Publication Information

{'id': 'https://openalex.org/W1516399319', 'doi': 'https://doi.org/10.1038/35087069', 'title': 'Nicastrin binds to membrane-tethered Notch', 'display_name': 'Nicastrin binds to membrane-tethered Notch', 'publication_year': 2001, 'publication_date': '2001-07-12', 'ids': {'openalex': 'https://openalex.org/W1516399319', 'doi': 'https://doi.org/10.1038/35087069', 'mag': '1516399319', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11483961'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/35087069', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151741590', 'display_name': 'Nature Cell Biology', 'issn_l': '1465-7392', 'issn': ['1465-7392', '1476-4679'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012238780', 'display_name': 'Fusheng Chen', 'orcid': 'https://orcid.org/0000-0002-8201-1234'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Fusheng Chen', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044342845', 'display_name': 'Gang Yu', 'orcid': 'https://orcid.org/0000-0003-4932-5757'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Gang Yu', 'raw_affiliation_strings': ['Departments of Medicine and Medical Biophysics, University of Toronto, Tanz Neuroscience Building, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicine and Medical Biophysics, University of Toronto, Tanz Neuroscience Building, Ontario, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009546157', 'display_name': 'Shigeki Arawaka', 'orcid': 'https://orcid.org/0000-0002-1505-3012'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Shigeki Arawaka', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103083897', 'display_name': 'Masaki Nishimura', 'orcid': 'https://orcid.org/0000-0003-4540-5733'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}, {'id': 'https://openalex.org/I160046202', 'display_name': 'Shiga University of Medical Science', 'ror': 'https://ror.org/00d8gp927', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I160046202']}], 'countries': ['CA', 'JP'], 'is_corresponding': False, 'raw_author_name': 'Masaki Nishimura', 'raw_affiliation_strings': ['Shiga University of Medical Science', 'University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Shiga University of Medical Science', 'institution_ids': ['https://openalex.org/I160046202']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082917295', 'display_name': 'Toshitaka Kawarai', 'orcid': 'https://orcid.org/0000-0003-4547-8131'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Toshitaka Kawarai', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024970198', 'display_name': 'Wen H. Yu', 'orcid': 'https://orcid.org/0000-0001-7186-6731'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Haung Yu', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105502537', 'display_name': 'Anurag Tandon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Anurag Tandon', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111969362', 'display_name': 'Agnes Supala', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Agnes Supala', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087582431', 'display_name': 'You‐Qiang Song', 'orcid': 'https://orcid.org/0000-0001-9407-2256'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'You Qiang Song', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012586710', 'display_name': 'Ekaterina Rogaeva', 'orcid': 'https://orcid.org/0000-0002-2852-0329'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Ekaterina Rogaeva', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109176597', 'display_name': 'Paul Milman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Paul Milman', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086851177', 'display_name': 'Christine Sato', 'orcid': 'https://orcid.org/0000-0001-7598-0996'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Christine Sato', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026928688', 'display_name': 'Cong Yu', 'orcid': 'https://orcid.org/0000-0002-8904-0644'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Cong Yu', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054504895', 'display_name': 'Christopher Janus', 'orcid': 'https://orcid.org/0000-0003-4044-1882'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Christopher Janus', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090981731', 'display_name': 'Julie Lee', 'orcid': 'https://orcid.org/0000-0001-8718-388X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Julie Lee', 'raw_affiliation_strings': ['Schering-Plough Biopharma'], 'affiliations': [{'raw_affiliation_string': 'Schering-Plough Biopharma', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089688459', 'display_name': 'Lixin Song', 'orcid': 'https://orcid.org/0000-0002-6758-2557'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Lixin Song', 'raw_affiliation_strings': ['Schering-Plough Biopharma'], 'affiliations': [{'raw_affiliation_string': 'Schering-Plough Biopharma', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100461181', 'display_name': 'Lili Zhang', 'orcid': 'https://orcid.org/0000-0002-3601-0150'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Lili Zhang', 'raw_affiliation_strings': ['Schering-Plough Biopharma'], 