Epithelial phenotype as a predictive marker for response to EGFR-TKIs in non-small cell lung cancer patients with wild-type EGFR

Name: Work Video:
Duration: 3 min 30 s
Shengxiang Ren; Chunxia Su; Zhaoye Wang; Jiayu Li; Lihong Fan; Bing Li; Xuefei Li; Cao Zhao; Chunyan Wu; Likun Hou; Yayi He; Guanghui Gao; Xiaoxia Chen; Jiawei Ren; Aiwu Li; Guo‐Tong Xu; Xiao Zhou; Caicun Zhou; Gerald Schmid‐Bindert
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1324, 1362, 1368, 1390, 1396, 1427], 'Medicine,': [46, 87, 162, 194, 226, 319, 344, 370, 402, 434, 458, 488, 512, 517, 545, 567, 604, 642, 670, 707, 768, 809, 884, 916, 948, 1041, 1066, 1092, 1124, 1156, 1180, 1210, 1234, 1239, 1267, 1289, 1326, 1364, 1392, 1429], 'Institute,': [52, 93, 168, 200, 232, 263, 294, 376, 408, 440, 494, 573, 648, 676, 774, 815, 890, 922, 954, 985, 1016, 1098, 1130, 1162, 1216, 1295, 1370, 1398], 'Shanghai,': [53, 94, 169, 201, 233, 264, 295, 320, 345, 377, 409, 441, 463, 495, 518, 546, 649, 775, 816, 891, 923, 955, 986, 1017, 1042, 1067, 1099, 1131, 1163, 1185, 1217, 1240, 1268, 1371], "People's": [54, 95, 129, 170, 202, 234, 265, 296, 321, 346, 378, 410, 442, 464, 496, 519, 547, 581, 612, 650, 684, 715, 776, 817, 851, 892, 924, 956, 987, 1018, 1043, 1068, 1100, 1132, 1164, 1186, 1218, 1241, 1269, 1303, 1334, 1372, 1406, 1437], 'Republic': [55, 96, 130, 171, 203, 235, 266, 297, 322, 347, 379, 411, 443, 465, 497, 520, 548, 582, 613, 651, 685, 716, 777, 818, 852, 893, 925, 957, 988, 1019, 1044, 1069, 1101, 1133, 1165, 1187, 1219, 1242, 1270, 1304, 1335, 1373, 1407, 1438], 'China': [57, 98, 132, 779, 820, 854], 'S.R.,': [58, 99, 133, 780, 821, 855], 'C.S.': [59, 100, 134, 781, 822, 856], 'and': [60, 101, 135, 251, 282, 782, 823, 857, 973, 1004, 1506, 1510, 1522, 1529, 1548, 1568, 1647, 1674, 1727, 1749, 1785, 1971, 2059, 2068, 2178, 2218, 2253, 2265, 2295, 2351, 2354, 2429, 2479, 2524, 2539, 2549, 2553, 2562, 2581, 2614, 2626, 2673, 2682, 2733, 2735, 2752, 2770, 2789, 2841, 2849, 2917, 2938, 2951, 2966, 2986, 3026, 3064, 3069, 3233, 3254, 3284, 3287, 3317, 3336, 3380, 3386, 3434, 3451, 3547, 3717, 3769, 3841, 3851, 3875, 3892, 3903, 3960, 4008, 4086, 4104, 4120, 4140], 'Z.W.': [61, 102, 136, 783, 824, 858], 'contributed': [62, 103, 137, 784, 825, 859], 'equally': [63, 104, 138, 785, 826, 860], 'this': [65, 71, 106, 112, 140, 146, 178, 210, 242, 273, 304, 329, 354, 386, 418, 450, 472, 504, 527, 624, 727, 751, 787, 793, 828, 834, 862, 868, 900, 932, 964, 995, 1026, 1051, 1076, 1108, 1140, 1172, 1194, 1226, 1249, 1346, 1449, 1473, 1543, 1815, 2973, 4111], 'workSearch': [66, 107, 141, 788, 829, 863], 'more': [68, 109, 143, 175, 207, 239, 270, 301, 326, 351, 383, 415, 447, 469, 501, 524, 621, 724, 748, 790, 831, 865, 897, 929, 961, 992, 1023, 1048, 1073, 1105, 1137, 1169, 1191, 1223, 1246, 1343, 1446, 1470, 1681, 1777, 2099, 3032, 3624, 3815], 'papers': [69, 110, 144, 176, 208, 240, 271, 302, 327, 352, 384, 416, 448, 470, 502, 525, 622, 725, 749, 791, 832, 866, 898, 930, 962, 993, 1024, 1049, 1074, 1106, 1138, 1170, 1192, 1224, 1247, 1344, 1447, 1471], 'by': [70, 111, 145, 177, 209, 241, 272, 303, 328, 353, 385, 417, 449, 471, 503, 526, 623, 726, 750, 792, 833, 867, 899, 931, 963, 994, 1025, 1050, 1075, 1107, 1139, 1171, 1193, 1225, 1248, 1345, 1448, 1472, 1676, 2052, 2157, 2257, 2361, 2368, 2448, 2632, 2658, 2755, 3188], 'authorChunxia': [72, 794], 'Su,': [73, 795], 'Chunxia': [74, 796], 'Su': [75, 797], 'authorZhaoye': [113, 835], 'Wang,': [114, 836], 'Zhaoye': [115, 837], 'Wang': [116, 838], 'Cardio-Thoracic': [119, 841], 'Surgery,': [120, 537, 596, 699, 734, 842, 1259, 1318, 1421, 1456], 'Zhoushan': [121, 843], 'Hospital': [122, 461, 844, 1183], 'Zhejiang': [124, 127, 846, 849], 'Province,': [125, 128, 847, 850], 'Zhoushan,': [126, 848], 'authorJiayu': [147, 869], 'Li,': [148, 212, 244, 474, 870, 934, 966, 1196], 'Jiayu': [149, 871], 'Li': [150, 214, 246, 476, 872, 936, 968, 1198], 'ChinaSearch': [173, 205, 237, 268, 299, 324, 349, 381, 413, 445, 467, 499, 522, 895, 927, 959, 990, 1021, 1046, 1071, 1103, 1135, 1167, 1189, 1221, 1244], 'authorLihong': [179, 901], 'Fan,': [180, 902], 'Lihong': [181, 903], 'Fan': [182, 904], 'authorBing': [211, 933], 'Bing': [213, 935], 'authorXuefei': [243, 965], 'Xuefei': [245, 967], 'Lung': [249, 