Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1525051702', 'doi': 'https://doi.org/10.4049/jimmunol.0902016', 'title': 'Functional Characterization of the Recombinant Human C1 Inhibitor Serpin Domain: Insights into Heparin Binding', 'display_name': 'Functional Characterization of the Recombinant Human C1 Inhibitor Serpin Domain: Insights into Heparin Binding', 'publication_year': 2010, 'publication_date': '2010-03-30', 'ids': {'openalex': 'https://openalex.org/W1525051702', 'doi': 'https://doi.org/10.4049/jimmunol.0902016', 'mag': '1525051702', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20351192'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0902016', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/184/9/4982/1322925/ji_0902016.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.aai.org/jimmunol/article-pdf/184/9/4982/1322925/ji_0902016.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046769409', 'display_name': 'Véronique Rossi', 'orcid': 'https://orcid.org/0000-0002-6700-3578'}, 'institutions': [{'id': 'https://openalex.org/I4210089144', 'display_name': 'Centre National pour la Recherche Scientifique et Technique (CNRST)', 'ror': 'https://ror.org/00675rp98', 'country_code': 'MA', 'type': 'government', 'lineage': ['https://openalex.org/I4210089144']}, {'id': 'https://openalex.org/I4210152516', 'display_name': 'Institut de Biologie Structurale', 'ror': 'https://ror.org/04szabx38', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I2738703131', 'https://openalex.org/I4210091409', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152516', 'https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I177483745', 'display_name': 'Université Joseph Fourier', 'ror': 'https://ror.org/02aj0kh94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I177483745']}, {'id': 'https://openalex.org/I899635006', 'display_name': 'Université Grenoble Alpes', 'ror': 'https://ror.org/02rx3b187', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I2738703131', 'display_name': "Commissariat à l'Énergie Atomique et aux Énergies Alternatives", 'ror': 'https://ror.org/00jjx8s55', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I2738703131']}], 'countries': ['FR', 'MA'], 'is_corresponding': False, 'raw_author_name': 'Véronique Rossi', 'raw_affiliation_strings': ["*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;"], 'affiliations': [{'raw_affiliation_string': "*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;", 'institution_ids': ['https://openalex.org/I4210089144', 'https://openalex.org/I4210152516', 'https://openalex.org/I177483745', 'https://openalex.org/I899635006', 'https://openalex.org/I2738703131']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071598397', 'display_name': 'Isabelle Bally', 'orcid': 'https://orcid.org/0000-0002-8315-6080'}, 'institutions': [{'id': 'https://openalex.org/I4210089144', 'display_name': 'Centre National pour la Recherche Scientifique et Technique (CNRST)', 'ror': 'https://ror.org/00675rp98', 'country_code': 'MA', 'type': 'government', 'lineage': ['https://openalex.org/I4210089144']}, {'id': 'https://openalex.org/I4210152516', 'display_name': 'Institut de Biologie Structurale', 'ror': 'https://ror.org/04szabx38', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I2738703131', 'https://openalex.org/I4210091409', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152516', 'https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I177483745', 'display_name': 'Université Joseph Fourier', 'ror': 'https://ror.org/02aj0kh94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I177483745']}, {'id': 'https://openalex.org/I899635006', 'display_name': 'Université Grenoble Alpes', 'ror': 'https://ror.org/02rx3b187', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I2738703131', 'display_name': "Commissariat à l'Énergie Atomique et aux Énergies Alternatives", 'ror': 'https://ror.org/00jjx8s55', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I2738703131']}], 'countries': ['FR', 'MA'], 'is_corresponding': False, 'raw_author_name': 'Isabelle Bally', 'raw_affiliation_strings': ["*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;"], 'affiliations': [{'raw_affiliation_string': "*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;", 'institution_ids': ['https://openalex.org/I4210089144', 'https://openalex.org/I4210152516', 'https://openalex.org/I177483745', 'https://openalex.org/I899635006', 'https://openalex.org/I2738703131']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089732796', 