Title: An experimental study of bisphosphonate-induced jaws osteonecrosis in Sprague-Dawley rats
Abstract: Journal of Oral Pathology & MedicineVolume 39, Issue 9 p. 697-702 An experimental study of bisphosphonate-induced jaws osteonecrosis in Sprague–Dawley rats Pía López-Jornet, Pía López-Jornet Department of Oral Medicine, University of Murcia, Murcia, SpainSearch for more papers by this authorFabio Camacho-Alonso, Fabio Camacho-Alonso Department of Oral Medicine, University of Murcia, Murcia, SpainSearch for more papers by this authorFrancisco Molina-Miñano, Francisco Molina-Miñano Department of Oral Medicine, University of Murcia, Murcia, SpainSearch for more papers by this authorFrancisco Gómez-García, Francisco Gómez-García Department of Oral Medicine, University of Murcia, Murcia, SpainSearch for more papers by this authorVicente Vicente-Ortega, Vicente Vicente-Ortega Department of Pathology, University of Murcia, Murcia, SpainSearch for more papers by this author Pía López-Jornet, Pía López-Jornet Department of Oral Medicine, University of Murcia, Murcia, SpainSearch for more papers by this authorFabio Camacho-Alonso, Fabio Camacho-Alonso Department of Oral Medicine, University of Murcia, Murcia, SpainSearch for more papers by this authorFrancisco Molina-Miñano, Francisco Molina-Miñano Department of Oral Medicine, University of Murcia, Murcia, SpainSearch for more papers by this authorFrancisco Gómez-García, Francisco Gómez-García Department of Oral Medicine, University of Murcia, Murcia, SpainSearch for more papers by this authorVicente Vicente-Ortega, Vicente Vicente-Ortega Department of Pathology, University of Murcia, Murcia, SpainSearch for more papers by this author First published: 31 August 2010 https://doi.org/10.1111/j.1600-0714.2010.00927.xCitations: 35 Pía López-Jornet, Clínica Odontológica Universitaria, Medicina Bucal Hospital Morales Meseguer, Avda. Marqués de los Velez s/n, 30008 – Murcia, Spain. Tel: 00 34 968 398588, Fax: 00 34 968 398576, E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract J Oral Pathol Med (2010) 39: 697–702 Objective: Patients undergoing treatment with bisphosphonates may develop jaw lesions consisting mainly of bone necrosis. The present study describes a model of maxillary osteonecrosis in Sprague–Dawley rats, applying bisphosphonates and examines the changes occurring after tooth extraction. Material and methods: A total 200 animals were included in a randomized prospective study involving the following groups: group I (control, 20 rats without drug treatment), group II (60 animals administered dexamethasone 1 mg/kg/day for 7, 14 and 21 days, in subgroups of 20 animals each), group III (60 animals administered pamidronate daily at a dose of 3 mg/kg) and group IV (60 animals administered pamidronate and dexamethasone). In all groups, molar extraction was carried out on the right upper maxillary or mandibular side 8, 15 and 22 days after the start of dosing. The rats were killed 14 and 28 days after extraction in all groups. Results: A total of 18 cases of osteonecrosis were recorded in the group administered pamidronate and dexamethasone. Osteonecrosis affected the upper maxilla in 10 cases and the mandible in eight cases, and was circumscribed to the extraction zone in all cases. Osteonecrosis was not seen in any of the other groups. Conclusions: The administration of pamidronate and dexamethasone in rats subjected to molar extraction increases the risk of osteonecrosis. Citing Literature Volume39, Issue9October 2010Pages 697-702 RelatedInformation
Publication Year: 2010
Publication Date: 2010-08-31
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 50
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