Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1515974526', 'doi': 'https://doi.org/10.18632/oncotarget.3128', 'title': 'DC120, a novel AKT inhibitor, preferentially suppresses nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2', 'display_name': 'DC120, a novel AKT inhibitor, preferentially suppresses nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2', 'publication_year': 2015, 'publication_date': '2015-02-04', 'ids': {'openalex': 'https://openalex.org/W1515974526', 'doi': 'https://doi.org/10.18632/oncotarget.3128', 'mag': '1515974526', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25749514', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4466661'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3128', 'pdf_url': 'https://www.oncotarget.com/article/3128/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/3128/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064290814', 'display_name': 'Juan Qin', 'orcid': 'https://orcid.org/0000-0002-0821-6290'}, 'institutions': [{'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Juan Qin', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I4210146711', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100991166', 'display_name': 'Jiao Ji', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiao Ji', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041146217', 'display_name': 'Rong Deng', 'orcid': 'https://orcid.org/0000-0003-3724-0326'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Rong Deng', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102856781', 'display_name': 'Jun Tang', 'orcid': 'https://orcid.org/0000-0002-9788-8389'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Tang', 'raw_affiliation_strings': ['Department of Breast Oncology, Sun Yat-sen University, Guangzhou, China', 'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}, {'raw_affiliation_string': 'Department of Breast Oncology, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102985006', 'display_name': 'Fen Yang', 'orcid': 'https://orcid.org/0000-0002-1600-7253'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fen Yang', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100836048', 'display_name': 'Gong-Kan Feng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Gong-Kan Feng', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I4210146711', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034200339', 'display_name': 'Wen-Dan Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wen-Dan Chen', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103357695', 'display_name': 'Xiao-Qi Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Qi Wu', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103343374', 'display_name': 'Xiao-Jun Qian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Jun Qian', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001466305', 'display_name': 'Ke Ding', 'orcid': 'https://orcid.org/0000-0001-9016-812X'}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I2802148028', 'display_name': 'Guangzhou Institutes of Biomedicine and Health', 'ror': 'https://ror.org/02c31t502', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802148028']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ke Ding', 'raw_affiliation_strings': ['Graduate School of Chinese Academy of Sciences, Beijing, China.', 'Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou China.'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou China.', 'institution_ids': ['https://openalex.org/I19820366', 'https://openalex.org/I2802148028']}, {'raw_affiliation_string': 'Graduate School of Chinese Academy of Sciences, Beijing, China.', 'institution_ids': ['https://openalex.org/I19820366']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101587495', 'display_name': 'Xiao‐Feng Zhu', 'orcid': 'https://orcid.org/0000-0002-1313-4783'}, 'institutions': [{'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Feng Zhu', 'raw_affiliation_strings': ['State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I4210146711', 'https://openalex.org/I157773358']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.782, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.999954, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '6', 'issue': '9', 'first_page': '6944', 'last_page': '6958'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.99, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.963, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/homeobox-protein-nanog', 'display_name': 'Homeobox protein NANOG', 'score': 0.4630857}], 'concepts': [{'id': 'https://openalex.org/C2778997737', 'wikidata': 'https://www.wikidata.org/wiki/Q1693598', 'display_name': 'Nasopharyngeal carcinoma', 'level': 3, 'score': 0.74915856}, {'id': 'https://openalex.org/C2777933648', 'wikidata': 