Publication Information

{'id': 'https://openalex.org/W1502961708', 'doi': 'https://doi.org/10.1038/ijos.2015.14', 'title': 'The Hedgehog signalling pathway in bone formation', 'display_name': 'The Hedgehog signalling pathway in bone formation', 'publication_year': 2015, 'publication_date': '2015-05-29', 'ids': {'openalex': 'https://openalex.org/W1502961708', 'doi': 'https://doi.org/10.1038/ijos.2015.14', 'mag': '1502961708', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26023726', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4817553'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/ijos.2015.14', 'pdf_url': 'https://www.nature.com/articles/ijos201514.pdf', 'source': {'id': 'https://openalex.org/S44743489', 'display_name': 'International Journal of Oral Science', 'issn_l': '1674-2818', 'issn': ['1674-2818', '2049-3169'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/ijos201514.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101500919', 'display_name': 'Jing Yang', 'orcid': 'https://orcid.org/0000-0002-4983-1660'}, 'institutions': [{'id': 'https://openalex.org/I4391768043', 'display_name': 'State Key Laboratory of Oral Diseases', 'ror': 'https://ror.org/00pvqk557', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I24185976', 'https://openalex.org/I4391768043']}, {'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Yang', 'raw_affiliation_strings': ['State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China', 'institution_ids': ['https://openalex.org/I4391768043', 'https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043481773', 'display_name': 'Philipp Andre', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210090236', 'display_name': 'National Human Genome Research Institute', 'ror': 'https://ror.org/00baak391', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210090236']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Philipp Andre', 'raw_affiliation_strings': ['Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210090236']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100646439', 'display_name': 'Ling Ye', 'orcid': 'https://orcid.org/0000-0001-5469-0017'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4391768043', 'display_name': 'State Key Laboratory of Oral Diseases', 'ror': 'https://ror.org/00pvqk557', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I24185976', 'https://openalex.org/I4391768043']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ling Ye', 'raw_affiliation_strings': ['State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4391768043']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016326637', 'display_name': 'Yingzi Yang', 'orcid': 'https://orcid.org/0000-0003-3933-887X'}, 'institutions': [{'id': 'https://openalex.org/I4210090236', 'display_name': 'National Human Genome Research Institute', 'ror': 'https://ror.org/00baak391', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210090236']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ying-Zi Yang', 'raw_affiliation_strings': ['Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210090236', 'https://openalex.org/I1299303238']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2290, 'currency': 'GBP', 'value_usd': 2808, 'provenance': 'doaj'}, 'apc_paid': {'value': 2290, 'currency': 'GBP', 'value_usd': 2808, 'provenance': 'doaj'}, 'fwci': 1.96, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 205, 'citation_normalized_percentile': {'value': 0.999741, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '7', 'issue': '2', 'first_page': '73', 'last_page': '79'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11919', 'display_name': 'dental development and anomalies', 'score': 0.9708, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13107', 'display_name': 'Congenital limb and hand anomalies', 'score': 0.9649, 'subfield': {'id': 'https://openalex.org/subfields/1309', 