Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1512570069', 'doi': 'https://doi.org/10.1080/19420862.2015.1022693', 'title': 'Dose – response relationship of bevacizumab in hereditary hemorrhagic telangiectasia', 'display_name': 'Dose – response relationship of bevacizumab in hereditary hemorrhagic telangiectasia', 'publication_year': 2015, 'publication_date': '2015-03-09', 'ids': {'openalex': 'https://openalex.org/W1512570069', 'doi': 'https://doi.org/10.1080/19420862.2015.1022693', 'mag': '1512570069', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25751241', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4622710'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/19420862.2015.1022693', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S169123381', 'display_name': 'mAbs', 'issn_l': '1942-0862', 'issn': ['1942-0862', '1942-0870'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315740', 'host_organization_name': 'Landes Bioscience', 'host_organization_lineage': ['https://openalex.org/P4310315740'], 'host_organization_lineage_names': ['Landes Bioscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.1080/19420862.2015.1022693', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070999281', 'display_name': 'Nicolas Azzopardi', 'orcid': 'https://orcid.org/0000-0003-1915-9065'}, 'institutions': [{'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Nicolas Azzopardi', 'raw_affiliation_strings': ['CNRS, GICC UMR 7292', 'Tours, France', 'Université François-Rabelais de Tours'], 'affiliations': [{'raw_affiliation_string': 'Tours, France', 'institution_ids': []}, {'raw_affiliation_string': 'CNRS, GICC UMR 7292', 'institution_ids': []}, {'raw_affiliation_string': 'Université François-Rabelais de Tours', 'institution_ids': ['https://openalex.org/I110017253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009255625', 'display_name': 'Sophie Dupuis‐Girod', 'orcid': 'https://orcid.org/0000-0002-8834-5526'}, 'institutions': [{'id': 'https://openalex.org/I4210140706', 'display_name': 'Centre Hospitalier Vétérinaire Frégis', 'ror': 'https://ror.org/03yzavx55', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140706']}, {'id': 'https://openalex.org/I100532134', 'display_name': 'Université Claude Bernard Lyon 1', 'ror': 'https://ror.org/029brtt94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I203339264']}, {'id': 'https://openalex.org/I4210100596', 'display_name': 'Hospices Civils de Lyon', 'ror': 'https://ror.org/01502ca60', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100596']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Sophie Dupuis-Girod', 'raw_affiliation_strings': ['Bron, France', 'Genetic Department and National Reference Center for Rendu-Osler Disease', 'Groupe Hospitalier Est', 'Hospices Civils de Lyon', 'Lyon, France', 'Université Lyon 1'], 'affiliations': [{'raw_affiliation_string': 'Genetic Department and National Reference Center for Rendu-Osler Disease', 'institution_ids': []}, {'raw_affiliation_string': 'Bron, France', 'institution_ids': []}, {'raw_affiliation_string': 'Groupe Hospitalier Est', 'institution_ids': ['https://openalex.org/I4210140706']}, {'raw_affiliation_string': 'Université Lyon 1', 'institution_ids': ['https://openalex.org/I100532134']}, {'raw_affiliation_string': 'Hospices Civils de Lyon', 'institution_ids': ['https://openalex.org/I4210100596']}, {'raw_affiliation_string': 'Lyon, France', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033266569', 'display_name': 'David Ternant', 'orcid': 'https://orcid.org/0000-0003-4020-4545'}, 'institutions': [{'id': 'https://openalex.org/I4210095477', 'display_name': 'Centre Hospitalier Universitaire de Tours', 'ror': 'https://ror.org/00jpq0w62', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210095477']}, {'id': 'https://openalex.org/I4210091644', 'display_name': 'Laboratoire de Biophotonique et Pharmacologie', 'ror': 'https://ror.org/0032sc770', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210091644', 'https://openalex.org/I4210096427', 'https://openalex.org/I68947357']}, {'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'David Ternant', 'raw_affiliation_strings': ['CHRU de Tours', 'CNRS, GICC UMR 7292', 'Laboratoire de Pharmacologie-Toxicologie', 'Tours, France', 'Université François-Rabelais de Tours'], 'affiliations': [{'raw_affiliation_string': 'CNRS, GICC UMR 7292', 'institution_ids': []}, {'raw_affiliation_string': 