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'specimens.': [66], 'TruSeq': [67], 'panel': [70], 'used': [72], 'detection': [75], 'somatic': [77], 'mutations': [78, 209, 236, 305, 346, 351], '48': [80], 'related': [82], 'genes': [83, 186, 211], 'followed': [84], '(Illumina)': [88], 'at': [89, 135], 'an': [90], 'average': [91], 'coverage': [92], 'approximately': [94], '3,400x.': [95], 'ALK,': [96], 'ROS1': [97], 'RET': [99], 'translocations': [100], 'EGFR,': [102], 'MET,': [103], 'PIK3CA,': [104], 'FGFR1': [105], 'FGFR2': [107, 229], 'amplifications': [108], 'were': [109, 129, 202, 237, 275, 316], 'also': [110, 203], 'detected': [111, 175, 204, 292, 319], 'multiplex': [113], 'RT-PCR': [114], 'quantitative': [116], 'PCR,': [117], 'respectively.': [118], 'Results:': [119], 'Between': [120], 'July': [121], '2011': [122], 'March': [124], '2013,': [125], '279': [126], 'consecutive': [127], 'enrolled': [130], 'this': [132, 256], 'prospective': [133], 'study': [134], 'Shizuoka': [136], 'Cancer': [137, 425, 436], 'Center:': [138], 'median': [139], 'age': [140], '69': [141], 'years': [142], '(range:': [143], '38-92);': [144], 'male': [145], '66%;': [146], 'never': [147], 'smoker': [148], '25.8%;': [149], 'histology:': [150], 'adenocarcinoma': [151, 326], '70.6%,': [152], 'squamous': [153], 'carcinoma': [155], '(SQ)': [156], '25.1%,': [157], 'others': [158], '4.3%;': [159], 'pathological': [160], 'stage:': [161], 'I': [162], '58.1%,': [163], 'II': [164], '22.6%,': [165], 'III': [166], '15.4%,': [167], 'IV': [168], '3.9%.': [169], 'TP53': [170], 'mutation': [171, 270], 'most': [173], 'frequently': [174, 276, 318], '(35.9%)': [176], 'all': [178, 286, 323], 'patients,': [179], 'particularly': [180], 'SQ': [182, 240, 245, 289, 301], '(59.2%).': [183], 'Mutations': [184], 'such': [187, 212], 'CTNNB1': [189], '(4.0%),': [190], 'SMAD4': [191, 234], '(1.5%),': [192], 'GNAS': [193], '(1.0%),': [194, 196], 'STK11': [195], 'HRAS': [197, 225], '(0.5%)': [198, 201], 'PTPN11': [200], 'addition': [206], 'to': [207, 333, 342, 367], 'major': [208], 'EGFR': [214, 260], '(44.8%),': [215], 'KRAS': [216], '(18.4%)': [217], 'PIK3CA': [219, 223, 280, 287, 324], '(4.5%)': [220], 'adenocarcinoma.': [222, 329], '(19.7%),': [224], '(2.8%),': [226], 'APC': [227], '(1.4%),': [228, 230], 'FGFR3': [231], '(1.4%)': [232, 235], 'notably,': [242], '40.9%': [243], 'harbored': [247], 'concurrent': [248], 'gene': [249], 'mutations,': [250], 'suggesting': [251], 'complexity': [254], 'histological': [257], 'subset.': [258], 'In': [259], 'mutation,': [261, 281], 'deletion': [262], 'exon': [264, 272, 294, 307], '19': [265], '(42.6%)': [266], 'L858R': [268], 'point': [269], '21': [273], '(41.5%)': [274], 'observed.': [277], 'As': [278], 'majority': [283], '(92.8%': [284], 'mutant': [288, 325], 'cases)': [290, 327], '9': [295], '(residues': [296, 311], 'E542': [297], 'E545)': [299], 'but': [302], 'contrast,': [304], '1': [308], '20': [310], 'G106': [312], 'H1047,': [314], 'respectively)': [315], 'more': [317], '(33.3%': [320], 'combined': [321], 'Conclusions:': [330], 'We': [331], 'managed': [332], 'detect': [334], 'wide': [336], 'range': [337], 'identify': [343], 'additional': [344], 'actionable': [345], 'along': [347], 'popular': [349], 'driver': [350], 'NSCLC': [353], 'next-generation': [355, 410], 'technology.': [357], 'These': [358], 'data': [359], 'should': [360], 'be': [361], 'incorporated': [362], 'into': [363], 'implement': [368], 'personalized': [369], 'medicine.': [371], 'Citation': [372], 'Format:': [373], 'Hirotsugu': [374], 'Kenmotsu,': [375], 'Yasuhiro': [376], 'Koh,': [377], 'Masakuni': [378], 'Serizawa,': [379], 'Mitsuhiro': [380], 'Isaka,': [381], 'Tomohiro': [382], 'Maniwa,': [383], 'Haruyasu': [384], 'Murakami,': [385], 'Keita': [386], 'Mori,': [387], 'Masahiro': [388], 'Endo,': [389], 'Takashi': [390], 'Nakajima,': [391], 'Yasuhisa': [392], 'Ohde,': [393], 'Toshiaki': [394], 'Takahashi,': [395], 'Nobuyuki': [396], 'Yamamoto.': [397], 'Prospective': [398], 'mutational': [399], 'characterization': [400], '[abstract].': [412], 'In:': [413], 'Proceedings': [414], '105th': [417], 'Annual': [418], 'Meeting': [419], 'American': [422], 'Association': [423], 'Research;': [426], '2014': [427], 'Apr': [428], '5-9;': [429], 'San': [430], 'Diego,': [431], 'CA.': [432], 'Philadelphia': [433], '(PA):': [434], 'AACR;': [435], 'Res': [437], '2014;74(19': [438], 'Suppl):Abstract': [439], 'nr': [440], '1537.': [441], 'doi:10.1158/1538-7445.AM2014-1537': [442]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1510350892', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}], 'updated_date': '2025-01-15T20:00:46.624729', 'created_date': '2016-06-24'}