'display_name': 'Sarah Ancelet', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089144', 'display_name': 'Centre National pour la Recherche Scientifique et Technique (CNRST)', 'ror': 'https://ror.org/00675rp98', 'country_code': 'MA', 'type': 'government', 'lineage': ['https://openalex.org/I4210089144']}, {'id': 'https://openalex.org/I4210152516', 'display_name': 'Institut de Biologie Structurale', 'ror': 'https://ror.org/04szabx38', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I2738703131', 'https://openalex.org/I4210091409', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152516', 'https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I177483745', 'display_name': 'Université Joseph Fourier', 'ror': 'https://ror.org/02aj0kh94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I177483745']}, {'id': 'https://openalex.org/I899635006', 'display_name': 'Université Grenoble Alpes', 'ror': 'https://ror.org/02rx3b187', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I2738703131', 'display_name': "Commissariat à l'Énergie Atomique et aux Énergies Alternatives", 'ror': 'https://ror.org/00jjx8s55', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I2738703131']}], 'countries': ['FR', 'MA'], 'is_corresponding': False, 'raw_author_name': 'Sarah Ancelet', 'raw_affiliation_strings': ["*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;"], 'affiliations': [{'raw_affiliation_string': "*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;", 'institution_ids': ['https://openalex.org/I4210089144', 'https://openalex.org/I4210152516', 'https://openalex.org/I177483745', 'https://openalex.org/I899635006', 'https://openalex.org/I2738703131']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100829018', 'display_name': 'Yuanyuan Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yuanyuan Xu', 'raw_affiliation_strings': ['University of Alabama at Birmingham, Birmingham, AL 35294.#TAB#'], 'affiliations': [{'raw_affiliation_string': 'University of Alabama at Birmingham, Birmingham, AL 35294.#TAB#', 'institution_ids': ['https://openalex.org/I32389192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025683973', 'display_name': 'Véronique Frémeaux‐Bacchi', 'orcid': 'https://orcid.org/0000-0002-4865-8528'}, 'institutions': [{'id': 'https://openalex.org/I4210102325', 'display_name': 'Hôpital Européen Georges-Pompidou', 'ror': 'https://ror.org/016vx5156', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210102325', 'https://openalex.org/I4210120235']}, {'id': 'https://openalex.org/I4210109141', 'display_name': 'Hôpital Européen', 'ror': 'https://ror.org/01tfhsg94', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210109141']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Véronique Frémeaux-Bacchi', 'raw_affiliation_strings': ['‡Hôpital Européen Georges Pompidou, Paris, France; and'], 'affiliations': [{'raw_affiliation_string': '‡Hôpital Européen Georges Pompidou, Paris, France; and', 'institution_ids': ['https://openalex.org/I4210102325', 'https://openalex.org/I4210109141']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037889329', 'display_name': 'Romain R. Vivès', 'orcid': 'https://orcid.org/0000-0003-4295-5449'}, 'institutions': [{'id': 'https://openalex.org/I2738703131', 'display_name': "Commissariat à l'Énergie Atomique et aux Énergies Alternatives", 'ror': 'https://ror.org/00jjx8s55', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I2738703131']}, {'id': 'https://openalex.org/I4210089144', 'display_name': 'Centre National pour la Recherche Scientifique et Technique (CNRST)', 'ror': 'https://ror.org/00675rp98', 'country_code': 'MA', 'type': 'government', 'lineage': ['https://openalex.org/I4210089144']}, {'id': 'https://openalex.org/I4210152516', 'display_name': 'Institut de Biologie Structurale', 'ror': 'https://ror.org/04szabx38', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I2738703131', 'https://openalex.org/I4210091409', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152516', 'https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I177483745', 'display_name': 'Université Joseph Fourier', 'ror': 'https://ror.org/02aj0kh94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I177483745']}, {'id': 'https://openalex.org/I899635006', 'display_name': 'Université Grenoble Alpes', 'ror': 'https://ror.org/02rx3b187', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I899635006']}], 'countries': ['FR', 'MA'], 'is_corresponding': False, 