Publication Information

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'https://openalex.org/W2000000541', 'https://openalex.org/W2001753204', 'https://openalex.org/W2001991657', 'https://openalex.org/W2012617112', 'https://openalex.org/W2014696732', 'https://openalex.org/W2029773366', 'https://openalex.org/W2030495747', 'https://openalex.org/W2031630601', 'https://openalex.org/W2034244905', 'https://openalex.org/W2037288057', 'https://openalex.org/W2041116703', 'https://openalex.org/W2052891209', 'https://openalex.org/W2054979979', 'https://openalex.org/W2072928113', 'https://openalex.org/W2075216567', 'https://openalex.org/W2078761996', 'https://openalex.org/W2088818435', 'https://openalex.org/W2097707959', 'https://openalex.org/W2100915449', 'https://openalex.org/W2117596244', 'https://openalex.org/W2130395392', 'https://openalex.org/W2131798870', 'https://openalex.org/W2164809985', 'https://openalex.org/W2165774181'], 'related_works': ['https://openalex.org/W2416176443', 'https://openalex.org/W2410922236', 'https://openalex.org/W2213636196', 'https://openalex.org/W2091539793', 'https://openalex.org/W2058567144', 'https://openalex.org/W2029408488', 'https://openalex.org/W2002261727', 'https://openalex.org/W1968908069', 'https://openalex.org/W1935625957', 'https://openalex.org/W1487095595'], 'abstract_inverted_index': {'Angiogenesis': [0, 237], 'is': [1, 67, 203, 214, 238, 304, 440, 451, 1001, 1026, 1121, 1253, 1412, 1558, 1636, 2854, 4448, 4460, 4510], 'associated': [2, 239], 'with': [3, 10, 240, 247, 916, 1732, 1972, 2043, 2372, 2489, 2497, 2578, 2640, 2663, 2668, 2695, 2708, 2759, 2884, 2902, 2968, 3027, 3246, 3261, 3413, 3440, 3461, 3501, 3788, 3804, 3931, 4167, 4257, 4263, 4267, 4290, 4413], 'several': [4, 241, 642, 1627], 'pathological': [5, 242], 'disorders': [6, 243], 'as': [7, 9, 232, 244, 246, 469, 907, 1028, 1665, 1688, 1741, 1899, 2058, 2115, 2269, 2418, 2518, 2748, 2800, 2907, 3048, 3093, 3142, 3186, 3194, 3285, 3357, 3711, 4162, 4234, 4248, 4343, 4411], 'well': [8, 245, 3483], 'normal': [11, 248], 'physiological': [12, 249], 'maintenance.': [13, 250], 'Components': [14, 251], 'of': [15, 38, 41, 63, 69, 75, 137, 163, 169, 177, 201, 210, 216, 224, 252, 275, 278, 300, 306, 312, 374, 400, 406, 414, 438, 447, 453, 461, 526, 570, 577, 594, 606, 622, 859, 862, 898, 1003, 1008, 1068, 1076, 1228, 1239, 1337, 1554, 1643, 1673, 1729, 1788, 1895, 1966, 2009, 2015, 2024, 2045, 2077, 2240, 2259, 2380, 2471, 2585, 2603, 2611, 2616, 2762, 2857, 2953, 2958, 3038, 3304, 3320, 3431, 3475, 3496, 3552, 3567, 3620, 3635, 3662, 3778, 3791, 3794, 3880, 3913, 4050, 4060, 4110, 4260, 4297, 4318, 4361, 4382, 4400, 4426, 4435, 4439, 4450, 4467, 4474, 4501, 4508], 'vascular': [16, 253, 1418, 3811], 'basement': [17, 254, 903, 1009, 1070, 1249], 'membrane': [18, 255, 1250], 'are': [19, 256, 520, 612, 857, 905, 920, 1051, 1074, 3785, 4160], 'speculated': [20, 257, 921], 'to': [21, 79, 85, 121, 205, 258, 316, 322, 358, 442, 574, 614, 922, 1061, 1123, 1243, 1329, 1494, 1600, 1638, 1910, 1962, 2047, 2091, 2101, 2196, 2203, 2485, 2635, 2704, 2949, 2976, 3481, 3512, 3525, 3587, 3609, 3751, 3885, 4149, 4176, 4199, 4253, 4484, 4490, 4552], 'regulate': [22, 259, 615, 649], 'angiogenesis': [23, 260, 650, 929, 1432], 'in': [24, 115, 132, 166, 183, 190, 261, 352, 369, 403, 420, 427, 911, 927, 1126, 1236, 1414, 1430, 1434, 1626, 1670, 1738, 1882, 1908, 1984, 2170, 2187, 2244, 2365, 2386, 2394, 2478, 2651, 2859, 2880, 2955, 3011, 3113, 3117, 3241, 3265, 3331, 3457, 3549, 3573, 3624, 3642, 3701, 3704, 3786, 3856, 3863, 4180, 4282, 4332, 4340, 4432, 4437], 'both': [25, 262, 3292], 'positive': [26, 263, 3188, 3287], 'and': [27, 45, 65, 103, 111, 123, 128, 172, 212, 222, 264, 282, 302, 340, 348, 360, 365, 409, 449, 459, 514, 518, 559, 609, 618, 651, 872, 896, 913, 1025, 1089, 1130, 1246, 1324, 1420, 1423, 1433, 1487, 1622, 1885, 1992, 2017, 2056, 2107, 2113, 2199, 2232, 2265, 2344, 2382, 2416, 2502, 2563, 2594, 2711, 2714, 2746, 2782, 2873, 2888, 2898, 3041, 3046, 3091, 3137, 3258, 3295, 3300, 3345, 3484, 3508, 3536, 3639, 3652, 3670, 3769, 3775, 3784, 3796, 3816, 3841, 3848, 3854, 3866, 3877, 3893, 3899, 3949, 4041, 4064, 4080, 4121, 4134, 4196, 4228, 4238, 4277, 4288, 4295, 4299, 4312, 4322, 4348, 4354, 4387, 4392, 4405, 4424, 4476], 'negative': [28, 265], 'manner.': [29, 135, 266, 372], 'Recently,': [30, 267, 1312], 'we': [31, 57, 268, 294, 1313, 1482], 'reported': [32, 269], 'that': [33, 59, 157, 197, 270, 296, 394, 434, 866, 1315, 1485, 1632, 4422, 4457], 'tumstatin': [34, 64, 122, 158, 202, 211, 226, 271, 301, 359, 395, 439, 448, 463, 1338, 1486, 1555, 1679, 1730, 1789, 1896, 2025, 2081, 2106, 2169, 2674, 4193, 4215, 4276, 4298, 4475, 4509], '(the': [35, 272], 'NC1': [36, 273, 1226], 'domain': [37, 274, 1094, 1227, 1915], 'α3': [39, 276], 'chain': [40, 277, 1794], 'type': [42, 279, 1229, 1240, 2586], 'IV': [43, 280, 999, 1119, 1230, 1241], 'collagen)': [44, 281], 'its': [46, 283, 4477], 'deletion': [47, 284, 1335, 1491, 1785, 2257, 4222, 4479, 4513], 'mutant': [48, 285, 1492, 2258, 4223, 4480, 4514], 'tum-5': [49, 66, 76, 125, 286, 303, 313, 362, 1490, 1557, 1607, 1620, 1900, 2108, 2167, 2671, 4051, 4224, 4231, 4246, 4269, 4279, 4321, 4324, 4353, 4373, 4427, 4436, 4446, 4515], 'possess': [50, 90, 287, 327], 'anti-angiogenic': [51, 61, 91, 151, 199, 288, 298, 328, 388, 436, 610, 644, 1322, 1552, 1604, 1628, 1634, 1914, 4465, 4499, 4506], 'activity.': [52, 92, 152, 289, 329, 389], 'In': [53, 290, 1479, 2103, 2572, 2598], 'the': [54, 60, 97, 124, 145, 150, 167, 178, 198, 225, 291, 297, 334, 361, 382, 387, 404, 415, 435, 462, 524, 567, 575, 603, 616, 619, 868, 1004, 1069, 1079, 1084, 1090, 1133, 1237, 1325, 1488, 1603, 1619, 1633, 1651, 1671, 1781, 1784, 1797, 