Mucin1 promotes the migration and invasion of hepatocellular carcinoma cells via JNK-mediated phosphorylation of Smad2 at the C-terminal and linker regions

Name: Work Video:
Duration: 3 min 30 s
Juan Wang; Guomu Liu; Qiongshu Li; Fang Wang; Fei Xie; Ruiping Zhai; Yingying Guo; Tanxiu Chen; Nannan Zhang; Weihua Ni; Hongyan Yuan; Guixiang Tai
{'id': 'https://openalex.org/W1507965558', 'doi': 'https://doi.org/10.18632/oncotarget.4267', 'title': 'Mucin1 promotes the migration and invasion of hepatocellular carcinoma cells via JNK-mediated phosphorylation of Smad2 at the C-terminal and linker regions', 'display_name': 'Mucin1 promotes the migration and invasion of hepatocellular carcinoma cells via JNK-mediated phosphorylation of Smad2 at the C-terminal and linker regions', 'publication_year': 2015, 'publication_date': '2015-05-25', 'ids': {'openalex': 'https://openalex.org/W1507965558', 'doi': 'https://doi.org/10.18632/oncotarget.4267', 'mag': '1507965558', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26057631', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4662489'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4267', 'pdf_url': 'https://www.oncotarget.com/article/4267/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/4267/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100347447', 'display_name': 'Juan Wang', 'orcid': 'https://orcid.org/0000-0002-5066-0926'}, 'institutions': [{'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}, {'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Juan Wang', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I194450716', 'https://openalex.org/I4210136497']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048507715', 'display_name': 'Guomu Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}, {'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Guomu Liu', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I4210136497', 'https://openalex.org/I194450716']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041356326', 'display_name': 'Qiongshu Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}, {'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiongshu Li', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I4210136497', 'https://openalex.org/I194450716']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100321458', 'display_name': 'Fang Wang', 'orcid': 'https://orcid.org/0000-0003-0871-3454'}, 'institutions': [{'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}, {'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fang Wang', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I4210136497', 'https://openalex.org/I194450716']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100785688', 'display_name': 'Fei Xie', 'orcid': 'https://orcid.org/0000-0003-3674-8216'}, 'institutions': [{'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}, {'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fei Xie', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I4210136497', 'https://openalex.org/I194450716']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108655018', 'display_name': 'Ruiping Zhai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}, {'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ruiping Zhai', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I4210136497', 'https://openalex.org/I194450716']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073538262', 'display_name': 'Yingying Guo', 'orcid': 'https://orcid.org/0000-0002-7829-6935'}, 'institutions': [{'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}, {'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yingying Guo', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I4210136497', 'https://openalex.org/I194450716']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049655184', 'display_name': 'Tanxiu Chen', 'orcid': 'https://orcid.org/0000-0003-4877-9423'}, 'institutions': [{'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}, {'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tanxiu Chen', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I194450716', 'https://openalex.org/I4210136497']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100693208', 'display_name': 'Nannan Zhang', 'orcid': 'https://orcid.org/0000-0003-0571-4099'}, 'institutions': [{'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}, {'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Nannan Zhang', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I194450716', 'https://openalex.org/I4210136497']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003472939', 'display_name': 'Weihua Ni', 'orcid': 'https://orcid.org/0000-0001-5511-1531'}, 'institutions': [{'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}, {'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weihua