Title: The influence of T lymphocytes and their products on hemopoietic precursor cell regeneration in spleen organ cultures
Abstract: T-Iymphocyte-mediated effects on hemopoietic progenitor cell regeneration (colony-forming cells.CFC) were analyzed in a recently developed spleen organ culture system.It was found that T lymphocytes allogeneic to the recipient or to the donor or to both are capable of significantly inhibiting CFC regeneration in spleen organ cultures.Furthermore.cell-free mixed lymphocyte culture (MLC) supernatants exhibit similar inhibitory activity when assayed in organ cultures.