1903, 1911, 1964, 1985, 2010, 2205, 2218, 2245, 2255, 2345, 2411, 2607, 2614, 2629, 2636, 2659, 2705, 2780, 2795, 2855, 2951, 2959, 3293, 3313, 3476, 3494, 3588, 3603, 3618, 3625, 3636, 3659, 3663, 3772, 3789, 3792, 3830, 3833, 3849, 3878, 3937, 3950, 3955, 4030, 4035, 4058, 4072, 4108, 4111, 4116, 4135, 4151, 4201, 4213, 4291, 4316, 4359, 4414, 4431, 4464, 4492, 4498, 4504], 'present': [55, 292, 1986], 'study,': [56, 293], 'confirm': [58, 295], 'activity': [62, 200, 299, 437, 1326, 1553, 1646, 3191, 4308, 4447, 4466, 4507], 'independent': [68, 215, 305, 452, 4449], 'disulfide': [70, 139, 217, 307, 376, 454, 1562, 1652, 4202, 4451, 4458], 'bond': [71, 140, 218, 308, 377, 455, 1563, 1653, 4203, 4452], 'requirement.': [72, 309], 'This': [73, 310, 1597, 1645, 2774, 3347, 3353, 4469], 'property': [74, 311, 1635], 'allowed': [77, 314, 3608, 4482], 'us': [78, 315, 1599, 4483], 'use': [80, 317, 3776], 'overlapping': [81, 318, 1616, 4555], 'synthetic': [82, 319, 1610, 2507, 2890, 3029, 3127, 3419, 3467, 3823, 4487], 'peptide': [83, 87, 99, 105, 146, 227, 320, 324, 336, 342, 383, 464, 1611, 1663, 2007, 2037, 2752, 3030, 3128, 3271, 3420, 3468, 3546, 3589, 3626, 3637, 3667, 4488], 'strategy': [84, 321, 4489, 4550], 'identify': [86, 323, 4177, 4491], 'sequence(s)': [88, 325], 'which': [89, 326, 648, 1056, 1252, 1901, 2687], 'Among': [93, 330], 'these': [94, 154, 194, 331, 391, 431, 1624, 2599], 'peptides,': [95, 119, 332, 356], 'only': [96, 333], 'T3': [98, 335, 2751, 3270, 3545, 3664, 3666], '(69–88': [100, 337], 'amino': [101, 107, 338, 344, 1330, 1892, 1906, 1917, 1958, 2013, 2022, 2039, 4493], 'acids)': [102, 108, 339, 345, 1918], 'T7': [104, 341], '(74–98': [106, 343], 'inhibited': [109, 346, 4358], 'proliferation': [110, 162, 347, 399, 1129, 2631, 4286], 'induced': [112, 349], 'apoptosis': [113, 350, 2978], 'specifically': [114, 351], 'endothelial': [116, 164, 353, 401, 479, 485, 568, 873, 917, 1127, 1435, 2335, 2341, 3000, 3812, 4284], 'cells.': [117, 354, 918], 'The': [118, 355, 1225, 1551, 1866, 1891, 1955, 2190, 2238, 2399, 2622, 2656, 2678, 2699, 2721, 2850, 2866, 2932, 2944, 3016, 3122, 3327, 3594, 3633, 3825, 3835, 3859, 3942, 4126], 'similar': [120, 357, 2570], 'domain,': [126, 363, 1083, 1088, 1621], 'bind': [127, 364, 1493], 'function': [129, 366, 4500], 'via': [130, 367, 4067], 'αvβ3': [131, 368, 1411, 1495, 2764, 3533], 'an': [133, 370, 595, 924, 3301, 3681, 3902, 4283], 'RGD-independent': [134, 371], 'Restoration': [136, 373], 'a': [138, 186, 206, 233, 375, 423, 443, 470, 481, 624, 1059, 1063, 1233, 1320, 1427, 1609, 1639, 1661, 1666, 1733, 1973, 2569, 2583, 2718, 2729, 2876, 2937, 2964, 2969, 3008, 3114, 3187, 3286, 3332, 3429, 3643, 3673, 4168, 4235, 4249, 4254, 4378, 4396, 4486], 'between': [141, 378, 1416, 1655], 'two': [142, 379], 'cysteines': [143, 380], 'within': [144, 381, 1606, 4512], 'did': [147, 384, 4301], 'not': [148, 385, 1559, 1648, 4302, 4429, 4461], 'alter': [149, 386, 4430], 'Additionally,': [153, 390], 'studies': [155, 392, 639, 3766], 'show': [156, 393, 4456], 'peptides': [159, 179, 396, 416, 1617, 1625, 1989, 1994, 2019, 2053, 2078], 'can': [160, 397, 4232], 'inhibit': [161, 398], 'cells': [165, 402, 480, 486, 569, 874, 1419, 1687, 2336, 2342, 2473, 2565, 2604, 2645, 2689, 2740, 2781, 2840, 2858, 2867, 2895, 2933, 2954, 3001, 3043, 3088, 3108, 3131, 3235, 3297, 3305, 3341, 3498, 3935], 'presence': [168, 405], 'vitronectin,': [170, 407], 'fibronectin,': [171, 408], 'collagen': [173, 410, 1000, 1120, 1231, 1242, 2588], 'I.': [174, 411], 'Anti-angiogenic': [175, 412], 'effect': [176, 413, 4317], 'was': [180, 417, 1327, 1647, 1680, 1790, 1870, 1880, 1982, 2041, 2193, 2201, 2221, 2248, 2261, 2404, 2495, 2516, 2626, 2661, 2757, 2776, 2947, 2974, 3024, 3098, 3129, 3140, 3184, 3192, 3283, 3323, 3329, 3349, 3355, 3426, 3479, 3499, 3547, 3597, 3605, 3607, 3628, 3647, 3656, 3668, 3709, 3802, 3838, 3891, 3905, 3952, 4132, 4145, 4174, 4188, 4194, 4225, 4338, 4551], 'further': [181, 418, 1057, 1602, 2620], 'confirmed': [182, 419, 2249, 3629, 3648], 'vivo': [184, 421, 3705, 4433], 'using': [185, 422, 1334, 1608, 1682, 1792, 1887, 2251, 2568, 2628, 2717, 2794, 2936, 3630, 3680, 3946, 3954], 'Matrigel': [187, 424, 3706, 3799, 3836, 3850, 3917], 'plug': [188, 425, 3707], 'assay': [189, 426, 2625, 2632, 3348, 3354, 3708, 4287], 'C57BL/6': [191, 428], 'mice.': [192, 429, 4334], 'Collectively,': [193, 430], 'experiments': [195, 432, 4420], 'suggest': [196, 433, 4421, 4445], 'localized': [204, 441, 1328, 1637], '25-amino': [207, 444, 1640], 'acid': [208, 445, 1641, 3694, 3700, 4494], 'region': [209, 446, 1642], 'it': [213, 229, 450, 466, 1424], 'linkage.': [219, 456, 4453], 'Structural': [220, 457], 'features': [221, 458], 'potency': [223, 460], 'make': [228, 465, 2204], 'highly': [230, 467], 'feasible': [231, 468], 'potential': [234, 471], 'anti-cancer': [235, 472], 'drug.': [236, 473], 'non-collagenous': [474, 1093], '1': [475, 2182, 2213, 2235, 4375], 'bovine': [476, 3443], 'pulmonary': [477, 2333], 'arterial': [478, 2334], 'human': [482, 1684, 2338, 2346, 2763, 3513, 3526, 4320, 4328, 4352, 4355, 4364, 4388], 'umbilical': [483, 2339], 'vein': [484, 2340], 'fetal': [487, 2374], 'calf': [488, 2375], 'serum': [489, 2376, 3444], 'phosphate-buffered': [490], 'saline': [491], 'polyacrylamide': [492], 'gel': [493], 'electrophoresis': [494], "Dulbecco's": [495], 'modified': [496], "Eagle's": [497], 'medium': [498, 2660, 3020], 'bromodeoxyuridine': [499], 'basis': [500], 'fibroblast': [501], 'growth': [502, 517, 653, 2842, 3813, 4153, 4360, 4380, 4398], 'factor': [503, 3814], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [504], 'bromide': [505], 'tumor': [506, 563, 578, 652, 4081, 4095, 4128, 4138, 4141, 4152, 4379, 4397, 4440], 