Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1525022089', 'doi': 'https://doi.org/10.1046/j.1471-4159.2002.01211.x', 'title': 'Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis', 'display_name': 'Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis', 'publication_year': 2002, 'publication_date': '2002-11-19', 'ids': {'openalex': 'https://openalex.org/W1525022089', 'doi': 'https://doi.org/10.1046/j.1471-4159.2002.01211.x', 'mag': '1525022089', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12437574'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1046/j.1471-4159.2002.01211.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1471-4159.2002.01211.x', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1471-4159.2002.01211.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5069055172', 'display_name': 'Makoto Urushitani', 'orcid': 'https://orcid.org/0000-0003-2773-9836'}, 'institutions': [{'id': 'https://openalex.org/I2800939219', 'display_name': 'RIKEN Center for Brain Science', 'ror': 'https://ror.org/04j1n1c04', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I2800939219', 'https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Makoto Urushitani', 'raw_affiliation_strings': ['Laboratory for Motor System Neurodegeneration, Brain Science Institute (BSI), RIKEN, Saitama, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Motor System Neurodegeneration, Brain Science Institute (BSI), RIKEN, Saitama, Japan', 'institution_ids': ['https://openalex.org/I2800939219']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078847536', 'display_name': 'Junko Kurisu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800939219', 'display_name': 'RIKEN Center for Brain Science', 'ror': 'https://ror.org/04j1n1c04', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I2800939219', 'https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Junko Kurisu', 'raw_affiliation_strings': ['Laboratory for Motor System Neurodegeneration, Brain Science Institute (BSI), RIKEN, Saitama, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Motor System Neurodegeneration, Brain Science Institute (BSI), RIKEN, Saitama, Japan', 'institution_ids': ['https://openalex.org/I2800939219']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058566438', 'display_name': 'Kayoko Tsukita', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800939219', 'display_name': 'RIKEN Center for Brain Science', 'ror': 'https://ror.org/04j1n1c04', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I2800939219', 'https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kayoko Tsukita', 'raw_affiliation_strings': ['Laboratory for Motor System Neurodegeneration, Brain Science Institute (BSI), RIKEN, Saitama, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Motor System Neurodegeneration, Brain Science Institute (BSI), RIKEN, Saitama, Japan', 'institution_ids': ['https://openalex.org/I2800939219']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100724728', 'display_name': 'Ryōsuke Takahashi', 'orcid': 'https://orcid.org/0000-0002-1407-9640'}, 'institutions': [{'id': 'https://openalex.org/I2800939219', 'display_name': 'RIKEN Center for Brain Science', 'ror': 'https://ror.org/04j1n1c04', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I2800939219', 'https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryosuke Takahashi', 'raw_affiliation_strings': ['Laboratory for Motor System Neurodegeneration, Brain Science Institute (BSI), RIKEN, Saitama, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Motor System Neurodegeneration, Brain Science Institute (BSI), RIKEN, Saitama, Japan', 'institution_ids': ['https://openalex.org/I2800939219']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 10.471, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 261, 'citation_normalized_percentile': {'value': 0.955294, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '83', 'issue': '5', 'first_page': '1030', 'last_page': '1042'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10855', 'display_name': 'Amyotrophic Lateral Sclerosis Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10855', 'display_name': 'Amyotrophic Lateral Sclerosis Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12400', 'display_name': 'Neurogenetic and Muscular Disorders Research', 'score': 