Title: Oxidative Modifications of Cu, Zn-Superoxide Dismutase (SOD1) – The Relevance to Amyotrophic Lateral Sclerosis (ALS)
Abstract: Oxidative Modifications of Cu, Zn-Superoxide Dismutase (SOD1) -The Relevance to Amyotrophic Lateral Sclerosis (ALS) 307 ConclusionThe findings mentioned above indicate that oxidative modification of SOD1 at cysteine residues is a critical factor to contribute to the oxidative stress, inclusion pathology and degeneration of motor neurons commonly to familial and sporadic ALS.Based on them, steric inhibition of cysteine oxidation, monomerization or exposure of the dimer interface can be the first-line treatment strategy of this incurable disease.9.