'necrosis': [507], 'factor-α': [508], 'high': [509, 2970, 3887], 'performance': [510], 'liquid': [511], 'chromatography': [512], 'reduced': [513, 4195, 4227], 'alkylated': [515, 4197], 'Tumor': [516], 'metastasis': [519], 'dependent': [521, 1560, 1649, 1675], 'on': [522, 1561, 1650, 1676, 2728, 4057, 4090, 4325], 'angiogenesis,': [523], 'formation': [525, 1259, 1564], 'new': [527, 1256], 'blood': [528, 571, 1257, 3881], 'vessels': [529, 572, 3882], 'from': [530, 562, 1796, 2080, 2355, 2406, 3520, 3543, 3883, 4147], 'pre-existing': [531], 'ones': [532], '(1Folkman': [533, 580, 626], 'J.': [534, 546, 581, 627, 695, 727, 762, 839, 1108, 1156, 1301, 1359, 1382, 1394, 1503, 1535, 1581, 1711, 1764, 1820, 1854, 1939, 2124, 2152, 2292, 2316, 2427, 2451, 2459, 2541, 2823, 3071, 3165, 3217, 3366, 3734, 3982, 4014, 4532], 'Nat.': [535, 582, 628, 666], 'Med.': [536, 583, 629, 667], '1995;': [537, 584, 630, 1041], '1:': [538, 585, 631], '27-31Crossref': [539, 586, 632], 'PubMed': [540, 552, 587, 633, 671, 703, 737, 773, 850, 885, 978, 993, 1020, 1044, 1113, 1167, 1220, 1267, 1280, 1307, 1370, 1405, 1448, 1474, 1514, 1546, 1592, 1722, 1775, 1831, 1863, 1950, 2071, 2133, 2161, 2303, 2327, 2438, 2552, 2834, 2927, 2994, 3082, 3176, 3228, 3377, 3404, 3745, 3990, 4024, 4543], 'Scopus': [541, 553, 588, 634, 672, 704, 738, 774, 851, 886, 979, 994, 1021, 1045, 1114, 1168, 1221, 1268, 1281, 1308, 1371, 1406, 1449, 1475, 1515, 1547, 1593, 1723, 1776, 1832, 1951, 2072, 2304, 2328, 2439, 2553, 2835, 2928, 2995, 3083, 3177, 3229, 3378, 3405, 3746, 3991, 4025, 4544], '(7188)': [542, 589, 635], 'Google': [543, 555, 590, 636, 674, 706, 740, 776, 817, 853, 888, 969, 981, 996, 1023, 1047, 1116, 1170, 1211, 1223, 1270, 1283, 1310, 1373, 1408, 1451, 1477, 1517, 1549, 1595, 1725, 1778, 1834, 1864, 1953, 2074, 2134, 2162, 2306, 2330, 2441, 2467, 2555, 2837, 2930, 2997, 3085, 3179, 3231, 3380, 3407, 3748, 3993, 4027, 4546], 'Scholar,': [544, 675, 707, 741, 777, 818, 970, 1171, 1212, 1284, 1374, 1452, 1518, 1835, 2135, 2307, 3381, 3994], '2Folkman': [545], 'Ann.': [547], 'Surg.': [548], '1972;': [549], '175:': [550], '409-416Crossref': [551], '(1063)': [554], 'Scholar).': [556, 591, 637, 854, 889, 997, 1048, 1117, 1224, 1311, 1409, 1478, 1550, 1596, 1726, 1779, 1865, 1954, 2163, 2331, 2468, 2556, 2838, 2931, 2998, 3086, 3180, 3232, 3408, 3749, 4028], 'Growth': [557], 'factors': [558], 'cytokines': [560], 'released': [561], 'cell': [564, 900, 1128, 1436, 2349, 2361, 2401, 2676, 2960, 3138, 3477, 4285, 4306], 'components': [565, 2618], 'stimulate': [566], 'leading': [573], 'expansion': [576], 'tissue': [579], 'A': [592, 2469, 3317, 4183], 'theory': [593], '“angiogenic': [596], 'switch”': [597], 'has': [598], 'been': [599], 'recently': [600, 1483], 'proposed,': [601], 'where': [602], 'net': [604], 'balance': [605], 'pro-angiogenic': [607], 'molecules': [608, 611, 645], 'hypothesized': [613], '“on”': [617], '“off,”': [620], 'respectively,': [621, 4410], 'such': [623], 'switch': [625], 'Recent': [638], 'have': [640], 'identified': [641, 1314, 1913], 'endogenous': [643], 'producedde': [646], 'novo': [647], '(3Jimenez': [654], 'B.': [655, 2987], 'Volpert': [656], 'O.V.': [657], 'Crawford': [658], 'S.E.': [659, 4165], 'Febbraio': [660], 'M.': [661, 687, 799, 801, 803, 876, 951, 953, 955, 1193, 1195, 1197, 1458, 1522, 1568, 1847, 2145, 2911, 2917, 2981, 3393, 3974, 4519], 'Silverstein': [662], 'R.L.': [663], 'Bouck': [664], 'N.': [665, 715, 4002], '2000;': [668, 765, 814, 842, 966, 990, 1159, 1208, 1362, 1397, 1506, 1714, 1767, 1823, 1942, 2295, 2430, 2544, 2826, 3074, 3168, 3220, 3369, 3737], '6:': [669], '41-48Crossref': [670], '(845)': [673], "4O'Reilly": [676], 'M.S.': [677, 709, 3964, 3996], 'Holmgren': [678, 3965], 'L.': [679, 3966], 'Shing': [680, 712, 3967, 3999], 'Y.': [681, 691, 713, 755, 785, 820, 834, 937, 1149, 1179, 1340, 1354, 1384, 1386, 1498, 1520, 1566, 1692, 1706, 1745, 1759, 1801, 1815, 1920, 1934, 2273, 2287, 2422, 2522, 2536, 2804, 2818, 3064, 3146, 3160, 3198, 3212, 3361, 3715, 3729, 3968, 3978, 4000, 4517], 'Chen': [682, 3969], 'C.': [683, 1524, 1570, 3970, 4521], 'Rosenthal': [684, 3971], 'R.A.': [685, 1441, 1460, 3972], 'Moses': [686, 3973], 'Lane': [688, 718, 3975, 4005], 'W.S.': [689, 719, 3976, 4006], 'Cao': [690, 3977], 'Sage': [692, 3979], 'E.H.': [693, 3980], 'Folkman': [694, 726, 3981, 4013], 'Cell.': [696, 728, 1467, 3983, 4015], '1994;': [697, 1445, 1468, 3984], '79:': [698, 1469, 3985], '315-328Abstract': [699, 3986], 'Full': [700, 732, 734, 768, 770, 845, 847, 1162, 1164, 1365, 1367, 1400, 1402, 1471, 1509, 1511, 1541, 1543, 1587, 1589, 1717, 1719, 1770, 1772, 1826, 1828, 1860, 1945, 1947, 2130, 2158, 2298, 2300, 2322, 2324, 2433, 2435, 2547, 2549, 2829, 2831, 3077, 3079, 3171, 3173, 3223, 3225, 3372, 3374, 3740, 3742, 3987, 4019, 4021, 4538, 4540], 'Text': [701, 733, 735, 769, 771, 846, 848, 1163, 1165, 1366, 1368, 1401, 1403, 1472, 1510, 1512, 1542, 1544, 1588, 1590, 1718, 1720, 1771, 1773, 1827, 1829, 1861, 1946, 1948, 2131, 2159, 2299, 2301, 2323, 2325, 2434, 2436, 2548, 2550, 2830, 2832, 3078, 3080, 3172, 3174, 3224, 3226, 3373, 3375, 3741, 3743, 3988, 4020, 4022, 4539, 4541], 'PDF': [702, 736, 772, 849, 1166, 1369, 1404, 1473, 1513, 1545, 1591, 1721, 1774, 1830, 1862, 1949, 2132, 2160, 2302, 2326, 2437, 2551, 2833, 3081, 3175, 3227, 3376, 3744, 3989, 4023, 4542], '(3151)': [705, 3992], "5O'Reilly": [708, 3995], 'Boehm': [710, 3997], 'T.': [711, 1462, 1845, 3998], 'Fukai': [714, 4001], 'Vasios': [716, 4003], 'G.': [717, 783, 935, 1177, 1464, 4004], 'Flynn': [720, 4007], 'E.': [721, 1376, 1883, 2066, 4008], 'Birkhead': [722, 4009], 'J.R.': [723, 4010], 'Olsen': [724, 4011], 'B.R.': [725, 1530, 1576, 4012, 4527], '1997;': [729, 975, 1217, 1264, 