Title: Abstract 13741: Increased HbA1c Level is Independently Associated With the Severity of Coronary Artery Diseases
Abstract: Objective: To evaluate the relationship between glycosylated hemoglobin (HbA1c) level and the severity of atherosclerotic cardiovascular diseases (CVD). Method: Totally 573 participants were enrolled from April of 2013 to May of 2014 and all subjects were underwent coronary angiography (CAG) for evaluating the number of coronary artery stenosis. According to clinical presentation, electrocardiography, cardiac biomarker, and CAG result, all participants were divided into control group (excluded CVD), stable angina group (SA), unstable angina group (UA) and acute myocardial infarction (AMI) group. One-way ANOVA, multivariate analysis and logistic regression analysis were performed to evaluate the relationship between HbA1c level and the severity of atherosclerotic cardiovascular diseases. Results: Values of HbA1c in the control, SA, UA and AMI groups were 6.05 ± 1.17 %, 6.49 ± 1.37 %, 6.53 ±1.20 %, and 6.98 ± 2.09 % respectively (P for trend = 0.001). After adjusted for age, gender, family history of CAD, smoking, hypertension, fasting blood glucose, LDL-C and uric acid, HbA1c level was still independently associated with the severity of CAD, with odd ratio of 1.621 (AMI group versus control group, 95 % confidence interval 1.196-2.198, P = 0.002). Additionally, the relationship between HbA1c level and the number of coronary artery stenosis was also assessed. Values of HbA1c in the control group, single-vessel stenosis group, and multiple-vessels stenoses group were 6.01 ± 1.04 %, 6.23 ± 1.22 %, and 6.74 ± 1.46 % respectively (P for trend Conclusion: Increased HbA1c level was independently associated with the severity of coronary artery diseases and by which mechanism needs further investigation.
Publication Year: 2014
Publication Date: 2014-11-25
Language: en
Type: article
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