280, 971, 1002], 'Immunology,': [252, 283, 974, 1005], 'University,': [257, 288, 744, 979, 1010, 1466], 'authorCao': [274, 996], 'Zhao,': [275, 997], 'Cao': [276, 998], 'Zhao': [277, 999], 'authorChunyan': [305, 1027], 'Wu,': [306, 1028], 'Chunyan': [307, 1029], 'Wu': [308, 1030], 'Pathology,': [311, 336, 1033, 1058], 'authorLikun': [330, 1052], 'Hou,': [331, 1053], 'Likun': [332, 1054], 'Hou': [333, 1055], 'authorYayi': [355, 1077], 'He,': [356, 1078], 'Yayi': [357, 1079], 'He': [358, 1080], 'authorGuanghui': [387, 1109], 'Gao,': [388, 1110], 'Guanghui': [389, 1111], 'Gao': [390, 1112], 'authorXiaoxia': [419, 1141], 'Chen,': [420, 1142], 'Xiaoxia': [421, 1143], 'Chen': [422, 1144], 'authorJiawei': [451, 1173], 'Jiawei': [453, 1175], 'Respiratory': [457, 1179], 'First': [460, 1182, 1475], 'Branch,': [462, 1184], 'authorAiwu': [473, 1195], 'Aiwu': [475, 1197], 'authorGuotong': [505, 1227], 'Xu,': [506, 1228], 'Guotong': [507, 1229], 'Xu': [508, 1230], 'Laboratory': [511, 1233], 'authorXiao': [528, 1250], 'Zhou,': [529, 553, 591, 626, 656, 694, 1251, 1275, 1313, 1348, 1378, 1416], 'Corresponding': [530, 627, 1252, 1349], 'Author': [531, 628, 1253, 1350], 'Xiao': [532, 590, 693, 1254, 1312, 1415], 'Zhou': [533, 630, 1255, 1352], 'Thoracic': [536, 595, 698, 1258, 1317, 1420], 'Shanghhai': [538, 597, 700, 1260, 1319, 1422], 'ChinaCorrespondence': [550, 653, 1272, 1375], 'to:': [551, 654, 1273, 1376], 'Caicun': [552, 629, 655, 1274, 1351, 1377], 'MD,': [554, 592, 657, 695, 1276, 1314, 1379, 1417], 'PhD,': [555, 658, 1277, 1380], 'No.': [574, 605, 677, 708, 1296, 1327, 1399, 1430, 3611], '507': [575, 606, 678, 709, 1297, 1328, 1400, 1431], 'Zheng': [576, 607, 679, 710, 1298, 1329, 1401, 1432], 'Min': [577, 608, 680, 711, 1299, 1330, 1402, 1433], 'Road,': [578, 609, 681, 712, 1300, 1331, 1403, 1434], '200433,': [580, 611, 683, 714, 1302, 1333, 1405, 1436], 'China,': [584, 615, 687, 718, 1306, 1337, 1409, 1440], 'Fax:': [585, 616, 688, 719, 1307, 1338, 1410, 1441], '+86-21-55660346,': [586, 617, 689, 720, 1308, 1339, 1411, 1442], 'E-mail:': [587, 618, 690, 721, 1309, 1340, 1412, 1443], '[email protected]': [588, 691, 1310, 1413], 'or': [589, 692, 1311, 1414, 1627, 1633, 1660, 1931, 1949, 2133, 2146, 2228, 2271, 2282, 2291, 2303, 2310, 2434, 2440, 2452, 2499, 2516, 2893, 3206, 3271, 3325, 3623], '[email protected]': [619, 722, 1341, 1444], 'authorCaicun': [625, 1347], 'authorGerald': [728, 1450], 'Schmid-Bindert,': [729, 1451], 'Gerald': [730, 1452], 'Schmid-Bindert': [731, 1453], 'Center': [737, 1459], 'Mannheim,': [738, 745, 1460, 1467], 'Faculty': [740, 1462], 'Mannheim': [741, 1463], 'Heidelberg': [743, 1465], 'GermanySearch': [746, 1468], 'author': [752, 1474], 'published:': [1476], '28': [1477], 'April': [1478], '2014': [1479], 'https://doi.org/10.1002/ijc.28925Citations:': [1480], '35': [1481, 3489, 3807], 'Conflicts': [1482], 'interest:': [1484], 'Nothing': [1485], 'report': [1487], 'AboutSectionsPDF': [1488], 'ToolsRequest': [1489], 'permissionExport': [1490], 'citationAdd': [1491], 'favoritesTrack': [1493], 'citation': [1494], 'ShareShare': [1495], 'Give': [1496], 'accessShare': [1497, 1500], 'full': [1498], 'text': [1499], 'full-text': [1501, 1516, 1540], 'accessPlease': [1502], 'review': [1503], 'our': [1504, 1643, 2865, 3262, 3789], 'Terms': [1505, 1528], 'Conditions': [1507, 1530], 'Use': [1509], 'check': [1511], 'box': [1512], 'below': [1513, 1536], 'share': [1515, 1538], 'version': [1517, 1541], 'article.I': [1519], 'have': [1520, 2127, 3795, 3799, 3802, 3808], 'read': [1521], 'accept': [1523], 'the': [1524, 1534, 1591, 1607, 1753, 1758, 1763, 1802, 1830, 1898, 1912, 1977, 2020, 2071, 2085, 2115, 2180, 2187, 2199, 2207, 2328, 2334, 2369, 2378, 2385, 2401, 2424, 2436, 2457, 2486, 2489, 2494, 2507, 2510, 2559, 2620, 2634, 2639, 2674, 2697, 2702, 2705, 2745, 2760, 2783, 2787, 2793, 2799, 2833, 2861, 2883, 2898, 2909, 2915, 2931, 2936, 2988, 3003, 3036, 3057, 3079, 3083, 3103, 3134, 3148, 3164, 3171, 3190, 3247, 3279, 3290, 3297, 3314, 3322, 3326, 3347, 3359, 3410, 3429, 3435, 3456, 3559, 3563, 3693, 3697, 3729, 3733, 3748, 3752, 3784, 3838, 3842, 3859, 3886, 3893, 3907, 3913, 3923, 3976, 3981, 3987, 3992, 4012, 4017, 4058, 4093, 4107, 4144, 4152, 4158], 'Wiley': [1525], 'Online': [1526], 