Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1502879542', 'doi': 'https://doi.org/10.1111/all.12680', 'title': 'Angioedema induced by cardiovascular drugs: new players join old friends', 'display_name': 'Angioedema induced by cardiovascular drugs: new players join old friends', 'publication_year': 2015, 'publication_date': '2015-06-26', 'ids': {'openalex': 'https://openalex.org/W1502879542', 'doi': 'https://doi.org/10.1111/all.12680', 'mag': '1502879542', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26119220'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/all.12680', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12680', 'source': {'id': 'https://openalex.org/S68090385', 'display_name': 'Allergy', 'issn_l': '0105-4538', 'issn': ['0105-4538', '1398-9995'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12680', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041541940', 'display_name': 'Murat Baş', 'orcid': 'https://orcid.org/0000-0002-0494-301X'}, 'institutions': [{'id': 'https://openalex.org/I62916508', 'display_name': 'Technical University of Munich', 'ror': 'https://ror.org/02kkvpp62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I62916508']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'M. Bas', 'raw_affiliation_strings': ['Otorhinolaryngology Department, University Hospital Rechts der Isar, Munich Technical University, Munich, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Otorhinolaryngology Department, University Hospital Rechts der Isar, Munich Technical University, Munich, Germany.', 'institution_ids': ['https://openalex.org/I62916508']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058228546', 'display_name': 'Jens Greve', 'orcid': 'https://orcid.org/0000-0003-0628-0608'}, 'institutions': [{'id': 'https://openalex.org/I196349391', 'display_name': 'Universität Ulm', 'ror': 'https://ror.org/032000t02', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I196349391']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'J. Greve', 'raw_affiliation_strings': ['Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.', 'institution_ids': ['https://openalex.org/I196349391']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024839071', 'display_name': 'Ulrich Straßen', 'orcid': 'https://orcid.org/0000-0002-3366-2137'}, 'institutions': [{'id': 'https://openalex.org/I62916508', 'display_name': 'Technical University of Munich', 'ror': 'https://ror.org/02kkvpp62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I62916508']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'U. Strassen', 'raw_affiliation_strings': ['Otorhinolaryngology Department, University Hospital Rechts der Isar, Munich Technical University, Munich, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Otorhinolaryngology Department, University Hospital Rechts der Isar, Munich Technical University, Munich, Germany.', 'institution_ids': ['https://openalex.org/I62916508']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054696784', 'display_name': 'Farbod Khosravani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I44260953', 'display_name': 'Heinrich Heine University Düsseldorf', 'ror': 'https://ror.org/024z2rq82', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I44260953']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'F. Khosravani', 'raw_affiliation_strings': ['Institute of Pharmacology and Clinical Pharmacology Heinrich Heine University Düsseldorf Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacology and Clinical Pharmacology Heinrich Heine University Düsseldorf Germany', 'institution_ids': ['https://openalex.org/I44260953']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101789276', 'display_name': 'Thomas K. Hoffmann', 'orcid': 'https://orcid.org/0000-0001-5127-3779'}, 'institutions': [{'id': 'https://openalex.org/I196349391', 'display_name': 'Universität Ulm', 'ror': 'https://ror.org/032000t02', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I196349391']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'T. K. Hoffmann', 'raw_affiliation_strings': ['Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.', 'institution_ids': ['https://openalex.org/I196349391']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016571719', 'display_name': 'Georg Kojda', 'orcid': 'https://orcid.org/0000-0001-6911-6990'}, 'institutions': [{'id': 'https://openalex.org/I44260953', 'display_name': 'Heinrich Heine University Düsseldorf', 'ror': 'https://ror.org/024z2rq82', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I44260953']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'G. Kojda', 