'display_name': 'Developmental Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/indian-hedgehog', 'display_name': 'Indian hedgehog', 'score': 0.78187287}, {'id': 'https://openalex.org/keywords/endochondral-ossification', 'display_name': 'Endochondral ossification', 'score': 0.7462042}, {'id': 'https://openalex.org/keywords/morphogen', 'display_name': 'Morphogen', 'score': 0.56283647}, {'id': 'https://openalex.org/keywords/homeostasis', 'display_name': 'Homeostasis', 'score': 0.4364602}, {'id': 'https://openalex.org/keywords/patched', 'display_name': 'Patched', 'score': 0.4271967}, {'id': 'https://openalex.org/keywords/smoothened', 'display_name': 'Smoothened', 'score': 0.4199611}], 'concepts': [{'id': 'https://openalex.org/C2776014264', 'wikidata': 'https://www.wikidata.org/wiki/Q1770532', 'display_name': 'Indian hedgehog', 'level': 4, 'score': 0.78187287}, {'id': 'https://openalex.org/C2778539099', 'wikidata': 'https://www.wikidata.org/wiki/Q6120', 'display_name': 'Hedgehog', 'level': 3, 'score': 0.77316797}, {'id': 'https://openalex.org/C17938293', 'wikidata': 'https://www.wikidata.org/wiki/Q3312710', 'display_name': 'Endochondral ossification', 'level': 3, 'score': 0.7462042}, {'id': 'https://openalex.org/C88498014', 'wikidata': 'https://www.wikidata.org/wiki/Q14859918', 'display_name': 'Hedgehog signaling pathway', 'level': 3, 'score': 0.6727786}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6488745}, {'id': 'https://openalex.org/C2778386714', 'wikidata': 'https://www.wikidata.org/wiki/Q417084', 'display_name': 'Morphogen', 'level': 3, 'score': 0.56283647}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.55041856}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.46176285}, {'id': 'https://openalex.org/C2778260815', 'wikidata': 'https://www.wikidata.org/wiki/Q917177', 'display_name': 'Osteoblast', 'level': 3, 'score': 0.44024295}, {'id': 'https://openalex.org/C63645605', 'wikidata': 'https://www.wikidata.org/wiki/Q103191', 'display_name': 'Homeostasis', 'level': 2, 'score': 0.4364602}, {'id': 'https://openalex.org/C2777994357', 'wikidata': 'https://www.wikidata.org/wiki/Q24781250', 'display_name': 'Patched', 'level': 4, 'score': 0.4271967}, {'id': 'https://openalex.org/C145837895', 'wikidata': 'https://www.wikidata.org/wiki/Q18031607', 'display_name': 'Smoothened', 'level': 4, 'score': 0.4199611}, {'id': 'https://openalex.org/C2780550940', 'wikidata': 'https://www.wikidata.org/wiki/Q502730', 'display_name': 'Cartilage', 'level': 2, 'score': 0.41682795}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.32746142}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.3123991}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.10630718}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001846', 'descriptor_name': 'Bone Development', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001847', 'descriptor_name': 'Bone Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001847', 'descriptor_name': 'Bone Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/ijos.2015.14', 'pdf_url': 'https://www.nature.com/articles/ijos201514.pdf', 'source': {'id': 'https://openalex.org/S44743489', 'display_name': 'International Journal of Oral Science', 'issn_l': '1674-2818', 'issn': ['1674-2818', '2049-3169'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4817553', 'pdf_url': 'https://europepmc.org/articles/pmc4817553?