'Tours, France', 'institution_ids': []}, {'raw_affiliation_string': 'CHRU de Tours', 'institution_ids': ['https://openalex.org/I4210095477']}, {'raw_affiliation_string': 'Laboratoire de Pharmacologie-Toxicologie', 'institution_ids': ['https://openalex.org/I4210091644']}, {'raw_affiliation_string': 'Université François-Rabelais de Tours', 'institution_ids': ['https://openalex.org/I110017253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055242632', 'display_name': 'Anne‐Emmanuelle Fargeton', 'orcid': 'https://orcid.org/0000-0003-3085-9580'}, 'institutions': [{'id': 'https://openalex.org/I4210100596', 'display_name': 'Hospices Civils de Lyon', 'ror': 'https://ror.org/01502ca60', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100596']}, {'id': 'https://openalex.org/I4210140706', 'display_name': 'Centre Hospitalier Vétérinaire Frégis', 'ror': 'https://ror.org/03yzavx55', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140706']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Anne-Emmanuelle Fargeton', 'raw_affiliation_strings': ['Bron, France', 'Genetic Department and National Reference Center for Rendu-Osler Disease', 'Groupe Hospitalier Est', 'Hospices Civils de Lyon'], 'affiliations': [{'raw_affiliation_string': 'Hospices Civils de Lyon', 'institution_ids': ['https://openalex.org/I4210100596']}, {'raw_affiliation_string': 'Bron, France', 'institution_ids': []}, {'raw_affiliation_string': 'Groupe Hospitalier Est', 'institution_ids': ['https://openalex.org/I4210140706']}, {'raw_affiliation_string': 'Genetic Department and National Reference Center for Rendu-Osler Disease', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056272290', 'display_name': 'Isabelle Ginon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210113288', 'display_name': 'Hôpital Lyon Sud', 'ror': 'https://ror.org/023xgd207', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100596', 'https://openalex.org/I4210113288']}, {'id': 'https://openalex.org/I4210136231', 'display_name': 'Institute of Cardiology', 'ror': 'https://ror.org/03h2xy876', 'country_code': 'PL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210136231']}, {'id': 'https://openalex.org/I4210100596', 'display_name': 'Hospices Civils de Lyon', 'ror': 'https://ror.org/01502ca60', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100596']}], 'countries': ['FR', 'PL'], 'is_corresponding': False, 'raw_author_name': 'Isabelle Ginon', 'raw_affiliation_strings': ['Cardiology Department', 'Centre Hospitalier Lyon Sud', 'Hospices Civils de Lyon', 'Pierre-Bénite, France'], 'affiliations': [{'raw_affiliation_string': 'Centre Hospitalier Lyon Sud', 'institution_ids': ['https://openalex.org/I4210113288']}, {'raw_affiliation_string': 'Pierre-Bénite, France', 'institution_ids': []}, {'raw_affiliation_string': 'Cardiology Department', 'institution_ids': ['https://openalex.org/I4210136231']}, {'raw_affiliation_string': 'Hospices Civils de Lyon', 'institution_ids': ['https://openalex.org/I4210100596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001544578', 'display_name': 'Frédéric Faure', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210123600', 'display_name': 'Hôpital Edouard Herriot', 'ror': 'https://ror.org/02qt1p572', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100596', 'https://openalex.org/I4210123600']}, {'id': 'https://openalex.org/I4210100596', 'display_name': 'Hospices Civils de Lyon', 'ror': 'https://ror.org/01502ca60', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100596']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Frédéric Faure', 'raw_affiliation_strings': ['Head and Neck Surgery Department', 'Hospices Civils de Lyon', 'Hôpital E. Herriot', 'Lyon, France'], 'affiliations': [{'raw_affiliation_string': 'Lyon, France', 'institution_ids': []}, {'raw_affiliation_string': 'Hôpital E. Herriot', 'institution_ids': ['https://openalex.org/I4210123600']}, {'raw_affiliation_string': 'Head and Neck Surgery Department', 'institution_ids': []}, {'raw_affiliation_string': 'Hospices Civils de Lyon', 'institution_ids': ['https://openalex.org/I4210100596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050740846', 'display_name': 'Évelyne Decullier', 'orcid': 'https://orcid.org/0000-0002-2412-4767'}, 'institutions': [{'id': 'https://openalex.org/I4210100596', 'display_name': 'Hospices Civils de Lyon', 'ror': 