0.9881, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lactacystin', 'display_name': 'Lactacystin', 'score': 0.7596885}], 'concepts': [{'id': 'https://openalex.org/C2777615887', 'wikidata': 'https://www.wikidata.org/wiki/Q15328137', 'display_name': 'SOD1', 'level': 4, 'score': 0.9197502}, {'id': 'https://openalex.org/C2776148510', 'wikidata': 'https://www.wikidata.org/wiki/Q6468907', 'display_name': 'Lactacystin', 'level': 4, 'score': 0.7596885}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.6894678}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.6661206}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.5879572}, {'id': 'https://openalex.org/C2780596555', 'wikidata': 'https://www.wikidata.org/wiki/Q206901', 'display_name': 'Amyotrophic lateral sclerosis', 'level': 3, 'score': 0.57693654}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.55066824}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.542868}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4725858}, {'id': 'https://openalex.org/C2776752467', 'wikidata': 'https://www.wikidata.org/wiki/Q1133903', 'display_name': 'Motor neuron', 'level': 3, 'score': 0.4214865}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.36164498}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3560871}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3458784}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.22387776}, {'id': 'https://openalex.org/C2778367456', 'wikidata': 'https://www.wikidata.org/wiki/Q7251235', 'display_name': 'Proteasome inhibitor', 'level': 3, 'score': 0.19679636}, {'id': 'https://openalex.org/C2780775167', 'wikidata': 'https://www.wikidata.org/wiki/Q9606', 'display_name': 'Spinal cord', 'level': 2, 'score': 0.17265326}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08782667}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.07060364}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.06469461}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0536395}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000690', 'descriptor_name': 'Amyotrophic Lateral Sclerosis', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000690', 'descriptor_name': 'Amyotrophic Lateral Sclerosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000690', 'descriptor_name': 'Amyotrophic Lateral Sclerosis', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011489', 'descriptor_name': 'Protein Denaturation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012995', 'descriptor_name': 'Solubility', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000072105', 'descriptor_name': 'Superoxide Dismutase-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1046/j.1471-4159.2002.01211.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1471-4159.2002.01211.x', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12437574', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1046/j.1471-4159.2002.01211.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1471-4159.2002.01211.x', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.49, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1555605403', 'https://openalex.org/W1903414318', 'https://openalex.org/W1977069725', 'https://openalex.org/W1977191092', 'https://openalex.org/W1981093402', 'https://openalex.org/W1983959956', 'https://openalex.org/W1984119181', 'https://openalex.org/W1985655958', 'https://openalex.org/W1997369314', 'https://openalex.org/W2009138784', 'https://openalex.org/W2010360189', 'https://openalex.org/W2012851706', 'https://openalex.org/W2013135033', 'https://openalex.org/W2016469736', 'https://openalex.org/W2025504772', 'https://openalex.org/W2027426714', 'https://openalex.org/W2029642537', 'https://openalex.org/W2037024974', 'https://openalex.org/W2039386747', 'https://openalex.org/W2045893780', 'https://openalex.org/W2051555156', 'https://openalex.org/W2053040219', 'https://openalex.org/W2053712580', 'https://openalex.org/W2055053674', 'https://openalex.org/W2056956751', 'https://openalex.org/W2064196264', 'https://openalex.org/W2066972790', 'https://openalex.org/W2068201081', 'https://openalex.org/W2069234959', 'https://openalex.org/W2073864172', 'https://openalex.org/W2076359142', 'https://openalex.org/W2081712047', 'https://openalex.org/W2085880812', 'https://openalex.org/W2086379763', 'https://openalex.org/W2089456608', 