'raw_author_name': 'Romain R. Vivès', 'raw_affiliation_strings': ["*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;"], 'affiliations': [{'raw_affiliation_string': "*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;", 'institution_ids': ['https://openalex.org/I2738703131', 'https://openalex.org/I4210089144', 'https://openalex.org/I4210152516', 'https://openalex.org/I177483745', 'https://openalex.org/I899635006']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015974345', 'display_name': 'Rabia Sadir', 'orcid': 'https://orcid.org/0000-0002-4084-4094'}, 'institutions': [{'id': 'https://openalex.org/I2738703131', 'display_name': "Commissariat à l'Énergie Atomique et aux Énergies Alternatives", 'ror': 'https://ror.org/00jjx8s55', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I2738703131']}, {'id': 'https://openalex.org/I4210089144', 'display_name': 'Centre National pour la Recherche Scientifique et Technique (CNRST)', 'ror': 'https://ror.org/00675rp98', 'country_code': 'MA', 'type': 'government', 'lineage': ['https://openalex.org/I4210089144']}, {'id': 'https://openalex.org/I4210152516', 'display_name': 'Institut de Biologie Structurale', 'ror': 'https://ror.org/04szabx38', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I2738703131', 'https://openalex.org/I4210091409', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152516', 'https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I177483745', 'display_name': 'Université Joseph Fourier', 'ror': 'https://ror.org/02aj0kh94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I177483745']}, {'id': 'https://openalex.org/I899635006', 'display_name': 'Université Grenoble Alpes', 'ror': 'https://ror.org/02rx3b187', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I899635006']}], 'countries': ['FR', 'MA'], 'is_corresponding': False, 'raw_author_name': 'Rabia Sadir', 'raw_affiliation_strings': ["*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;"], 'affiliations': [{'raw_affiliation_string': "*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;", 'institution_ids': ['https://openalex.org/I2738703131', 'https://openalex.org/I4210089144', 'https://openalex.org/I4210152516', 'https://openalex.org/I177483745', 'https://openalex.org/I899635006']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054747782', 'display_name': 'Nicole M. Thielens', 'orcid': 'https://orcid.org/0000-0002-7354-0302'}, 'institutions': [{'id': 'https://openalex.org/I4210089144', 'display_name': 'Centre National pour la Recherche Scientifique et Technique (CNRST)', 'ror': 'https://ror.org/00675rp98', 'country_code': 'MA', 'type': 'government', 'lineage': ['https://openalex.org/I4210089144']}, {'id': 'https://openalex.org/I4210152516', 'display_name': 'Institut de Biologie Structurale', 'ror': 'https://ror.org/04szabx38', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I2738703131', 'https://openalex.org/I4210091409', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152516', 'https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I177483745', 'display_name': 'Université Joseph Fourier', 'ror': 'https://ror.org/02aj0kh94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I177483745']}, {'id': 'https://openalex.org/I899635006', 'display_name': 'Université Grenoble Alpes', 'ror': 'https://ror.org/02rx3b187', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I2738703131', 'display_name': "Commissariat à l'Énergie Atomique et aux Énergies Alternatives", 'ror': 'https://ror.org/00jjx8s55', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I2738703131']}], 'countries': ['FR', 'MA'], 'is_corresponding': False, 'raw_author_name': 'Nicole Thielens', 'raw_affiliation_strings': ["*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;"], 'affiliations': [{'raw_affiliation_string': "*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;", 'institution_ids': ['https://openalex.org/I4210089144', 'https://openalex.org/I4210152516', 'https://openalex.org/I177483745', 'https://openalex.org/I899635006', 'https://openalex.org/I2738703131']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5105935832', 'display_name': 'Gérard J. Arlaud', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089144', 'display_name': 'Centre National pour la Recherche Scientifique et Technique (CNRST)', 'ror': 'https://ror.org/00675rp98', 'country_code': 'MA', 'type': 'government', 'lineage': ['https://openalex.org/I4210089144']}, {'id': 'https://openalex.org/I4210152516', 'display_name': 