Ni', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I4210136497', 'https://openalex.org/I194450716']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100650337', 'display_name': 'Hongyan Yuan', 'orcid': 'https://orcid.org/0000-0001-8225-0211'}, 'institutions': [{'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}, {'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hongyan Yuan', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I4210136497', 'https://openalex.org/I194450716']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080135772', 'display_name': 'Guixiang Tai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136497', 'display_name': 'Jilin Medical University', 'ror': 'https://ror.org/03mzw7781', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210136497']}, {'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Guixiang Tai', 'raw_affiliation_strings': ['Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, College of Basic Medical Science, Jilin University, Changchun, China.', 'institution_ids': ['https://openalex.org/I4210136497', 'https://openalex.org/I194450716']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.897, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 42, 'citation_normalized_percentile': {'value': 0.887653, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '6', 'issue': '22', 'first_page': '19264', 'last_page': '19278'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation and Glycoproteins Research', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/matrigel', 'display_name': 'Matrigel', 'score': 0.4276621}], 'concepts': [{'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.7220467}, {'id': 'https://openalex.org/C22615655', 'wikidata': 'https://www.wikidata.org/wiki/Q203221', 'display_name': 'Small interfering RNA', 'level': 4, 'score': 0.6770663}, {'id': 'https://openalex.org/C137738243', 'wikidata': 'https://www.wikidata.org/wiki/Q189092', 'display_name': 'Cell migration', 'level': 3, 'score': 0.6533507}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.5505984}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.4600328}, {'id': 'https://openalex.org/C128240485', 'wikidata': 'https://www.wikidata.org/wiki/Q786998', 'display_name': 'Autocrine signalling', 'level': 3, 'score': 0.45664972}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.44166994}, {'id': 'https://openalex.org/C2778608917', 'wikidata': 'https://www.wikidata.org/wiki/Q6787805', 'display_name': 'Matrigel', 'level': 3, 'score': 0.4276621}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38155144}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3796899}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.36086002}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.29900765}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.28245863}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.2637827}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.060341895}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056945', 'descriptor_name': 'Hep G2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018396', 'descriptor_name': 'Mucin-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051899', 'descriptor_name': 'Smad2 Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4267', 'pdf_url': 'https://www.oncotarget.com/article/4267/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4662489', 'pdf_url': 'https://europepmc.org/articles/pmc4662489?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662489', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26057631', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4267', 'pdf_url': 'https://www.oncotarget.com/article/4267/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1517506484', 'https://openalex.org/W1524760790', 'https://openalex.org/W1526736180', 'https://openalex.org/W1538896828', 'https://openalex.org/W1581102649', 'https://openalex.org/W1598771153', 'https://openalex.org/W1928679079', 'https://openalex.org/W1954506475', 'https://openalex.org/W1963896652', 'https://openalex.org/W1972128179', 'https://openalex.org/W1974203539', 'https://openalex.org/W1977760450', 'https://openalex.org/W1978739865', 'https://openalex.org/W1982945640', 'https://openalex.org/W1983487545', 'https://openalex.org/W1984162437', 'https://openalex.org/W1986907203', 'https://openalex.org/W1996344455', 'https://openalex.org/W1999124213', 'https://openalex.org/W2004099033', 'https://openalex.org/W2007121859', 'https://openalex.org/W2016956014', 'https://openalex.org/W2020228459', 'https://openalex.org/W2022130522', 'https://openalex.org/W2034102636', 'https://openalex.org/W2034451570', 'https://openalex.org/W2052394132', 'https://openalex.org/W2063322294', 'https://openalex.org/W2066172269', 