'https://openalex.org/W2094149679', 'https://openalex.org/W2094478098', 'https://openalex.org/W2096386031', 'https://openalex.org/W2103467758', 'https://openalex.org/W2104912043', 'https://openalex.org/W2105378817', 'https://openalex.org/W2106392233', 'https://openalex.org/W2106526071', 'https://openalex.org/W2108102646', 'https://openalex.org/W2110580010', 'https://openalex.org/W2112147967', 'https://openalex.org/W2115659695', 'https://openalex.org/W2133400638', 'https://openalex.org/W2133408527', 'https://openalex.org/W2135747052', 'https://openalex.org/W2146880144', 'https://openalex.org/W2166155593', 'https://openalex.org/W2398038094', 'https://openalex.org/W4234635809', 'https://openalex.org/W4293417072', 'https://openalex.org/W69871636'], 'related_works': ['https://openalex.org/W4253737590', 'https://openalex.org/W4229061875', 'https://openalex.org/W3151746898', 'https://openalex.org/W2624190431', 'https://openalex.org/W2586253893', 'https://openalex.org/W2357993352', 'https://openalex.org/W2158695265', 'https://openalex.org/W2100640924', 'https://openalex.org/W2029435936', 'https://openalex.org/W1998275064'], 'abstract_inverted_index': {'Abstract': [0], 'Accumulating': [1], 'evidence': [2], 'indicates': [3], 'that': [4, 196], 'abnormal': [5], 'conformation': [6], 'of': [7, 20, 33, 45, 51, 56, 71, 76, 91, 122, 133, 170, 200, 217], 'mutant': [8, 21, 38, 52, 72, 92, 104, 113, 134, 140, 201, 218], 'superoxide': [9], 'dismutase': [10], '1': [11], '(SOD1)': [12], 'is': [13], 'an': [14], 'essential': [15], 'feature': [16], 'underlying': [17], 'the': [18, 31, 37, 43, 49, 69, 95, 120, 129, 138, 155, 171, 180, 197, 215], 'pathogenesis': [19, 216], 'SOD1‐linked': [22, 219], 'familial': [23], 'amyotrophic': [24], 'lateral': [25], 'sclerosis': [26], '(ALS).': [27], 'Here': [28], 'we': [29], 'investigated': [30], 'role': [32], 'ubiquitin‐proteasome': [34], 'pathway': [35], 'in': [36, 65, 94, 212], 'SOD1‐related': [39], 'cell': [40], 'death': [41], 'and': [42, 131, 137, 207], 'effect': [44], 'oxidative': [46], 'stress': [47], 'on': [48], 'misfolding': [50], 'SOD1.': [53], 'Transient': [54], 'overexpression': [55], 'ubiquitin': [57], 'with': [58, 83, 115, 125], 'human': [59, 152], 'SOD1': [60, 93, 105, 114, 135, 141, 153, 202], '(wild‐type,': [61], 'ala4val,': [62], 'gly85arg,': [63], 'gly93ala)': [64], 'Neuro2A': [66, 148], 'cells': [67, 124, 149], 'decreased': [68, 163], 'amount': [70], 'SOD1,': [73], 'but': [74], 'not': [75], 'wild‐type,': [77], 'while': [78], 'only': [79], 'mutants': [80], 'were': [81, 143, 185], 'co‐immunoprecipitated': [82], 'poly‐ubiquitin.': [84], 'Proteasome': [85], 'inhibition': [86, 206], 'by': [87, 159], 'lactacystin': [88, 189], 'augmented': [89], 'accumulation': [90], 'non‐ionic': [96], 'detergent‐insoluble': [97], 'fraction.': [98], 'The': [99], 'spinal': [100, 183], 'cord': [101, 184], 'lysates': [102], 'from': [103, 179], 'transgenic': [106], 'mice': [107], 'showed': [108], 'multiple': [109], 'carbonylated': [110], 'proteins,': [111], 'including': [112], 'SDS‐resistant': [116], 'dimer': [117], 'formation.': [118], 'Furthermore,': [119], 'treatment': [121], 'hSOD1‐expressing': [123], 'hydrogen': [126], 'peroxide': [127], 'promoted': [128], 'oligomerization,': [130], 'detergent‐insolubility': [132], 'alone,': [136], 'oxidized': [139], 'proteins': [142], 'more': [144, 186], 'heavily': [145], 'poly‐ubiquitinated.': [146], 'In': [147], 'stably': [150], 'expressing': [151], 'protein,': [154], 'proteasome': [156], 'function': [157], 'measured': [158], 'chymotrypsin‐like': [160], 'activity,': [161], 'was': [162], 'over': [164], 'time': [165], 'without': [166], 'a': [167], 'quantitative': [168], 'alteration': [169], '20S': [172], 'proteasomal': [173, 205], 'component.': [174], 'Finally,': [175], 'primary': [176], 'motor': [177, 208], 'neurons': [178], 'mouse': [181], 'embryonic': [182], 'vulnerable': [187], 'to': [188, 204], 'than': [190], 'non‐motor': [191], 'neurons.': [192], 'These': [193], 'results': [194], 'indicate': [195], 'sustained': [198], 'expression': [199], 'leads': [203], 'neuronal': [209], 'death,': [210], 'which': [211], 'part': [213], 'explains': [214], 'ALS.': [220]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1525022089', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2024-12-24T13:43:08.958993', 'created_date': '2016-06-24'}