Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1519776165', 'doi': None, 'title': 'Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts.', 'display_name': 'Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts.', 'publication_year': 2002, 'publication_date': '2002-02-01', 'ids': {'openalex': 'https://openalex.org/W1519776165', 'mag': '1519776165', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11830518'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11830518', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5015301183', 'display_name': 'Kiyohito Mizutani', 'orcid': 'https://orcid.org/0000-0003-1758-8026'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}, {'id': 'https://openalex.org/I161296585', 'display_name': 'Tokyo University of Science', 'ror': 'https://ror.org/05sj3n476', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I161296585']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kiyohito Mizutani', 'raw_affiliation_strings': ['Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.', 'institution_ids': ['https://openalex.org/I74801974', 'https://openalex.org/I161296585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003411661', 'display_name': 'Hiroaki Miki', 'orcid': 'https://orcid.org/0000-0003-0454-7006'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hiroaki Miki', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022302377', 'display_name': 'Hong He', 'orcid': 'https://orcid.org/0000-0002-2342-8750'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hong He', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101548568', 'display_name': 'Hiroshi Maruta', 'orcid': 'https://orcid.org/0000-0002-9087-3387'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Maruta', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103477987', 'display_name': 'Tadaomi Takenawa', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Tadaomi Takenawa', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.299, 'has_fulltext': False, 'cited_by_count': 226, 'citation_normalized_percentile': {'value': 0.92558, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '62', 'issue': '3', 'first_page': '669', 'last_page': '74'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11190', 'display_name': '3D Printing in Biomedical Research', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10540', 'display_name': 'Advanced Fluorescence Microscopy Techniques', 'score': 0.9812, 'subfield': {'id': 'https://openalex.org/subfields/1304', 'display_name': 'Biophysics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/podosome', 'display_name': 'Podosome', 'score': 0.9918107}, {'id': 'https://openalex.org/keywords/cortactin', 'display_name': 'Cortactin', 'score': 0.95017684}, {'id': 'https://openalex.org/keywords/invadopodia', 'display_name': 'Invadopodia', 'score': 0.849766}, {'id': 'https://openalex.org/keywords/wiskott–aldrich-syndrome-protein', 'display_name': 'Wiskott–Aldrich syndrome protein', 'score': 0.6089556}], 'concepts': [{'id': 'https://openalex.org/C141073059', 'wikidata': 'https://www.wikidata.org/wiki/Q7207063', 'display_name': 'Podosome', 'level': 4, 'score': 0.9918107}, {'id': 'https://openalex.org/C2776000893', 'wikidata': 'https://www.wikidata.org/wiki/Q14906154', 'display_name': 'Cortactin', 'level': 4, 'score': 0.95017684}, {'id': 'https://openalex.org/C200786668', 'wikidata': 'https://www.wikidata.org/wiki/Q3498029', 'display_name': 'Invadopodia', 'level': 4, 'score': 0.849766}, {'id': 'https://openalex.org/C86492073', 'wikidata': 'https://www.wikidata.org/wiki/Q413766', 'display_name': 'Fibronectin', 'level': 3, 'score': 0.71719897}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.71382415}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.61969763}, {'id': 'https://openalex.org/C108636557', 'wikidata': 'https://www.wikidata.org/wiki/Q21109354', 'display_name': 'Proto-oncogene tyrosine-protein kinase Src', 'level': 3, 'score': 0.61057276}, {'id': 'https://openalex.org/C2780939953', 'wikidata': 'https://www.wikidata.org/wiki/Q8027658', 'display_name': 'Wiskott–Aldrich syndrome protein', 'level': 5, 'score': 0.6089556}, {'id': 'https://openalex.org/C125705527', 'wikidata': 'https://www.wikidata.org/wiki/Q185269', 'display_name': 'Actin', 'level': 2, 'score': 0.5791956}, {'id': 'https://openalex.org/C196347352', 'wikidata': 'https://www.wikidata.org/wiki/Q24771787', 'display_name': 'SH3 domain', 'level': 4, 'score': 0.48030657}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41666245}, {'id': 'https://openalex.org/C2993400109', 'wikidata': 'https://www.wikidata.org/wiki/Q329638', 'display_name': 'Actin cytoskeleton', 'level': 4, 'score': 0.20491916}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.18707609}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.17784333}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.1512664}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.090815544}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07868773}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.05576372}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016391', 