3401, 4016], '88:': [730, 4017], '277-285Abstract': [731, 4018], '(4221)': [739, 4026], '6Kamphaus': [742], 'G.D.': [743, 1137, 3052], 'Colorado': [744, 821, 1138, 1341, 1499, 1693, 1746, 1802, 1921, 2274, 2423, 2523, 2805, 3053, 3147, 3199, 3362, 3716], 'P.C.': [745, 779, 822, 931, 1139, 1173, 1342, 1393, 1439, 1454, 1500, 1694, 1747, 1803, 1922, 2275, 2424, 2524, 2806, 3054, 3148, 3200, 3363, 3717], 'Panka': [746, 1140, 3055], 'D.J.': [747, 1035, 1141, 3056], 'Hopfer': [748, 786, 831, 938, 1142, 1180, 1351, 1527, 1573, 1703, 1756, 1812, 1931, 2284, 2533, 2815, 3057, 3157, 3209, 3726, 4524], 'H.': [749, 787, 832, 939, 1099, 1104, 1143, 1181, 1352, 1528, 1574, 1704, 1757, 1813, 1932, 2285, 2453, 2461, 2534, 2816, 3058, 3158, 3210, 3727, 4525], 'Ramchandran': [750, 1144, 2914, 3059], 'R.': [751, 761, 791, 811, 838, 943, 963, 983, 1012, 1097, 1145, 1155, 1185, 1205, 1272, 1358, 1502, 1534, 1580, 1710, 1763, 1819, 1839, 1938, 2064, 2137, 2291, 2309, 2426, 2540, 2822, 2913, 2915, 3060, 3070, 3164, 3216, 3365, 3733, 4531], 'Torre': [752, 780, 823, 932, 1146, 1174, 1343, 1695, 1748, 1804, 1923, 2276, 2525, 2807, 3061, 3149, 3201, 3718], 'A.': [753, 781, 824, 933, 1147, 1175, 1344, 1378, 1380, 1696, 1749, 1805, 1924, 2277, 2449, 2526, 2808, 3062, 3150, 3202, 3400, 3719], 'Maeshima': [754, 784, 936, 1148, 1178, 3063], 'Mier': [756, 1150, 3065], 'J.W.': [757, 1151, 3066], 'Sukhatme': [758, 808, 960, 984, 1152, 1202, 2918, 3067], 'V.P.': [759, 809, 961, 985, 1153, 1203, 2919, 3068], 'Kalluri': [760, 810, 837, 962, 1154, 1204, 1357, 1501, 1533, 1579, 1709, 1762, 1818, 1838, 1937, 2290, 2425, 2539, 2821, 3069, 3163, 3215, 3364, 3732, 4530], 'Biol.': [763, 840, 881, 1016, 1157, 1276, 1303, 1360, 1395, 1504, 1536, 1582, 1712, 1765, 1821, 1855, 1940, 2125, 2153, 2293, 2317, 2428, 2542, 2824, 3072, 3166, 3218, 3367, 3735, 4533], 'Chem.': [764, 841, 1158, 1361, 1396, 1505, 1537, 1583, 1713, 1766, 1822, 1856, 1941, 2126, 2154, 2294, 2318, 2429, 2543, 2825, 3073, 3167, 3219, 3368, 3736, 4534], '275:': [766, 843, 1160, 1363, 1398, 1507, 1715, 1768, 1824, 1943, 2296, 2431, 2545, 2827, 3075, 3169, 3221, 3370, 3738], '1209-1215Abstract': [767, 1161, 3076], '(407)': [775, 1169, 3084], '7Colorado': [778, 1172], 'Kamphaus': [782, 934, 1176], 'Takahashi': [788, 940, 1182], 'K.': [789, 941, 1106, 1183, 2455], 'Volk': [790, 942, 1184, 2912], 'Zamborsky': [792, 944, 1186], 'E.D.': [793, 945, 1187], 'Herman': [794, 946, 1188], 'S.': [795, 947, 1189, 1532, 1578, 1843, 2121, 2139, 3399, 4529], 'Ericksen': [796, 829, 948, 1190, 1349, 1701, 1754, 1810, 1929, 2282, 2531, 2813, 3155, 3207, 3724], 'M.B.': [797, 949, 1191], 'Dhanabal': [798, 950, 1192], 'Simons': [800, 952, 1194, 2916], 'Post': [802, 954, 1196], 'Kufe': [804, 956, 1198], 'D.W.': [805, 957, 1199], 'Weichselbaum': [806, 958, 1200], 'R.R.': [807, 959, 1201], 'Cancer': [812, 964, 1206, 2462], 'Res.': [813, 965, 1207, 2463, 2922], '60:': [815, 967, 1209], '2520-2526PubMed': [816, 968, 1210], '8Maeshima': [819], 'Holthaus': [825, 1345, 1525, 1571, 1697, 1750, 1806, 1925, 2278, 2527, 2809, 3151, 3203, 3720, 4522], 'K.A.': [826, 1346, 1526, 1572, 1698, 1751, 1807, 1926, 2279, 2528, 2810, 3152, 3204, 3721, 4523], 'Grunkemeyer': [827, 1347, 1699, 1752, 1808, 1927, 2280, 2529, 2811, 3153, 3205, 3722], 'J.A.': [828, 972, 1214, 1261, 1348, 1700, 1753, 1809, 1928, 2281, 2530, 2812, 3154, 3206, 3723], 'M.D.': [830, 1350, 1702, 1755, 1811, 1930, 2283, 2532, 2814, 3156, 3208, 3725], 'Xiao': [833, 1353, 1705, 1758, 1814, 1933, 2286, 2535, 2817, 3159, 3211, 3728], 'Stillman': [835, 1355, 1707, 1760, 1816, 1935, 2288, 2537, 2819, 3161, 3213, 3730], 'I.E.': [836, 1356, 1708, 1761, 1817, 1936, 2289, 2538, 2820, 3162, 3214, 3731], '21340-21348Abstract': [844, 1364, 1716, 1769, 1825, 1944, 2297, 2546, 2828, 3170, 3222, 3739], '(328)': [852, 1372, 1724, 1777, 1833, 1952, 2305, 2554, 2836, 3178, 3230, 3747], 'Basement': [855, 890], 'membranes': [856, 891, 904, 1010], 'composed': [858, 1075], 'thin': [860], 'layers': [861], 'specialized': [863], 'extracellular': [864, 1421], 'matrix': [865, 1422], 'provide': [867, 1062, 1660], 'scaffold': [869, 1064], 'for': [870, 1065, 1255, 2111, 2181, 2212, 2683, 2692, 2768, 2784, 2847, 2900, 2972, 3134, 3255, 3325, 3434, 3447, 3469, 3486, 3611, 3658, 3907, 4155, 4463, 4497], 'epithelial': [871], '(9Paulsson': [875], 'Crit.': [877], 'Rev.': [878, 1039], 'Biochem.': [879, 1040, 1109, 2920], 'Mol.': [880], '1992;': [882], '27:': [883], '93-127Crossref': [884], '(465)': [887], 'also': [892, 2027, 4226], 'influence': [893, 4303], 'differentiation,': [894], 'proliferation,': [895], 'migration': [897], 'various': [899], 'types.': [901], 'Vascular': [902], 'located': [906], 'insoluble': [908], 'structural': [909, 4472], 'walls': [910], 'capillaries': [912], 'they': [914], 'interact': [915], 'They': [919], 'play': [923], 'important': [925, 1125, 1254], 'role': [926, 1235, 1429], 'regulating': [928], '(7Colorado': [930], '10Madri': [971, 1213], 'Transpl.': [973, 1215, 1262], 'Immunol.': [974, 1216, 1263], '5:': [976, 1218, 1265], '179-183Crossref': [977, 1219, 1266], '(59)': [980, 1222, 1269], 'Scholar,11Kalluri': [982], 'Curr.': [986, 1013, 1273], 'Opin.': [987, 1014, 1274], 'Nephrol.': [988], 'Hypertens.': [989], '9:': [991], '413-418Crossref': [992], '(83)': [995], 'Type': [998, 1118, 2357], 'one': [1002, 4169], 'major': [1005], 'macromolecular': [1006], 'constituent': [1007], '(12Timpl': [1011], 'Cell': [1015, 1275, 1302, 3096], '1996;': [1017, 1277, 2319], '8:': [1018, 1278], '618-624Crossref': [1019, 1279], '(551)': [1022, 1282], 'Scholar)': [1024], 'expressed': [1027, 1681, 1737, 1881, 1898, 4161], 'six': [1029], 'distinct': [1030], 'α-chains,': [1031], 'namely,': [1032], 'α1-α6': [1033], '(13Prockop': [1034], 