': [172], 'by': [176], 'sustained': [177], 'TCR': [178], 'represent': [183], 'simple': [185], 'efficient': [187], 'procedure': [188], 'for': [189], 'expansion': [191], 'vitro.': [197]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1525304663', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-12T04:45:36.464632', 'created_date': '2016-06-24'}