'https://ror.org/01502ca60', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100596']}, {'id': 'https://openalex.org/I100532134', 'display_name': 'Université Claude Bernard Lyon 1', 'ror': 'https://ror.org/029brtt94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I203339264']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Evelyne Decullier', 'raw_affiliation_strings': ['Hospices Civils de Lyon', 'Lyon, France', 'Université Lyon 1', 'pôle IMER'], 'affiliations': [{'raw_affiliation_string': 'Hospices Civils de Lyon', 'institution_ids': ['https://openalex.org/I4210100596']}, {'raw_affiliation_string': 'Lyon, France', 'institution_ids': []}, {'raw_affiliation_string': 'Université Lyon 1', 'institution_ids': ['https://openalex.org/I100532134']}, {'raw_affiliation_string': 'pôle IMER', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025443652', 'display_name': 'Adeline Roux', 'orcid': 'https://orcid.org/0000-0002-8269-6544'}, 'institutions': [{'id': 'https://openalex.org/I4210100596', 'display_name': 'Hospices Civils de Lyon', 'ror': 'https://ror.org/01502ca60', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100596']}, {'id': 'https://openalex.org/I100532134', 'display_name': 'Université Claude Bernard Lyon 1', 'ror': 'https://ror.org/029brtt94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I203339264']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Adeline Roux', 'raw_affiliation_strings': ['Hospices Civils de Lyon', 'Lyon, France', 'Université Lyon 1', 'pôle IMER'], 'affiliations': [{'raw_affiliation_string': 'Hospices Civils de Lyon', 'institution_ids': ['https://openalex.org/I4210100596']}, {'raw_affiliation_string': 'Lyon, France', 'institution_ids': []}, {'raw_affiliation_string': 'Université Lyon 1', 'institution_ids': ['https://openalex.org/I100532134']}, {'raw_affiliation_string': 'pôle IMER', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108259139', 'display_name': 'Marie‐France Carette', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210150674', 'display_name': 'University Radiology', 'ror': 'https://ror.org/058fx5466', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210150674']}, {'id': 'https://openalex.org/I4210166768', 'display_name': 'Hôpital Tenon', 'ror': 'https://ror.org/05h5v3c50', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166768']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}], 'countries': ['FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Marie-France Carette', 'raw_affiliation_strings': ['Assistance Publique–Hôpitaux de Paris', 'Hôpital Tenon', 'Paris, France', 'Radiology Department', 'Université Pierre et Marie Curie (Paris VI)'], 'affiliations': [{'raw_affiliation_string': 'Université Pierre et Marie Curie (Paris VI)', 'institution_ids': ['https://openalex.org/I39804081']}, {'raw_affiliation_string': 'Radiology Department', 'institution_ids': ['https://openalex.org/I4210150674']}, {'raw_affiliation_string': 'Hôpital Tenon', 'institution_ids': ['https://openalex.org/I4210166768', 'https://openalex.org/I39804081']}, {'raw_affiliation_string': 'Paris, France', 'institution_ids': []}, {'raw_affiliation_string': 'Assistance Publique–Hôpitaux de Paris', 'institution_ids': ['https://openalex.org/I4210097159']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039650463', 'display_name': 'Brigitte Gilbert‐Dussardier', 'orcid': 'https://orcid.org/0000-0001-7182-9914'}, 'institutions': [{'id': 'https://openalex.org/I4210153075', 'display_name': 'Laboratoire de Génétique Cellulaire', 'ror': 'https://ror.org/05k317v03', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210088668', 'https://openalex.org/I4210153075']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Brigitte Gilbert-Dussardier', 'raw_affiliation_strings': ['CHU La Milétrie', 'Genetic Department', 'Poitiers, France'], 'affiliations': [{'raw_affiliation_string': 'CHU La Milétrie', 'institution_ids': ['https://openalex.org/I4210153075']}, {'raw_affiliation_string': 'Genetic Department', 'institution_ids': []}, {'raw_affiliation_string': 'Poitiers, France', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108100485', 'display_name': 'Pierre‐Yves Hatron', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2279609970', 'display_name': 'Université de Lille', 'ror': 'https://ror.org/02kzqn938', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2279609970']}, {'id': 'https://openalex.org/I3018718406', 