Title: Calcium-regulated parathyroid hormone release in primary hyperparathyroidism
Abstract: Abstract Dispersed parathyroid cells were prepared from three normal human parathyroid glands as well as from pathologic parathyroid tissue of 30 patients with primary hyperparathyroidism (17 with adenoma, 12 with primary hyperplasia and one with carcinoma). Immunoreactive parathyroid hormone (PTH) release from cells of normal glands showed a set-point (the calcium concentration half-maximally inhibiting PTH release) of 1.0 mM, similar to that of normal bovine and canine parathyroid cells. Cells from parathyroid tissue of one patient each with multiple endocrine neoplasia type I (MEN I) and unclassified familial hyperparathyroidism, and from eight of 12 glands from patients with sporadic hyperplasia had setpoints of 1.0 to 1.1 mM. By contrast, only two of 17 cell preparations from adenomas had set-points of The present results and previous data from this laboratory in 20 additional patients with primary hyperparathyroidism suggest heterogeneous responsiveness to calcium in this disorder. In some cases (most primary hyperplasia and occasional adenomas), calcium-regulated PTH release is relatively normal. In others (most adenomas and some sporadic primary hyperplasia), maximal suppressibility of secretion is normal but with an elevated set-point. In the remaining adenomas, in rare primary hyperplasia and in the single carcinoma in this series, relative autonomy was observed. The relationship of these various secretory patterns to the pathophysiology of primary hyperparathyroidism is discussed.
Publication Year: 1979
Publication Date: 1979-06-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 144
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