'Library': [1527], 'UseShareable': [1532], 'LinkUse': [1533], 'link': [1535], 'article': [1544], 'your': [1546], 'friends': [1547], 'colleagues.': [1549], 'Learn': [1550], 'more.Copy': [1551], 'URL': [1552], 'Share': [1553], 'linkShare': [1555], 'onFacebookTwitterLinked': [1556], 'InRedditWechat': [1557], 'Abstract': [1558, 1817], 'Epithelial-to-mesenchymal': [1559, 3479], 'transition': [1560, 1883, 2026], '(EMT)': [1561, 1884, 2027], 'has': [1562, 1920, 2043], 'profound': [1563, 2044], 'impacts': [1564, 2045], 'on': [1565, 1570, 1881, 1917, 2046, 2251, 2529, 2546, 2774, 2832, 3078, 3163, 3210, 4084], 'progression': [1567, 2309, 2480, 2498], 'also': [1569, 2093], 'drug': [1571], 'resistance,': [1572], 'including': [1573], 'epidermal': [1574, 1831, 1941], 'growth': [1575, 1832, 1942], 'factor': [1576, 1833, 1943, 4015], 'receptor': [1577, 1834, 1944], 'tyrosine': [1578, 1841, 1945], 'kinase': [1579, 1842, 1946], 'inhibitors': [1580, 1947], '(EGFR-TKIs).': [1581], 'Nowadays,': [1582], 'there': [1583, 1846, 1994, 3831], 'is': [1584, 2028, 2050, 3107, 3161, 3930], 'still': [1585, 4083, 4090], 'no': [1586, 1848, 1997, 2722, 2982, 3008, 3833, 4025], 'biomarker': [1588, 1885, 1918, 2839, 2879, 3029], 'identified': [1589, 2332, 2999, 3910], 'use': [1592, 2386], '(NSCLC)': [1600, 1861, 2194], 'EGFR.': [1604], 'To': [1605, 2175], 'clarify': [1606, 2177], 'role': [1608, 2083, 2182], 'EMT': [1610, 1667, 1803, 1892, 2049, 2079, 2143, 2184, 2202, 2254, 2828, 3282, 3452, 3461, 3767, 3785, 3839, 3904, 4009, 4138], 'EGFR-TKI,': [1617, 2864], 'we': [1618, 2197, 3197], 'performed': [1619, 2528, 4055], 'retrospective': [1621], 'study': [1622, 2159, 2365, 2866, 4112], '202': [1624, 2212, 2324, 3457, 3468, 3778], 'stage': [1625, 2230], 'IV': [1626, 2231], 'recurrent': [1628, 2229], 'NSCLC': [1629, 1794, 1903, 2168, 2215, 3074, 3459, 3545, 3582, 3715, 3759], 'receiving': [1631], 'gefitinib': [1632, 2270, 2283, 3432], 'erlotinib': [1634, 2281, 3442], 'therapy': [1635, 1813, 1915, 1939, 2018, 2467, 2513, 4063], 'from': [1636, 1838, 1911, 1937, 1989, 2340, 2356, 2485, 2509, 3118, 3252], 'June': [1637, 2341], '2008': [1638, 2342], 'September': [1640, 2344], '2012': [1641], 'institute.': [1644], 'Clinical': [1645], 'data': [1646, 1889, 2348, 2358, 2764, 2784, 2896, 4096], 'mutational': [1649, 3112], 'status': [1650, 1828, 2239, 3071, 3454, 3850, 3902], 'were': [1651, 1663, 1867, 2098, 2299, 2331, 2349, 2443, 2544, 2556, 2571, 2588, 2606, 2630, 2655, 2749, 2858, 3031, 3038, 3186, 3208, 3259, 3294, 3303, 3311, 3334, 3383, 3551, 3689, 3721, 3744, 3780, 3814, 3832, 3906, 4037, 4054, 4082, 4089, 4113, 4143], 'collected,': [1652], 'while': [1653, 3035, 3806], 'epithelial,': [1654], 'epithelial': [1655, 1744, 1774, 2035, 2055, 2121, 2165, 2561, 2837, 2975, 3061, 3073, 3796, 3803, 3945], 'mesenchymal,': [1657, 1746, 3800, 3805], 'not': [1658, 1747, 2300, 3039, 3690, 3745, 3809, 3961], 'specified': [1659, 1748, 3485, 3810, 3962], 'mesenchymal': [1661, 1750, 2040, 2062, 2096, 2563, 2842, 2856, 2869, 2873, 2878, 2923, 2968, 2989, 2996, 3004, 3027, 3090, 3956], 'classified': [1664], 'according': [1665, 2317, 2637, 3787], 'markers': [1668, 1999, 2007, 2097, 2122, 2857, 2870], 'such': [1669, 2064, 2845, 3845], 'E-cadherin,': [1671, 2521], 'fibronectin,': [1672, 2522, 2847, 2891], 'N-cadherin': [1673, 2523, 2537, 2848, 2892], 'vimentin': [1675, 2067, 2525, 2540, 3068], 'immunohistochemistry.': [1677], 'was': [1680, 1694, 1776, 1786, 2092, 2305, 2315, 2366, 2398, 2468, 2483, 2504, 2527, 2649, 2685, 2717, 2796, 2830, 2880, 2908, 2930, 2943, 2977, 2998, 3021, 3116, 3141, 3204, 3218, 3250, 3275, 3339, 3368, 3890, 3898, 3920, 3978, 4011, 4029], 'frequently': [1682, 2100], 'found': [1683, 1868, 2854, 3817, 3836], 'mutation': [1688, 1784, 1930, 2249, 3416, 3678, 3901, 4036, 4136], '(p': [1689, 3827, 3940], '=': [1690, 1711, 3426, 3439, 3467, 3472, 3477, 3482, 3488, 3828, 3973, 4006, 4048], '0.044).': [1691, 3829], 'associated': [1695, 1787, 2859], 'significantly': [1698, 3931, 3950], 'higher': [1699, 2129, 3932, 3951], 'objective': [1700, 3887], 'rate': [1702, 2131, 3896], '(23.5': [1703, 3997], 'vs.': [1704, 1706, 1708, 1717, 1719, 1721, 1732, 1734, 1736, 3965, 3967, 3969, 3998, 4000, 4002, 4040, 4042, 4044], '11.1': [1705, 