'https://www.wikidata.org/wiki/Q21114866', 'display_name': 'SOX2', 'level': 4, 'score': 0.72683835}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.64654696}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.55159307}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5183647}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.48508444}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.47567263}, {'id': 'https://openalex.org/C207701140', 'wikidata': 'https://www.wikidata.org/wiki/Q420522', 'display_name': 'Homeobox protein NANOG', 'level': 5, 'score': 0.4630857}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.457514}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.44139364}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.41178453}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.34819138}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.34096676}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.3211967}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29459673}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.19191134}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.15328172}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.099847645}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0975377}, {'id': 'https://openalex.org/C107459253', 'wikidata': 'https://www.wikidata.org/wiki/Q674925', 'display_name': 'Induced pluripotent stem cell', 'level': 4, 'score': 0.08577174}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07518259}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009303', 'descriptor_name': 'Nasopharyngeal Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D055748', 'descriptor_name': 'SOXB1 Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013844', 'descriptor_name': 'Thiazoles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002277', 'descriptor_name': 'Carcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002469', 'descriptor_name': 'Cell Separation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020868', 'descriptor_name': 'Gene Silencing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D038362', 'descriptor_name': 'Glycogen Synthase Kinase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D038362', 'descriptor_name': 'Glycogen Synthase Kinase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071679', 'descriptor_name': 'Glycogen Synthase Kinase 3 beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020128', 'descriptor_name': 'Inhibitory Concentration 50', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077274', 'descriptor_name': 'Nasopharyngeal Carcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009303', 'descriptor_name': 'Nasopharyngeal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009364', 'descriptor_name': 'Neoplasm Recurrence, Local', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055748', 'descriptor_name': 'SOXB1 Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013844', 'descriptor_name': 'Thiazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3128', 'pdf_url': 'https://www.oncotarget.com/article/3128/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4466661', 'pdf_url': 'https://europepmc.org/articles/pmc4466661?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466661', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25749514', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3128', 'pdf_url': 'https://www.oncotarget.com/article/3128/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.42, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1487234933', 'https://openalex.org/W1569089611', 'https://openalex.org/W1905441360', 'https://openalex.org/W1970944737', 'https://openalex.org/W1984236546', 'https://openalex.org/W1984621921', 'https://openalex.org/W1989141849', 'https://openalex.org/W1996695017', 'https://openalex.org/W2007114641', 'https://openalex.org/W2009094422', 'https://openalex.org/W2009129665', 'https://openalex.org/W2011383633', 'https://openalex.org/W2013975797', 'https://openalex.org/W2014691022', 'https://openalex.org/W2019768326', 'https://openalex.org/W2021401668', 'https://openalex.org/W2022557634', 'https://openalex.org/W2026790277', 'https://openalex.org/W2027102742', 'https://openalex.org/W2028298372', 'https://openalex.org/W2034949142', 'https://openalex.org/W2038149829', 'https://openalex.org/W2040608994', 'https://openalex.org/W2048158327', 'https://openalex.org/W2049225296', 'https://openalex.org/W2059426385', 'https://openalex.org/W2064511217', 'https://openalex.org/W2069263914', 'https://openalex.org/W2076039769', 'https://openalex.org/W2081779672', 'https://openalex.org/W2084946596', 'https://openalex.org/W2088153666', 'https://openalex.org/W2100297011', 'https://openalex.org/W2102085111', 'https://openalex.org/W2106771830', 'https://openalex.org/W2107400278', 