'Kivirikko': [1036], 'K.I.': [1037], 'Annu.': [1038], '64:': [1042], '403-434Crossref': [1043], '(1368)': [1046], 'These': [1049, 1072, 1658, 2052, 2360, 4419, 4442], 'α-chains': [1050, 1073], 'assembled': [1052], 'into': [1053, 1872, 3936, 4039], 'triple': [1054, 1086], 'helices': [1055], 'form': [1058, 1244], 'network': [1060], 'other': [1066, 4239], 'macromolecules': [1067], 'membrane.': [1071], 'three': [1077, 3351, 3914], 'domains,': [1078], 'N-terminal': [1080, 1904, 2011], '7': [1081, 3886], 'S': [1082, 2860], 'middle': [1085], 'helical': [1087], 'C-terminal': [1091], 'globular': [1092], '(NC1)1': [1095], '(14Timpl': [1096], 'Wiedemann': [1098], 'van': [1100], 'Delden': [1101], 'V.': [1102], 'Furthmayr': [1103], 'Kuhn': [1105], 'Eur.': [1107], '1981;': [1110], '120:': [1111], '203-211Crossref': [1112], '(653)': [1115], 'thought': [1122], 'be': [1124], 'behavior': [1131], 'during': [1132], 'angiogenic': [1134, 1417], 'process': [1135], '(6Kamphaus': [1136, 3051], 'plays': [1232, 1426], 'crucial': [1234], 'assembly': [1238], 'trimers,': [1245], 'thus': [1247], 'influences': [1248], 'organization,': [1251], 'vessel': [1258], '(10Madri': [1260], 'Scholar,12Timpl': [1271], '15Tsilibary': [1285], 'E.C.': [1286], 'Reger': [1287], 'L.A.': [1288], 'Vogel': [1289], 'A.M.': [1290, 1456, 2119], 'Koliakos': [1291], 'G.G.': [1292], 'Anderson': [1293], 'S.S.': [1294], 'Charonis': [1295], 'A.S.': [1296], 'Alegre': [1297], 'J.N.': [1298], 'Furcht': [1299], 'L.T.': [1300], '1990;': [1304, 2464], '111:': [1305], '1583-1591Crossref': [1306], '(46)': [1309], 'α3(IV)NC1': [1316], '(termed': [1317], '“tumstatin”)': [1318], 'possessed': [1319], 'novel': [1321, 1662], 'activity,': [1323], 'acids': [1331, 1893, 1907, 1959, 2014, 2023], '54–132': [1332, 2021], '(tum-5)': [1333], 'mutagenesis': [1336], '(8Maeshima': [1339, 1691, 1744, 1800, 1919, 2272, 2521, 2803, 3145, 3197, 3714], '16Petitclerc': [1375], 'Boutaud': [1377], 'Prestayko': [1379], 'Xu': [1381], 'Sado': [1383], 'Ninomiya': [1385], 'Sarras': [1387], 'Jr.,': [1388], 'M.P.': [1389], 'Hudson': [1390, 1852, 2150, 2312], 'B.G.': [1391, 1853, 2151, 2313], 'Brooks': [1392], '8051-8061Abstract': [1399], '(274)': [1407], 'Integrin': [1410], 'involved': [1413], 'interactions': [1415], 'potentially': [1425], 'critical': [1428, 4462], 'promoting': [1431], 'survival': [1437], '(17Brooks': [1438], 'Clark': [1440], 'Cheresh': [1442, 1465], 'D.A.': [1443, 1466], 'Science.': [1444, 2067], '264:': [1446], '569-571Crossref': [1447], '(2721)': [1450], '18Brooks': [1453], 'Montgomery': [1455], 'Rosenfeld': [1457], 'Reisfeld': [1459], 'Hu': [1461], 'Klier': [1463], '1157-1164Abstract': [1470], '(2170)': [1476], 'this': [1480, 2863], 'regard,': [1481], 'showed': [1484], 'active': [1489, 4478], 'integrin': [1496, 2765, 3515, 3538], '(19Maeshima': [1497, 2421, 3360], '23745-23750Abstract': [1508, 2432, 3371], '(232)': [1516, 2440, 3379], '20Maeshima': [1519], 'Manfredi': [1521, 1567, 4518], 'Reimer': [1523, 1569, 4520], 'Chandamuri': [1529, 1575, 4526], 'Kharbanda': [1531, 1577, 4528], '2001;': [1538, 1584, 4535], '276:': [1539, 1585, 4536], '15240-15248Abstract': [1540, 1586, 4537], '(206)': [1548, 1594, 4545], 'or': [1556, 2168, 2393, 2506, 2582, 2613, 2669, 2672, 3031, 3273, 3418, 3451, 3466, 3695, 3820, 3915, 4052], '(20Maeshima': [1565, 4516], 'prompted': [1598], 'examine': [1601], 'site': [1605], 'strategy.': [1612], 'We': [1613, 1630, 4314], 'synthesized': [1614, 2042, 2055], 'eight,': [1615], 'covering': [1618, 2020], 'tested': [1623], 'assays.': [1629], 'demonstrate': [1631], 'tumstatin.': [1644, 4220, 4468, 4502], 'linkage': [1654, 4459], 'cysteine': [1656], 'residues.': [1657], 'results': [1659, 4443, 4455], 'fragment': [1664, 1869], 'possible': [1667], 'drug': [1668], 'candidate': [1669], 'treatment': [1672, 2602, 4040, 4112], 'diseases': [1674], 'angiogenesis.': [1677], 'Recombinant': [1678, 4192], '293': [1683], 'embryonic': [1685], 'kidney': [1686], 'previously': [1689, 1742, 1912, 2059, 2270, 2419, 2519, 2801, 2908, 3143, 3195, 3358, 3712], 'described': [1690, 1743, 2060, 2116, 2271, 2420, 2520, 2749, 2802, 2909, 3049, 3094, 3144, 3196, 3359, 3713], 'Deletion': [1727], 'mutants': [1728, 1786], '(tum-1–5)': [1731, 1787], '6-histidine': [1734], 'tag': [1735], 'were': [1736, 1897, 1960, 1996, 2026, 2054, 2109, 2179, 2352, 2363, 2483, 2566, 2576, 2605, 2619, 2646, 2680, 2690, 2701, 2723, 2741, 2792, 2841, 2871, 2896, 2934, 3005, 3044, 3089, 3111, 3132, 3239, 3251, 3298, 3310, 3343, 3411, 3438, 3459, 3518, 3541, 3580, 3762, 3767, 3846, 3852, 3861, 3872, 3897, 3929, 3944, 4032, 4037, 4055, 4065, 4076, 4083, 4100, 4105, 4118, 4124, 4280], 'Escherichia': [1739], 'coli': [1740, 1884], 'Briefly,': [1780, 2164, 2643, 2999, 3233], 'sequence': [1782, 4495], 'encoding': [1783], 'amplified': [1791], 'polymerase': [1793], 'reaction': [1795, 2191, 3595, 3645], 'α3(IV)NCI/pDS': [1798], 'vector': [1799], '21Neilson': [1836], 'E.G.': [1837, 2315], 'Sun': [1840, 2310], 'M.J.': [1841, 2311], 'Gunwar': [1842, 2138], 'Danoff': [1844], 'Mariyama': [1846, 2144], 'Myers': [1848], 'J.C.': [1849], 'Reeders': [1850, 2140], 'S.T.': [1851, 2141], '1993;': [1857], '268:': [1858], '8402-8405Abstract': [1859], 'resulting': [1867, 2219], 'cDNA': [1868], 'ligated': [1871], 'pET28a(+)': [1873], '(Novagen,': [1874], 'Madison,': [1875], 'WI).': [1876], 'Each': [1877, 3910], 'recombinant': [1878, 2256, 2504, 3416], 'protein': [1879, 1967, 1971, 2505, 2766, 2967, 3417, 4256], 'purified': [1886], 'Ni-NTA-agarose': [1888], 'column': [1889, 3677], '(Qiagen).': [1890], '45–132': [1894], 'includes': [1902], '9': [1905, 1957], 'addition': [1909], '(54–132': [1916], 'additional': [1956], 'added': [1961, 2202, 2484, 2778, 3025, 3480, 3581], 