'display_name': 'Centre Hospitalier Universitaire de Lille', 'ror': 'https://ror.org/02ppyfa04', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018718406']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Pierre-Yves Hatron', 'raw_affiliation_strings': ['CHRU de Lille', 'Internal Medicine Department', 'Lille, France', 'Université Lille 2'], 'affiliations': [{'raw_affiliation_string': 'Université Lille 2', 'institution_ids': ['https://openalex.org/I2279609970']}, {'raw_affiliation_string': 'CHRU de Lille', 'institution_ids': ['https://openalex.org/I3018718406']}, {'raw_affiliation_string': 'Internal Medicine Department', 'institution_ids': []}, {'raw_affiliation_string': 'Lille, France', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080891466', 'display_name': 'Pascal Lacombe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I4210150674', 'display_name': 'University Radiology', 'ror': 'https://ror.org/058fx5466', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210150674']}, {'id': 'https://openalex.org/I3020261445', 'display_name': 'CHU Ambroise Paré', 'ror': 'https://ror.org/02d9v9944', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3020261445']}], 'countries': ['BE', 'FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Pascal Lacombe', 'raw_affiliation_strings': ['Assistance Publique–Hôpitaux de Paris', 'Hôpital Ambroise Paré', 'Paris, France', 'Radiology Department', 'Université Boulogne'], 'affiliations': [{'raw_affiliation_string': 'Université Boulogne', 'institution_ids': []}, {'raw_affiliation_string': 'Paris, France', 'institution_ids': []}, {'raw_affiliation_string': 'Assistance Publique–Hôpitaux de Paris', 'institution_ids': ['https://openalex.org/I4210097159']}, {'raw_affiliation_string': 'Radiology Department', 'institution_ids': ['https://openalex.org/I4210150674']}, {'raw_affiliation_string': 'Hôpital Ambroise Paré', 'institution_ids': ['https://openalex.org/I3020261445']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052351492', 'display_name': 'V. Leguy‐Seguin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210116240', 'display_name': 'Centre Hospitalier Universitaire Dijon Bourgogne', 'ror': 'https://ror.org/0377z4z10', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116240']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Vanessa Leguy-Seguin', 'raw_affiliation_strings': ['Dijon, France', 'Hôpital de Dijon', 'Internal Medicine Department'], 'affiliations': [{'raw_affiliation_string': 'Hôpital de Dijon', 'institution_ids': ['https://openalex.org/I4210116240']}, {'raw_affiliation_string': 'Internal Medicine Department', 'institution_ids': []}, {'raw_affiliation_string': 'Dijon, France', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026495111', 'display_name': 'Sophie Rivière', 'orcid': None}, 'institutions': [], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Sophie Rivière', 'raw_affiliation_strings': ['Centre Hospitalier Universitaire', 'Internal Medicine Department', 'Montpellier, France'], 'affiliations': [{'raw_affiliation_string': 'Centre Hospitalier Universitaire', 'institution_ids': []}, {'raw_affiliation_string': 'Internal Medicine Department', 'institution_ids': []}, {'raw_affiliation_string': 'Montpellier, France', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032332349', 'display_name': 'R. Corre', 'orcid': 'https://orcid.org/0000-0002-5624-4798'}, 'institutions': [{'id': 'https://openalex.org/I4210124872', 'display_name': 'Hôpital Pontchaillou', 'ror': 'https://ror.org/02r25sw81', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124872', 'https://openalex.org/I4210155724']}, {'id': 'https://openalex.org/I4210121564', 'display_name': 'Clinica de Pneumologie Iaşi', 'ror': 'https://ror.org/02m1pay40', 'country_code': 'RO', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210121564']}], 'countries': ['FR', 'RO'], 'is_corresponding': False, 'raw_author_name': 'Romain Corre', 'raw_affiliation_strings': ['Hôpital Pontchaillou', 'Pneumology Department', 'Rennes, France'], 'affiliations': [{'raw_affiliation_string': 'Rennes, France', 'institution_ids': []}, {'raw_affiliation_string': 'Hôpital Pontchaillou', 'institution_ids': ['https://openalex.org/I4210124872']}, {'raw_affiliation_string': 'Pneumology Department', 'institution_ids': ['https://openalex.org/I4210121564']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042357351', 'display_name': 