'https://openalex.org/W2067954451', 'https://openalex.org/W2072440487', 'https://openalex.org/W2075060074', 'https://openalex.org/W2076370383', 'https://openalex.org/W2087422732', 'https://openalex.org/W2091400173', 'https://openalex.org/W2094772268', 'https://openalex.org/W2100877370', 'https://openalex.org/W2114003084', 'https://openalex.org/W2136280424', 'https://openalex.org/W2149016816', 'https://openalex.org/W2149136061', 'https://openalex.org/W2150548551', 'https://openalex.org/W2161098075', 'https://openalex.org/W2162297313', 'https://openalex.org/W2164858199', 'https://openalex.org/W2166064381', 'https://openalex.org/W3141873631', 'https://openalex.org/W4239776133'], 'related_works': ['https://openalex.org/W4361264821', 'https://openalex.org/W3104612526', 'https://openalex.org/W2969534121', 'https://openalex.org/W2742636697', 'https://openalex.org/W2394061064', 'https://openalex.org/W2060407805', 'https://openalex.org/W2026866823', 'https://openalex.org/W1975676036', 'https://openalex.org/W1973423407', 'https://openalex.org/W1507965558'], 'abstract_inverted_index': {'//': [0, 66], 'Juan': [1], 'Wang': [2, 14], '1': [3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 48, 155], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36, 40], 'Guomu': [5], 'Liu': [6], 'Qiongshu': [9], 'Li': [10], 'Fang': [13], 'Fei': [17], 'Xie': [18], 'Ruiping': [21], 'Zhai': [22], 'Yingying': [25], 'Guo': [26], 'Tanxiu': [29], 'Chen': [30], 'Nannan': [33], 'Zhang': [34], 'Weihua': [37], 'Ni': [38], 'Hongyan': [41], 'Yuan': [42], 'and': [44, 102, 114, 128, 134, 174, 180, 236, 249], 'Guixiang': [45, 63], 'Tai': [46], 'Department': [49], 'of': [50, 53, 104, 182, 213, 228, 239, 251], 'Immunology,': [51], 'College': [52], 'Basic': [54], 'Medical': [55], 'Science,': [56], 'Jilin': [57], 'University,': [58], 'Changchun,': [59], 'China': [60], 'Correspondence': [61], 'to:': [62], 'Tai,': [64], 'email:': [65], 'Keywords': [67], ':': [68, 75, 80, 85], 'Mucin1,': [69], 'HCC,': [70], 'JNK,': [71], 'TGF-β,': [72], 'Smad2L/C': [73], 'Received': [74], 'March': [76], '20,': [77], '2015': [78, 83, 88], 'Accepted': [79], 'May': [81, 86], '13,': [82], 'Published': [84], '25,': [87], 'Abstract': [89], 'Mucin1': [90], '(MUC1),': [91], 'as': [92], 'an': [93, 259], 'oncogene,': [94], 'plays': [95], 'a': [96], 'key': [97], 'role': [98], 'in': [99, 262], 'the': [100, 171, 178, 211, 226], 'progression': [101], 'tumorigenesis': [103], 'many': [105], 'human': [106, 122], 'adenocarcinomas.': [107], 'In': [108, 176], 'this': [109], 'study,': [110], 'wound-healing,': [111], 'transwell': [112], 'migration': [113, 127, 173, 179, 248], 'matrigel': [115], 'invasion': [116, 129, 181, 250], 'assays': [117], 'showed': [118], 'that': [119, 163, 194, 204, 256], 'MUC1': [120, 131, 257], 'promotes': [121, 170], 'hepatocellular': [123], 'carcinoma': [124], '(HCC)': [125], 'cell': [126, 172, 247], 'by': [130, 189, 195], 'gene': [132], 'silencing': [133], 'overexpressing.': [135], 'Treatment': [136], 'with': [137, 193], 'exogenous': [138], 'transforming': [139], 'growth': [140], 'factor': [141], 'beta': [142], '(TGF-β)1,': [143], 'TGF-β': [144, 166], 'type': [145], 'I': [146], 'receptor': [147], '(TβRI)': [148], 'inhibitor,': [149], 'TGF-β1': [150, 199], 'siRNAs,': [151], 'or': [152, 198], 'activator': [153], 'protein': [154], '(AP-1)': [156], 'inhibitor': [157, 191, 197], 'to': [158, 242], 'MUC1-overexpressing': [159], 'HCC': [160, 183], 'cells': [161, 184], 'revealed': [162], 'MUC1-induced': [164], 'autocrine': [165], 'via': [167], 'JNK/AP-1': [168], 'pathway': [169], 'invasion.': [175], 'addition,': [177], 'were': [185], 'more': [186], 'significantly': [187], 'inhibited': [188], 'JNK': [190, 206], 'compared': [192], 'TβRI': [196], 'siRNAs.': [200], 'Further': [201], 'studies': [202], 'demonstrated': [203], 'MUC1-mediated': [205], 'activation': [207], 'not': [208], 'only': [209], 'enhances': [210, 225], 'phosphorylation': [212, 227], 'Smad2': [214, 229], 'C-terminal': [215], 'at': [216, 232], 'Ser-465/467': [217], 'site': [218, 234], '(Smad2C)': [219], 'through': [220], 'TGF-β/TβRI,': [221], 'but': [222], 'also': [223], 'directly': [224], 'linker': [230], 'region': [231], 'Ser-245/250/255': [233], '(Smad2L),': [235], 'then': [237], 'both': [238], 'them': [240], 'collaborate': [241], 'upregulate': [243], 'matrix': [244], 'metalloproteinase': [245], '(MMP)-9-mediated': [246], 'HCC.': [252], 'These': [253], 'results': [254], 'indicate': [255], 'is': [258], 'attractive': [260], 'target': [261], 'liver': [263], 'cancer': [264], 'therapy.': [265]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1507965558', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2025-01-20T19:46:43.915041', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