4001], '0.0': [1707], '2.4%,': [1709], 'p': [1710, 1724, 1739, 3342, 3490, 3972, 4005, 4047], '0.011),': [1712], 'longer': [1713, 1728, 2134], 'progression-free': [1714, 2135], 'survival': [1715, 1730, 2136, 2502, 3291], '(4.4': [1716], '1.9': [1718], '1.7': [1720], '1.0': [1722], 'months,': [1723, 1738], '<': [1725, 1740, 3343, 3941], '0.001)': [1726, 1741], 'overall': [1729], '(11.5': [1731], '8.9': [1733], '4.5': [1735], '4.9': [1737], 'compared': [1742, 1874, 3318], 'subgroup.': [1756, 2023], 'In': [1757, 1772, 2070, 4157], 'subgroup': [1759, 1985, 3550, 3556, 3720, 3726, 4129], 'mutation,': [1762, 3928], 'trend': [1764, 2125], 'remained': [1765, 3995], 'but': [1766], 'without': [1767], 'statistically': [1769, 4026], 'significant': [1770, 1935, 3834, 4027], 'difference.': [1771], 'conclusion,': [1773], 'likely': [1778, 1908, 3816], 'expressed': [1779, 2101], 'better': [1790, 1871, 2176], 'outcome': [1791], 'advanced': [1793, 2214, 2227, 3403, 3458], 'EGFR,': [1798, 1983, 3986], 'which': [1799, 2034, 2161, 3106, 3160, 3301, 3929], 'indicates': [1800], 'that': [1801, 1891, 2095, 2855, 2903, 3196, 4134], 'might': [1805], 'be': [1806, 1895, 3100, 3306], 'potential': [1808], 'guide': [1811], 'EGFR-TKI': [1812, 2139, 2267, 2427, 2492, 3630, 3916, 4020, 4150], 'population.': [1816], "What's": [1818], 'new?': [1819], 'Although': [1820], 'small': [1822], 'number': [1823, 3565, 3735], '(EGFR)': [1835], 'gene': [1836], 'benefit': [1837, 1910, 1936, 1988, 2015], 'mutation-targeted': [1839], 'inhibitor': [1843, 1991], '(TKI)': [1844], 'therapy,': [1845], 'are': [1847, 1906, 1995, 2008, 3045], 'biomarkers': [1849, 1893, 2255, 2844, 2991, 3006], 'capable': [1850], 'identifying': [1852, 2001], 'them.': [1853], 'Here,': [1854], 'treated': [1863], 'TKIs': [1866], 'experience': [1870], 'efficacy': [1872, 2208], 'outcomes': [1873, 3310, 4051], 'other': [1876, 3843], 'phenotypes,': [1879], 'based': [1880, 1916, 2831, 3077, 3162, 3209], 'epithelial-to-mesenchymal': [1882, 2025, 3019, 3094, 3958], 'immunohistochemistry': [1886, 2258], 'scoring.': [1887], 'The': [1888, 2024, 2346, 2364, 2411, 2739, 2827, 3041, 3167, 3193, 3257, 3365, 3374, 3918, 4101, 4128], 'indicate': [1890], 'could': [1894], 'useful': [1896], 'identification': [1899], 'who': [1905, 2326, 4060], 'most': [1907, 3173], 'inhibitors.': [1913, 1951], 'Tailored': [1914], 'analysis': [1919, 2901, 3267, 3561, 3695, 3731, 3750, 3977, 4130], 'entered': [1921], 'reality': [1922], 'treatment.': [1926, 3917], 'Patients': [1927, 3389, 3943], 'EGFR-activated': [1929], 'ALK/ROS1': [1932], 'fusion': [1933], 'gain': [1934], 'targeted': [1938], '(EGFR-TKIs)': [1948], 'ALK': [1950], 'However,': [1952, 3830, 4024], 'only': [1953, 4013], 'minority': [1955], 'express': [1958], 'these': [1959, 2002, 2888, 3567, 3737], 'markers,': [1960, 2056, 2063, 2890], 'mutations': [1963, 3178], 'detected': [1964], '∼30–40%': [1966], 'East': [1968], 'Asian': [1969], 'population1-3': [1970], 'EML4-ALK': [1972], 'fusions4': [1973], '∼4%.': [1975], 'For': [1976, 2709, 3289], 'majority': [1978], 'appears': [1986], 'treatment,5-7': [1992], 'although': [1993], 'currently': [1996, 3179], 'validated': [1998, 2005], 'patients.8': [2003], 'Thus,': [2004], 'needed': [2009], 'accurately': [2011], 'predict': [2012, 2913, 2935], 'likelihood': [2013], 'EGFR-targeted': [2017], 'fundamental': [2030], 'biological': [2031], 'process': [2032], 'during': [2033], 'cells': [2036, 2667, 2677, 2743, 2805, 2814, 2823, 3076], 'change': [2037], 'phenotype;': [2041], 'it': [2042], 'progression.': [2048], 'characterized': [2051], 'downregulation': [2053], 'particularly': [2057], 'E-cadherin': [2058, 2533, 2840, 2965, 2980, 3014, 3025], 'upregulation': [2060], 'N-cadherin,': [2066], 'fibronectin.9-12': [2069], 'EGFR-TKI-sensitive': [2072], 'mutant': [2074], 'line,': [2078], 'plays': [2080], 'an': [2081, 2164, 2233, 2381], 'important': [2082], 'primary': [2086], 'resistance': [2087, 2109, 2151, 2862], 'erlotinib.13,': [2089], '14': [2090], 'It': [2091], 'reported': [2094], 'rebiopsy': [2103], 'samples': [2104, 3779], 'acquired': [2108], 'EGFR-TKI.15,': [2111], '16': [2112], 'Moreover,': [2113], 'limited': [2116, 3564, 3698, 3734, 3753, 3979], 'clinical': [2117, 2357], 'data,17-19': [2118], 'showed': [2123, 2902, 3948, 