'Sabine Bailly', 'orcid': 'https://orcid.org/0000-0003-1043-7030'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I285663978', 'display_name': 'Weatherford College', 'ror': 'https://ror.org/02xwsbr93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I285663978']}, {'id': 'https://openalex.org/I899635006', 'display_name': 'Université Grenoble Alpes', 'ror': 'https://ror.org/02rx3b187', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I899635006']}, {'id': 'https://openalex.org/I4210108440', 'display_name': 'Biology of Infection', 'ror': 'https://ror.org/01x3ftb23', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I157536573', 'https://openalex.org/I4210098000', 'https://openalex.org/I4210108440']}], 'countries': ['FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Sabine Bailly', 'raw_affiliation_strings': ['Biology of Cancer and Infection', 'Grenoble, France', 'INSERM', 'U1036', 'Univ. Grenoble-Alpes'], 'affiliations': [{'raw_affiliation_string': 'INSERM', 'institution_ids': ['https://openalex.org/I154526488']}, {'raw_affiliation_string': 'U1036', 'institution_ids': ['https://openalex.org/I285663978']}, {'raw_affiliation_string': 'Univ. Grenoble-Alpes', 'institution_ids': ['https://openalex.org/I899635006']}, {'raw_affiliation_string': 'Grenoble, France', 'institution_ids': []}, {'raw_affiliation_string': 'Biology of Cancer and Infection', 'institution_ids': ['https://openalex.org/I4210108440']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039278929', 'display_name': 'Gilles Paintaud', 'orcid': 'https://orcid.org/0000-0003-0158-1356'}, 'institutions': [{'id': 'https://openalex.org/I110017253', 'display_name': 'Université de Tours', 'ror': 'https://ror.org/02wwzvj46', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I110017253']}, {'id': 'https://openalex.org/I4210095477', 'display_name': 'Centre Hospitalier Universitaire de Tours', 'ror': 'https://ror.org/00jpq0w62', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210095477']}, {'id': 'https://openalex.org/I4210091644', 'display_name': 'Laboratoire de Biophotonique et Pharmacologie', 'ror': 'https://ror.org/0032sc770', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210091644', 'https://openalex.org/I4210096427', 'https://openalex.org/I68947357']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Gilles Paintaud', 'raw_affiliation_strings': ['CHRU de Tours', 'CNRS, GICC UMR 7292', 'Laboratoire de Pharmacologie-Toxicologie', 'Tours, France', 'Université François-Rabelais de Tours'], 'affiliations': [{'raw_affiliation_string': 'Tours, France', 'institution_ids': []}, {'raw_affiliation_string': 'Université François-Rabelais de Tours', 'institution_ids': ['https://openalex.org/I110017253']}, {'raw_affiliation_string': 'CHRU de Tours', 'institution_ids': ['https://openalex.org/I4210095477']}, {'raw_affiliation_string': 'Laboratoire de Pharmacologie-Toxicologie', 'institution_ids': ['https://openalex.org/I4210091644']}, {'raw_affiliation_string': 'CNRS, GICC UMR 7292', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 5, 'institutions_distinct_count': 24, 'corresponding_author_ids': ['https://openalex.org/A5039278929'], 'corresponding_institution_ids': ['https://openalex.org/I110017253', 'https://openalex.org/I4210095477', 'https://openalex.org/I4210091644'], 'apc_list': {'value': 2915, 'currency': 'GBP', 'value_usd': 3575, 'provenance': 'doaj'}, 'apc_paid': {'value': 2915, 'currency': 'GBP', 'value_usd': 3575, 'provenance': 'doaj'}, 'fwci': 3.163, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.905202, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '7', 'issue': '3', 'first_page': '630', 'last_page': '637'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12199', 'display_name': 'Vascular Anomalies and Treatments', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12199', 'display_name': 'Vascular Anomalies and Treatments', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11260', 'display_name': 'Tracheal and airway disorders', 'score': 0.9462, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/regimen', 'display_name': 'Regimen', 'score': 0.638106}, {'id': 'https://openalex.org/keywords/pharmacodynamics', 'display_name': 'Pharmacodynamics', 'score': 0.52844954}, {'id': 'https://openalex.org/keywords/loading-dose', 'display_name': 'Loading dose', 'score': 0.49045393}, {'id': 'https://openalex.org/keywords/maintenance-dose', 