Publication Information

{'id': 'https://openalex.org/W1509881064', 'doi': 'https://doi.org/10.18632/oncotarget.3253', 'title': 'Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers', 'display_name': 'Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers', 'publication_year': 2015, 'publication_date': '2015-02-17', 'ids': {'openalex': 'https://openalex.org/W1509881064', 'doi': 'https://doi.org/10.18632/oncotarget.3253', 'mag': '1509881064', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34381570', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8351607'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3253', 'pdf_url': 'https://www.oncotarget.com/article/3253/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/3253/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100449361', 'display_name': 'Ye Zhang', 'orcid': 'https://orcid.org/0000-0003-4157-8696'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ye Zhang', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006455181', 'display_name': 'Xiujuan Qu', 'orcid': 'https://orcid.org/0009-0005-9366-2314'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiujuan Qu', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078066178', 'display_name': 'Yuee Teng', 'orcid': 'https://orcid.org/0000-0002-9198-9795'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuee Teng', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100382293', 'display_name': 'Zhi Li', 'orcid': 'https://orcid.org/0000-0002-6437-0348'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhi Li', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064398090', 'display_name': 'Ling Xu', 'orcid': 'https://orcid.org/0000-0001-9355-6136'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ling Xu', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082687712', 'display_name': 'Jing Liu', 'orcid': 'https://orcid.org/0000-0002-0493-296X'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Liu', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040310365', 'display_name': 'Yanju Ma', 'orcid': 'https://orcid.org/0000-0001-6462-7994'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanju Ma', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027439235', 'display_name': 'Yibo Fan', 'orcid': 'https://orcid.org/0000-0001-7589-4158'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yibo Fan', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101599428', 'display_name': 'Ce Li', 'orcid': 'https://orcid.org/0000-0003-1465-4905'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ce Li', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008140692', 'display_name': 'Shizhou Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shizhou Liu', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034711230', 'display_name': 'Zhenning Wang', 'orcid': 'https://orcid.org/0000-0003-0557-3097'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhenning Wang', 'raw_affiliation_strings': ['Department of Surgical Oncology and General Surgery, the First Hospital of China Medical University, Shenyang 110001, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgical Oncology and General Surgery, the First Hospital of China Medical University, Shenyang 110001, China', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091458494', 'display_name': 'Xuejun Hu', 'orcid': 'https://orcid.org/0000-0001-5141-7437'}, 'institutions': [{'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xuejun Hu', 'raw_affiliation_strings': ['Department of Medical Respiratory, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Respiratory, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I91656880']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100769089', 'display_name': 'Jingdong Zhang', 'orcid': 'https://orcid.org/0000-0002-0711-2764'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jingdong Zhang', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081310064', 'display_name': 'Yunpeng Liu', 'orcid': 'https://orcid.org/0000-0001-9800-4373'}, 'institutions': [{'id': 'https://openalex.org/I4210140515', 'display_name': 'First Hospital of China Medical University', 'ror': 'https://ror.org/04wjghj95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140515']}, {'id': 'https://openalex.org/I91656880', 'display_name': 'China Medical University', 'ror': 'https://ror.org/032d4f246', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91656880']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yunpeng Liu', 'raw_affiliation_strings': ['Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.', 'institution_ids': ['https://openalex.org/I4210140515', 'https://openalex.org/I91656880']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.379, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.775763, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '6', 