Title: [27] Glutathione reductase from bovine brain
Abstract: Glutathione reductase (GR, NADPH:oxidized-glutathione oxidoreductase, EC1.6.4.2) catalyzes the reduction of glutathione disulfide (GSSG) during the glutathione redox cycling. GSSG is generated by the nonenzymatic reaction of radicals with reduced glutathione (GSH) and is product of the reactions catalyzed by glutathione peroxidases, which use GSH as an electron donor for the reduction of peroxides. Glutathione-dependent disposal of peroxides and radicals appears to be especially important for the brain, as this organ has an intense oxidative metabolism but is disadvantaged regarding the detoxification of reactive oxygen species. Enzymes such as glutathione peroxidases, superoxide dismutases, and catalase are present in brain in lower activities than in other tissues. This is also the case for GR.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 54
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