'raw_affiliation_strings': ['Institute of Pharmacology and Clinical Pharmacology Heinrich Heine University Düsseldorf Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pharmacology and Clinical Pharmacology Heinrich Heine University Düsseldorf Germany', 'institution_ids': ['https://openalex.org/I44260953']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4900, 'currency': 'USD', 'value_usd': 4900, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.197, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.696629, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '70', 'issue': '10', 'first_page': '1196', 'last_page': '1200'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11917', 'display_name': 'Hereditary Angioedema: Molecular Mechanisms and Clinical Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11917', 'display_name': 'Hereditary Angioedema: Molecular Mechanisms and Clinical Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13004', 'display_name': 'Role of Vitamin K in Health', 'score': 0.9819, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.9794, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hereditary-angioedema', 'display_name': 'Hereditary angioedema', 'score': 0.4892821}, {'id': 'https://openalex.org/keywords/angiotensin', 'display_name': 'Angiotensin', 'score': 0.477703}, {'id': 'https://openalex.org/keywords/concomitant', 'display_name': 'Concomitant', 'score': 0.41797847}], 'concepts': [{'id': 'https://openalex.org/C2777995640', 'wikidata': 'https://www.wikidata.org/wiki/Q1129007', 'display_name': 'Angioedema', 'level': 2, 'score': 0.9469298}, {'id': 'https://openalex.org/C2779591629', 'wikidata': 'https://www.wikidata.org/wiki/Q24745328', 'display_name': 'Bradykinin', 'level': 3, 'score': 0.8550956}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.754971}, {'id': 'https://openalex.org/C104826730', 'wikidata': 'https://www.wikidata.org/wiki/Q414232', 'display_name': 'Neprilysin', 'level': 3, 'score': 0.62365067}, {'id': 'https://openalex.org/C2775940317', 'wikidata': 'https://www.wikidata.org/wiki/Q422185', 'display_name': 'Enalapril', 'level': 4, 'score': 0.5095868}, {'id': 'https://openalex.org/C2777788586', 'wikidata': 'https://www.wikidata.org/wiki/Q2096745', 'display_name': 'Hereditary angioedema', 'level': 2, 'score': 0.4892821}, {'id': 'https://openalex.org/C27016395', 'wikidata': 'https://www.wikidata.org/wiki/Q128861', 'display_name': 'Angiotensin-converting enzyme', 'level': 3, 'score': 0.47655538}, {'id': 'https://openalex.org/C2779611605', 'wikidata': 'https://www.wikidata.org/wiki/Q288280', 'display_name': 'ACE inhibitor', 'level': 4, 'score': 0.42528588}, {'id': 'https://openalex.org/C2779384505', 'wikidata': 'https://www.wikidata.org/wiki/Q17007513', 'display_name': 'Concomitant', 'level': 2, 'score': 0.41797847}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3963837}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.37446585}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.25703722}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.23147693}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.16721562}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.10846037}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.08110234}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000799', 'descriptor_name': 'Angioedema', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D002317', 'descriptor_name': 'Cardiovascular Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D000799', 'descriptor_name': 'Angioedema', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000799', 'descriptor_name': 'Angioedema', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000806', 'descriptor_name': 'Angiotensin-Converting Enzyme Inhibitors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000806', 'descriptor_name': 'Angiotensin-Converting Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001920', 'descriptor_name': 'Bradykinin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001920', 'descriptor_name': 'Bradykinin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002317', 'descriptor_name': 'Cardiovascular Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012084', 'descriptor_name': 'Renin-Angiotensin System', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012084', 'descriptor_name': 'Renin-Angiotensin System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/all.12680', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12680', 'source': {'id': 