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817553', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26023726', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/ijos.2015.14', 'pdf_url': 'https://www.nature.com/articles/ijos201514.pdf', 'source': {'id': 'https://openalex.org/S44743489', 'display_name': 'International Journal of Oral Science', 'issn_l': '1674-2818', 'issn': ['1674-2818', '2049-3169'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.68, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 134, 'referenced_works': ['https://openalex.org/W141355430', 'https://openalex.org/W1532026954', 'https://openalex.org/W1550806320', 'https://openalex.org/W1554074914', 'https://openalex.org/W1554676002', 'https://openalex.org/W1555047203', 'https://openalex.org/W1698663755', 'https://openalex.org/W1901208108', 'https://openalex.org/W1963493647', 'https://openalex.org/W1964495903', 'https://openalex.org/W1971060771', 'https://openalex.org/W1973485093', 'https://openalex.org/W1974506260', 'https://openalex.org/W1976571762', 'https://openalex.org/W1977203585', 'https://openalex.org/W1979061689', 'https://openalex.org/W1982824007', 'https://openalex.org/W1983404438', 'https://openalex.org/W1983408060', 'https://openalex.org/W1987913532', 'https://openalex.org/W1989465440', 'https://openalex.org/W1990944246', 'https://openalex.org/W199263423', 'https://openalex.org/W1992865216', 'https://openalex.org/W1993035406', 'https://openalex.org/W1993484166', 'https://openalex.org/W1993851741', 'https://openalex.org/W1994553956', 'https://openalex.org/W1994643992', 'https://openalex.org/W1995499476', 'https://openalex.org/W2000572318', 'https://openalex.org/W2002355858', 'https://openalex.org/W2007784353', 'https://openalex.org/W2009998759', 'https://openalex.org/W2010863761', 'https://openalex.org/W2012303068', 'https://openalex.org/W2012535690', 'https://openalex.org/W2014254246', 'https://openalex.org/W2014364643', 'https://openalex.org/W2017518343', 'https://openalex.org/W2019150363', 'https://openalex.org/W2019663306', 'https://openalex.org/W2021410288', 'https://openalex.org/W2023005600', 'https://openalex.org/W2023537681', 'https://openalex.org/W2024715929', 'https://openalex.org/W2025963445', 'https://openalex.org/W2028108335', 'https://openalex.org/W2029053273', 'https://openalex.org/W2032117264', 'https://openalex.org/W2032792789', 'https://openalex.org/W2033134304', 'https://openalex.org/W2035548935', 'https://openalex.org/W2037387112', 'https://openalex.org/W2040203747', 'https://openalex.org/W2042064995', 'https://openalex.org/W2042524126', 'https://openalex.org/W2042932723', 'https://openalex.org/W2043289157', 'https://openalex.org/W2044315923', 'https://openalex.org/W2044687174', 'https://openalex.org/W2045795509', 'https://openalex.org/W2046409391', 'https://openalex.org/W2047078034', 'https://openalex.org/W2047469626', 'https://openalex.org/W2047985933', 'https://openalex.org/W2049727086', 'https://openalex.org/W2051861464', 'https://openalex.org/W2052141859', 'https://openalex.org/W2054300900', 'https://openalex.org/W2055296003', 'https://openalex.org/W2055792519', 'https://openalex.org/W2058177751', 'https://openalex.org/W2058549159', 'https://openalex.org/W2062159807', 'https://openalex.org/W2066277462', 'https://openalex.org/W2068760238', 'https://openalex.org/W2070184849', 'https://openalex.org/W2072714763', 'https://openalex.org/W2073521369', 'https://openalex.org/W2074166336', 'https://openalex.org/W2074542365', 'https://openalex.org/W2077802746', 'https://openalex.org/W2080254801', 'https://openalex.org/W2082466119', 'https://openalex.org/W2083216482', 'https://openalex.org/W2088342479', 'https://openalex.org/W2089749296', 'https://openalex.org/W2091684557', 'https://openalex.org/W2092827845', 'https://openalex.org/W2095243783', 'https://openalex.org/W2095244767', 'https://openalex.org/W2095437525', 'https://openalex.org/W2096823486', 'https://openalex.org/W2097288660', 'https://openalex.org/W2099268945', 'https://openalex.org/W2102085111', 'https://openalex.org/W2105475061', 'https://openalex.org/W2107552781', 'https://openalex.org/W2108707301', 'https://openalex.org/W2110341920', 'https://openalex.org/W2110753649', 'https://openalex.org/W2110975457', 'https://openalex.org/W2114702304', 'https://openalex.org/W2114824375', 'https://openalex.org/W2116201213', 'https://openalex.org/W2118756200', 'https://openalex.org/W2130034708', 