'enhance': [1963], 'efficiency': [1965], 'expression.': [1968], 'Only': [1969], 'soluble': [1970, 4319], 'low': [1974], 'endotoxin': [1975], 'level': [1976, 4184], '(less': [1977], 'than': [1978, 4218], '50': [1979, 2185, 3274, 3809], 'enzyme': [1980], 'units/mg)': [1981], 'used': [1983, 2948, 2975, 3185, 3284, 3324, 3344, 3427, 3657, 4175, 4281], 'study.': [1987], 'Synthetic': [1988], 'CDCRGDCFC': [1990], '(RGD-4C)': [1991], 'control': [1993, 3826, 4042, 4054, 4140, 4417], 'CNGRC': [1995], 'kindly': [1997, 2028], 'provided': [1998, 2029], 'by': [1999, 2030, 2250, 2263, 2844, 3100, 3649, 3771, 3874, 3901, 4085, 4211, 4345], 'Ilex': [2000, 2031], 'Oncology,': [2001, 2032], 'Inc.': [2002, 2033], '(San': [2003], 'Antonio,': [2004], 'TX).': [2005], 'T1': [2006], 'consisting': [2008], '20': [2012, 2174, 3125, 3805], 'tumstatin,': [2016, 2260], 'T2-T7': [2018], '(Table': [2034], 'I).': [2035], 'T8': [2036, 2084, 2094], '(69–95': [2038], 'acid)': [2040], 'mutation': [2044], 'Leu': [2046, 2086, 2096], 'Lys': [2048], 'at': [2049, 2087, 2097, 2184, 2215, 2410, 2686, 2771, 2787, 2862, 3336, 3428, 3489, 3561, 3584, 3591, 3614, 4071, 4107, 4374, 4390], 'position': [2050, 2088, 2098], '69.': [2051], 'characterized': [2057], '(22Arap': [2061], 'W.': [2062], 'Pasqualini': [2063], 'Ruoslahti': [2065], '1998;': [2068, 2991], '279:': [2069], '377-380Crossref': [2070], '(1852)': [2073], 'Scholar).Table': [2075], 'ISequence': [2076], 'derived': [2079], '(amino': [2082], 'acid)150,': [2083], 'peptide:': [2085, 2095], '69': [2089, 2099], 'mutated': [2090, 2100], 'Lys.': [2092, 2102], '150,': [2093], 'some': [2104, 2573, 2641], 'experiments,': [2105], 'processed': [2110, 2899, 3047, 3092, 3311], 'reduction': [2112, 4423], 'alkylation': [2114, 4296, 4425], 'elsewhere': [2117, 3050], '(23Crestfield': [2118], 'Moore': [2120], 'Stein': [2122], 'W.H.': [2123], '1963;': [2127], '238:': [2128], '622-627Abstract': [2129], '24Kalluri': [2136], 'Morrison': [2142], 'K.C.': [2143], 'Ebner': [2146], 'K.E.': [2147], 'Noelken': [2148], 'M.E.': [2149], '1991;': [2155], '266:': [2156], '24018-24024Abstract': [2157], '2.5': [2165], 'mg/ml': [2166, 2384, 3442, 3569], '6': [2171, 3843], 'm': [2172], 'guanidine-HCl,': [2173], 'mm': [2175, 2225, 2236], 'Tris-HCl': [2176], '(pH': [2177, 3559, 3578], '7.5)': [2178], 'incubated': [2180, 2682, 2758, 2783, 3133, 3460, 3485], 'h': [2183, 2214, 2230, 2685, 2694, 2786, 2852, 3037, 3613], '°C': [2186], '10': [2188, 3414, 3463, 3550, 3555, 3574, 3817, 3821], 'mmdithiothreitol.': [2189], 'mixture': [2192, 2584, 2615, 2775, 3596, 3646, 3837], 'then': [2194, 2681, 2702, 2715, 2777, 3259], 'brought': [2195], 'room': [2197, 2216, 2772, 3585, 3615], 'temperature,': [2198, 2217], 'iodoacetamide': [2200], 'final': [2206, 2246, 2609, 2755, 3644, 3660], 'concentration': [2207, 2610, 3430], '25': [2208], 'mm.': [2209], 'Following': [2210], 'incubation': [2211], 'solution': [2220, 3590, 3627], 'dialyzed': [2222], 'against': [2223, 2234, 4102], '5': [2224, 2229, 3582, 4393, 4554], 'HCl': [2226], '(two': [2227], 'changes,': [2228], 'each)': [2231], 'finally': [2233], 'HCl.': [2237], 'absence': [2239, 3619, 3634], 'free': [2241, 3621], 'thiol': [2242, 3622], 'groups': [2243, 2558, 2735, 3623, 4043], 'product': [2247], 'Ellman': [2252, 3631], 'reagent.': [2253, 3632], 'Tum-5,': [2254], 'analyzed': [2262, 2567, 2935], 'SDS-PAGE': [2264, 3650, 4212], 'Coomassie': [2266], 'Blue': [2267], 'staining': [2268, 2515, 2798, 2901], '25Kalluri': [2308], 'Neilson': [2314], '271:': [2320], '9062-9068Abstract': [2321], '(75)': [2329], 'Bovine': [2332], '(C-PAE),': [2337], '(HUVEC),': [2343], 'prostate': [2347], 'adenocarcinoma': [2348], 'line': [2350, 2402], '(PC-3)': [2351, 3342], 'all': [2353], 'obtained': [2354, 2405], 'American': [2356], 'Culture': [2358], 'Collection.': [2359], 'lines': [2362], 'maintained': [2364, 2417], 'DMEM': [2366, 2479, 2498, 2652, 2664, 3118, 3266], '(C-PAE;': [2367], 'Life': [2368, 3521], 'Technologies,': [2369], 'Inc.)': [2370], 'supplemented': [2371, 2883], '10%': [2373, 2654, 3012, 3022, 3120], '(FCS),': [2377], '100': [2378, 2383, 3441, 3473, 4033, 4144], 'units/ml': [2379, 3806], 'penicillin,': [2381], 'streptomycin,': [2385], 'EGM-2': [2387], '(HUVEC;': [2388], 'Clonetics,': [2389], 'San': [2390], 'Diego,': [2391], 'CA),': [2392], 'F12K': [2395], '(Mediatech,': [2396], 'Herndon,': [2397], 'VA).': [2398], 'melanoma': [2400], 'WM-164': [2403, 2562], 'Dr.': [2407], 'Meenhard': [2408], 'Herlyn': [2409], 'Wistar': [2412], 'Institute': [2413], '(Philadelphia,': [2414], 'PA),': [2415], 'Scholar,26Herlyn': [2442], 'D.': [2443, 2445], 'Iliopoulos': [2444], 'Jensen': [2446], 'P.J.': [2447], 'Parmiter': [2448], 'Baird': [2450], 'Hotta': [2452], 'Adachi': [2454], 'Ross': [2456], 'A.H.': [2457], 'Jambrosic': [2458], 'Koprowski': [2460], '50:': [2465], '2296-2302PubMed': [2466], 'suspension': [2470, 3478], 'C-PAE': [2472, 2644, 2739, 2839, 3107, 3234], '(7,000': [2474, 3109], 'cells/well,': [2475], 'passage': [2476], '2–6)': [2477], 'containing': [2480, 2499, 2653, 2665, 3014, 3021, 3119, 3269], '0.5%': [2481], 'FCS': [2482, 2501, 2667, 2882, 3013, 3023], '96-well': [2486, 2649, 2744, 3115, 3409], 'plates': [2487, 2575, 2650, 2679, 2722, 2745, 3410], 'pre-coated': [2488], 'fibronectin.': [2490], 'After': [2491, 2892, 3035, 3289, 3492], '24': [2492, 2893, 3135, 3256, 3290], 'h,': [2493, 2512, 2894, 3136, 3257, 3291], 'media': [2494], 'replaced': [2496, 2662], '20%': [2500], 'either': [2503, 3028, 3462], 'peptide.': [2508, 3665, 3824], 'Then,': [2509, 3472, 3617], 'after': [2510, 3602, 3842], '48': [2511, 2785, 2848], 'methylene': [2513, 2796, 3502], 'blue': [2514, 2797, 3503], 'performed': [2517, 2793, 3356, 3710], 'All': [2557, 2734, 3764, 3895, 4158], 