'https://openalex.org/S68090385', 'display_name': 'Allergy', 'issn_l': '0105-4538', 'issn': ['0105-4538', '1398-9995'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26119220', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/all.12680', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12680', 'source': {'id': 'https://openalex.org/S68090385', 'display_name': 'Allergy', 'issn_l': '0105-4538', 'issn': ['0105-4538', '1398-9995'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.85, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1569639383', 'https://openalex.org/W180946569', 'https://openalex.org/W1919376524', 'https://openalex.org/W1954040225', 'https://openalex.org/W1969867564', 'https://openalex.org/W1971042333', 'https://openalex.org/W1979363233', 'https://openalex.org/W1983734540', 'https://openalex.org/W1987529569', 'https://openalex.org/W1988251619', 'https://openalex.org/W1988500109', 'https://openalex.org/W2016587814', 'https://openalex.org/W2025267980', 'https://openalex.org/W2028328768', 'https://openalex.org/W2031123437', 'https://openalex.org/W2047425163', 'https://openalex.org/W2053292076', 'https://openalex.org/W2064130493', 'https://openalex.org/W2066833658', 'https://openalex.org/W2079064476', 'https://openalex.org/W2084666115', 'https://openalex.org/W2087322815', 'https://openalex.org/W2113698123', 'https://openalex.org/W2114792859', 'https://openalex.org/W2124521810', 'https://openalex.org/W2128921112', 'https://openalex.org/W2134751690', 'https://openalex.org/W2152798629', 'https://openalex.org/W2156262926', 'https://openalex.org/W2158869730', 'https://openalex.org/W2160643831', 'https://openalex.org/W2161832913', 'https://openalex.org/W2164980913', 'https://openalex.org/W2166848757', 'https://openalex.org/W2168907840', 'https://openalex.org/W2170568891', 'https://openalex.org/W2600740694', 'https://openalex.org/W329280961', 'https://openalex.org/W4252939281'], 'related_works': ['https://openalex.org/W47014614', 'https://openalex.org/W4379465895', 'https://openalex.org/W3127674858', 'https://openalex.org/W2799334882', 'https://openalex.org/W2443625755', 'https://openalex.org/W2412776582', 'https://openalex.org/W2071694201', 'https://openalex.org/W2066408420', 'https://openalex.org/W2052110965', 'https://openalex.org/W1995980503'], 'abstract_inverted_index': {'Abstract': [0], 'During': [1], 'the': [2, 39, 77, 111, 128], 'last': [3], 'years,': [4], 'two': [5], 'new': [6], 'cardiovascular': [7], 'drug': [8], 'classes,': [9], 'namely': [10], 'inhibitors': [11, 53], 'of': [12, 38, 47, 68, 94, 107, 130], 'DPP': [13, 51], 'IV': [14, 52], 'or': [15, 119], 'neprilysin,': [16], 'have': [17, 143], 'been': [18], 'developed.': [19], 'In': [20, 74], 'both': [21], 'cases,': [22], 'there': [23, 99], 'is': [24, 62, 100], 'clinical': [25, 102], 'evidence': [26, 103], 'for': [27], 'their': [28], 'potential': [29], 'to': [30, 147], 'induce': [31], 'angioedema': [32, 48, 81, 122, 131], 'as': [33], 'known': [34], 'already': [35], 'from': [36], 'blockers': [37], 'renin–angiotensin–aldosterone': [40], 'system': [41], '(': [42], 'RAAS': [43], ').': [44], 'The': [45], 'majority': [46], 'induced': [49, 82], 'by': [50, 66, 83, 124], 'occurs': [54], 'during': [55], 'concomitant': [56], 'treatment': [57, 116], 'with': [58], 'ACE': [59], 'i': [60], 'and': [61], 'therefore': [63], 'likely': [64], 'mediated': [65], 'overactivation': [67], 'bradykinin': [69, 95], 'type': [70], '2': [71], 'receptors': [72], '(B2).': [73], 'striking': [75], 'contrast,': [76], 'molecular': [78], 'pathways': [79], 'causing': [80], 'neprilysin': [84], 'inhibitors,': [85], 'that': [86, 105], 'is,': [87], 'sacubitril,': [88], 'are': [89], 'unclear,': [90], 'although': [91], 'a': [92], 'contribution': [93], 'appears': [96], 'likely.': [97], 'Nevertheless,': [98], 'no': [101, 144], 'suggesting': [104], 'inhibition': [106], 'B2': [108], 'might': [109], 'relieve': [110], 'symptoms': [112], 'and/or': [113], 'prevent': [114], 'invasive': [115], 'including': [117], 'coniotomy': [118], 'tracheotomy': [120], 'in': [121, 137], 'caused': [123], 'these': [125], 'drugs.': [126], 'Therefore,': [127], 'risk': [129], 'should': [132], 'always': [133], 'be': [134], 'considered,': [135], 'especially': [136], 'ambulatory': [138], 'care': [139], 'situations': [140], 'where': [141], 'patients': [142], 'rapid': [145], 'access': [146], 'intensive': [148], 'care.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1502879542', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-24T03:57:15.765322', 'created_date': '2016-06-24'}