4133], '(RR)': [2132], '(PFS)': [2137], 'therapy.': [2140], 'Importantly,': [2141], 'targeting': [2142], 'may': [2144], 'reverse': [2145], 'prevent': [2147], 'acquisition': [2148], 'therapeutic': [2150], 'inhibitors,': [2154], 'illustrated': [2156], 'one': [2158, 3001], 'restoration': [2162], 'lines': [2170], 'restored': [2171], 'sensitivity': [2172, 2188], 'gefitinib.20': [2174], 'validate': [2179], 'EGFR-TKIs,': [2196], 'investigated': [2198], 'association': [2200, 3280], 'at': [2204, 2274, 2284, 2596, 2617, 2679, 3109, 3296, 3300, 4092], 'baseline': [2205, 3449, 3773], 'Chinese': [2213], 'patients.': [2216], 'Material': [2217], 'Methods': [2219], 'Patient': [2220, 3363], 'selection': [2221], 'All': [2222, 2260, 2278, 2377, 2653, 3184, 3308, 3331], 'had': [2224, 2262, 2413, 3390, 3420, 3868, 3872, 3877], 'pathologically': [2225], 'confirmed': [2226], 'NSCLC,': [2232], 'Eastern': [2234], 'Cooperative': [2235], 'Oncology': [2236], 'Group': [2237], 'performance': [2238], '0–3,': [2241], 'sufficient': [2242], 'tumor': [2243, 2389, 2396, 2497, 2707, 2713, 2742, 3075, 3648, 3883], 'sample': [2244, 3203], 'test': [2246, 3270, 3274, 3324], '(based': [2250], 'PCR)': [2252], '[measured': [2256], '(IHC)].': [2259], 'measurable': [2263], 'disease': [2264, 2308, 2478, 3404, 3874, 3879, 3894], 'received': [2266, 2280, 3391, 3431, 3441, 4061], 'treatment,': [2268], 'either': [2269], 'erlotinib,': [2272], 'least': [2275], '4': [2276], 'weeks.': [2277], 'fixed': [2286], 'oral': [2287], 'dose': [2288], '150': [2290], '250': [2292], 'mg': [2293], 'daily': [2294], 'concomitant': [2296], 'chemotherapeutic': [2297], 'agents': [2298], 'used.': [2301], 'Erlotinib': [2302, 3638], 'getitinib': [2304], 'administered': [2306], 'until': [2307, 2359], 'intolerable': [2311], 'toxicity.': [2312], 'Dose': [2313], 'reduction': [2314], 'permitted': [2316], 'related': [2319], 'guidelines.': [2320], 'A': [2321, 3268, 3775], 'total': [2322, 3776], 'met': [2327], 'above': [2329], 'criteria': [2330, 2404, 3080], '2012.': [2345], 'laboratory': [2347], 'obtained': [2350], 'recorded': [2352, 2754], 'independently': [2353, 2657], 'blinded': [2355], 'analyses': [2360, 3113, 4053], 'biostatistician.': [2363], 'approved': [2367], 'Institutional': [2370], 'Ethic': [2371], 'Committee': [2372], 'Hospital.': [2376], 'signed': [2380], 'informed': [2382], 'consent': [2383], 'their': [2388, 3770, 3881], 'tissues.': [2390], 'Evaluation': [2391, 2459], 'treatment': [2393, 2428, 3406, 3433, 4021], 'Objective': [2395], 'determined': [2399], 'using': [2400, 2633, 3121, 3147, 3313], 'evaluation': [2403], 'solid': [2406], 'tumors': [2407, 3120], '(RECIST': [2408], 'Version': [2409], '1.1).': [2410], 'computed': [2414], 'tomography': [2415], 'scan': [2416], 'covering': [2417], 'target': [2418], 'lesions': [2419], '4–6': [2420], 'weeks': [2421, 2433], 'later': [2422], 'after': [2423, 2585], 'initiating': [2425], 'then': [2430, 2753], 'every': [2431, 2445], '8': [2432], 'when': [2435, 3000, 3557, 3727, 4031], 'symptom': [2437], 'indicated.': [2438], 'Brain': [2439], 'bone': [2441, 2453], 'metastases': [2442], 'evaluated': [2444, 2557, 2656], '6': [2446], 'months': [2447, 4071, 4115, 4122], 'magnetic': [2449], 'resonance': [2450], 'imaging': [2451], 'scintigraphy.': [2454], 'According': [2455], 'Response': [2458], 'Criteria': [2460], 'Solid': [2462], 'Tumors': [2463], 'guideline,': [2464], 'categorized': [2469], 'into': [2470], 'four': [2471, 2720, 3058, 3993], 'groups:': [2472], 'complete': [2473], 'response,': [2474, 2476, 3870], 'partial': [2475, 3869], 'stable': [2477, 3873], 'disease.': [2481], 'PFS': [2482, 2916, 2937, 4103, 4132, 4148], 'calculated': [2484, 2505, 2797], 'date': [2487, 2495, 3299], 'beginning': [2490, 2511], 'death.': [2500], 'Overall': [2501], '(OS)': [2503], 'time': [2508, 4068], 'death': [2515], 'last': [2517, 3298, 4094], 'follow-up.': [2518], 'IHC': [2519, 2526, 2763, 2772, 2794, 3043], 'formalin-fixed,': [2530], 'paraffin-embedded': [2531], 'samples.': [2532], '(E),': [2534], 'fibronectin': [2535], '(FN),': [2536], '(N)': [2538], '(V)': [2541], 'score': [2542, 2698, 2795, 2835, 2876, 2886, 2905, 2927, 2940, 2956, 2981, 2992, 3015], 'immunostainings': [2543], 'assessed': [2545, 2750], 'whole-tissue': [2547], 'sections,': [2548], 'FN,': [2550, 