'represent': [2559, 2736], 'triplicate': [2560, 2737], 'samples.': [2561, 2738], 'PC-3': [2564, 3087], 'protocol.': [2571], 'assays,': [2574, 2600], 'coated': [2577, 3412], 'vitronectin': [2579, 2591, 2612], '(2.5': [2580, 2592], 'µg/ml)': [2581, 2906], 'I': [2587], '(10': [2589, 2596, 2697, 3248, 3272], 'µg/ml),': [2590, 2593], 'fibronectin': [2595, 3247], 'µg/ml).': [2597, 3249, 3275], 'when': [2601], 'started,': [2606], 'same': [2608], 'three-matrix': [2617], 'added.': [2621], 'BrdUrd': [2623, 2630, 2696], 'incorporation': [2624], 'conducted': [2627], 'kit': [2633], 'according': [2634], "manufacturer's": [2637], 'instructions': [2638], '(Calbiochem)': [2639], 'modifications.': [2642], 'seeded': [2647, 3006], 'onto': [2648, 2743, 2779, 2875, 3007, 3672], 'FCS.': [2655, 3121], 'next': [2657, 3017, 3123], 'day': [2658, 4059, 4091], '2%': [2666], 'without': [2670], 'full-length': [2673], '(293': [2675], 'expressed).': [2677], '46': [2684], 'time': [2688, 2864, 3601], 'pulsed': [2691], '2': [2693, 3448, 3568, 3612, 3932, 4556], 'nm).': [2698], 'cells/DNA': [2700], 'fixed': [2703, 3855], 'wells,': [2706], 'reacted': [2707], 'anti-BrdUrd': [2709], 'primary': [2710, 4327], 'secondary': [2712], 'antibodies,': [2713], 'developed': [2716], 'colorimetric': [2719], 'reaction.': [2720], 'read': [2724], 'atA': [2725], '450': [2726], 'nm': [2727], 'Molecular': [2730], 'Devices': [2731], 'plate': [2732, 2879, 3010, 3116], 'reader.': [2733], 'plated': [2742, 2874, 3112, 3240], 'serum-depleted': [2747], 'above.': [2750, 3095], '(20': [2753], 'µg/ml,': [2754], 'concentration)': [2756], 'varying': [2760], 'concentrations': [2761], '(Chemicon)': [2767], '30': [2769, 3688], 'min': [2770, 3488], 'temperature.': [2773, 3616], '37': [2788, 3490], '°C.': [2789, 3491], 'Proliferation': [2790], 'assays': [2791], 'method': [2799], 'arrested': [2843], 'contact': [2845], 'inhibition': [2846, 4154, 4381, 4399, 4438], 'h.': [2849, 3449], '0': [2851], 'value': [2853], 'percentage': [2856, 2952], 'phase': [2861], 'point.': [2865], '(0.2': [2868], '×': [2869, 3003, 3237, 3307, 3454, 3933, 3959, 3961, 4143], '106/well)': [2870, 3004, 3238], 'harvested': [2872, 2897, 3045], 'fibronectin-coated,': [2877], '6-well': [2878, 3009], '1%': [2881], '3': [2885], 'ng/ml': [2886, 3033, 3810], 'bFGF': [2887, 3262], 'tumstatin-derived': [2889], 'peptides.': [2891, 3834], 'propidium': [2903], 'iodide': [2904], '(5': [2905], '(27Dhanabal': [2910], 'Biophys.': [2921], 'Commun.': [2923], '1999;': [2924], '258:': [2925], '345-352Crossref': [2926], '(197)': [2929], 'Becton': [2938], 'Dickinson': [2939], 'FACStar': [2940], 'plus': [2941], 'flow': [2942], 'cytometer.': [2943], 'Modfit': [2945], 'software': [2946], 'calculate': [2950], 'different': [2956], 'phases': [2957], 'cycle.': [2961], 'Annexin': [2962], 'V,': [2963], 'calcium-dependent': [2965], 'phospholipid-binding': [2966], 'affinity': [2971], 'phosphatidylserine': [2973], 'detect': [2977], '(28van': [2979], 'Engeland': [2980], 'Nieland': [2982], 'L.J.': [2983], 'Ramaekers': [2984], 'F.C.': [2985], 'Schutte': [2986], 'Reutelingsperger': [2988], 'C.P.': [2989], 'Cytometry.': [2990], '31:': [2992], '1-9Crossref': [2993], '(1531)': [2996], '(0.5': [3002], 'DMEM.': [3015], 'day,': [3018, 3124], 'fresh': [3019], 'together': [3026], '80': [3032], 'TNF-α.': [3034], '18': [3036], 'treatment,': [3039], 'floating': [3040], 'attached': [3042, 3296, 3497], 'treated': [3090, 4137], 'viability': [3097, 3139], 'assessed': [3099], 'MTT': [3101], '(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl': [3102], 'tetrasolium': [3103], 'bromide,': [3104], 'Chemicon)': [3105], 'assay.': [3106], 'cells/well)': [3110], 'µg/ml': [3126, 3415, 3433, 3464, 3818, 3822], 'added,': [3130, 3606], 'evaluated': [3141], 'TNF-α': [3181, 3280], '(80': [3182, 3281], 'ng/ml)': [3183, 3264, 3282], 'control.': [3189, 3288], 'Caspase-3': [3190], 'determined': [3193, 3500], '(0.4': [3236], '6-cm': [3242], 'Petri': [3243], 'dishes': [3244], 'precoated': [3245], 'Cells': [3250], 'serum-starved': [3252], '(2%': [3253, 3267], 'FCS)': [3254, 3268], 'stimulated': [3260], '(3': [3263], 'Controls': [3276], 'received': [3277, 3828], 'PBS': [3278], 'buffer.': [3279], 'supernatant': [3294], 'combined': [3299], 'equal': [3302], 'number': [3303, 3495, 3879], '(4': [3306], '107': [3308], 'cells/ml)': [3309], 'following': [3312], 'manufacturers': [3314], 'instruction': [3315], '(CLONTECH).': [3316], 'specific': [3318], 'inhibitor': [3319], 'caspase-3,': [3321], 'DEVD-fmk,': [3322], 'specificity.': [3326], 'absorbance': [3328], 'measured': [3330, 3945], 'microplate': [3333], 'reader': [3334], '(Bio-Rad)': [3335], '405': [3337], 'nm.': [3338], 'Similarly,': [3339, 4221], 'nonendothelial': [3340], 'analyzed.': [3346], 'repeated': [3350], 'times.': [3352], '29Senger': [3382], 'D.R.': [3383], 'Claffey': [3384], 'K.P.': [3385], 'Benes': [3386], 'J.E.': [3387], 'Perruzzi': [3388], 'C.A.': [3389], 'Sergiou': [3390], 'A.P.': [3391], 'Detmar': [3392], 'Proc.': [3394], 'Natl.': [3395], 'Acad.': [3396], 'Sci.': [3397], 'U.': [3398], '94:': [3402], '13612-13617Crossref': [3403], '(455)': [3406], 'overnight.': [3421], 'Vitronectin': [3422], '(Collaborative': [3423, 3800], 'Biomedical': [3424], 'Products)': [3425], '0.5–2.5': [3432], 'coating': [3435], 'plates.': [3436], 'Plates': [3437], 'blocked': [3439], 'albumin': [3445], '(Sigma)': [3446], 'HUVECs': [3450], 'C-PAEs': [3452], '(1.5': [3453], '105': [3455], 'cells/ml,': [3456], 'M-199)': [3458], 'antibody': [3465, 3511, 3524], '15': [3470], 'min.': [3471], 'µl': [3474], 'each': [3482, 4156], '45': [3487], 'washing,': [3493], 'staining.': [3504, 3654], 'Control': [3505], 'mouse': [3506, 3509], 'IgG1': [3507], 'monoclonal': [3510], 'β1': [3514], '(clone': [3516, 