'Institut de Biologie Structurale', 'ror': 'https://ror.org/04szabx38', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I2738703131', 'https://openalex.org/I4210091409', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152516', 'https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I177483745', 'display_name': 'Université Joseph Fourier', 'ror': 'https://ror.org/02aj0kh94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I177483745']}, {'id': 'https://openalex.org/I899635006', 'display_name': 'Université Grenoble Alpes', 'ror': 'https://ror.org/02rx3b187', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I2738703131', 'display_name': "Commissariat à l'Énergie Atomique et aux Énergies Alternatives", 'ror': 'https://ror.org/00jjx8s55', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I2738703131']}], 'countries': ['FR', 'MA'], 'is_corresponding': False, 'raw_author_name': 'Gérard J. Arlaud', 'raw_affiliation_strings': ["*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;"], 'affiliations': [{'raw_affiliation_string': "*Institut de Biologie Structurale Jean-Pierre Ebel, Unité Mixte de Recherche 5075, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique-Université Joseph Fourier, Grenoble;", 'institution_ids': ['https://openalex.org/I4210089144', 'https://openalex.org/I4210152516', 'https://openalex.org/I177483745', 'https://openalex.org/I899635006', 'https://openalex.org/I2738703131']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 8, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.767, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.892461, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '184', 'issue': '9', 'first_page': '4982', 'last_page': '4989'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11917', 'display_name': 'Hereditary Angioedema: Molecular Mechanisms and Clinical Management', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11917', 'display_name': 'Hereditary Angioedema: Molecular Mechanisms and Clinical Management', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Role of Fibroblast Activation in Cancer Progression', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10881', 'display_name': 'Thrombosis and Coagulation Disorders', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/c1-inhibitor', 'display_name': 'C1-inhibitor', 'score': 0.87410396}, {'id': 'https://openalex.org/keywords/serpin', 'display_name': 'Serpin', 'score': 0.8527101}, {'id': 'https://openalex.org/keywords/protease-inhibitor', 'display_name': 'Protease inhibitor (pharmacology)', 'score': 0.6628998}, {'id': 'https://openalex.org/keywords/c1-inhibitor-deficiency', 'display_name': 'C1 Inhibitor Deficiency', 'score': 0.521426}], 'concepts': [{'id': 'https://openalex.org/C2779931649', 'wikidata': 'https://www.wikidata.org/wiki/Q416510', 'display_name': 'C1-inhibitor', 'level': 3, 'score': 0.87410396}, {'id': 'https://openalex.org/C2778965386', 'wikidata': 'https://www.wikidata.org/wiki/Q420068', 'display_name': 'Serpin', 'level': 3, 'score': 0.8527101}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.73375714}, {'id': 'https://openalex.org/C2781143361', 'wikidata': 'https://www.wikidata.org/wiki/Q55761529', 'display_name': 'Protease inhibitor (pharmacology)', 'level': 5, 'score': 0.6628998}, {'id': 'https://openalex.org/C2777807008', 'wikidata': 'https://www.wikidata.org/wiki/Q87324999', 'display_name': 'Serine protease', 'level': 4, 'score': 0.60491526}, {'id': 'https://openalex.org/C2777557582', 'wikidata': 'https://www.wikidata.org/wiki/Q190016', 'display_name': 'Heparin', 'level': 2, 'score': 0.592321}, {'id': 'https://openalex.org/C180577832', 'wikidata': 'https://www.wikidata.org/wiki/Q127920', 'display_name': 'Covalent bond', 'level': 2, 'score': 0.5396071}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.49027947}, {'id': 'https://openalex.org/C106847996', 'wikidata': 'https://www.wikidata.org/wiki/Q898756', 'display_name': 'Surface plasmon resonance', 'level': 3, 'score': 0.48243174}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.47752538}, {'id': 'https://openalex.org/C2776714187', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Protease', 'level': 3, 'score': 0.4600077}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.4013397}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.2149168}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.10963744}, {'id': 'https://openalex.org/C2777995640', 'wikidata': 'https://www.wikidata.org/wiki/Q1129007', 