'display_name': 'Maintenance dose', 'score': 0.47564268}, {'id': 'https://openalex.org/keywords/cardiac-index', 'display_name': 'Cardiac index', 'score': 0.46503466}, {'id': 'https://openalex.org/keywords/therapeutic-index', 'display_name': 'Therapeutic index', 'score': 0.42179137}], 'concepts': [{'id': 'https://openalex.org/C2777802072', 'wikidata': 'https://www.wikidata.org/wiki/Q413299', 'display_name': 'Bevacizumab', 'level': 3, 'score': 0.94459957}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8831183}, {'id': 'https://openalex.org/C2777288759', 'wikidata': 'https://www.wikidata.org/wiki/Q4164182', 'display_name': 'Dosing', 'level': 2, 'score': 0.691792}, {'id': 'https://openalex.org/C2776330896', 'wikidata': 'https://www.wikidata.org/wiki/Q1634800', 'display_name': 'Telangiectasia', 'level': 2, 'score': 0.6733939}, {'id': 'https://openalex.org/C2781413609', 'wikidata': 'https://www.wikidata.org/wiki/Q7308373', 'display_name': 'Regimen', 'level': 2, 'score': 0.638106}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.59013623}, {'id': 'https://openalex.org/C111113717', 'wikidata': 'https://www.wikidata.org/wiki/Q725307', 'display_name': 'Pharmacodynamics', 'level': 3, 'score': 0.52844954}, {'id': 'https://openalex.org/C35294091', 'wikidata': 'https://www.wikidata.org/wiki/Q6663385', 'display_name': 'Loading dose', 'level': 2, 'score': 0.49045393}, {'id': 'https://openalex.org/C27924281', 'wikidata': 'https://www.wikidata.org/wiki/Q17126475', 'display_name': 'Maintenance dose', 'level': 2, 'score': 0.47564268}, {'id': 'https://openalex.org/C31861589', 'wikidata': 'https://www.wikidata.org/wiki/Q618068', 'display_name': 'Cardiac index', 'level': 4, 'score': 0.46503466}, {'id': 'https://openalex.org/C19831878', 'wikidata': 'https://www.wikidata.org/wiki/Q659446', 'display_name': 'Therapeutic index', 'level': 3, 'score': 0.42179137}, {'id': 'https://openalex.org/C2777025900', 'wikidata': 'https://www.wikidata.org/wiki/Q29725', 'display_name': 'Vascular endothelial growth factor', 'level': 3, 'score': 0.41925454}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.39996567}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.38578337}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.32049394}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.25763613}, {'id': 'https://openalex.org/C178853913', 'wikidata': 'https://www.wikidata.org/wiki/Q1642137', 'display_name': 'Hemodynamics', 'level': 2, 'score': 0.25043774}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.23228857}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.17308909}, {'id': 'https://openalex.org/C139940330', 'wikidata': 'https://www.wikidata.org/wiki/Q596579', 'display_name': 'Cardiac output', 'level': 3, 'score': 0.15447819}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.14905682}], 'mesh': [{'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000068258', 'descriptor_name': 'Bevacizumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013683', 'descriptor_name': 'Telangiectasia, Hereditary Hemorrhagic', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D013683', 'descriptor_name': 'Telangiectasia, Hereditary Hemorrhagic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D000068258', 'descriptor_name': 'Bevacizumab', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D000068258', 'descriptor_name': 'Bevacizumab', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013683', 'descriptor_name': 'Telangiectasia, Hereditary Hemorrhagic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/19420862.2015.1022693', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S169123381', 'display_name': 'mAbs', 'issn_l': '1942-0862', 'issn': ['1942-0862', '1942-0870'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315740', 'host_organization_name': 'Landes Bioscience', 'host_organization_lineage': ['https://openalex.org/P4310315740'], 'host_organization_lineage_names': ['Landes Bioscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-01769884', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-01769884', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4622710', 'pdf_url': 'https://europepmc.org/articles/pmc4622710?