3528, 3531, 3534, 3539], 'P4C10)': [3517], 'purchased': [3519, 3542], 'Technologies.': [3522], 'Monoclonal': [3523], 'αv': [3527], 'NKI-M9),': [3529], 'β3': [3530], 'B3A),': [3532], 'LM609),': [3535], 'αvβ5': [3537], 'P1F6)': [3540], 'Chemicon.': [3544], 'dissolved': [3548, 3572], 'ml': [3551], '50%': [3553], 'acetonitrile,': [3554], 'mmammonium': [3556, 3575], 'bicarbonate': [3557, 3576], 'buffer': [3558, 3577, 3686, 3696], '7.3)': [3560, 3579], '0.25': [3562], 'mg/ml.': [3563], 'Aliquots': [3564], '(30': [3565], 'µl)': [3566], 'potassium': [3570], 'ferricyanide': [3571], 'times': [3583], 'temperature': [3586], '5-min': [3592], 'intervals.': [3593], 'shortly': [3598], 'vortexed': [3599], 'every': [3600], 'oxidizer': [3604], 'stay': [3610], 'dimers': [3638], 'higher': [3640], 'oligomers': [3641], '(16.5%)': [3651], 'silver': [3653], 'HPLC': [3655], 'purification': [3661], 'applied': [3669], 'run': [3671], 'C-18': [3674], '300-Å': [3675], 'Jupiter': [3676], '(Phenomenex,': [3678], 'CA)': [3679], 'acetonitrile': [3682], '(CH3CN)': [3683], 'gradient': [3684], '(20–60%': [3685], 'B,': [3687, 3697], 'min).': [3689], 'Buffer': [3690], 'A,': [3691], '0.1%': [3692, 3698], 'trifluoroacetic': [3693, 3699], 'acetonitrile.': [3702], 'An': [3703], 'Five': [3750], 'six-week': [3752], 'old': [3753], 'male': [3754], 'C57/BL6': [3755], 'mice': [3756, 3845, 4045, 4117], '(Jackson': [3757], 'Laboratories,': [3758], 'Bar': [3759], 'Harbor,': [3760], 'ME)': [3761], 'obtained.': [3763], 'animal': [3765, 3773], 'reviewed': [3768], 'approved': [3770], 'care': [3774], 'committee': [3777], 'Beth': [3779], 'Israel': [3780], 'Deaconess': [3781], 'Medical': [3782], 'Center': [3783], 'accordance': [3787], 'guidelines': [3790], 'Department': [3793], 'Health': [3795], 'Human': [3797, 4372], 'Services.': [3798], 'Biomolecules)': [3801], 'mixed': [3803], 'heparin': [3807], '(Pierce),': [3808], '(R&D),': [3815], 'tum-1': [3819], 'group': [3827, 3911, 4131], 'neither': [3829], 'proteins': [3831], 'nor': [3832], 'injected': [3839, 4416], 'subcutaneously,': [3840], 'days': [3844], 'sacrificed': [3847], 'plugs': [3851, 3860], 'removed': [3853], '4%': [3857], 'paraformaldehyde.': [3858], 'embedded': [3862], 'paraffin,': [3864], 'sectioned,': [3865], 'H': [3867], '&': [3868], 'E': [3869], 'stained.': [3870], 'Sections': [3871], 'examined': [3873, 4315], 'light': [3875], 'microscopy,': [3876], '4': [3884], 'power': [3888], 'fields': [3889], '(×400)': [3890], 'counted': [3892], 'averaged.': [3894], 'sections': [3896], 'coded': [3898], 'observed': [3900, 4339], 'investigator': [3903], 'who': [3904], 'blinded': [3906], 'study': [3908], 'protocols.': [3909], 'consists': [3912], 'four': [3916], 'plugs.': [3918], 'Female': [3919], 'nude': [3920, 4333], 'NCRNU': [3921], 'mice,': [3922], '5–6': [3923], 'weeks': [3924], 'old,': [3925], 'weighing': [3926], '∼20': [3927], 'g': [3928], 'implanted': [3930], '106MDAMB-435': [3934], 'subaxillary': [3938], 'mammary': [3939], 'fat': [3940], 'pad.': [3941], 'tumors': [3943, 4031, 4123, 4331], 'Vernier': [3947], 'calipers': [3948, 4086], 'volume': [3951, 4096], 'calculated': [3953], 'standard': [3956], 'formula': [3957], '(width2': [3958], 'length': [3960], '0.52)': [3962], "(4O'Reilly": [3963], 'When': [4029], 'mm3,': [4034], 'animals': [4036], 'pair-matched': [4038], '(7': [4044], 'per': [4046, 4130], 'group).': [4047], 'Initial': [4048], 'doses': [4049, 4073], 'vehicle': [4053, 4415], 'given': [4056], 'pair-matching': [4061], '(day': [4062], '1),': [4063], 'administered': [4066], 'intraperitoneal': [4068], 'injection': [4069], 'bi-daily': [4070], 'indicated.': [4074], 'Mice': [4075, 4104], 'weighed': [4077], 'twice': [4078, 4087], 'weekly,': [4079, 4088], 'measurements': [4082], 'taken': [4084], 'starting': [4089], '1.': [4092], 'Mean': [4093], 'fractional': [4094], 'ratios': [4097], '(V/V': [4098], 'o)': [4099], 'plotted': [4101], 'time.': [4103], 'euthenized': [4106], 'end': [4109], 'period.': [4113], 'Upon': [4114], 'termination,': [4115], 'weighed,': [4119], 'sacrificed,': [4120], 'their': [4122, 4304], 'excised.': [4125], 'mean': [4127, 4136, 4163], 'weight': [4129, 4346], 'calculated,': [4133], 'ratio/mean': [4139], 'ratio': [4142], 'subtracted': [4146], '100%': [4148], 'give': [4150], 'group.': [4157, 4418], 'values': [4159], '±': [4164], 'ANOVA': [4166], 'tailed': [4170], "Student's": [4171], 't': [4172], 'test': [4173], 'significant': [4178], 'differences': [4179], 'multiple': [4181], 'comparisons.': [4182], 'ofp': [4185], '<': [4186], '0.05': [4187], 'considered': [4189], 'statistically': [4190], 'significant.': [4191], '(RA)': [4198], 'remove': [4200], 'linkages': [4204], '(Fig.': [4205, 4241, 4271, 4309, 4368], '1,': [4206, 4242, 4272, 4369], 'panel': [4207, 4243, 4273, 4370], 'A).': [4208], 'As': [4209], 'expected,': [4210], 'RA': [4214, 4245, 4275, 4278, 4323], 'migrated': [4216], 'slower': [4217], 'non-reduced': [4219, 4292], 'alkylated.': [4229], 'Non-reduced': [4230], 'exist': [4233], 'monomer,': [4236], 'dimer,': [4237], 'multimers': [4240], 'B).': [4244, 4274], 'migrates': [4247], 'single': [4250], 'band': [4251], 'corresponding': [4252], 'monomeric': [4255], 'molecular': [4258], 'mass': [4259], '∼12': [4261], 'kDa,': [4262], 'retarded': [4264], 'mobility': [4265], 'compared': [4266, 4289, 4412], 'unreduced': [4268], 'monomer': [4270], 'protein.': [4293], 'Reduction': [4294], 'tum-5,': [4300, 4481], 'anti-endothelial': [4305], 'proliferative': [4307], '1,panels': [4310], 'C': [4311], 'D).': [4313], 'established': [4326], 'orthotopic': [4329], 'breast': [4330, 4365], 'No': [4335], 'evident': [4336], 'toxicity': [4337], 'any': [4341], 'groups,': [4342], 'judged': [4344], 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