'display_name': 'Angioedema', 'level': 2, 'score': 0.084589005}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.077346146}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C3013748606', 'wikidata': 'https://www.wikidata.org/wiki/Q15787', 'display_name': 'Human immunodeficiency virus (HIV)', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2993143319', 'wikidata': 'https://www.wikidata.org/wiki/Q583050', 'display_name': 'Antiretroviral therapy', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C142462285', 'wikidata': 'https://www.wikidata.org/wiki/Q2528140', 'display_name': 'Viral load', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C155672457', 'wikidata': 'https://www.wikidata.org/wiki/Q61231', 'display_name': 'Nanoparticle', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003172', 'descriptor_name': 'Complement C1', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D003172', 'descriptor_name': 'Complement C1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050718', 'descriptor_name': 'Complement C1 Inhibitor Protein', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D006493', 'descriptor_name': 'Heparin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015843', 'descriptor_name': 'Serpins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016367', 'descriptor_name': 'Baculoviridae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016367', 'descriptor_name': 'Baculoviridae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002241', 'descriptor_name': 'Carbohydrates', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002241', 'descriptor_name': 'Carbohydrates', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002241', 'descriptor_name': 'Carbohydrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003172', 'descriptor_name': 'Complement C1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050718', 'descriptor_name': 'Complement C1 Inhibitor Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050718', 'descriptor_name': 'Complement C1 Inhibitor Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050718', 'descriptor_name': 'Complement C1 Inhibitor Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003173', 'descriptor_name': 'Complement C1s', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003173', 'descriptor_name': 'Complement C1s', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D003173', 'descriptor_name': 'Complement C1s', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006493', 'descriptor_name': 'Heparin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006493', 'descriptor_name': 'Heparin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008970', 'descriptor_name': 'Molecular Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009036', 'descriptor_name': 'Moths', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009036', 'descriptor_name': 'Moths', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015843', 'descriptor_name': 'Serpins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015843', 'descriptor_name': 'Serpins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015843', 'descriptor_name': 'Serpins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018411', 'descriptor_name': 'Spodoptera', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018411', 'descriptor_name': 'Spodoptera', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013552', 'descriptor_name': 'Swine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0902016', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/184/9/4982/1322925/ji_0902016.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-01073615', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-01073615', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20351192', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.0902016', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/184/9/4982/1322925/ji_0902016.