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622710', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25751241', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/19420862.2015.1022693', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S169123381', 'display_name': 'mAbs', 'issn_l': '1942-0862', 'issn': ['1942-0862', '1942-0870'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315740', 'host_organization_name': 'Landes Bioscience', 'host_organization_lineage': ['https://openalex.org/P4310315740'], 'host_organization_lineage_names': ['Landes Bioscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.67}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 18, 'referenced_works': ['https://openalex.org/W1496317234', 'https://openalex.org/W1970122794', 'https://openalex.org/W1971463294', 'https://openalex.org/W1996684935', 'https://openalex.org/W1999521622', 'https://openalex.org/W2008751117', 'https://openalex.org/W2019450513', 'https://openalex.org/W2040624495', 'https://openalex.org/W2041444113', 'https://openalex.org/W2058213101', 'https://openalex.org/W2062756251', 'https://openalex.org/W2080299984', 'https://openalex.org/W2082535104', 'https://openalex.org/W2087638201', 'https://openalex.org/W2092559291', 'https://openalex.org/W2135747342', 'https://openalex.org/W2160176331', 'https://openalex.org/W3094616800'], 'related_works': ['https://openalex.org/W7331692', 'https://openalex.org/W2885965830', 'https://openalex.org/W2793779452', 'https://openalex.org/W2528069950', 'https://openalex.org/W2388626260', 'https://openalex.org/W2144937882', 'https://openalex.org/W2137187002', 'https://openalex.org/W2060202662', 'https://openalex.org/W2023864318', 'https://openalex.org/W2015690038'], 'abstract_inverted_index': {'Hereditary': [0], 'hemorrhagic': [1], 'telangiectasia': [2], '(HHT),': [3], 'a': [4, 86, 94, 105], 'genetic': [5], 'vascular': [6, 26], 'disorder': [7], 'associated': [8], 'with': [9, 44, 78, 159, 171, 185], 'epistaxis': [10, 39, 60, 120, 174], 'and': [11, 38, 54, 59, 80, 116, 119, 127, 146, 155, 183, 219], 'hepatic': [12], 'shunts,': [13], 'is': [14], 'responsible': [15], 'for': [16, 104], 'high-output': [17], 'cardiac': [18, 35, 217], 'failure': [19], 'in': [20, 41, 56, 85], 'rare': [21], 'cases.': [22], 'Bevacizumab,': [23], 'which': [24], 'targets': [25], 'endothelial': [27], 'growth': [28], 'factor,': [29], 'was': [30, 62, 177], 'shown': [31], 'to': [32, 64, 151, 179], 'decrease': [33], 'both': [34, 57, 117, 216], 'index': [36, 218], '(CI)': [37], 'duration': [40, 61, 121], 'HHT': [42, 76], 'patients': [43, 77, 158, 170], 'severe': [45], 'liver': [46], 'involvement.': [47], 'The': [48, 110, 132, 167], 'relationship': [49], 'between': [50, 112], 'its': [51], 'serum': [52, 114], 'concentration': [53, 115], 'change': [55], 'CI': [58, 82, 118, 160], 'investigated': [63], 'design': [65], 'the': [66, 196], 'bevacizumab': [67, 92, 113, 210], 'maintenance': [68, 136, 200], 'dosing': [69, 201], 'regimen': [70], 'of': [71, 96, 107, 134, 157, 169, 195, 198, 209, 215], 'future': [72], 'therapeutic': [73], 'studies.': [74], 'Twenty-five': [75], 'dyspnea': [79], 'high': [81], 'were': [83, 122, 138, 149], 'included': [84], 'prospective': [87], 'non-comparative': [88], 'study.': [89], 'They': [90], 'received': [91], 'at': [93, 163], 'dose': [95], '5': [97, 206], 'mg/kg': [98, 207], 'per': [99, 175], 'infusion': [100, 186], 'every': [101, 143, 187], '14': [102], 'days': [103], 'total': [106], '6': [108], 'injections.': [109], 'relationships': [111], 'described': [123], 'using': [124, 140], 'transit': [125], 'compartments': [126], 'direct': [128], 'inhibition': [129], 'pharmacokinetic-pharmacodynamic': [130], 'models.': [131], 'performances': [133], 'different': [135, 199], 'regimens': [137, 202], 'evaluated': [139], 'simulation.': [141], 'Infusions': [142], '3,': [144, 188], '2': [145, 189], 'one': [147, 191], 'months': [148], 'predicted': [150, 178], 'maintain': [152], '41%,': [153], '45%': [154], '50%': [156], '<4': [161], 'L/min/m2': [162], '24': [164], 'months,': [165, 192], 'respectively.': [166, 193], 'fraction': [168], '<20': [172], 'min': [173], 'month': [176], 'be': [180], '34%,': [181], '43%': [182], '60%,': [184], 'or': [190], 'Simulations': [194], 'effects': [197], 'predict': [203], 'that': [204], 'monthly': [205], 'infusions': [208], 'should': [211], 'allow': [212], 'sustained': [213], 'control': [214], 'epistaxis.': [220]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1512570069', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}], 'updated_date': '2024-12-17T12:51:54.768993', 'created_date': '2016-06-24'}