'descriptor_name': 'Genes, src', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019556', 'descriptor_name': 'COS Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051356', 'descriptor_name': 'Cortactin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016391', 'descriptor_name': 'Genes, src', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008840', 'descriptor_name': 'Microfilament Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008840', 'descriptor_name': 'Microfilament Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051316', 'descriptor_name': 'Wiskott-Aldrich Syndrome Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11830518', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Life on land', 'score': 0.46, 'id': 'https://metadata.un.org/sdg/15'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W100209535', 'https://openalex.org/W1524475817', 'https://openalex.org/W1571919210', 'https://openalex.org/W1575892864', 'https://openalex.org/W1832262637', 'https://openalex.org/W1964616832', 'https://openalex.org/W1965607913', 'https://openalex.org/W1965860054', 'https://openalex.org/W2007556078', 'https://openalex.org/W2007586038', 'https://openalex.org/W2009582035', 'https://openalex.org/W2010781630', 'https://openalex.org/W2021329171', 'https://openalex.org/W2044084413', 'https://openalex.org/W2063988619', 'https://openalex.org/W2068669952', 'https://openalex.org/W2070263067', 'https://openalex.org/W2072837740', 'https://openalex.org/W2079099921', 'https://openalex.org/W2081916410', 'https://openalex.org/W2096679179', 'https://openalex.org/W2106516212', 'https://openalex.org/W2107625881', 'https://openalex.org/W2110640625', 'https://openalex.org/W2121889667', 'https://openalex.org/W2136184845', 'https://openalex.org/W2137022580', 'https://openalex.org/W2137829134', 'https://openalex.org/W2145258568', 'https://openalex.org/W2153482320', 'https://openalex.org/W2166120011', 'https://openalex.org/W69306716'], 'related_works': ['https://openalex.org/W2963416869', 'https://openalex.org/W2159413732', 'https://openalex.org/W2133400063', 'https://openalex.org/W2128844598', 'https://openalex.org/W2084390938', 'https://openalex.org/W2080619090', 'https://openalex.org/W1990518931', 'https://openalex.org/W1988787904', 'https://openalex.org/W1976402994', 'https://openalex.org/W1519776165'], 'abstract_inverted_index': {'Transformation': [0], 'of': [1, 56, 59, 67, 71, 88, 104, 108, 136, 151, 169], 'cells': [2, 121], 'by': [3, 26, 139], 'the': [4, 30, 73, 101, 109, 126, 130, 134, 143, 149, 166], 'src': [5], 'oncogene': [6], 'causes': [7], 'dramatic': [8], 'changes': [9], 'in': [10, 53, 84, 90, 153], 'adhesive': [11], 'structures.': [12], 'In': [13, 37], 'v-src-transformed': [14], '3Y1': [15], 'rat': [16], 'fibroblasts': [17], '(3Y1-src),': [18], 'there': [19], 'are': [20, 69, 161], 'actin-rich': [21], 'protrusive': [22], 'structures': [23], 'called': [24], 'podosomes': [25, 91, 131], 'which': [27, 68, 160], 'attachment': [28], 'to': [29, 35, 93, 96, 164], 'extracellular': [31, 157], 'matrix': [32, 158], 'is': [33, 82], 'thought': [34, 163], 'occur.': [36], 'this': [38, 85], 'study,': [39], 'we': [40], 'found': [41], 'that': [42, 80, 119, 133], 'neural': [43], 'Wiskott-Aldrich': [44], 'syndrome': [45], 'protein': [46], '(N-WASP)': [47], 'colocalizes': [48], 'with': [49], 'filamentous': [50], 'actin': [51], '(F-actin)': [52], 'podosomes.': [54], 'Expression': [55], 'dominant-negative': [57], 'mutants': [58], 'N-WASP,': [60, 65], 'Deltacof': [61, 140], 'N-WASP': [62, 81, 89, 99, 141, 152], 'and': [63, 100, 132, 156], 'DeltaVPH': [64], 'both': [66], 'incapable': [70], 'activating': [72], 'Arp2/3': [74], 'complex,': [75], 'suppressed': [76, 113], 'podosome': [77, 114, 137, 154], 'formation,': [78], 'suggesting': [79], 'essential': [83], 'process.': [86], 'Localization': [87], 'appears': [92], 'be': [94], 'attributable': [95], 'interaction': [97], 'between': [98], 'SH3': [102, 111], 'domain': [103, 112], 'cortactin.': [105], 'Indeed,': [106], 'microinjection': [107], 'cortactin': [110], 'formation.': [115], 'We': [116], 'also': [117], 'observed': [118], '3Y1-src': [120, 170], 'cultured': [122], 'on': [123], 'fibronectin': [124, 127, 144], 'degrade': [125], 'primarily': [128], 'at': [129], 'inhibition': [135], 'formation': [138, 155], 'abolishes': [142], 'degradation.': [145], 'These': [146], 'results': [147], 'suggest': [148], 'importance': [150], 'degradation,': [159], 'processes': [162], 'underlie': [165], 'invasive': [167], 'phenotype': [168], 'cells.': [171]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1519776165', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-14T18:57:23.710802', 'created_date': '2016-06-24'}