2623, 2767], 'E,': [2551, 2624, 2768], 'N': [2552, 2579, 2625, 2769, 3466], 'V': [2554, 2582, 2771], 'immunoreactivities': [2555], 'neoplastic': [2560], 'component,': [2564], 'respectively': [2565, 3947], '(epitomics': [2566], 'company).': [2567], 'Primary': [2568, 3647], 'antibodies': [2569, 2629], 'used': [2570, 2650, 2759, 3198, 3276, 3346, 3781], 'rabbit': [2572], 'polyclonal': [2573], 'FN': [2575], '(1:250),': [2576], 'E': [2577], '(1:500),': [2578], '(1:500)': [2580], '(1:250).': [2583], 'Briefly,': [2584, 3213], 'deparaffinization,': [2586], 'sections': [2587, 2710], 'heated': [2589], 'microwave': [2592], 'oven': [2593], '(20': [2594], 'min': [2595, 2613], '90°C)': [2597], 'citrate': [2599], 'buffer': [2600], 'antigen': [2602], 'retrieval.': [2603], 'Then,': [2604], 'they': [2605, 3302], 'washed': [2607], 'phosphate-buffered': [2609], 'saline': [2610], '10': [2612, 3214], 'incubated': [2615], 'overnight': [2616], '4°C': [2618], 'presence': [2621], 'V.': [2627], 'Bound': [2628], 'visualized': [2631], 'SP': [2635], 'method': [2636, 3316], "supplier's": [2640], 'recommendations': [2641], '(SP': [2642], 'Kit;': [2643, 3127], 'kangwei': [2644], 'tech': [2645], 'com,': [2646], 'China).': [2647], 'Diaminobenzidine': [2648], 'chromogen.': [2652], 'specimens': [2654], 'two': [2659, 3395], 'observers': [2660], 'evaluate': [2662], 'staining': [2663, 2678, 2715, 2723, 2726, 2729, 2737, 2747, 2806, 2815, 2824], 'intensity': [2664, 2700, 2716, 2788], 'analyzed': [2666, 4038], '(on': [2668], 'scale': [2670, 2777], '0–3)': [2672], 'fraction': [2675], 'each': [2680, 3239], 'intensity,': [2681], 'interobserver': [2683], 'agreement': [2684], 'reached': [2686], 'all': [2688, 2987, 4057], 'cases.': [2689], 'We': [2690, 2758, 2953, 3345], 'adopted': [2691, 2867], 'scoring': [2693], 'system21': [2694], 'calculate': [2696], 'times': [2701], 'percentage': [2703], 'stained': [2706], 'cells.': [2708], 'analyzable': [2712], 'cells,': [2714], 'scored': [2718], 'categories:': [2721], '(0),': [2724], 'weak': [2725], '(1+),': [2727], 'intermediate': [2728], '(2+,': [2730], 'between': [2731, 3281, 3448, 3837], '1+': [2732], '3+)': [2734], 'strong': [2736], '(3+).': [2738], 'percentages': [2740], 'showing': [2744], 'different': [2746], 'intensities': [2748], 'visually': [2751], 'trained': [2756], 'pathologists.': [2757], 'prospectively': [2761], 'collected': [2762, 3251], 'generate': [2766], 'scores': [2773, 3007, 3030], 'continuous': [2776], '0–300.': [2779], 'By': [2780], 'integration': [2781], 'relating': [2785], 'frequency': [2790], 'staining,': [2792], 'formula:': [2800], '1': [2801, 2950, 3622], '×': [2802, 2811, 2820], '(percentage': [2803, 2812, 2821], 'weakly': [2807], '[1+])': [2808], '+': [2809, 2818], '2': [2810], 'moderately': [2816], '[2+])': [2817], '3': [2819], 'strongly': [2825], '[3+]).': [2826], 'H': [2834, 2875, 2885, 2904, 2926, 2939, 2955], 'vimentin.': [2850, 2894], 'As': [2851, 2921], 'previous': [2852, 3263, 3613], 'studies17-19': [2853], 'three': [2868, 2889, 3568, 3738], 'identify': [2872, 3170], 'phenotype.': [2874, 3811], 'defined': [2881, 2978, 3022, 3340, 3790], 'highest': [2884], 'Our': [2895], 'cutoff': [2899, 2961], 'point': [2900, 2962], '100': [2907, 2929, 2958, 2985, 3011], 'best': [2910, 2932, 2944, 3882], 'value': [2911, 2933], 'both': [2914, 2963, 3024], 'OS': [2918, 2946, 4105], 'E-cadherin.': [2920], 'biomarkers,': [2925], '80': [2942], '(Supporting': [2947], 'Information': [2948], 'Tables': [2949], '2).': [2952, 4023, 4156], 'choose': [2954], 'biomarkers.': [2970], 'So,': [2971], 'study,': [2974], 'less': [2983, 2993, 3009, 3016], 'than': [2984, 2994, 3010, 3017, 3033, 3823, 3933, 3953], '100;': [2995, 3018], 'together': [3012], '100,': [3034], 'remains': [3037], 'specified.': [3040], 'representative': [3042], 'figures': [3044], 'shown': [3046], 'Figure': [3048, 3050], '1.': [3049, 3446], '1Open': [3051], 'figure': [3053, 3098], 'viewerPowerPoint': [3054], 'Examples': [3055], 'classifications': [3059], '(E-cadherin)': [3063], 'mesenchyme': [3065], '(fibronectin,': [3067], 'N-cadherin)': [3070], 'described': [3081, 3180, 3260], 'results.': [3084], '(a)': [3085], 'phenotype:': [3087, 3091, 3095], 'E-cadherin+/fibronectin–;': [3088], '(b)': [3089], 'E-cadherin–/vimentin+;': [3092], '(c)': [3093], 