'affiliations': [{'raw_affiliation_string': 'Schering-Plough Biopharma', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104831909', 'display_name': 'Paul E. Fraser', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Paul E. Fraser', 'raw_affiliation_strings': ['University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068533952', 'display_name': 'Peter St George‐Hyslop', 'orcid': 'https://orcid.org/0000-0003-0796-7209'}, 'institutions': [{'id': 'https://openalex.org/I2802948906', 'display_name': 'Health Net', 'ror': 'https://ror.org/03nzj6y61', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802948906']}, {'id': 'https://openalex.org/I1325899441', 'display_name': 'University Health Network', 'ror': 'https://ror.org/042xt5161', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441']}, {'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'P. H. St George-Hyslop', 'raw_affiliation_strings': ['University Health Network', 'University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'University Health Network', 'institution_ids': ['https://openalex.org/I2802948906', 'https://openalex.org/I1325899441']}, {'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 10.063, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 129, 'citation_normalized_percentile': {'value': 0.864081, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '3', 'issue': '8', 'first_page': '751', 'last_page': '754'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11772', 'display_name': 'Genetics and Neurodevelopmental Disorders', 'score': 0.987, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11772', 'display_name': 'Genetics and Neurodevelopmental Disorders', 'score': 0.987, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9601, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Neurogenesis and neuroplasticity mechanisms', 'score': 0.9499, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nicastrin', 'display_name': 'Nicastrin', 'score': 0.76735497}], 'concepts': [{'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.79752815}, {'id': 'https://openalex.org/C2779658117', 'wikidata': 'https://www.wikidata.org/wiki/Q7024546', 'display_name': 'Nicastrin', 'level': 5, 'score': 0.76735497}, {'id': 'https://openalex.org/C161879069', 'wikidata': 'https://www.wikidata.org/wiki/Q904082', 'display_name': 'Notch signaling pathway', 'level': 3, 'score': 0.58302}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42344594}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.42315888}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3762408}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.16752434}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16358241}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.10358599}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.07738954}, {'id': 'https://openalex.org/C175344181', 'wikidata': 'https://www.wikidata.org/wiki/Q907198', 'display_name': 'Presenilin', 'level': 4, 'score': 0.054728687}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053829', 'descriptor_name': 'Amyloid Precursor Protein Secretases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016282', 'descriptor_name': 'Aspartic Acid Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D051880', 'descriptor_name': 'Receptors, Notch', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/35087069', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151741590', 'display_name': 'Nature Cell Biology', 'issn_l': '1465-7392', 'issn': ['1465-7392', '1476-4679'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11483961', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1480987708', 'https://openalex.org/W1518012529', 'https://openalex.org/W1529142120', 'https://openalex.org/W1534001036', 'https://openalex.org/W1595935608', 'https://openalex.org/W1626267121', 'https://openalex.org/W1655397332', 'https://openalex.org/W1655404681', 'https://openalex.org/W1660631781', 'https://openalex.org/W1675105744', 'https://openalex.org/W1972706019', 'https://openalex.org/W1973130935', 'https://openalex.org/W1982825693', 'https://openalex.org/W1985784930', 'https://openalex.org/W2010684406', 'https://openalex.org/W2045153164', 'https://openalex.org/W2046209489', 'https://openalex.org/W2049130898', 'https://openalex.org/W2063886117', 'https://openalex.org/W2081733923', 'https://openalex.org/W2081998222', 'https://openalex.org/W2082669967', 'https://openalex.org/W2082795767', 'https://openalex.org/W209357470', 'https://openalex.org/W2150970420', 'https://openalex.org/W2154196079', 'https://openalex.org/W2154693189', 'https://openalex.org/W2164742714', 'https://openalex.org/W2167310720', 'https://openalex.org/W4250522654'], 'related_works': ['https://openalex.org/W95532655', 'https://openalex.org/W3215076932', 'https://openalex.org/W2794550884', 'https://openalex.org/W2133438193', 'https://openalex.org/W2112117960', 'https://openalex.org/W2100564482', 'https://openalex.org/W2089508549', 'https://openalex.org/W2082860237', 'https://openalex.org/W1980868631', 'https://openalex.org/W1970816518'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1516399319', 'counts_by_year': [{'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-14T11:46:11.629225', 'created_date': '2016-06-24'}