'issue': '9', 'first_page': '6737', 'last_page': '6748'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12793', 'display_name': 'Caveolin-1 and cellular processes', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12793', 'display_name': 'Caveolin-1 and cellular processes', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9838, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/p-glycoprotein', 'display_name': 'P-glycoprotein', 'score': 0.5551213}, {'id': 'https://openalex.org/keywords/lipid-raft', 'display_name': 'Lipid raft', 'score': 0.52941734}, {'id': 'https://openalex.org/keywords/caveolin-1', 'display_name': 'Caveolin 1', 'score': 0.42992973}], 'concepts': [{'id': 'https://openalex.org/C49866891', 'wikidata': 'https://www.wikidata.org/wiki/Q1051872', 'display_name': 'Caveolae', 'level': 3, 'score': 0.8665366}, {'id': 'https://openalex.org/C138626823', 'wikidata': 'https://www.wikidata.org/wiki/Q916504', 'display_name': 'Chromosomal translocation', 'level': 3, 'score': 0.5577519}, {'id': 'https://openalex.org/C2778707650', 'wikidata': 'https://www.wikidata.org/wiki/Q412902', 'display_name': 'P-glycoprotein', 'level': 4, 'score': 0.5551213}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.53726023}, {'id': 'https://openalex.org/C79266657', 'wikidata': 'https://www.wikidata.org/wiki/Q424178', 'display_name': 'Lipid raft', 'level': 3, 'score': 0.52941734}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.49636012}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.48738772}, {'id': 'https://openalex.org/C133936738', 'wikidata': 'https://www.wikidata.org/wiki/Q643839', 'display_name': 'Multiple drug resistance', 'level': 3, 'score': 0.45073476}, {'id': 'https://openalex.org/C2780870201', 'wikidata': 'https://www.wikidata.org/wiki/Q17855958', 'display_name': 'Caveolin 1', 'level': 2, 'score': 0.42992973}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39540547}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.36609164}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35406417}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.33768755}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.31342268}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.23841718}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1440222}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07183269}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D021941', 'descriptor_name': 'Caveolae', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018432', 'descriptor_name': 'Drug Resistance, Multiple', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D050721', 'descriptor_name': 'Proto-Oncogene Proteins c-cbl', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018435', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018435', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D021941', 'descriptor_name': 'Caveolae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021941', 'descriptor_name': 'Caveolae', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051242', 'descriptor_name': 'Caveolin 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051242', 'descriptor_name': 'Caveolin 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051242', 'descriptor_name': 'Caveolin 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017024', 'descriptor_name': 'Chemotherapy, Adjuvant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059748', 'descriptor_name': 'Proteolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050721', 'descriptor_name': 'Proto-Oncogene Proteins c-cbl', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050721', 'descriptor_name': 'Proto-Oncogene Proteins c-cbl', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016392', 'descriptor_name': 'Proto-Oncogene Proteins pp60(c-src)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016392', 'descriptor_name': 'Proto-Oncogene Proteins pp60(c-src)', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3253', 'pdf_url': 'https://www.oncotarget.com/article/3253/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4466646', 'pdf_url': 'https://europepmc.org/articles/pmc4466646?