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1501179348', 'https://openalex.org/W1505900720', 'https://openalex.org/W1530639541', 'https://openalex.org/W1541482973', 'https://openalex.org/W1648294627', 'https://openalex.org/W1651806643', 'https://openalex.org/W1672094780', 'https://openalex.org/W1826270762', 'https://openalex.org/W1966382197', 'https://openalex.org/W1967358462', 'https://openalex.org/W1974713427', 'https://openalex.org/W1983623773', 'https://openalex.org/W1985484598', 'https://openalex.org/W1988606065', 'https://openalex.org/W1990099683', 'https://openalex.org/W1996868603', 'https://openalex.org/W2005402525', 'https://openalex.org/W2005986251', 'https://openalex.org/W2007282272', 'https://openalex.org/W2019173140', 'https://openalex.org/W2024889997', 'https://openalex.org/W2037289992', 'https://openalex.org/W2037472649', 'https://openalex.org/W2038708777', 'https://openalex.org/W2047937242', 'https://openalex.org/W2066834102', 'https://openalex.org/W2074367238', 'https://openalex.org/W2083333009', 'https://openalex.org/W2093523386', 'https://openalex.org/W2106313529', 'https://openalex.org/W2112164142', 'https://openalex.org/W2112402269', 'https://openalex.org/W2131992185', 'https://openalex.org/W2132087438', 'https://openalex.org/W2169339414', 'https://openalex.org/W2197421314', 'https://openalex.org/W2404266606', 'https://openalex.org/W2496355390', 'https://openalex.org/W276947371', 'https://openalex.org/W4205170238', 'https://openalex.org/W621513029'], 'related_works': ['https://openalex.org/W4200554124', 'https://openalex.org/W3084160745', 'https://openalex.org/W2605134710', 'https://openalex.org/W2599198170', 'https://openalex.org/W2505444873', 'https://openalex.org/W2082377325', 'https://openalex.org/W2036509277', 'https://openalex.org/W2016458708', 'https://openalex.org/W1988090148', 'https://openalex.org/W1970752940'], 'abstract_inverted_index': {'Abstract': [0], 'Variants': [1], 'of': [2, 46, 101, 118, 135, 173, 176, 202, 209, 212], 'the': [3, 47, 74, 99, 168, 174, 200, 210, 234, 240], 'human': [4], 'C1': [5, 71, 79, 93, 119, 177, 216, 241], 'inhibitor': [6, 94, 120, 178, 242], 'serpin': [7, 243], 'domain': [8, 238], 'containing': [9, 188], 'three': [10], 'N-linked': [11], 'carbohydrates': [12], 'at': [13, 23, 49], 'positions': [14], '216,': [15], '231,': [16], 'and': [17, 64, 70, 95, 121, 147, 179, 190, 239, 246], '330': [18, 25, 51], '(C1inhΔ97),': [19, 146], 'a': [20, 33, 220, 224], 'single': [21], 'carbohydrate': [22, 29], 'position': [24, 50], '(C1inhΔ97DM),': [26], 'or': [27], 'no': [28], 'were': [30, 61], 'produced': [31], 'in': [32, 73], 'baculovirus/insect': [34], 'cells': [35], 'system.': [36], 'An': [37], 'N-terminally': [38], 'His-tagged': [39], 'C1inhΔ97': [40], 'variant': [41], 'was': [42, 126, 183, 229], 'also': [43, 154], 'produced.': [44], 'Removal': [45], 'oligosaccharide': [48], 'dramatically': [52], 'decreased': [53], 'expression,': [54], 'precluding': [55], 'further': [56], 'analysis.': [57, 92], 'All': [58], 'other': [59], 'variants': [60, 97, 123], 'characterized': [62], 'chemically': [63], 'shown': [65, 89, 230], 'to': [66, 104, 156, 181, 231], 'inhibit': [67], 'C1s': [68, 87, 153, 180, 213, 235], 'activity': [69, 214], 'activation': [72], 'same': [75, 169], 'way': [76], 'as': [77, 88], 'native': [78], 'inhibitor.': [80], 'Likewise,': [81], 'they': [82], 'formed': [83], 'covalent': [84, 111], 'complexes': [85, 112], 'with': [86, 113, 124, 158, 199, 219, 233], 'by': [90, 128, 215], 'SDS-PAGE': [91], 'its': [96, 122], 'inhibited': [98], 'ability': [100], 'C1r-like': [102], 'protease': [103, 237], 'activate': [105], 'C1s,': [106], 'but': [107], 'did': [108], 'not': [109], 'form': [110], 'this': [114], 'protease.': [115], 'The': [116], 'interaction': [117], 'heparin': [125, 182, 186, 228], 'investigated': [127], 'surface': [129], 'plasmon': [130], 'resonance,': [131], 'yielding': [132, 206], 'KD': [133], 'values': [134, 196], '16.7': [136], '×': [137, 143, 149, 164], '10−8': [138, 144, 150, 165], 'M': [139, 145, 151], '(C1': [140], 'inhibitor),': [141], '2.3': [142], '3.6': [148], '(C1inhΔ97DM).': [152], 'bound': [155], 'heparin,': [157], 'lower': [159], 'affinity': [160], '(KD': [161], '=': [162], '108': [163], 'M).': [166], 'Using': [167, 223], 'technique,': [170], '50%': [171], 'inhibition': [172, 211], 'binding': [175], 'achieved': [184], 'using': [185], 'oligomers': [187], 'eight': [189], 'six': [191], 'saccharide': [192, 204], 'units,': [193], 'respectively.': [194, 251], 'These': [195], 'roughly': [197], 'correlate': [198], 'size': [201], '10': [203], 'units': [205], 'half-maximal': [207], 'potentiation': [208], 'inhibitor,': [217], 'consistent': [218], '“sandwich”': [221], 'mechanism.': [222], 'thermal': [225, 249], 'shift': [226], 'assay,': [227], 'interact': [232], 'serine': [236], 'domain,': [244], 'increasing': [245], 'decreasing': [247], 'their': [248], 'stability,': [250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1525051702', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-09-24T10:09:33.161849', 'created_date': '2016-06-24'}