'E-cadherin+/N-cadherin+.': [3096], '[Color': [3097], 'can': [3099, 3169], 'viewed': [3101], 'online': [3104], 'issue,': [3105], 'available': [3108, 3150, 3413, 3862], 'wileyonlinelibrary.com.]': [3110], 'Genomic': [3114], 'DNA': [3115, 3125, 3217, 3229], 'extracted': [3117], 'standard': [3122], 'protocols': [3123], '(QiAamp': [3124], 'Mini': [3126], 'Qiagen,': [3128], 'Hilden,': [3129], 'Germany).': [3130], 'Cycle': [3131], 'sequencing': [3132], 'purified': [3135], 'polymerase': [3136], 'chain': [3137], 'reaction': [3138], '(PCR)': [3139], 'products': [3140], 'carried': [3142], 'out': [3143], 'PCR': [3145, 3223, 3227, 3231], 'primers': [3146, 3232], 'commercially': [3149], 'ADx': [3151], 'Mutation': [3152], 'Detection': [3153], 'Kits': [3154], '(Amoy': [3155], 'Diagnostics': [3156], 'Company,': [3157], 'Xiamen,': [3158], 'China),': [3159], 'ARMS': [3165], 'technology.': [3166], 'assay': [3168], '29': [3172], 'common': [3174], 'types': [3175], 'cancers.': [3183], 'experiments': [3185], 'done': [3187], 'following': [3189], "manufacturer's": [3191], 'protocols.': [3192], 'Ct': [3194], 'values': [3195], 'determine': [3200], 'whether': [3201], 'positive': [3205], 'negative': [3207], 'extensive': [3211], 'validation.': [3212], 'ng': [3215], 'genomic': [3216], 'added': [3219], '45': [3221, 4087], 'μL': [3222], 'master': [3224], 'mix': [3225], 'containing': [3226], 'buffer,': [3228], 'polymerase,': [3230], 'fluorescent': [3234, 3248], 'Taqman': [3235], 'probe': [3236], 'specific': [3237], 'individual': [3240], 'mutation.': [3242], 'After': [3243], '47': [3244], 'amplification': [3245], 'cycles,': [3246], 'signal': [3249], 'FAM': [3253], 'HEX': [3255], 'channels.': [3256], 'details': [3258], 'articles.22,': [3264], '23': [3265], 'Statistical': [3266], 'χ2': [3269], 'Fisher': [3272], 'exact': [3273], 'analyze': [3278], 'clinicopathologic': [3285], 'variables': [3286], 'RR.': [3288], 'analysis,': [3292, 4160], 'censored': [3295], 'known': [3304], 'alive.': [3307], 'time-to-event': [3309], 'estimated': [3312], 'Kaplan–Meier': [3315], 'across': [3319], 'groups': [3320, 3994], 'log-rank': [3323], 'Cox': [3327], 'proportional': [3328], 'hazards': [3329], 'model.': [3330], 'statistical': [3332, 3337, 3349, 3360, 3560, 3694, 3730, 3749], 'tests': [3333], 'two-sided,': [3335], 'significance': [3338], '0.05.': [3344], 'SPSS': [3348], 'software': [3350], 'package': [3351], '(version': [3352], '13.0;': [3353], 'SPSS,': [3354], 'Chicago,': [3355], 'IL)': [3356], 'perform': [3358], 'analysis.': [3361], 'Results': [3362], 'characteristics': [3364, 3450, 3774, 3844], 'median': [3366, 3393, 4066, 4102], 'age': [3367], '59': [3369], 'years': [3370], '(range,': [3371, 3399], '30–80': [3372], 'years).': [3373], 'proportions': [3375], 'males,': [3377], 'ever': [3378], 'smokers': [3379], 'squamous': [3381], 'carcinomas': [3382], '54.9,': [3384], '40.6': [3385], '19.3%,': [3387], 'respectively.': [3388, 4127], 'prior': [3396], 'chemotherapy': [3397, 3614], 'regimens': [3398], '0–3': [3400], 'regimens)': [3401], 'before': [3405], 'EGFR-TKIs.': [3408], 'Of': [3409, 3858], '196': [3411], 'status,': [3417, 4137], '97': [3418], 'activated': [3421, 3926, 4034], 'mutation;': [3423], '29.7%': [3424], '(n': [3425, 3438], '60)': [3427], 'remaining': [3436], '70.3%': [3437], '142)': [3440], '(Table': [3443, 3854, 4155], '1).': [3444, 3855], 'Table': [3445], 'Correlations': [3447], 'Characteristics': [3463], 'Number': [3464], '(%),': [3465, 3470, 3475, 3480, 3486], 'n': [3471, 3476, 3481, 3487], '70': [3473, 3794], 'Mesenchymal': [3474, 3812], '66': [3478, 3798], '31': [3483, 3801], 'Not': [3484], 'Age': [3491], '(years)': [3492], '>65': [3493], '54(26.7)': [3494, 3673], '23(11.4)': [3495], '15(7.4)': [3496, 3511, 3636, 3706], '5(2.5)': [3497, 3609], '11(5.4)': [3498], '0.256': [3499], '≤65': [3500], '148(73.3)': [3501], '47(23.3)': [3502, 3641], '51(25.2)': [3503], '26(12.9)': [3504, 3533, 3602], '24(11.9)': [3505], 'Gender': [3506], 'Male': [3507], '111(54.9)': [3508], '43(21.3)': [3509, 3573], '36(17.8)': [3510, 3681], '17(8.0)': [3512], '0.511': [3513], 'Female': [3514], '91(45.1)': [3515], '27(13.4)': [3516, 3653, 3676], '30(14.9)': [3517, 3532, 3606], '16(7.9)': [3518, 3539, 3666, 3667, 3684], '18(8.9)': [3519, 