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466646', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25788263', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3253', 'pdf_url': 'https://www.oncotarget.com/article/3253/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1605218758', 'https://openalex.org/W1981273409', 'https://openalex.org/W1983920125', 'https://openalex.org/W1992496728', 'https://openalex.org/W1999849371', 'https://openalex.org/W2006957534', 'https://openalex.org/W2008351137', 'https://openalex.org/W2010633862', 'https://openalex.org/W2018168242', 'https://openalex.org/W2020388614', 'https://openalex.org/W2021555444', 'https://openalex.org/W2029191620', 'https://openalex.org/W2030372924', 'https://openalex.org/W2034459992', 'https://openalex.org/W2044167052', 'https://openalex.org/W2045005486', 'https://openalex.org/W2048003573', 'https://openalex.org/W2060326410', 'https://openalex.org/W2063551504', 'https://openalex.org/W2079188678', 'https://openalex.org/W2079276761', 'https://openalex.org/W2090453777', 'https://openalex.org/W2118856012', 'https://openalex.org/W2122758063', 'https://openalex.org/W2126061580', 'https://openalex.org/W2131196310', 'https://openalex.org/W2133408654', 'https://openalex.org/W2140667096', 'https://openalex.org/W2146331622', 'https://openalex.org/W2147226780', 'https://openalex.org/W2316842100', 'https://openalex.org/W3146134512', 'https://openalex.org/W42971214'], 'related_works': ['https://openalex.org/W37336485', 'https://openalex.org/W2395604880', 'https://openalex.org/W2165467938', 'https://openalex.org/W2114481572', 'https://openalex.org/W2076606695', 'https://openalex.org/W2062372028', 'https://openalex.org/W2055781207', 'https://openalex.org/W2022368219', 'https://openalex.org/W1989210142', 'https://openalex.org/W1976350481'], 'abstract_inverted_index': {'//': [0], 'Ye': [1], 'Zhang': [2, 50], '1': [3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 51, 55, 56], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, 52], 'Xiujuan': [5, 110], 'Qu': [6], 'Yuee': [9], 'Teng': [10], 'Zhi': [13], 'Li': [14, 34], 'Ling': [17], 'Xu': [18], 'Jing': [21], 'Liu': [22, 38, 54], 'Yanju': [25], 'Ma': [26], 'Yibo': [29], 'Fan': [30], 'Ce': [33], 'Shizhou': [37], 'Zhenning': [41], 'Wang': [42], '2': [43, 71], 'Xuejun': [45], 'Hu': [46], '3': [47, 89], 'Jingdong': [49], 'Yunpeng': [53, 106], 'Department': [57, 72, 90], 'of': [58, 64, 73, 82, 91, 97, 136, 147, 152, 166, 186, 212, 223, 231, 238, 269], 'Medical': [59, 66, 84, 92, 99], 'Oncology,': [60], 'the': [61, 79, 94, 159, 164, 173, 184, 210, 215, 218, 221, 229, 234], 'First': [62, 80, 95], 'Hospital': [63, 81, 96], 'China': [65, 70, 83, 88, 98, 103], 'University,': [67, 85, 100], 'Shenyang': [68, 86, 101], '110001,': [69, 87, 102], 'Surgical': [74], 'Oncology': [75], 'and': [76, 150, 200, 236, 250, 277], 'General': [77], 'Surgery,': [78], 'Respiratory,': [93], 'Correspondence': [104], 'to:': [105], 'Liu,': [107], 'e-mail:': [108, 112], '[email protected]': [109], 'Qu,': [111], '[email protected]': [113], 'Keywords:': [114], 'Cbl-b,': [115], 'P-gp,': [116], 'Caveolae,': [117], 'Multiple': [118], 'Drug-resistant': [119], 'Received:': [120], 'November': [121], '30,': [122], '2014': [123], 'Accepted:': [124], 'January': [125], '29,': [126], '2015': [127, 131], 'Published:': [128], 'February': [129], '17,': [130], 'ABSTRACT': [132], 'The': [133], 'transport': [134, 156, 271], 'function': [135, 272], 'P-glycoprotein': [137], '(P-gp)': [138], 'requires': [139], 'its': [140], 'efficient': [141], 'localization': [142, 222], 'to': [143, 217, 225], 'caveolae,': [144, 189], 'a': [145, 206, 243, 265], 'subset': [146], 'lipid': [148], 'rafts,': [149], 'disruption': [151], 'caveolae': [153, 169, 226], 'suppresses': [154], 'P-gp': [155, 167, 187, 224, 253, 270], 'function.': [157], 'However,': [158], 'regulatory': [160, 267], 'molecules': [161], 'involved': [162], 'in': [163, 191, 194, 228, 252, 273], 'translocation': [165, 185, 211], 'into': [168, 188], 'remain': [170], 'unknown.': [171], 'In': [172, 205], 'present': [174], 'study,': [175], 'we': [176], 'showed': [177, 242], 'that': [178], 'c-Src': [179], 'dependent': [180], 'Caveolin-1': [181], 'phosphorylation': [182], 'promoted': [183], 'resulting': [190, 227], 'multidrug': [192], 'resistance': [193], 'adriamycin': [195], 'resistant': [196], 'gastric': [197, 276], 'cancer': [198, 202, 256], 'SGC7901/Adr': [199], 'breast': [201, 255, 278], 'MCF-7/Adr': [203], 'cells.': [204], 'negative': [207], 'feedback': [208], 'loop,': [209], 'Cbl-b': [213, 248], 'from': [214], 'nucleus': [216], 'cytoplasm': [219], 'prevented': [220], 'reversal': [230], 'MDR': [232], 'through': [233], 'ubiquitination': [235], 'degradation': [237], 'c-Src.': [239], 'Clinical': [240], 'data': [241], 'significant': [244], 'positive': [245, 254], 'relationship': [246], 'between': [247], 'expression': [249], 'survival': [251], 'patients': [257], 'who': [258], 'received': [259], 'anthracycline-based': [260], 'chemotherapy.': [261], 'Our': [262], 'findings': [263], 'identified': [264], 'new': [266], 'mechanism': [268], 'multiple': [274], 'drug-resistant': [275], 'cancers.': [279]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1509881064', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2024-12-15T15:30:06.344950', 'created_date': '2016-06-24'}