'https://openalex.org/W2130320900', 'https://openalex.org/W2138187950', 'https://openalex.org/W2138351218', 'https://openalex.org/W2140908395', 'https://openalex.org/W2145484925', 'https://openalex.org/W2147083273', 'https://openalex.org/W2147822820', 'https://openalex.org/W2152072269', 'https://openalex.org/W2154085568', 'https://openalex.org/W2154656849', 'https://openalex.org/W2155343233', 'https://openalex.org/W2155861726', 'https://openalex.org/W2155993944', 'https://openalex.org/W2156632504', 'https://openalex.org/W2160416650', 'https://openalex.org/W2163838718', 'https://openalex.org/W2164310262', 'https://openalex.org/W2164662707', 'https://openalex.org/W2166741473', 'https://openalex.org/W2168256871', 'https://openalex.org/W2170048206', 'https://openalex.org/W2180754398', 'https://openalex.org/W2189378924', 'https://openalex.org/W2274730818', 'https://openalex.org/W2371962997', 'https://openalex.org/W2469584286'], 'related_works': ['https://openalex.org/W2520110631', 'https://openalex.org/W2384707782', 'https://openalex.org/W2183682993', 'https://openalex.org/W2137937100', 'https://openalex.org/W2124176030', 'https://openalex.org/W2116707180', 'https://openalex.org/W2067761409', 'https://openalex.org/W2050001638', 'https://openalex.org/W1987228418', 'https://openalex.org/W1529799967'], 'abstract_inverted_index': {'The': [0, 14], 'Hedgehog': [1, 66, 79], '(Hh)': [2], 'signalling': [3, 19, 38, 49, 96, 107, 130, 139, 154, 160], 'pathway': [4, 50], 'plays': [5, 120], 'many': [6], 'important': [7, 122, 169], 'roles': [8], 'in': [9, 20, 26, 51, 73, 85, 92, 124, 161], 'development,': [10, 53, 64, 110, 163], 'homeostasis': [11, 54, 164], 'and': [12, 55, 88, 105, 114, 127, 156, 165, 176], 'tumorigenesis.': [13], 'critical': [15], 'function': [16, 84], 'of': [17, 46, 61, 137, 158], 'Hh': [18, 37, 48, 95, 104, 118, 129, 138, 159], 'bone': [21, 52, 112, 125, 134, 144, 162, 172], 'formation': [22, 113], 'has': [23, 81], 'been': [24], 'identified': [25], 'the': [27, 34, 44, 47, 58, 75, 93, 153], 'past': [28], 'two': [29], 'decades.': [30], 'Here,': [31], 'we': [32], 'review': [33], 'evolutionarily': [35], 'conserved': [36], 'mechanisms': [39, 155], 'with': [40], 'an': [41, 82, 121], 'emphasis': [42], 'on': [43], 'functions': [45, 157], 'diseases.': [56], 'In': [57], 'early': [59], 'stages': [60], 'embryonic': [62], 'limb': [63, 76], 'Sonic': [65], '(Shh)': [67], 'acts': [68], 'as': [69, 147], 'a': [70], 'major': [71], 'morphogen': [72], 'patterning': [74], 'buds.': [77], 'Indian': [78], '(Ihh)': [80], 'essential': [83], 'endochondral': [86, 111], 'ossification': [87], 'induces': [89], 'osteoblast': [90], 'differentiation': [91], 'perichondrium.': [94], 'is': [97], 'also': [98, 119], 'involved': [99], 'intramembrane': [100], 'ossification.': [101], 'Interactions': [102], 'between': [103], 'Wnt': [106], 'regulate': [108], 'cartilage': [109], 'synovial': [115], 'joint': [116], 'formation.': [117], 'role': [123], 'homeostasis,': [126], 'reducing': [128], 'protects': [131], 'against': [132], 'age-related': [133], 'loss.': [135], 'Disruption': [136], 'regulation': [140], 'leads': [141], 'to': [142], 'multiple': [143], 'diseases,': [145], 'such': [146], 'progressive': [148], 'osseous': [149], 'heteroplasia.': [150], 'Therefore,': [151], 'understanding': [152], 'diseases': [166], 'will': [167], 'provide': [168], 'insights': [170], 'into': [171], 'disease': [173], 'prevention,': [174], 'diagnoses': [175], 'therapeutics.': [177]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1502961708', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 28}, {'year': 2022, 'cited_by_count': 27}, {'year': 2021, 'cited_by_count': 32}, {'year': 2020, 'cited_by_count': 36}, {'year': 2019, 'cited_by_count': 20}, {'year': 2018, 'cited_by_count': 22}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2025-01-04T10:46:03.094244', 'created_date': '2016-06-24'}