3616], 'Smoking': [3520], 'history': [3521], 'Never': [3522], 'smoker': [3523], '120(59.4)': [3524], '40(19.8)': [3525, 3526], '19(9.4)': [3527, 3634], '21(10.4)': [3528, 3574], '0.971': [3529], 'Smoker': [3530], '82(40.6)': [3531], '12(5.9)': [3534], '14(6.9)': [3535, 3608, 3658], 'Pathology': [3536], 'Squamous': [3537], '39(19.3)': [3538], '10(5.0)': [3540, 3584], '6(3.0)': [3541, 3708], '7(3.5)': [3542], '0.683aa': [3543], 'Squ-adno,': [3544, 3714], 'NOS': [3546, 3583, 3716], 'large': [3548, 3718], 'regarded': [3552, 3722], 'combined': [3555, 3725], 'performing': [3558, 3728], 'subgroups.': [3569, 3739], 'Adenocarcinoma': [3570], '134(66.3)': [3571], '48(23.8)': [3572], '22(10.9)': [3575, 3642, 3675], 'Adeno-squa': [3576], '17(8.4)': [3577, 3633], '3(1.5)': [3578, 3580, 3581, 3585, 3588, 3610, 3618, 3620], '8(4.0)': [3579, 3661, 3669], '4(2.0)': [3586, 3711], '0(0.0)': [3587, 3592, 3595, 3709], 'Large': [3589], '2(1.0)': [3591, 3619, 3660], '1(0.5)': [3593, 3594, 3710, 3712], 'ECOG': [3596, 4141], 'PS': [3597, 4142], '0–1': [3598], '172(85.1)': [3599], '62(30.7)': [3600], '52(25.7)': [3601], '32(15.8)': [3603, 3629], '0.273': [3604], '2–3': [3605], '8(3.9)': [3607], '0': [3615], '10(4.9)': [3617], '0.233': [3621], '184(91.1)': [3625], '60(29.7)': [3626, 3632], '63(31.2)': [3627], '29(14.4)': [3628, 3652], 'Gefitinib': [3631], '9(4.5)': [3635, 3659, 3668, 3705], '0.271': [3637], '142(70.3)': [3639], '53(26.2)': [3640], '20(9.9)': [3643], 'Site': [3644], 'biopsy': [3646], '169(83.7)': [3649], '56(27.7)': [3650], '57(28.2)': [3651], '0.227': [3654], 'Metastatic': [3655], 'sizes': [3656], '33(16.3)': [3657], 'Tissue': [3662], 'specimen': [3663], 'Resection': [3664], '49(24.3)': [3665], '0.920': [3670], 'Biopsy': [3671], '153(75.7)': [3672], '50(24.8)': [3674], 'Activated': [3679], '97(48.0)': [3680], '25(12.4)': [3682], '20(10.0)': [3683], '0.044bb': [3685], 'unknown': [3687, 3742], 'included': [3691, 3746], 'number.': [3699, 3754], 'Wild': [3700], 'type': [3701, 3853], '99(49.0)': [3702], '34(16.8)': [3703], '41(20.3)': [3704], 'Unknown': [3707], 'b': [3740], 'Abbreviations:': [3755], 'Adeno-squa:': [3756], 'adeno-squamous': [3757], 'carcinoma;': [3758], 'NOS:': [3760], 'non-small-cell': [3761], '(not': [3764], 'otherwise': [3765], 'specified).': [3766], 'phenotypes': [3768, 3813, 3840], 'relations': [3771], 'classify': [3783], 'criteria.': [3791], 'Among': [3792, 4077], 'them,': [3793, 4078], 'phenotype,': [3797, 3957], 'mutated': [3825], 'associations': [3835], 'gender,': [3847], 'age,': [3848], 'smoking': [3849], 'histological': [3852], 'Tumor': [3856], '201': [3860], 'evaluation,': [3865], '76': [3866], '54': [3871], '71': [3876], 'progressive': [3878], 'response.': [3884], 'Therefore,': [3885], 'RR': [3888, 3952, 3990], '(ORR)': [3889], '37.8%': [3891], 'control': [3895], '(DCR)': [3897], '64.7%.': [3899], 'main': [3908, 4145], 'factors': [3909], 'predicting': [3912], 'ORR': [3919], '64.1%': [3921], '10.1%': [3934], '0.001).': [3942], 'those': [3954], '(52.9': [3964], '23.1': [3966], '41.9': [3968], '31.4%,': [3970], 'respectively;': [3971, 4004, 4046], '0.004).': [3974], 'When': [3975], '99': [3982], 'difference': [3988, 4028], 'among': [3991], 'unchanged': [3996], '2.4': [3999], '0.0%,': [4003], '0.011)': [4007], '(Fig.': [4022], 'observed': [4030], '(80.6': [4039], '58.3': [4041], '54.5': [4043], '55.0%,': [4045], '0.114).': [4049], 'Survival': [4050, 4052], 'follow-up': [4067, 4095], '13.1': [4070], '[95%': [4072], 'confidence': [4073], 'interval': [4074], '(CI),': [4075], '13.47–16.64].': [4076], '24': [4079], '(11.9%)': [4081], '(22.3%)': [4088], 'alive': [4091], 'February': [4098], '15,': [4099], '2013.': [4100], 'evaluable': [4108], '5.6': [4114], '(95%': [4116, 4123], 'CI,': [4117, 4124], '4.31–6.89': [4118], 'months)': [4119], '12.6': [4121], '9.27–15.93': [4125], 'months),': [4126], 'predictors': [4146], 'whole': [4153], 'population': [4154], 'univariate': [4159], 'female': [4161], 'patients,': [4162], 'never': [4163], 'smokers,': [4164], 'ECO': [4165]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1504476997', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-12-12T15:39:23.283119', 'created_date': '2016-06-24'}
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