'https://openalex.org/W2111511846', 'https://openalex.org/W2114496027', 'https://openalex.org/W2123877065', 'https://openalex.org/W2131697316', 'https://openalex.org/W2132405590', 'https://openalex.org/W2137941402', 'https://openalex.org/W2141417189', 'https://openalex.org/W2145647116', 'https://openalex.org/W2149522334', 'https://openalex.org/W2153730286', 'https://openalex.org/W2157195219', 'https://openalex.org/W2157949003', 'https://openalex.org/W2158046625', 'https://openalex.org/W2158219515', 'https://openalex.org/W2158865822', 'https://openalex.org/W2159664205', 'https://openalex.org/W2160160749', 'https://openalex.org/W2161655114', 'https://openalex.org/W2162674813', 'https://openalex.org/W2167650288', 'https://openalex.org/W2168854899'], 'related_works': ['https://openalex.org/W4323566320', 'https://openalex.org/W2911073388', 'https://openalex.org/W2795110280', 'https://openalex.org/W2602092987', 'https://openalex.org/W2525877122', 'https://openalex.org/W2517286276', 'https://openalex.org/W2335409602', 'https://openalex.org/W2083646121', 'https://openalex.org/W2058675403', 'https://openalex.org/W1597633061'], 'abstract_inverted_index': {'//': [0], 'Juan': [1], 'Qin': [2], '1,': [3, 8, 13, 18], '*': [4, 9, 14, 108], ',': [5, 10, 15, 20, 24, 28, 32, 36, 40, 45], 'Jiao': [6], 'Ji': [7], 'Rong': [11], 'Deng': [12], 'Jun': [16], 'Tang': [17], '2': [19, 65], 'Fen': [21], 'Yang': [22], '1': [23, 27, 31, 35, 39, 48, 49], 'Gong-Kan': [25], 'Feng': [26], 'Wen-Dan': [29], 'Chen': [30], 'Xiao-Qi': [33], 'Wu': [34], 'Xiao-Jun': [37], 'Qian': [38], 'Ke': [41], 'Ding': [42], '3,': [43], '4': [44, 85], 'Xiao-Feng': [46, 119], 'Zhu': [47], 'State': [50], 'Key': [51, 86], 'Laboratory': [52, 87], 'of': [53, 67, 78, 81, 88, 93, 98, 104, 196, 201, 205, 220, 237, 244, 250, 270], 'Oncology': [54], 'in': [55, 175, 180, 188, 216, 262, 265], 'South': [56], 'China,': [57], 'Cancer': [58], 'Center,': [59], 'Sun': [60, 70], 'Yat-sen': [61, 71], 'University,': [62, 72], 'Guangzhou,': [63, 73], 'China': [64, 74, 84, 107], 'Department': [66], 'Breast': [68], 'Oncology,': [69], '3': [75], 'Graduate': [76], 'School': [77], 'Chinese': [79, 102], 'Academy': [80, 103], 'Sciences,': [82, 105], 'Beijing,': [83], 'Regenerative': [89], 'Biology': [90], 'and': [91, 100, 165, 177, 207, 218, 246, 252, 264], 'Institute': [92], 'Chemical': [94], 'Biology,': [95], 'Guangzhou': [96, 106], 'Institutes': [97], 'Biomedicine': [99], 'Health,': [101], 'These': [109], 'authors': [110], 'have': [111], 'contributed': [112], 'equally': [113], 'to': [114, 242], 'this': [115, 153], 'work': [116], 'Correspondence': [117], 'to:': [118], 'Zhu,': [120], 'e-mail:': [121], '[email protected]': [122], 'Keywords:': [123], 'DC120,': [124, 192], 'PKB/AKT,': [125], 'nasopharyngeal': [126, 160], 'carcinoma,': [127], 'cancer': [128, 148], 'stem-like': [129, 149], 'cells': [130, 150, 158, 169, 258], 'Received:': [131], 'December': [132], '12,': [133], '2014': [134], 'Accepted:': [135], 'January': [136], '09,': [137], '2015': [138, 142], 'Published:': [139], 'February': [140], '04,': [141], 'ABSTRACT': [143], 'Side': [144], 'population': [145], '(SP)': [146], 'contains': [147], '(CSLCs).': [151], 'In': [152], 'study,': [154], 'we': [155], 'characterized': [156], 'SP': [157, 168, 190, 211], 'from': [159], 'carcinoma': [161], '(NPC)': [162], 'cell': [163], 'lines': [164], 'found': [166], 'that': [167], 'had': [170], 'a': [171, 193], 'higher': [172], 'self-renewal': [173], 'ability': [174, 215], 'vitro': [176, 217, 263], 'greater': [178], 'tumorigenicity': [179], 'vivo': [181, 266], '.': [182, 267], 'The': [183], 'AKT': [184], 'pathway': [185], 'was': [186, 232], 'activated': [187], 'NPC': [189, 257], 'cells.': [191], '2-pyrimidyl-5-amidothiazole': [194], 'inhibitor': [195], 'the': [197, 213], 'ATP': [198], 'binding': [199], 'site': [200], 'AKT,': [202], 'inhibited': [203, 210, 256], 'phosphorylation': [204], 'FKHRL1': [206], 'GSK-3β.': [208], 'DC120': [209, 251, 271], 'fraction,': [212], 'sphere-forming': [214], 'growth': [219], 'primary': [221], 'xenografts': [222], 'as': [223, 225], 'well': [224], 'secondary': [226], "xenografts'": [227], 'tumor': [228], 'recurrence.': [229], 'This': [230], 'inhibition': [231], 'accompanied': [233], 'by': [234], 'reduced': [235], 'expression': [236], 'stem-related': [238], 'gene': [239], 'Sox2': [240], 'due': [241], 'induction': [243], 'p27': [245], 'miR-30a.': [247], 'A': [248], 'combination': [249], 'CDDP': [253], 'more': [254], 'effectively': [255], 'compared': [259], 'with': [260], 'monotherapy': [261], 'Clinical': [268], 'evaluation': [269], 'is': [272], 'warranted.': [273]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1515974526', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 5}], 'updated_date': '2024-12-13T04:58:27.378726', 'created_date': '2016-06-24'}